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Review

Dendritic cells as promoters of transplant tolerance

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Pages 325-339 | Published online: 21 Mar 2006

Bibliography

  • DENTON MD, MAGEE CC, SAYEGH MH: Immunosuppressive strategies in transplantation. Lancet (1999) 353(9158):1083-1091.
  • WOMER KL, VELLA JP, SAYEGH MH: Chronic allograft dysfunction: mechanisms and new approaches to therapy. Semin. Nephrol. (2000) 20(2):126-147.
  • STEINMAN RM, HAWIGER D, NUSSENZWEIG MC: Tolerogenic dendritic cells. Annu. Rev. Immunol. (2003) 21:685-711.
  • STEINMAN RM: The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. (1991) 9:271-296.
  • BANCHEREAU J, BRIERE F, CAUX C et al.: Immunobiology of dendritic cells. Annu. Rev. Immunol. (2000) 18:767-811.
  • JANEWAY CA JR, BOTTOMLY K: Signals and signs for lymphocyte responses. Cell (1994) 76(2):275-285.
  • WATTS C: Capture and processing of exogenous antigens for presentation on MHC molecules. Annu. Rev. Immunol. (1997) 15:821-850.
  • CYSTER JG: Chemokines and cell migration in secondary lymphoid organs. Science (1999) 286(5447):2098-2102.
  • DIEU MC, VANBERVLIET B, VICARI A et al.: Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J. Exp. Med. (1998) 188(2):373-386.
  • CELLA M, ENGERING A, PINET V, PIETERS J, LANZAVECCHIA A: Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature (1997) 388(6644):782-787.
  • TURLEY SJ, INABA K, GARRETT WS et al.: Transport of peptide-MHC class II complexes in developing dendritic cells. Science (2000) 288(5465):522-527.
  • GLIMCHER LH: Lineage commitment in lymphocytes: controlling the immune response. J. Clin. Invest. (2001) 108(7):s25-s30.
  • KALINSKI P, HILKENS CM, WIERENGA EA, KAPSENBERG ML: T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol. Today (1999) 20(12):561-567.
  • REID SD, PENNA G, ADORINI L: The control of T cell responses by dendritic cell subsets. Curr. Opin. Immunol. (2000) 12(1):114-121.
  • MOSER M, MURPHY KM: Dendritic cell regulation of TH1-TH2 development. Nat. Immunol. (2000) 1(3):199-205.
  • LAMBRECHT BN, DE VEERMAN M, COYLE AJ et al.: Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation. J. Clin. Invest. (2000) 106(4):551-559.
  • TRINCHIERI G: Interleukin-12: a cytokine at the interface of inflammation and immunity. Adv. Immunol. (1998) 70:83-243.
  • MACATONIA SE, HOSKEN NA, LITTON M et al.: Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J. Immunol. (1995) 154(10):5071-5079.
  • WINZLER C, ROVERE P, RESCIGNO M et al.: Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures. J. Exp. Med. (1997) 185(2):317-328.
  • RESCIGNO M, GRANUCCI F, CITTERIO S, FOTI M, RICCIARDI-CASTAGNOLI P: Coordinated events during bacteria-induced DC maturation. Immunol. Today (1999) 20(5):200-203.
  • VERDIJK RM, MUTIS T, ESENDAM B et al.: Polyriboinosinic polyribocytidylic acid (poly(I:C)) induces stable maturation of functionally active human dendritic cells. J. Immunol. (1999) 163(1):57-61.
  • CELLA M, SALIO M, SAKAKIBARA Y et al.: Maturation, activation, and protection of dendritic cells induced by double-stranded RNA. J. Exp. Med. (1999) 189(5):821-829.
  • VIEIRA PL, DE JONG EC, WIERENGA EA, KAPSENBERG ML, KALINSKI P: Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction. J. Immunol. (2000) 164(9):4507-4512.
  • D’OSTIANI CF, DEL SERO G, BACCI A et al.: Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo. J. Exp. Med. (2000) 191(10):1661-1674.
  • WHELAN M, HARNETT MM, HOUSTON KM et al.: A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cells. J. Immunol. (2000) 164(12):6453-6460.
