Gene transfer to epidermal stem cells: implications for tissue engineering

Bibliography

• DOVER R: Cell kinetics of keratinocytes. In: The Keratinocyte Handbook Leigh IM, Lane EB, Watt FM (Eds), Cambridge University Press (1994):203–234.
   Google Scholar
• BARRANDON Y, GREEN H: Three clonal types of keratinocyte with different capacities for multiplication. Proc. Nati Acad. Sci. USA (1987) 84:2302–2306.
   PubMed Web of Science ®Google Scholar
• WATT FM, HOGAN BL: Out of Eden: stem cells and their niches. Science (2000) 287:1427–1430.
   PubMed Web of Science ®Google Scholar
• BICKENBACH JR, MACKENZIE IC: Identification and localization of label-retaining cells in hamster epithelia. Invest. Dennatol (1984) 82:618–622.
   PubMed Web of Science ®Google Scholar
• BICKENBACH JR, MCCUTECHEON J, MACKENZIE IC: Rate of loss of tritiated thymidine label in basal cells in mouse epithelial tissues. Cell Tissue Kinet. (1986) 19:325–333.
   Google Scholar
• COTSARELIS G, SUN TT, LAVKER RIVI: Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell (1990) 61:1329–1337.
   PubMed Web of Science ®Google Scholar
• MORRIS RJ, POTTEN CS: Slowly cycling (label-retaining) epidermal cells behave like clonogenic stem cells in vitro. Cell Prolif (1994) 27:279–289.
   PubMed Web of Science ®Google Scholar
• ALONSO L, FUCHS E: Stem cells of the skin epithelium. Proc. Nati Acad. Sci. USA (2003) 100:11830–11835.
   PubMed Web of Science ®Google Scholar
• POTTEN CS, SCHOFIELD R, LAJTHA LG: A comparison of cell replacement in bone marrow, testis and three regions of surface epithelium. Biochlin. Biophys. Acta (1979) 560:281–299.
   PubMed Web of Science ®Google Scholar
• MACKENZIE IC: Retroviral transduction of murine epidermal stem cells demonstrates clonal units of epidermal structure. J. Invest. Dennatol (1997) 109:377–383.
   PubMed Web of Science ®Google Scholar
• TUMBAR T, GUASCH G, GRECO V et al: Defining the epithelial stem cell niche in skin. Science (2004) 303:359–363.
   PubMed Web of Science ®Google Scholar
• MORRIS RJ, LIU Y, MARLES L et al.: Capturing and profiling adult hair follicle stem cells. Nat. Biotechnol (2004) 22:411–417.
   PubMed Web of Science ®Google Scholar
• JONES PH, WATT FM: Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell (1993) 73:713–724.
   PubMed Web of Science ®Google Scholar
• JENSEN UB, LOWELL S, WATT FM: The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: a new view based on whole-mount labelling and lineage analysis. Development (1999) 126:2409–2418.
   PubMed Web of Science ®Google Scholar
• ALBERT MR, FOSTER RA, VOGEL JC: Murine epidermal label-retaining cells isolated by flow cytometry do not express the stem cell markers CD34, Sca-1, or Flk-1. j Invest. Dermatol (2001) 117:943–948.
   PubMed Web of Science ®Google Scholar
• PELLEGRINI G, DELLAMBRA E, GOLISANO 0 et al: p63 identifies keratinocyte stem cells. Proc. Natl. Acad. Sci. USA (2001) 98:3156–3161.
   PubMed Web of Science ®Google Scholar
• LYLE S, CHRISTOFIDOU-SOLOMIDOU M, LIU Yet al.: The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J. Cell Sci. (1998) 111:3179–3188.
   Google Scholar
• BATA-CSORGO Z, HAMMERBERG C, VOORHEES JJ, COOPER KD: Flow cytometric identification of proliferative subpopulations within normal human epidermis and the localization of the primary hyperproliferative population in psoriasis. J. Exp. Med. (1993) 178:1271–1281.
   PubMed Web of Science ®Google Scholar
• LI A, SIMMONS PJ, KAUR P: Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype. Proc. Nati Acad. Sci. USA (1998) 95:3902–3907.
   PubMed Web of Science ®Google Scholar
• KAUR P, LI A: Adhesive properties of human basal epidermal cells: an analysis of keratinocyte stem cells, transit amplifying cells, and postmitotic differentiating cells. .1. Invest. Dermatol (2000) 114:413–420.
   PubMed Web of Science ®Google Scholar
• TANI H, MORRIS RJ, KAUR P: Enrichment for murine keratinocyte stem cells based on cell surface phenotype. Proc. Natl. Acad. Sci. USA (2000) 97:10960–10965.
   PubMed Web of Science ®Google Scholar
• TREMPUS CS, MORRIS RJ, BORTNER CD et al.: Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34.1 Invest. Dermatol (2003) 120:501–511.
   Google Scholar
• BICKENBACH JR, CHISM E: Selectionand extended growth of murine epidermal stem cells in culture. Exp. Cell Res. (1998) 244:184–195.
