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Review

Hepatocyte growth factor gene therapy for islet transplantation

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Pages 507-518 | Published online: 03 Mar 2005

Bibliography

  • MOSKALEWSKI S: Isolation and culture of the islets of Langerhans of the guinea pig. Gen. Comp. Endocrinol. (1965) 5:342–353.
  • SUTHERLAND D, GRUESSNER R: Current status of pancreas transplantation for the treatment of type 1 diabetes. Clin. Blab. (1997) 2:152–156.
  • BECKER BN, ODORICO JS, BECKER YT et al: Simultaneous pancreas-kidney and pancreas transplantation. J. Am. Soc. Nephrol. (2001) 12:2517–2527.
  • SHAPIRO AM, LAKEY JR, RYAN EA et al.: Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl. I Med. (2000) 343:230–238.
  • ••The Edmonton protocol and itssuccessful application in patients with type 1 diabetes.
  • RYAN EA, LAKEY JR, RAJOTTE RV et al.: Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes (2001) 50:710–719.
  • RYAN EA, LAKEY JR, PATY BW et al.: Successful islet transplantation: continued insulin reserve provides long-term glycemic control. Diabetes (2002) 51:2148–2157.
  • BRETZEL RG, HERING BJ, FEDERLIN KF: Islet cell transplantation in diabetes mellitus-from bench to bedside. Exp. Clin. Endocrinol. Diabetes (1995) 103\(Suppl. 2):143–159.
  • HAYEK A, BEATTIE GM: Alternatives to unmodified human islets for transplantation. Curr. Blab. Rep. (2002) 2:371–376.
  • •Different approaches to improve islet transplantation.
  • SORENSON RL, BRELJE TC: Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones. Horm. Metab. Res. (1997) 29:301–307.
  • BONNER-WEIR S, DEERY D, LEAHY JL, WEIR GC: Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion. Diabetes (1989) 38:49–53.
  • HAHN VON DORSCHE H, SCHAFER H, TITLBACH M: Histophysiology of the obesity-diabetes syndrome in sand rats. Adv. Anat. Embryo]. Cell Biol. (1994) 130:1–95.
  • BOUVVENS L, KLOPPEL G: Islet cell neogenesis in the pancreas. Virchows Arch. (1996) 427:553–560.
  • SCAGLIA L, SMITH FE, BONNER-WEIR S: Apoptosis contributes to the involution of beta cell mass in the post partum rat pancreas. Endocrinology (1995) 136:5461–5468.
  • MIZUNO N, YOSHITOMI H, ISHIDA H et al.: Altered bc1-2 and bax expression and intracellular Ca2+ signaling in apoptosis of pancreatic cells and the impairment of glucose-induced insulin secretion. Endocrinology (1998) 139:1429–1439.
  • MATHIS D, VENCE L, BENOIST C: Beta-cell death during progression to diabetes. Nature (2001) 414:792–798.
  • DAVALLI AM, SCAGLIA L, ZANGEN DH, HOLLISTER J, BONNER-WEIR S, WEIR GC: Vulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function. Diabetes (1996) 45:1161–1167.
  • ••Reports drastic decreases in beta cell massafter islet transplantation under the kidney capsule of mice.
  • BUTLER AE, JANSON J, BONNER-WEIR S, RITZEL R, PIZZA RA, BUTLER PC: Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes (2003) 52:102–110.
  • GARCIA-OCANA A, VASAVADA RC, TAKANE KK, CEBRIAN A, LOPEZ-TALAVERA JC, STEWART AF: Using beta-cell growth factors to enhance human pancreatic Islet transplantation. Clin. Endocrinol. Metab. (2001) 86:984–988.
  • •Describes in vitro and in vivo actions of different growth factors in the beta cell.
  • NAKAMURA T, NAWA K, ICHIHARA A: Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats. Biochem. Biophys. Res. Commun. (1984) 122:1450–1459.