  • GAGLIARDI MC, SALLUSTO F, MARINARO M et al.: Cholera toxin induces maturation of human dendritic cells and licences them for Th2 priming. Eur. J. Immunol. (2000) 30(8):2394-2403.
  • DE SMEDT T, VAN MECHELEN M, DE BECKER G et al.: Effect of interleukin-10 on dendritic cell maturation and function. Eur. J. Immunol. (1997) 27(5):1229-1235.
  • ABBAS AK, MURPHY KM, SHER A: Functional diversity of helper T lymphocytes. Nature (1996) 383(6603):787-793.
  • KALINSKI P, SCHUITEMAKER JH, HILKENS CM, KAPSENBERG ML: Prostaglandin E2 induces the final maturation of IL-12-deficient CD1a+CD83+ dendritic cells: the levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation. J. Immunol. (1998) 161(6):2804-2809.
  • PANINA-BORDIGNON P, MAZZEO D, LUCIA PD et al.: Beta2-agonists prevent Th1 development by selective inhibition of interleukin 12. J. Clin. Invest. (1997) 100(6):1513-1519.
  • VAN DER POUW KRAAN TC, SNIJDERS A, BOEIJE LC et al.: Histamine inhibits the production of interleukin-12 through interaction with H2 receptors. J. Clin. Invest. (1998) 102(10):1866-1873.
  • SORNASSE T, FLAMAND V, DE BECKER G et al.: Antigen-pulsed dendritic cells can efficiently induce an antibody response in vivo. J. Exp. Med. (1992) 175(1):15-21.
  • STUMBLES PA, THOMAS JA, PIMM CL et al.: Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity. J. Exp. Med. (1998) 188(11):2019-2031.
  • WYKES M, POMBO A, JENKINS C, MACPHERSON GG: Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response. J. Immunol. (1998) 161(3):1313-1319.
  • SHORTMAN K, LIU YJ: Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. (2002) 2(3):151-161.
  • ARDAVIN C: Origin, precursors and differentiation of mouse dendritic cells. Nat. Rev. Immunol. (2003) 3(7):582-590.
  • MATZINGER P: Tolerance, danger, and the extended family. Annu. Rev. Immunol. (1994) 12:991-1045.
  • GALLUCCI S, MATZINGER P: Danger signals: SOS to the immune system. Curr. Opin. Immunol. (2001) 13(1):114-119.
  • LECHLER R, NG WF, STEINMAN RM: Dendritic cells in transplantation--friend or foe? Immunity (2001) 14(4):357-368.
  • LARSEN CP, MORRIS PJ, AUSTYN JM: Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection. J. Exp. Med. (1990) 171(1):307-314.
  • LARSEN CP, STEINMAN RM, WITMER-PACK M et al.: Migration and maturation of Langerhans cells in skin transplants and explants. J. Exp. Med. (1990) 172(5):1483-1493.
  • LAFFERTY KJ, BOOTES A, DART G, TALMAGE DW: Effect of organ culture on the survival of thyroid allografts in mice. Transplantation (1976) 22(2):138-149.
  • LAFFERTY KJ, COOLEY MA, WOOLNOUGH J, WALKER KZ: Thyroid allograft immunogenicity is reduced after a period in organ culture. Science (1975) 188(4185):259-261.
  • TALMAGE DW, DART G, RADOVICH J, LAFFERTY KJ: Activation of transplant immunity: effect of donor leukocytes on thyroid allograft rejection. Science (1976) 191(4225):385-388.
  • BOWEN KM, ANDRUS L, LAFFERTY KJ: Successful allotransplantation of mouse pancreatic islets to nonimmunosuppressed recipients. Diabetes (1980) 29(Suppl. 1):98-104.
  • LECHLER RI, BATCHELOR JR: Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells. J. Exp. Med. (1982) 155(1):31-41.
  • PIETRA BA, WISEMAN A, BOLWERK A, RIZEQ M, GILL RG: CD4 T cell-mediated cardiac allograft rejection requires donor but not host MHC class II. J. Clin. Invest. (2000) 106(8):1003-1010.
