65
Views
15
CrossRef citations to date
0
Altmetric
Review

The clinical potential of antiepileptic gene therapy

Pages 1771-1776 | Published online: 23 Feb 2005

Bibliography

  • HAUSER WA, HESDORFFER DC: Epilepsy: Frequency Causes and Consequences. Hauser WA, Hesdorffer DC (Eds),Demos Publications, New York, USA (1990).
  • KWAN P, BRODIE MJ: Early identification of refractory epilepsy. N Engl. J. Med. (2000) 342:314–319.
  • MCCOWN TJ, XIAO X, LI J,BREESE GR, SAMULSKI RJ: Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector. Brain Res. (1996) 713:99–107.
  • NALDININ L, BLOMER U, GAGE FH, TRONO D, VERMA IM: Efficient transfer, integration and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc. Nat. Acad. Sci (1996) 93:11382–11388.
  • LE GAL LA SALLE G, ROBERT JJ, BERRAD S et al.: An adenovirus vector for gene transfer into neurons and glia in the brain. Science (1993) 259:988–990.
  • DURING MJ, NAEGELE JRO'MALLEY KL, GELLER Al: Long-term behavioral recovery in Parkinsonian rats by an HSV vector expressing tyrosine hydoxylase. Science (1994) 266:1399–1640.
  • XIAO X, LI J, SAMULSKI RJ: Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus. Virol. (1998) 72:2224–2232.
  • GRIMM D, KERN A, RITTNER K, KLEINSCHMIDT JA: Novel tools for production and purification of recombinant adeno-associated virus vectors. Hum. Gene Ther. (1998) 9:2745–2760.
  • STILWELL JL, SAMULSKI RJ: Adeno-associated virus vectors for therapeutic gene transfer. Biotechniques (1993) 34:148–154.
  • •This article provides a good review of both the properties and clinical applications of AAV vectors.
  • ENGEL J: Excitation and inhibition inepilepsy. Can. J. Neural. Sci (1996) 23:167–174.
  • HOLMES GL: Epilepsy in the developing brain: lessons from the laboratory and clinic. Epilepsia (1997) 38:12–30.
  • BERNARD C, HIRSCH JC, BEN-ARI Y: Excitation and inhibition in temporal lobe epilepsy: a close encounter. Adv. Neurol (1999) 79:821–828.
  • YING Z, NAJM IM: Mechanisms of epileptogenicity in focal malformation caused by abnormal cortical development. Neurosurg. Clin. N Am. (2002) 13:27–33.
  • MAZARATI AM, LIU H, SOOMETS U et al.: Galanin modulation of seizures and seizure modulation of hippocampal galanin in animal models of status epilepticus. J.Neurosci. (1998) 18:10070–10077.
  • WOLDBYE DP, LARSEN PJ,MIKKELSEN JD et al.: Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors. Nat. Med. (1997) 3:761–764.
  • VEZZANI A, SPERK G, COLMERS WF: Neuropeptide Y: emerging evidence for a functional role in seizure modulation. Trends Neurosci (1991) 22:25–30.
  • PATRYLO PR, VAN DEN POL AN, SPENCER DD, WILLIAMSON A: NPY inhibits glutaminergic excitation in the epileptic human dentate gyrus.Neurophysiol (1999) 82:478–483.
  • MAZARATI AM, WASTERLAIN CG: Anticonvulsant effects of four neuropeptides in the rat hippocampus duringself-sustaining status epilepticus. Neurosci. Lett. (2002) 331:123–127.
  • •These investigations compare the antiseizure profiles of galanin, neuropeptide Y, somatostatin and dynorphin, showing both similarities and differences.
  • GERNERT M, THOMPSON KW, LOSCHER W, TOBIN AJ: Genetically engineered GABA-producing cells demonstrate anticonvulsant effects and long-term transgene expression when transplanted into the central piriform cortex of rats. Exp. Neurol (2002) 176:183–192.