  • FURGE KA, ZHANG YW, VANDE WOUDE GF: Met receptor tyrosine kinase: enhanced signaling through adapter proteins. Oncogene (2000) 19:5582–5589.
  • STUART KA, RIORDAN SM, LIDDER S, CROSTELLA L, WILLIAMS R, SKOUTERIS GG: Hepatocyte growth factor/scatter factor-induced intracellular signalling. hat. J. Exp. Pathol. (2000) 81:17–30.
  • KITTA K, DAY RIVI, IKEDA T, SUZUKI YJ: Hepatocyte growth factor protects cardiac myocytes against oxidative stress-induced apoptosis. Free Radic. Biol. Med. (2001) 31:902–910.
  • FAN S, MAO YX, WANG J-A et al.: The cytokine hepatocyte growth factor/ scatter factor inhibits apoptosis and enhances DNA repair by a common mechanism involving signaling through phosphatidyl inositol 3' kinase. Oncogene (2000) 19:2212–2223.
  • LIU Y: Hepatocyte growth factor promotes renal epithelial cell survival by dual mechanisms. Am. J. Physiol. (1999) 277:F624–F633.
  • ZHANG L, HIMI T, MORITA I, MUROTA S: Hepatocyte growth factor protects cultured rat cerebellar granule neurons from apoptosis via the phosphatidylinosito1-3 kinase/Akt pathway. Neurosci. Res. (2000) 59:489–496.
  • KOSAI K, MATSUMOTO K, NAGATA S, TSUJIMOTO Y, NAKAMURA T: Abrogation of Fas-induced fulminant hepatic failure in mice by hepatocyte growth factor. Biochem. Biophys. Res. Commun. (1998) 244:683–690.
  • BLADT F, RIETHMACHER D, ISENMANN S, AGUZZI A, BIRCHMEIER C: Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature (1995) 376:768–771.
  • UEHARA Y, MINOWA O, MORI C et al.: Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/ scatter factor. Nature (1995) 373:702–705.
  • CALVO EL, BOUCHER C, PELLETIER G, MORISSET J: Ontogeny of hepatocyte growth factor and c-met/hgf receptor in rat pancreas. Biochem. Biophys. Res. Commun. (1996) 229:257–263.
  • TSUDA H, IWASE T, MATSUMOTO K et al.: Immunohistochemical localization of hepatocyte growth factor protein in pancreas islet A-cells of man and rats. fpn. Cancer Res. (1992) 83:1262–1266.
  • OTONKOSKI T, CIRULLI V, BEATTIE M et al.: A role for hepatocyte growth factor/scatter factor in fetal mesenchyme-induced pancreatic beta-cell growth. Endocrinology (1996) 137:3131–3139.
  • BULOTTA A, DI CESARE E, PONTE E et al.: Increased c-met expression during ductal beta cell neogenesis in experimental autoimmune diabetes. Growth Factors (2001) 19:259–267.
  • MENKE A, YAMAGUCHI H, GIEHL K, ADLER G: Hepatocyte growth factor and fibroblast growth factor 2 are overexpressed after cerulein-induced acute pancreatitis. Pancreas (1999) 18:28–33.
  • WARZECHA Z, DEMBINSKI A, KONTUREK PC et al.: Hepatocyte growth factor attenuates pancreatic damage in caerulein-induced pancreatitis in rats. Ear: .1. Pharmacol (2001) 430:113–121.
  • BEATTIE GM, RUBIN JS, MALLY MI, OTONKOSKI T, HAYEK A: Regulation of proliferation and differentiation of human fetal pancreatic islet cells by extracellular matrix, hepatocyte growth factor, and cell-cell contact. Diabetes (1996) 45:1223–1228.
  • HAYEK A, BEATTIE GM, CIRULLI V, LOPEZ AD, RICORDI C, RUBIN JS: Growth factor/matrix-induced proliferation of human adult beta-cells. Diabetes (1995) 44:1458–1460.
  • •First study describing the mitogenic effects of HGF in the adult human beta cell.