  • LECHLER RI, BATCHELOR JR: Immunogenicity of retransplanted rat kidney allografts. Effect of inducing chimerism in the first recipient and quantitative studies on immunosuppression of the second recipient. J. Exp. Med. (1982) 156(6):1835-1841.
  • GOULD DS, AUCHINCLOSS H JR: Direct and indirect recognition: the role of MHC antigens in graft rejection. Immunol. Today (1999) 20(2):77-82.
  • BENICHOU G, TAKIZAWA PA, OLSON CA, MCMILLAN M, SERCARZ EE: Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection. J. Exp. Med. (1992) 175(1):305-308.
  • FANGMANN J, DALCHAU R, FABRE JW: Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides. J. Exp. Med. (1992) 175(6):1521-1529.
  • AUCHINCLOSS H JR, LEE R, SHEA S et al.: The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice. Proc. Natl. Acad. Sci. USA (1993) 90(8):3373-3377.
  • HONJO K, XU X, BUCY RP: CD4+ T-cell receptor transgenic T cells alone can reject vascularized heart transplants through the indirect pathway of alloantigen recognition. Transplantation (2004) 77(3):452-455.
  • INABA K, TURLEY S, YAMAIDE F et al.: Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells. J. Exp. Med. (1998) 188(11):2163-2173.
  • JIANG S, HERRERA O, LECHLER RI: New spectrum of allorecognition pathways: implications for graft rejection and transplantation tolerance. Curr. Opin. Immunol. (2004) 16(5):550-557.
  • HERRERA OB, GOLSHAYAN D, TIBBOTT R et al.: A novel pathway of alloantigen presentation by dendritic cells. J. Immunol. (2004) 173(8):4828-4837.
  • ZITVOGEL L, REGNAULT A, LOZIER A et al.: Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat. Med. (1998) 4(5):594-600.
  • BEDFORD P, GARNER K, KNIGHT SC: MHC class II molecules transferred between allogeneic dendritic cells stimulate primary mixed leukocyte reactions. Int. Immunol. (1999) 11(11):1739-1744.
  • RUSSO V, ZHOU D, SARTIRANA C et al.: Acquisition of intact allogeneic human leukocyte antigen molecules by human dendritic cells. Blood (2000) 95(11):3473-3477.
  • HARSHYNE LA, WATKINS SC, GAMBOTTO A, BARRATT-BOYES SM: Dendritic cells acquire antigens from live cells for cross-presentation to CTL. J. Immunol. (2001) 166(6):3717-3723.
  • MATZINGER P, GUERDER S: Does T-cell tolerance require a dedicated antigen-presenting cell? Nature (1989) 338(6210):74-76.
  • BROCKER T, RIEDINGER M, KARJALAINEN K: Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo. J. Exp. Med. (1997) 185(3):541-550.
  • STEINMAN RM, TURLEY S, MELLMAN I, INABA K: The induction of tolerance by dendritic cells that have captured apoptotic cells. J. Exp. Med. (2000) 191(3):411-416.
  • LUTZ MB, SCHULER G: Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol. (2002) 23(9):445-449.
  • FINKELMAN FD, LEES A, BIRNBAUM R, GAUSE WC, MORRIS SC: Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion. J. Immunol. (1996) 157(4):1406-1414.
  • HAWIGER D, INABA K, DORSETT Y et al.: Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J. Exp. Med. (2001) 194(6):769-779.
  • BONIFAZ L, BONNYAY D, MAHNKE K et al.: Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J. Exp. Med. (2002) 196(12):1627-1638.
  • SUSS G, SHORTMAN K: A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis. J. Exp. Med. (1996) 183(4):1789-1796.
  • MUNN DH, ZHOU M, ATTWOOD JT et al.: Prevention of allogeneic fetal rejection by tryptophan catabolism. Science (1998) 281(5380):1191-1193.
  • FALLARINO F, VACCA C, ORABONA C et al.: Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cells. Int. Immunol. (2002) 14(1):65-68.
  • MUNN DH, SHARMA MD, LEE JR et al.: Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science (2002) 297(5588):1867-1870.