   PubMed Web of Science ®Google Scholar
• TERUNUMA A, JACKSON KL, KAPOOR V, TELFORD WG, VOGEL JC: Side population keratinocytes resembling bone marrow side population stem cells are distinct from label-retaining keratinocyte stem cells. J. Invest. Dermatol (2003) 121:1095–1103.
   PubMed Web of Science ®Google Scholar
• LIANG L, BICKENBACH JR: Somatic epidermal stem cells can produce multiple cell lineages during development. Stem Cells (2002) 20:21–31.
   PubMed Web of Science ®Google Scholar
• MANSBRIDGE J: Tissue-engineered skin substitutes. Expert Opin. Biol. Ther: (2002) 2:25–34.
   PubMed Web of Science ®Google Scholar
• PINNEY E, LIU K, SHEEMAN B, MANSBRIDGE J: Human three-dimensional fibroblast cultures express angiogenic activity.Physiol (2000)183:74–82.
   Web of Science ®Google Scholar
• LIU K, YANG Y, MANSBRIDGE J: Comparison of the stress response to cryopreservation in monolayer and three-dimensional human fibroblast cultures: stress proteins, MAP kinases, and growth factor gene expression. Tissue Eng. (2000) 6:539–554.
   PubMedGoogle Scholar
• BELL E, EHRLICH HP, BUTTLE DJ, NAKATSUJI T: Living tissue formed M vitro and accepted as skin-equivalent tissue of full thickness. Science (1981) 211:1052–1054.
   PubMed Web of Science ®Google Scholar
• BELL E, EHRLICH HP, SHER S et al.: Development and use of a living skin equivalent. Plast. Reconsic &rig. (1981) 67:386–392.
   PubMed Web of Science ®Google Scholar
• PARENTEAU NL, BILBO P, NOLTE CJ, MASON VS, ROSENBERG M: The organotypic culture of human skin keratinocytes and fibroblasts to achieve form and function. Cytotechnology (1992) 9:163–171.
   PubMed Web of Science ®Google Scholar
• WILKINS LM, WATSON SR, PROSKY SJ, MEUNIER SF, PARENTEAU NL: Development of a bilayered living skin equivalent construct for clinical applications. Biotechnol Bioeng. (1994) 43:747–756.
   PubMed Web of Science ®Google Scholar
• BRISCOE DM, DHARNIDHARKA VR, ISAACS C et al: The allogeneic response to cultured human skin equivalent in the hu-PBL-SCID mouse model of skin rejection. Transplantation (1999) 67:1590–1599.
   PubMed Web of Science ®Google Scholar
• MEANA A, IGLESIAS J, DEL RIO M et al.: Large surface of cultured human epithelium obtained on a dermal matrix based on live fibroblast-containing fibrin gels. Burns (1998) 24:621–630.
   Google Scholar
• RIO MD, LARCHER F, MEANA A et al: Nonviral transfer of genes to pig primary keratinocytes. Induction of angiogenesis by composite grafts of modified keratinocytes overexpressing VEGF driven by a keratin promoter. Gene Ther: (1999) 6:1734–1741.
   Google Scholar
• GEER DJ, ANDREADIS ST: A novel role of fibrin in epidermal healing: plasminogen-mediated migration and selective detachment of differentiated keratinocytes. Livest. Dermatol (2003) 121:1210–1216.
   PubMed Web of Science ®Google Scholar
• PELLEGRINI G, RANNO R, STRACUZZI G et al.: The control of epidermal stem cells (holoclones) in the treatment of massive full-thickness burns with autologous keratinocytes cultured on fibrin. Transplantation (1999) 68:868–879.
   PubMed Web of Science ®Google Scholar
• SAKIYAMA SE, SCHENSE JC, HUBBELL JA: Incorporation of heparin-binding peptides into fibrin gels enhances neurite extension: an example of designer matrices in tissue engineering. FASEB (1999) 13:2214–2224.
   PubMed Web of Science ®Google Scholar
• SAKIYAMA-ELBERT SE, HUBBELL JA: Development of fibrin derivatives for controlled release of heparin-binding growth factors. Control. Release (2000) 65:389–402.
   PubMed Web of Science ®Google Scholar
• SAKIYAMA-ELBERT SE, HUBBELL JA:Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix. Control. Release (2000) 69:149–158.
   PubMed Web of Science ®Google Scholar
• PANDIT AS, WILSON DJ, FELDMAN DS: Fibrin scaffold as an effective vehicle for the delivery of acidic fibroblast growth factor (FGF-1). Biomater: Appl. (2000) 14:229–242.
   PubMed Web of Science ®Google Scholar
• GEER DJ, SWARTZ DD, ANDREADIS ST: Cell-controlled delivery of keratinocyte growth factor promotes wound healing M vitro and in vivo. (2004) (In Press).
   Google Scholar
• ASBILL C, KIM N, EL-KATTAN A et al.: Evaluation of a human bio-engineered skin equivalent for drug permeation studies. Pharm. Res. (2000) 17:1092–1097.
   PubMed Web of Science ®Google Scholar
• ROBINSON MK, OSBORNE R, PERKINS MA: In vitro and human testing strategies for skin irritation. Ann. NY Acad. Sci. (2000) 919:192–204.