  • OTONKOSKI T, BEATTIE GM, RUBIN JS, LOPEZ AD, BAIRD A, HAYEK A: Hepatocyte growth factor/ scatter factor has insulinotropic activity in human fetal pancreatic cells. Diabetes (1994) 43:947–953.
  • •First study describing the mitogenic effects of HGF in the fetal human beta cell.
  • OTONKOSKI T, MALLY MI, HAYEK A: Opposite effects of beta-cell differentiation and growth on reg expression in human fetal pancreatic cells. Diabetes (1994) 43:1164–1166.
  • GAHR S, MERGER M, BOLLHEIMER LC, HAMMERSCHMIED CG, SCHOLMERICH J, HUGL SR: Hepatocyte growth factor stimulates proliferation of pancreatic beta-cells particularly in the presence of subphysiological glucose concentrations. J. MM. Endocrinol (2002) 28:99–110.
  • BOUWENS L, LU WG, DE KRUGER R: Proliferation and differentiation in the human fetal endocrine pancreas. Diabetologia (1997) 40:398–404.
  • HALBAN PA, PRAZ GZ, WOLLHEIM CB: Abnormal glucose metabolism accompanies failure of glucose to stimulate release from a rat pancreatic cell line (RINm5F). Biochem. 1 (1983) 212:439–443.
  • BEATTIE GM, MONTGOMERY AM, LOPEZ AD et al.: A novel approach to increase human islet cell mass while preserving beta-cell function. Diabetes (2002) 51:3435–3439.
  • ••Describes how HGF can be used to expandhuman beta cells in vitro while preserving their function.
  • MASHIMA H, SHIBATA H, MINE T, KOJIMA I: Formation of insulin-producing cells from pancreatic acinar AR42J cells by hepatocyte growth factor. Endocrinology (1996) 137:3969–3976.
  • GARCIA-OCANA A, TAKANE KK, REDDY VT, LOPEZ-TALAVERA J-C, VASAVADA RC, STEWART AF: Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death. J. Biol. Chem. (2003) 278:343–351.
  • ••First study describing the use of genetherapy with HGF gene to improve islet transplant performance in mice.
  • GARCIA-OCANA A, TAKANE KK, SYED MA, PHILBRICK WM, VASAVADA RC, STEWART AF: Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia. I Biol. Chem. (2000) 275:1226–1232.
  • ••First study describing the in vivo effects ofHGF overexpression in the pancreatic beta cell of transgenic mice.
  • SCAGLIA L, CAHILL CJ, FINEGOOD DT, BONNER-WEIR S: Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat. Endocrinology(1997) 138:1736–1741.
  • XIAO GH, JEFFERS M, BELLACOSA A, MITSUUCHI Y, VANDE WOUDE GF, TESTA JR: Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. Proc. Natl. Acad. Sci. USA (2001) 98:247–252.
  • SUZUKI A, HAYASHIDA M, KAWANO H, SUGIMOTO K, NAKANO T, SHIRAKI K: Hepatocyte growth factor promotes cell survival from fas-mediated cell death in hepatocellular carcinoma cells via Akt activation and Fas-death-inducing signaling complex suppression. Hepatology (2000) 32:796–802.
  • DAI C, LI Y, YANG J, LIU Y: Hepatocytegrowth factor preserves beta cell mass and mitigates hyperglycemia in streptozotocin-induced diabetic mice. J. Biol. Chem. (2003) 278:27080–27087.
  • GARCIA-OCANA A, VASAVADA R C, CEBRIAN A et al.: Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice. Diabetes (2001) 50:2752–2762.
  • ••Study indicating the potential of HGFoverexpression in the beta cell as a therapeutic strategy for improving islet transplant performance.
  • HALVORSEN TL, BEATTIE GM, LOPEZ AD, HAYEK A, LEVINE F: Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide M vitro. I Endocrinol (2000) 166:103–109.