  • SCHWARTZ RH: T cell anergy. Annu. Rev. Immunol. (2003) 21:305-334.
  • KUWANA M, KABURAKI J, WRIGHT TM, KAWAKAMI Y, IKEDA Y: Induction of antigen-specific human CD4(+) T cell anergy by peripheral blood DC2 precursors. Eur. J. Immunol. (2001) 31(9):2547-2557.
  • KAWAHATA K, MISAKI Y, YAMAUCHI M et al.: Peripheral tolerance to a nuclear autoantigen: dendritic cells expressing a nuclear autoantigen lead to persistent anergic state of CD4+ autoreactive T cells after proliferation. J. Immunol. (2002) 168(3):1103-1112.
  • SHEVACH EM: Regulatory T cells in autoimmmunity*. Annu. Rev. Immunol. (2000) 18:423-449.
  • SAKAGUCHI S: Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. (2004) 22:531-562.
  • BENDELAC A, RIVERA MN, PARK SH, ROARK JH: Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu. Rev. Immunol. (1997) 15:535-562.
  • GROUX H, O'GARRA A, BIGLER M et al.: A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature (1997) 389(6652):737-742.
  • WEINER HL: Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol. Rev. (2001) 182:207-214.
  • CHANG CC, CIUBOTARIU R, MANAVALAN JS et al.: Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. Nat. Immunol. (2002) 3(3):237-243.
  • ZHANG ZX, YANG L, YOUNG KJ, DUTEMPLE B, ZHANG L: Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat. Med. (2000) 6(7):782-789.
  • JONULEIT H, SCHMITT E, SCHULER G, KNOP J, ENK AH: Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med. (2000) 192(9):1213-1222.
  • DHODAPKAR MV, STEINMAN RM, KRASOVSKY J, MUNZ C, BHARDWAJ N: Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J. Exp. Med. (2001) 193(2):233-238.
  • AKBARI O, DEKRUYFF RH, UMETSU DT: Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat. Immunol. (2001) 2(8):725-731.
  • ALPAN O, RUDOMEN G, MATZINGER P: The role of dendritic cells, B cells, and M cells in gut-oriented immune responses. J. Immunol. (2001) 166(8):4843-4852.
  • IWASAKI A, KELSALL BL: Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells. J. Exp. Med. (1999) 190(2):229-239.
  • AKBARI O, FREEMAN GJ, MEYER EH et al.: Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat. Med. (2002) 8(9):1024-1032.
  • MIN WP, ZHOU D, ICHIM TE et al.: Inhibitory feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant tolerance. J. Immunol. (2003) 170(3):1304-1312.
  • LU L, MCCASLIN D, STARZL TE, THOMSON AW: Bone marrow-derived dendritic cell progenitors (NLDC 145+, MHC class II+, B7-1dim, B7-2-) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes. Transplantation (1995) 60(12):1539-1545.
  • RASTELLINI C, LU L, RICORDI C et al.: Granulocyte/macrophage colony-stimulating factor-stimulated hepatic dendritic cell progenitors prolong pancreatic islet allograft survival. Transplantation (1995) 60(11):1366-1370.
  • FU F, LI Y, QIAN S et al.: Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80dim, CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipients. Transplantation (1996) 62(5):659-665.
  • HAYAMIZU K, HUIE P, SIBLEY RK, STROBER S: Monocyte-derived dendritic cell precursors facilitate tolerance to heart allografts after total lymphoid irradiation. Transplantation (1998) 66(10):1285-1291.
  • LUTZ MB, KUKUTSCH NA, MENGES M, ROSSNER S, SCHULER G: Culture of bone marrow cells in GM-CSF plus high doses of lipopolysaccharide generates exclusively immature dendritic cells which induce alloantigen-specific CD4 T cell anergy in vitro. Eur. J. Immunol. (2000) 30(4):1048-1052.
  • LUTZ MB, SURI RM, NIIMI M et al.: Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo. Eur. J. Immunol. (2000) 30(7):1813-1822.
  • GEISSMANN F, REVY P, REGNAULT A et al.: TGF-beta 1 prevents the noncognate maturation of human dendritic Langerhans cells. J. Immunol. (1999) 162(8):4567-4575.