   PubMedGoogle Scholar
• WAGNER H, KOSTKA KH, LEHR CM, SCHAEFER UF: Interrelation of permeation and penetration parameters obtained from M vitro experiments with human skin and skin equivalents. J. Control. Release (2001) 75:283–295.
   PubMed Web of Science ®Google Scholar
• HAYDEN PJ, AYEHUNIE S, JACKSON GR et al: In vitro skin equivalent models for toxicity testing. In: Alternative Toxicological Methods for the New Millennium. Katz S, Salem H (Eds), CRC Press, Boca Raton, FL, USA (2003):225–242.
   Google Scholar
• MEDALIE DA, TOMPKINS RG, MORGAN JR: Evaluation of acellular human dermis as a dermal analog in a composite skin graft. ASAIO J. (1996) 42:M455–M462.
   Google Scholar
• MEDALIE DA, EMING SA, TOMPKINS RG et al.: Evaluation of human skin reconstituted from composite grafts of cultured keratinocytes and human acellular dermis transplanted to athymic mice. J. Invest. Dermatol (1996) 107:121–127.
   PubMed Web of Science ®Google Scholar
• MEDALIE DA, EMING SA, COLLINS ME et al.: Differences in dermal analogs influence subsequent pigmentation, epidermal differentiation, basement membrane, and rete ridge formation of transplanted composite skin grafts. Transplantation (1997) 64:454–465.
   PubMed Web of Science ®Google Scholar
• MEDALIE DA, TOMPKINS RG, MORGAN JR: Characterization of a composite tissue model that supports clonal growth of human melanocytes M vitro and M vivo. J. Invest. Dermatol (1998) 111:810–816.
   PubMed Web of Science ®Google Scholar
• ANDREADIS ST, HAMDEN KE, YARMUSH ML, MORGAN JR: Keratinocyte growth factor induces hyperproliferation and delays differentiation in a skin equivalent model system. FASEB (2001) 15:898–906.
   PubMed Web of Science ®Google Scholar
• GEER DJ, SWARTZ DD, ANDREADIS ST: Fibrin promotes migration in a three-dimensional in vitro model of wound regeneration. Tissue Eng. (2002) 8:787–798.
   PubMedGoogle Scholar
• TODD C, HEWITT SD, KEMPENAARJ et al.: Co-culture of human melanocytes and keratinocytes in a skin equivalent model: effect of ultraviolet radiation. Arch. Dermatol Res. (1993) 285:455–459.
   PubMed Web of Science ®Google Scholar
• BOYCE ST, MEDRANO EE, ABDEL-MALEK Z et al.: Pigmentation and inhibition of wound contraction by cultured skin substitutes with adult melanocytes after transplantation to athymic mice. " Invest. Dermatol (1993) 100:360–365.
   Google Scholar
• LIMAT A, SALOMON D, CARRAUX P, SAURAT JH, HUNZIKER T: Human melanocytes grown in epidermal equivalents transfer their melanin to follicular outer root sheath keratinocytes. Arch. Dermatol. Res. (1999) 291:325–332.
   PubMed Web of Science ®Google Scholar
• ANDREADIS ST: Gene enhanced tissue engineering. In: Biomedical Technology and Devices Handbook. Moore J, Zouridakis G (Eds), CRC Press, Boca Raton, FL, USA (2003).
   Google Scholar
• CAPLAN Al, BRUDER SP: Mesenchymal stem cells: building blocks for molecular medicine in the 21st century. Trends MM. Med. (2001) 7:259–264.
   PubMed Web of Science ®Google Scholar
• MILLER DG, ADAM MA, MILLER AD: Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Ma Cell. Biol. (1990) 10:4239–4242.
   Web of Science ®Google Scholar
• ANDREADIS S, FULLER AO, PALSSON BO: Cell cycle dependence of retroviral transduction: An issue of overlapping time scales. Biotechnol Bioeng. (1998) 58:272–281.
   PubMed Web of Science ®Google Scholar
• ROE T, REYNOLDS TC, YU G, BROWN PO: Integration of murine leukemia virus DNA depends on mitosis. EMBO J. (1993) 12:2099–2108.
   PubMed Web of Science ®Google Scholar
• ANDREADIS S, PALSSON BO: Kinetics of retrovirus mediated gene transfer: the importance of the intracellular half-life of retroviruses.j Them: Biol. (1996) 182:1–20.
   PubMed Web of Science ®Google Scholar
• ANDREADIS S, BROTT DA, FULLER AO, PALSSON BO: Moloney murine leukemia virus-derived retroviral vectors decay intracellularly with a half-life in the range of 5.5 to 7.5 hours. J. Vim/. (1997) 71:7541–7548.
   Google Scholar
• KUHN U, TERUNUMA A, PFUTZNERW, FOSTER RA, VOGEL JC: In vivo assessment of gene delivery to keratinocytes by lentiviral vectors.Virol (2002) 76:1496–1504.
   Web of Science ®Google Scholar
• GERRARD AJ, HUDSON DL, BROWNLEE GG, WATT FM: Towards gene therapy for haemophilia B using primary human keratinocytes. Nat. Genet. (1993) 3:180–183.