  • HUBER A, PADRUN V, DEGLON N, AEBISCHER P, MOHLER H,BOISON D: Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy. Proc. Nat. Acad. Sci. USA (2001) 98:7611–7616.
  • MONYER H, SPRENGEL R, SCHOEPFER R et al.: Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science (1992) 256:1217–1221.
  • HOLLMANN M, HEINEMANN S: Cloned glutamate receptors. Anna. Rev Neurosci (1994) 17:31–108.
  • HABERMAN RP, CRISWELL HE, SNOWDY S et al.: Therapeutic liabilities of in vivo viral vector tropism: adeno-associated virus (AAV) vectors, NMDAR 1 antisense and focal seizure sensitivity. MoL Titer (2002) 6:495–500.
  • ••These studies not only show thatvector-derived antisense works in vivo, but also demonstrate the liability of vector/ promoter tropism inherent to the fmal outcome of receptor or ion channel manipulation.
  • HABERMAN RP, MCCOWN TJ, SAMULSKI RJ: Inducible long-term gene expression in brain with adeno-associated virus gene transfer. Gene Ther. (1998) 5:1604–1611.
  • CHRISTIE JM, SCHOPPA NE, WESTBROOK GL: Tufted cell dendrodendritic inhibition in the olfactory bulb is dependent on NMDA receptor activity.j Neurophysiol (2001) 85:169–173.
  • HABERMAN RP, SMAULSKI RJ, MCCOWN TJ: Attenuation of seizures and neuronal death by adeno-associated virus (AAV) vector galanin expression and secretion. Nat. Med. (2003) 9:1076–1080.
  • ••These studies established the ability ofAAV-mediated galanin expression and constitutive secretion of the peptide to attenuate focal seizures and prevent seizure-induced cell death in vivo.
  • UN ED, RICHICHI C, YOUNG D, BAER K, VEZZANI A, DURING MJ: Recombinant AAV-mediated expression of galanin in rat hippocampus suppresses seizure development. Eur. Neurosci. (2003) 18:2087–2092.
  • RICHICHI C, UN ED, STEFANIN E et al: Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virusvector neuropeptide Y expression in the rat hippocampus.j. Neurosci (2003) 24:3051-3059.These studies established the ability of AAV-mediated expression of prepro-neuropeptide Y to attenuate seizures in vivo.
  • BLACKLOW NR, HOGGAN MD, ROWE WP: Serologic evidence for human infections with adenovirus-associated viruses. J. Natl. Cancer Inst. (1968) 40:319–327.
  • BLACKLOW NR, HOGGAN MD, SERENO MS et al.: A seroepidemiologic study of adenovirus-associated virus infection in infants and children. Am. Epidemiol (1971) 94:359–366.
  • CHIRMULE NK, PROPERT K, MAGOSIN S, QIAN Y, QIAN R, WILSON J: Immune responses to adenovirus and adeno-associated virus in humans. Gene Ther (1999) 6:1574–1583.
  • ERLES KP, SEBOKOVA P, SCHLEHOFER JR: Update on the prevalence of serum antibodies (IgG and IgM) to adeno-associated virus. J. Med. Vim]. (1999) 59:406–411.
  • PEDEN SC, BURGER C,MUZYCZKA N, MANDEL RL: Circulating anti-wild type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain. J. Vim]. (2004) 78:6344–6359.
  • ••These studies dramatically illustrate theinfluence of wild-type AAV pre-immunisation on recombinant AAV vector transduction viability in vivo.
  • HOLMES GL, BEN-ARI Y: Seizing hold of seizures. Nat. Med. (2003) 9:994–996.
  • •A good commentary on issues pertinent to antiepileptic gene therapy.
  • RABINOWITZ JE, BOWLES DE, FAUST SM et al.: Cross-dressing the virion: the transcapsidation of adeno-associated virus serotypes functionally defines subgroups. J. Vim]. (2004) 78:4421–4432.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.