  • STEINBRINK K, WOLFL M, JONULEIT H, KNOP J, ENK AH: Induction of tolerance by IL-10-treated dendritic cells. J. Immunol. (1997) 159(10):4772-4780.
  • STEINBRINK K, GRAULICH E, KUBSCH S, KNOP J, ENK AH: CD4(+) and CD8(+) anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity. Blood (2002) 99(7):2468-2476.
  • SATO K, YAMASHITA N, BABA M, MATSUYAMA T: Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells. Blood (2003) 101(9):3581-3589.
  • OYAMA T, RAN S, ISHIDA T et al.: Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells. J. Immunol. (1998) 160(3):1224-1232.
  • LU L, LI W, FU F et al.: Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival. Transplantation (1997) 64(12):1808-1815.
  • MARKEES TG, PHILLIPS NE, GORDON EJ et al.: Prolonged skin allograft survival in mice treated with Flt3-ligand-induced dendritic cells and anti-CD154 monoclonal antibody. Transplant. Proc. (1999) 31(1-2):884-885.
  • NIIMI M, SHIRASUGI N, IKEDA Y et al.: Operational tolerance induced by pretreatment with donor dendritic cells under blockade of CD40 pathway. Transplantation (2001) 72(9):1556-1562.
  • WANG Z, MORELLI AE, HACKSTEIN H, KANEKO K, THOMSON AW: Marked inhibition of transplant vascular sclerosis by in vivo-mobilized donor dendritic cells and anti-CD154 mAb. Transplantation (2003) 76(3):562-571.
  • SATO K, YAMASHITA N, BABA M, MATSUYAMA T: Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse. Immunity (2003) 18(3):367-379.
  • HACKSTEIN H, THOMSON AW: Dendritic cells: emerging pharmacological targets of immunosuppressive drugs. Nat. Rev. Immunol. (2004) 4(1):24-34.
  • MATASIC R, DIETZ AB, VUK-PAVLOVIC S: Cyclooxygenase-independent inhibition of dendritic cell maturation by aspirin. Immunology (2000) 101(1):53-60.
  • HACKSTEIN H, MORELLI AE, LARREGINA AT et al.: Aspirin inhibits in vitro maturation and in vivo immunostimulatory function of murine myeloid dendritic cells. J. Immunol. (2001) 166(12):7053-7062.
  • PENNA G, ADORINI L: 1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J. Immunol. (2000) 164(5):2405-2411.
  • GRIFFIN MD, LUTZ W, PHAN VA et al.: Dendritic cell modulation by 1alpha,25 dihydroxyvitamin D3 and its analogs: a vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo. Proc. Natl. Acad. Sci. USA (2001) 98(12):6800-6805.
  • GREGORI S, CASORATI M, AMUCHASTEGUI S et al.: Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J. Immunol. (2001) 167(4):1945-1953.
  • MA L, RUDERT WA, HARNAHA J et al.: Immunosuppressive effects of glucosamine. J. Biol. Chem. (2002) 277(42):39343-39349.
  • VERHASSELT V, VANDEN BERGHE W, VANDERHEYDE N et al.: N-acetyl-L-cysteine inhibits primary human T cell responses at the dendritic cell level: association with NF-kappaB inhibition. J. Immunol. (1999) 162(5):2569-2574.
  • NOURI-SHIRAZI M, GUINET E: Direct and indirect cross-tolerance of alloreactive T cells by dendritic cells retained in the immature stage. Transplantation (2002) 74(7):1035-1044.
  • VOSTERS O, NEVE J, DE WIT D et al.: Dendritic cells exposed to nacystelyn are refractory to maturation and promote the emergence of alloreactive regulatory t cells. Transplantation (2003) 75(3):383-389.
  • PIEMONTI L, MONTI P, ALLAVENA P et al.: Glucocorticoids affect human dendritic cell differentiation and maturation. J. Immunol. (1999) 162(11):6473-6481.
  • MATYSZAK MK, CITTERIO S, RESCIGNO M, RICCIARDI-CASTAGNOLI P: Differential effects of corticosteroids during different stages of dendritic cell maturation. Eur. J. Immunol. (2000) 30(4):1233-1242.