   PubMed Web of Science ®Google Scholar
• FENJVES ES, YAO SN, KURACHI K, TAICHMAN LB: Loss of expression of a retrovirus-transduced gene in human keratinocytes." Invest. Dermatol (1996) 106:576–578.
   PubMed Web of Science ®Google Scholar
• CHOATE KA, MEDALIE DA, MORGAN JR, KHAVARI PA: Corrective gene transfer in the human skin disorder lamellar ichthyosis. Nat. Med. (1996) 2:1263–1267.
   PubMed Web of Science ®Google Scholar
• FREIBERG RA, CHOATE KA, DENG H et al.: A model of corrective gene transfer in X-linked ichthyosis. Hum. MM. Genet. (1997) 6:927–933.
   PubMed Web of Science ®Google Scholar
• MATHOR MB, FERRARI G, DELLAMBRA E et al.: Clonal analysis of stably transduced human epidermal stem cells in culture. Proc. Nati Acad. Sci. USA (1996) 93:10371–10376.
   PubMed Web of Science ®Google Scholar
• DENG H, LIN Q, KHAVARI PA: Sustainable cutaneous gene delivery. Nat. Biotechnol (1997) 15:1388–1391.
   PubMed Web of Science ®Google Scholar
• WHITE SJ, PAGE SM, MARGARITIS P, BROWNLEE GG: Long-term expression of human clotting Factor IX from retrovirally transduced primary human keratinocytes M vivo. Hum. Gene Ther. (1998) 9:1187–1195.
   PubMed Web of Science ®Google Scholar
• DELLAMBRA E, VAILLY J, PELLEGRINI G et al: Corrective transduction of human epidermal stem cells in laminin-5-dependent junctional epidermolysis bullosa. Hum. Gene Ther. (1998) 9:1359–1370.
   PubMed Web of Science ®Google Scholar
• KOLODKA TM, GARLICK JA, TAICHMAN LB: Evidence for keratinocyte stem cells M vitro: long term engraftment and persistence of transgene expression from retrovirus-transduced keratinocytes. Proc. Natl. Acad. Sci. USA (1998) 95:4356–4361.
   PubMed Web of Science ®Google Scholar
• ADAMS JC, WATT FM: Fibronectin inhibits the terminal differentiation of human keratinocytes. Nature (1989) 340:307–309.
   PubMed Web of Science ®Google Scholar
• LEI P, BAJAJ B, ANDREADIS ST: Retrovirus-associated heparan sulfate mediates immobilization and gene transfer on recombinant fibronectin. Virol (2002) 76:8722–8728.
   Web of Science ®Google Scholar
• BAJAJ B, LEI P, ANDREADIS ST: High efficiencies of gene transfer with immobilized recombinant retrovirus: kinetics and optimization. Biotechnol Frog. (2001) 17:587–596.
   Google Scholar
• HANENBERG H, XIAO XL, DILLOO D et al: Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells. Nat. Med. (1996) 2:876–882.
   PubMed Web of Science ®Google Scholar
• HANENBERG H, HASHINO K, KONISHI H et al: Optimization of fibronectin-assisted retroviral gene transfer into human CD34+ hematopoietic cells. Hum. Gene The]: (1997) 8:2193–2206.
   Google Scholar
• BAJAJ BG, BEHSHAD S, ANDREADIS ST: Retroviral gene transfer to human epidermal keratinocytes correlates with integrin expression and is significantly enhanced on fibronectin. Hum. Gene Ther. (2002) 13:1821–1831.
   PubMed Web of Science ®Google Scholar
• JONES PH, HARPERS, WATT FM: Stem cell patterning and fate in human epidermis. Cell (1995) 80:83–93.
   PubMed Web of Science ®Google Scholar
• ZHU AJ, HAASE I, WATT FM: Signaling via betal integrins and mitogen-activated protein kinase determines human epidermal stem cell fate M vitro Proc. Natl. Acad. Sci. USA (1999) 96:6728–6733.
   PubMed Web of Science ®Google Scholar
• BAJAJ BG, LEI P, ANDREADIS SF: Efficient gene transfer to human epidermal keratinocytes: in vitro evidence for transduction of epidermal stem cells. (2004) (In Press).
   Google Scholar
• UITTO J, PULKKINEN L, CHRISTIANO AM: Molecular basis of the dystrophic and junctional forms of epidermolysis bullosa: mutations in the type VII collagen and kalinin (laminin 5) genes. J. Invest. Dermatol. (1994) 103:39S–46S.
   Google Scholar
• UITTO J, CHRISTIANO AM: Molecular basis for the dystrophic forms of epidermolysis bullosa: mutations in the type VII collagen gene. Arch. Dermatol. Res. (1994) 287:16–22.
   PubMed Web of Science ®Google Scholar
• HILAL L, ROCHAT A, DUQUESNOY P et al.: A homozygous insertion-deletion in the type VII collagen gene (COL7A1) in Hallopeau-Siemens dystrophic epidermolysis bullosa. Nat. Genet. (1993) 5:287–293.