  • DAVALLI AM, OGAWA Y, RICORDI C, SCHARP DW, BONNER-WEIR S, WEIR GC: A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice. Transplantation (1995) 59:817–820.
  • CONTRERAS JL, ECKHOFF DE, CARTNER S et al.: Long-term functional islet mass and metabolic function after xenoislet transplantation in primates. Transplantation (2000) 69:195–201.
  • PILEGGI A, RICORDI C, ALESSIANI M, INVERARDI L: Factors influencing Islet of Langerhans graft function and monitoring. Chim. Acta (2001) 310:3–16.
  • MELLERT J, HERING BJ, LIU X et al.: Critical islet mass for successful porcine islet autotransplantation. MM. Med. (1999) 77:126–129.
  • NAKANO M, YASUNAMI Y, MAKI T et al.: Hepatocyte growth factor is essential for amelioration of hyperglycemia in streptozotocin-induced diabetic mice receiving a marginal mass of intrahepatic islet grafts. Transplantation (2000) 69:214–221.
  • ••First study describing the use of in vivoadministration of HGF and dextran sulfate to improve islet transplantation in rodents.
  • ZIONCHECK TF, RICHARDSON L, LIU J et al.: Sulfated oligosaccharides promote hepatocyte growth factor association and govern its mitogenic activity. J. Biol. Chem. (1995) 270:16871–16878.
  • ZIONCHECK TF, RICHARDSON L, DEGUZMAN GG, MODI NB, HANSEN SE, GOD OWSKI PJ: The pharmacolkinetics, tissue localization, and metabolic processing of recombinant human hepatocyte growth factor after intravenous administration in rats. Endocrinology (1994) 134:1879–1887.
  • ROOS F, RYAN AM, CHAMOW SM, BENNETT GL, SCHWALL RH: Induction of liver growth in normal mice by infusion of hepatocyte growth factor/scatter factor. Jim. .1 Physiol (1995) 268:G380–G386.
  • TAKAYAMA H, LAROCHELLE WJ, SHARP R et al: Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor. Proc. Natl. Acad. Sci. USA (1997) 94:701–706.
  • TAKAYAMA H, LAROCHELLE WJ, ABNIS SG, OTSUKAT, MERLINO G: Renal tubular hyperplasia, polycystic disease, and glomerulosclerosis in transgenic mice overexpressing hepatocyte growth factor/scatter factor. Lab. Invest. (1997) 77:131–138.
  • BECKER TC, NOEL RJ, COATS WS et al.: Use of recombinant adenovirus for metabolic engineering of mammalian cells. Methods Cell Biol. (1994) 43:161–189.
  • WEBER M, DENG S, KUCHER T, SHAKED A, KETCHUM RJ, BRAYMAN KL: Adenoviral transfection of isolated pancreatic islets: a study of programmed cell death (apoptosis) and islet function. &mg. Res. (1997) 69:23–32.
  • LEIBOWITZ G, BEATTIE GM, KAFRI T et al.: Gene transfer to human pancreatic endocrine cells using viral vectors. Diabetes (1999) 48:745–753.
  • MURUVE DA, MANFRO RC, STROM TB, LIBERMANN TA: Ex vivo adenovirus-mediated gene delivery leads to long-term expression in pancreatic islet transplants. Transplantation (1997) 64:542–546.
  • LOPEZ-TALAVERA JC, GARCIA-OCANA A, SIPULA I et al.: Hepatocyte growth factor gene therapy for pancreatic islets in diabetes: reducing the minimal islet transplant mass required in a glucocorticoid-free rat model of allogeneic portal vein islet transplantation. Endocrinology (2004) 145:467–474.
  • ••Study describing the usefulness of genetherapy with HGF gene to improve islet allograft performance in rats treated with the irnmunosuppressive regime used in the Edmonton protocol.
  • ZENG Y, RICORDI C, LENDOIRE J et al.: The effect of prednisone on pancreatic islet autografts in dogs. Surgery (1993) 113:98–102.

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