  • ROELEN DL, SCHUURHUIS DH, VAN DEN BOOGAARDT DE et al.: Prolongation of skin graft survival by modulation of the alloimmune response with alternatively activated dendritic cells. Transplantation (2003) 76(11):1608-1615.
  • LEE JI, GANSTER RW, GELLER DA et al.: Cyclosporine A inhibits the expression of costimulatory molecules on in vitro-generated dendritic cells: association with reduced nuclear translocation of nuclear factor kappa B. Transplantation (1999) 68(9):1255-1263.
  • HACKSTEIN H, TANER T, ZAHORCHAK AF et al.: Rapamycin inhibits IL-4--induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo. Blood (2003) 101(11):4457-4463.
  • THOMAS JM, CONTRERAS JL, JIANG XL et al.: Peritransplant tolerance induction in macaques: early events reflecting the unique synergy between immunotoxin and deoxyspergualin. Transplantation (1999) 68(11):1660-1673.
  • MEHLING A, GRABBE S, VOSKORT M et al.: Mycophenolate mofetil impairs the maturation and function of murine dendritic cells. J. Immunol. (2000) 165(5):2374-2381.
  • GIANNOUKAKIS N, BONHAM CA, QIAN S et al.: Prolongation of cardiac allograft survival using dendritic cells treated with NF-kB decoy oligodeoxyribonucleotides. Mol. Ther. (2000) 1(5 Pt 1):430-437.
  • XU MQ, SUO YP, GONG JP, ZHANG MM, YAN LN: Prolongation of liver allograft survival by dendritic cells modified with NF-kappaB decoy oligodeoxynucleotides. World J. Gastroenterol. (2004) 10(16):2361-2368.
  • TAKAYAMA T, NISHIOKA Y, LU L et al.: Retroviral delivery of viral interleukin-10 into myeloid dendritic cells markedly inhibits their allostimulatory activity and promotes the induction of T-cell hyporesponsiveness. Transplantation (1998) 66(12):1567-1574.
  • COATES PT, KRISHNAN R, KIRETA S, JOHNSTON J, RUSS GR: Human myeloid dendritic cells transduced with an adenoviral interleukin-10 gene construct inhibit human skin graft rejection in humanized NOD-scid chimeric mice. Gene Ther. (2001) 8(16):1224-1233.
  • GORCZYNSKI RM, BRANSOM J, CATTRAL M et al.: Synergy in induction of increased renal allograft survival after portal vein infusion of dendritic cells transduced to express TGFbeta and IL-10, along with administration of CHO cells expressing the regulatory molecule OX-2. Clin. Immunol. (2000) 95(3):182-189.
  • LU L, GAMBOTTO A, LEE WC et al.: Adenoviral delivery of CTLA4Ig into myeloid dendritic cells promotes their in vitro tolerogenicity and survival in allogeneic recipients. Gene Ther. (1999) 6(4):554-563.
  • TAKAYAMA T, MORELLI AE, ROBBINS PD, TAHARA H, THOMSON AW: Feasibility of CTLA4Ig gene delivery and expression in vivo using retrovirally transduced myeloid dendritic cells that induce alloantigen-specific T cell anergy in vitro. Gene Ther. (2000) 7(15):1265-1273.
  • BONHAM CA, PENG L, LIANG X et al.: Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig. J. Immunol. (2002) 169(6):3382-3391.
  • O’ROURKE RW, KANG SM, LOWER JA et al.: A dendritic cell line genetically modified to express CTLA4-IG as a means to prolong islet allograft survival. Transplantation (2000) 69(7):1440-1446.
  • TERNESS P, BAUER TM, ROSE L et al.: Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites. J. Exp. Med. (2002) 196(4):447-457.
  • MIN WP, GORCZYNSKI R, HUANG XY et al.: Dendritic cells genetically engineered to express Fas ligand induce donor-specific hyporesponsiveness and prolong allograft survival. J. Immunol. (2000) 164(1):161-167.