   PubMed Web of Science ®Google Scholar
• GAGNOUX-PALACIOS L, VAILLY J, DURAND-CLEMENT M et al: Functional Re-expression of laminin-5 in laminin-gamma2-deficient human keratinocytes modifies cell morphology, motility, and adhesion. j Biol. Chem. (1996) 271:18437–18444.
   PubMed Web of Science ®Google Scholar
• VAILLY J, GAGNOUX-PALACIOS L, DELL'AMBRA E et al.: Corrective gene transfer of keratinocytes from patients with junctional epidermolysis bullosa restores assembly of hemidesmosomes in reconstructed epithelia. Gene Ther. (1998) 5:1322–1332.
   Google Scholar
• DELLAMBRA E, PELLEGRINI G, GUERRA L et al.: Toward epidermal stem cell-mediated ex vivo gene therapy of junctional epidermolysis bullosa. Hum. Gene The]: (2000) 11:2283–2287.
   PubMed Web of Science ®Google Scholar
• CHEN M, O& TOOLE EA, MUELLENHOFF M et al.: Development and characterization of a recombinant truncated type VII collagen `minigene'. Implication for gene therapy of dystrophic epidermolysis bullosa. Biol. Chem. (2000) 275:24429–24435.
   Google Scholar
• CHEN M, KASAHARA N, KEENE DR et al.: Restoration of type VII collagen expression and function in dystrophic epidermolysis bullosa. Nat. Genet. (2002) 32:670–675.
   PubMed Web of Science ®Google Scholar
• CHOATE KA, KINSELLA TM, WILLIAMS ML, NOLAN GP, KHAVARI PA: Transglutaminase 1 delivery to lamellar ichthyosis keratinocytes. Hum. Gene The]: (1996) 7:2247–2253.
   Google Scholar
• WRAIGHT CJ, WHITE PJ, MCKEAN SC et al.: Reversal of epidermal hyperproliferation in psoriasis by insulin-like growth Factor I receptor antisense oligonucleotides. Nat. Biotechnol. (2000) 18:521–526.
   PubMed Web of Science ®Google Scholar
• SCHERR M, MORGAN MA, EDER M: Gene silencing mediated by small interfering RNAs in mammalian cells. Carr. Med. Chem. (2003) 10:245–256.
   PubMed Web of Science ®Google Scholar
• EMING SA, LEE J, SNOW RG et al.: Genetically modified human epidermis overexpressing PDGF-A directs the development of a cellular and vascular connective tissue stroma when transplanted to athymic mice-implications for the use of genetically modified keratinocytes to modulate dermal regeneration. J. Invest. Dermatol. (1995) 105:756–763.
   PubMed Web of Science ®Google Scholar
• EMING SA, MEDALIE DA, TOMPKINS RG, YARMUSH ML, MORGAN JR: Genetically modified human keratinocytes overexpressing PDGF-A enhance the performance of a composite skin graft. Hum. Gene Tiler. (1998) 9:529–539.
   PubMed Web of Science ®Google Scholar
• EMING SA, SNOW RG, YARMUSH ML, MORGAN JR: Targeted expression of insulin-like growth factor to human keratinocytes: modification of the autocrine control of keratinocyte proliferation. j Invest. Dermatol. (1996) 107:113–120.
   PubMed Web of Science ®Google Scholar
• EMING SA, YARMUSH ML, KRUEGER GG, MORGAN JR: Regulation of the spatial organization of mesenchymal connective tissue: effects of cell-associated versus released isoforms of platelet-derived growth factor. Am. .1 Pathol. (1999) 154:281–289.
   PubMed Web of Science ®Google Scholar
• SUPP DM, SUPP AP, BELL SM, BOYCE ST: Enhanced vascularization of cultured skin substitutes genetically modified to overexpress vascular endothelial growth factor. J. Invest. Dermatol. (2000) 114:5–13.
   PubMed Web of Science ®Google Scholar
• SUPP DM, BOYCE ST: Overexpression of vascular endothelial growth factor accelerates early vascularization and improves healing of genetically modified cultured skin substitutes. J. Burn Care Rehabil. (2002) 23:10–20.
   PubMedGoogle Scholar
• LIECHTY KW, NESBIT M, HERLYN M et al.: Adenoviral-mediated overexpression of platelet-derived growth factor-B corrects ischemic impaired wound healing. I Invest. Dermatol. (1999) 113:375–383.
   PubMed Web of Science ®Google Scholar
• MUSTOE TA, CUTLER NR, ALLMAN RIVI et al: A Phase II study to evaluate recombinant platelet-derived growth factor-BB in the treatment of stage 3 and 4 pressure ulcers. Arch. Surg. (1994) 129:213–219.
   PubMed Web of Science ®Google Scholar
• WIEMAN TJ, SMIELL JM, SU Y: Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (becaplermin) in patients with chronic neuropathic diabetic ulcers. A Phase III randomized placebo-controlled double-blind study. Diabetes Care (1998) 21:822–827.
   PubMed Web of Science ®Google Scholar
• LIECHTY KW, SABLICH TJ, ADZICK NS, CROMBLEHOLME TM: Recombinant adenoviral mediated gene transfer in ischemic impaired wound healing. Wound Repair Regen. (1999) 7:148–153.
   PubMed Web of Science ®Google Scholar
• KLEIN RM, WOLF ED, WU R, SANFORD JC: High-velocity microprojectiles for delivering nucleic acids into living cells. 1987. Biotechnology (1992) 24:384–386.
   Google Scholar
• ANDREE C, SWAIN WE PAGE CP et al: In vivo transfer and expression of a human epidermal growth factor gene accelerates wound repair. Proc. Natl. Acad. Sci. USA (1994) 91:12188–12192.
   PubMed Web of Science ®Google Scholar
• BENN SI, WHITSITT JS, BROADLEY KN et al: Particle-mediated gene transfer with transforming growth factor-betal cDNAs enhances wound repair in rat skin. J. Clin. Invest. (1996) 98:2894–2902.
   PubMed Web of Science ®Google Scholar
• EMING SA, WHITSITT JS, HE L et al.: Particle-mediated gene transfer of PDGF isoforms promotes wound repair. J. Invest. Dermatol. (1999) 112:297–302.
   PubMed Web of Science ®Google Scholar
• ERIKSSON E, YAO F, SVENSJO T et al: In vivo gene transfer to skin and wound by microseeding. Surg. Res. (1998) 78:85–91.
   PubMed Web of Science ®Google Scholar
• CIERNIK IF, KRAYENBUHL BH, CARBONE DP: Puncture-mediated gene transfer to the skin. Hum. Gene The]: (1996) 7:893–899.
   PubMed Web of Science ®Google Scholar
• SUN L, XU L, CHANG H et al: Transfection with aFGF cDNA improves wound healing. Invest. Dermatol (1997) 108:313–318.
   PubMed Web of Science ®Google Scholar
• TAUB PJ, MARMUR JD, ZHANG WX et al.: Locally administered vascular endothelial growth factor cDNA increases survival of ischemic experimental skin flaps. Plast. Reconsm. Sorg. (1998) 102:2033–2039.
   PubMed Web of Science ®Google Scholar
• CHOI BM, KWAK HJ, JUN CD et al.: Control of scarring in adult wounds using antisense transforming growth factor-beta 1 oligodeoxynucleotides. Immunol Cell Biol. (1996) 74:144–150.
   PubMed Web of Science ®Google Scholar
• KIM HM, CHOI DH, LEE YM: Inhibition of wound-induced expression of transforming growth factor-beta 1 mRNA by its antisense oligonucleotides. Pharmacol Res. (1998) 37:289–293.
   PubMed Web of Science ®Google Scholar
• SUPERSAXO A, HEIN WR, STEFFEN H: Effect of molecular weight on the lymphatic absorption of water-soluble compounds following subcutaneous administration. Pharm. Res. (1990) 7:167–169.
   PubMed Web of Science ®Google Scholar
• MORGAN JR, BARRANDON Y, GREEN H, MULLIGAN RC: Expression of an exogenous growth hormone gene by transplantable human epidermal cells. Science (1987) 237:1476–1479.
   PubMed Web of Science ®Google Scholar
• SELDEN RF, SKOSKIEWICZ MJ, HOWIE KB, RUSSELL PS, GOODMAN HM: Implantation of genetically engineered fibroblasts into mice: implications for gene therapy. Science (1987) 236:714–718.
   PubMed Web of Science ®Google Scholar
• TEUMER J, LINDAHL A, GREEN H: Human growth hormone in the blood of athymic mice grafted with cultures of hormone-secreting human keratinocytes. FASEB J. (1990) 4:3245–3250.
   PubMed Web of Science ®Google Scholar
• JENSEN UB, JENSEN TG, JENSEN PK et al.: Gene transfer into cultured human epidermis and its transplantation onto immunodeficient mice: an experimental model for somatic gene therapy. Invest. Dermatol (1994) 103:391–394.
   PubMed Web of Science ®Google Scholar
• GORDON DA, FENJVES ES, WILLIAMS DL, TAICHMAN LB: Synthesis and secretion of apolipoprotein E by cultured human keratinocytes. J. Invest. Dermatol (1989) 92:96–99.
   PubMed Web of Science ®Google Scholar
• FENJVES ES, SMITH J, ZARADIC S, TAICHMAN LB: Systemic delivery of secreted protein by grafts of epidermal keratinocytes: prospects for keratinocyte gene therapy. Hum. Gene Ther. (1994) 5:1241–1248.
   PubMed Web of Science ®Google Scholar
• FENJVES ES, SCHWARTZ PM, BLAESE RIVI, TAICHMAN LB: Keratinocyte gene therapy for adenosine deaminase deficiency: a model approach for inherited metabolic disorders. Hum. Gene Ther. (1997) 8:911–917.
   PubMed Web of Science ®Google Scholar
• JENSEN TG, SULLIVAN DM, MORGAN RA et al: Retrovirus-mediated gene transfer of ornithine-delta-aminotransferase into keratinocytes from gyrate atrophy patients. Hum. Gene The]: (1997) 8:2125–2132.