  • GARROVILLO M, ALI A, OLUWOLE SF: Indirect allorecognition in acquired thymic tolerance: induction of donor-specific tolerance to rat cardiac allografts by allopeptide-pulsed host dendritic cells. Transplantation (1999) 68(12):1827-1834.
  • ALI A, GARROVILLO M, JIN MX, HARDY MA, OLUWOLE SF: Major histocompatibility complex class I peptide-pulsed host dendritic cells induce antigen-specific acquired thymic tolerance to islet cells. Transplantation (2000) 69(2):221-226.
  • OLUWOLE OO, DEPAZ HA, GOPINATHAN R et al.: Indirect allorecognition in acquired thymic tolerance: induction of donor-specific permanent acceptance of rat islets by adoptive transfer of allopeptide-pulsed host myeloid and thymic dendritic cells. Diabetes (2001) 50(7):1546-1552.
  • GARROVILLO M, ALI A, DEPAZ HA et al.: Induction of transplant tolerance with immunodominant allopeptide-pulsed host lymphoid and myeloid dendritic cells. Am. J. Transplant. (2001) 1(2):129-137.
  • MATSUE H, MATSUE K, KUSUHARA M et al.: Immunosuppressive properties of CD95L-transduced ‘killer’ hybrids created by fusing donor- and recipient-derived dendritic cells. Blood (2001) 98(12):3465-3472.
  • MIRENDA V, BERTON I, READ J et al.: Modified dendritic cells coexpressing self and allogeneic major histocompatability complex molecules: an efficient way to induce indirect pathway regulation. J. Am. Soc. Nephrol. (2004) 15(4):987-997.
  • TANER T, HACKSTEIN H, WANG Z, MORELLI AE, THOMSON AW: Rapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survival. Am. J. Transplant. (2005) 5(2):228-236.
  • BITTENCOURT MC, PERRUCHE S, CONTASSOT E et al.: Intravenous injection of apoptotic leukocytes enhances bone marrow engraftment across major histocompatibility barriers. Blood (2001) 98(1):224-230.
  • FERGUSON TA, HERNDON J, ELZEY B et al.: Uptake of apoptotic antigen-coupled cells by lymphoid dendritic cells and cross-priming of CD8(+) T cells produce active immune unresponsiveness. J. Immunol. (2002) 168(11):5589-5595.
  • LIU K, IYODA T, SATERNUS M et al.: Immune tolerance after delivery of dying cells to dendritic cells in situ. J. Exp. Med. (2002) 196(8):1091-1097.
  • MORELLI AE, LARREGINA AT, SHUFESKY WJ et al.: Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production. Blood (2003) 101(2):611-620.
  • XU DL, LIU Y, TAN JM et al.: Marked prolongation of murine cardiac allograft survival using recipient immature dendritic cells loaded with donor-derived apoptotic cells. Scand. J. Immunol. (2004) 59(6):536-544.
  • DE VRIES IJ, EGGERT AA, SCHARENBORG NM et al.: Phenotypical and functional characterization of clinical grade dendritic cells. J. Immunother. (2002) 25(5):429-438.
  • FEUERSTEIN B, BERGER TG, MACZEK C et al.: A method for the production of cryopreserved aliquots of antigen-preloaded, mature dendritic cells ready for clinical use. J. Immunol. Meth. (2000) 245(1-2):15-29.
  • LEWALLE P, ROUAS R, LEHMANN F, MARTIAT P: Freezing of dendritic cells, generated from cryopreserved leukaphereses, does not influence their ability to induce antigen-specific immune responses or functionally react to maturation stimuli. J. Immunol. Meth. (2000) 240(1-2):69-78.
  • GALLUCCI S, LOLKEMA M, MATZINGER P: Natural adjuvants: endogenous activators of dendritic cells. Nat. Med. (1999) 5(11):1249-1255.
  • VOLL RE, HERRMANN M, ROTH EA et al.: Immunosuppressive effects of apoptotic cells. Nature (1997) 390(6658):350-351.
  • SHU S, COHEN P: Tumor-dendritic cell fusion technology and immunotherapy strategies. J. Immunother. (2001) 24(2):99-100.

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