   PubMed Web of Science ®Google Scholar
• SULLIVAN DM, JENSEN TG, TAICHMAN LB, CSAKY KG: Ornithine-delta-aminotransferase expression and ornithine metabolism in cultured epidermal keratinocytes: toward metabolic sink therapy for gyrate atrophy. Gene Ther. (1997) 4:1036–1044.
   PubMed Web of Science ®Google Scholar
• CHRISTENSEN R, KOLVRAA S, BLAESE RIVI, JENSEN TG: Development of a skin-based metabolic sink for phenylalanine by overexpression of phenylalanine hydroxylase and GTP cyclohydrolase in primary human keratinocytes. Gene The]: (2000) 7:1971–1978.
   Google Scholar
• FAKHARZADEH SS, ZHANG Y, SARKAR R, KAZAZIAN HH JR: Correction of the coagulation defect in hemophilia A mice through Factor VIII expression in skin. Blood (2000) 95:2799–2805.
   PubMed Web of Science ®Google Scholar
• LARCHER F, DEL RIO M, SERRANO F et al.: A cutaneous gene therapy approach to human leptin deficiencies: correction of the murine ob/ob phenotype using leptin-targeted keratinocyte grafts. FASEB (2001) 15:1529–1538.
   PubMed Web of Science ®Google Scholar
• NOEL D, DAZARD JE, PELE GRIN M, JACQUET C, PIECHACZYK M: Skin as a potential organ for ectopic monoclonal antibody production. J. Invest. Dermatol (2002) 118:288–294.
   PubMed Web of Science ®Google Scholar
• TAI IT, SUN AM: Microencapsulation of recombinant cells: a new delivery system for gene therapy. FASEB J. (1993) 7:1061–1069.
   PubMed Web of Science ®Google Scholar
• GARVER RI JR, CHYTIL A, COURTNEY M, CRYSTAL RG: Clonal gene therapy: transplanted mouse fibroblast clones express human alpha 1-antitrypsin gene in vivo. Science (1987) 237:762–764.
   PubMed Web of Science ®Google Scholar
• DWARKI VJ, BELLONI P, NIJJAR T et al.: Gene therapy for hemophilia A: production of therapeutic levels of human Factor VIII in vivoin mice. Proc. Natl. Acad. Sci. USA (1995) 92:1023–1027.
   PubMed Web of Science ®Google Scholar
• ST LOUIS D, VERMA IM: An alternative approach to somatic cell gene therapy. Proc. Natl. Acad. Sci. USA (1988) 85:3150–3154.
   PubMed Web of Science ®Google Scholar
• QIU X, LU D, ZHOU J et aL: Implantation of autologous skin fibroblast genetically modified to secrete clotting Factor IX partially corrects the hemorrhagic tendencies in two hemophilia B patients. Chin. Med..). (Engl.) (1996) 109:832–839.
   PubMed Web of Science ®Google Scholar
• FALQUI L, MARTINENGHI S, SEVERINI GM et al.: Reversal of diabetes in mice by implantation of human fibroblasts genetically engineered to release mature human insulin. Hum. Gene Ther. (1999) 10:1753–1762.
   PubMed Web of Science ®Google Scholar
• KRUEGER GG: Fibroblasts and dermal gene therapy: a minireview. Hum. Gene The]: (2000) 11:2289–2296.
   PubMed Web of Science ®Google Scholar
• CHRISTENSEN R, GUTTLER F, JENSEN TG: Comparison of epidermal keratinocytes and dermal fibroblasts as potential target cells for somatic gene therapy of phenylketonuria. MM. Genet. Metab. (2002) 76:313–318.
   PubMed Web of Science ®Google Scholar
• SETOGUCHI Y, JAFFE HA, DANEL C, CRYSTAL RG: Ex vivo and in vivo gene transfer to the skin using replication-deficient recombinant adenovirus vectors. J. Invest. Dermatol (1994) 102:415–421.
   PubMed Web of Science ®Google Scholar
• SUN WH, BURKHOLDER JK, SUN J et al.: In vivo cytokine gene transfer by gene gun reduces tumor growth in mice. Proc. Natl. Acad. Sci. USA (1995) 92:2889–2893.
   PubMed Web of Science ®Google Scholar
• HENGGE UR, CHAN EF, FOSTER RA, WALKER PS, VOGEL JC: Cytokine gene expression in epidermis with biological effects following injection of naked DNA. Nat. Genet. (1995) 10:161–166.
   PubMed Web of Science ®Google Scholar
• HENGGE UR, WALKER PS, VOGEL JC: Expression of naked DNA in human, pig, and mouse skin. Clin. Invest. (1996) 97:2911–2916.
   Google Scholar
• MENG X, SAWAMURA D, TAMAI K et al.: Keratinocyte gene therapy for systemic diseases. Circulating interleukin 10 released from gene-transferred keratinocytes inhibits contact hypersensitivity at distant areas of the skin. Clin. Invest. (1998) 101:1462–1467.
   Google Scholar
• GEER DJ, SWARTZ DD, ANDREADIS ST: An in vivo model of wound healing based on transplanted tissue engineered skin. Tissue Eng. (2004) (In Press).
   Google Scholar
• KORIA P, ANDREADIS ST: Life at the interface: transcriptional profiling of tissue engineered skin at the air-liquid interface. J. Invest. Dermal-el (2004) (In Press).
   Google Scholar
• KORIA P, BRAZEAU D, KIRKWOOD K et al.: Gene expression profile of tissue engineered skin subjected to acute barrier disruption.' Invest. Dermal-el (2003) 121:368–382.
   PubMed Web of Science ®Google Scholar
• GARLICK JA, TAICHMAN LB: Fate of human keratinocytes during reepithelialization in an organotypic culture model. Lab. Invest. (1994) 70:916–924.
   PubMed Web of Science ®Google Scholar
• GARLICK JA, TAICHMAN LB: Effect of TGF-beta 1 on re-epithelialization of human keratinocytes in vitro: an organotypic model. J. Invest. Dermatel. (1994) 103:554–559.
   PubMed Web of Science ®Google Scholar
• VACCARIELLO M, JAVAHERIAN A, WANG Y, FUSENIG NE, GARLICK JA: Cell interactions control the fate of malignant keratinocytes in an organotypic model of early neoplasia." Invest. Dermatel. (1999) 113:384–391.
   PubMed Web of Science ®Google Scholar
• MUDGIL AV, SEGAL N, ANDRIANI F et al.: Ultraviolet B irradiation induces expansion of intraepithelial tumor cells in a tissue model of early cancer progression. J. Invest. Dermal-el (2003) 121:191–197.
   PubMed Web of Science ®Google Scholar
• HAMOEN KE, MORGAN JR: Transient hyperproliferation of a transgenic human epidermis expressing hepatocyte growth factor. Cell Transplant. (2002) 11:385–395.
   PubMed Web of Science ®Google Scholar
• ANDREE C, VOIGT M, WENGER A et al.: Plasmid gene delivery to human keratinocytes through a fibrin-mediated transfection system. Tissue Eng. (2001) 7:757–766.
   PubMedGoogle Scholar
• BREITBART AS, MASON JM, URMACHER C et al.: Gene-enhanced tissue engineering: applications for wound healing using cultured dermal fibroblasts transduced retrovirally with the PDGF-B gene. Ann. Plast. Sing. (1999) 43:632–639.
   PubMed Web of Science ®Google Scholar
• BREITBART AS, GRANDE DA, LASER J et al.: Treatment of ischemic wounds using cultured dermal fibroblasts transduced retrovirally with PDGF-B and VEGF121 genes. Ann. Plast. Sing. (2001) 46:555-561; discussion 561–562.
   Google Scholar
• RINSCH C, QUINODOZ P, PITTET B et al.: Delivery of FGF-2 but not VEGF by encapsulated genetically engineered myoblasts improves survival and vascularization in a model of acute skin flap ischemia. Gene Ther. (2001) 8:523–533.
   PubMed Web of Science ®Google Scholar
• JESCHKE MG, RICHTER G, HERNDON DN et al: Therapeutic success and efficacy of nonviral liposomal eDNA gene transfer to the skin in vivo is dose dependent. Gene Tiler. (2001) 8:1777–1784.
   Web of Science ®Google Scholar
• JESCHKE MG, RICHTER G, HOFSTADTER F et al.: Non-viral liposomal keratinocyte growth factor (KGF) cDNA gene transfer improves dermal and epidermal regeneration through stimulation of epithelial and mesenchymal factors. Gene Ther. (2002) 9:1065–1074.
   PubMed Web of Science ®Google Scholar
• SHEA LD, SMILEY E, BONADIO J, MOONEY DJ: DNA delivery from polymer matrices for tissue engineering. Nat. Bietechnel. (1999) 17:551–554.
   PubMed Web of Science ®Google Scholar
• TYRONE JW, MOGFORD JE, CHANDLER LA et al.: Collagen-embedded platelet-derived growth factor DNA plasmid promotes wound healing in a dermal ulcer model. J. Sing. Res. (2000) 93:230–236.
   Google Scholar
• CHANDLER LA, DOUKAS J, GONZALEZ AM et al.: FGF2-Targeted adenovirus encoding platelet-derived growth factor-B enhances de neve tissue formation. Mel Tiler. (2000) 2:153–160.
   PubMed Web of Science ®Google Scholar
• CHANDLER LA, GU DL, MA C et al.: Matrix-enabled gene transfer for cutaneous wound repair. Wound Repair Regen. (2000) 8:473–479.
   PubMed Web of Science ®Google Scholar
• YAMASAKI K, EDINGTON HD, MCCLOSKY C et al.: Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer. " Clin. Invest. (1998) 101:967–971.
   Google Scholar
• SEN CK, KHANNA S, BABIOR BM et al.: Oxidant-induced vascular endothelial growth factor expression in human keratinocytes and cutaneous wound healing. Chen]. (2002) 277:33284–33290.
   PubMed Web of Science ®Google Scholar
• OZAWA K, KONDO T, HORI 0 et al.: Expression of the oxygen-regulated protein ORP150 accelerates wound healing by modulating intracellular VEGF transport. Clin. Invest. (2001) 108:41–50.
   Google Scholar