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Expert Opinion on Biological Therapy Volume 7, 2007 - Issue 1
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Perspective

Limbal epithelial stem cell therapy

Julie T Daniels UCL Institute of Ophthalmology, Cells for Sight Transplantation and Research Programme, Ocular Repair and Regeneration Biology Unit, Division of Pathology, 11 – 43 Bath Street, London, EC1V 9EL, UK. [email protected]
,
Maria Notara UCL Institute of Ophthalmology, Cells for Sight Transplantation and Research Programme, Ocular Repair and Regeneration Biology Unit, Division of Pathology, 11 – 43 Bath Street, London, EC1V 9EL, UK. [email protected]
,
Alex J Shortt UCL Institute of Ophthalmology, Cells for Sight Transplantation and Research Programme, Ocular Repair and Regeneration Biology Unit, Division of Pathology, 11 – 43 Bath Street, London, EC1V 9EL, UK. [email protected]
,
Genevieve Secker UCL Institute of Ophthalmology, Cells for Sight Transplantation and Research Programme, Ocular Repair and Regeneration Biology Unit, Division of Pathology, 11 – 43 Bath Street, London, EC1V 9EL, UK. [email protected]
,
Anna Harris UCL Institute of Ophthalmology, Cells for Sight Transplantation and Research Programme, Ocular Repair and Regeneration Biology Unit, Division of Pathology, 11 – 43 Bath Street, London, EC1V 9EL, UK. [email protected]
&
Stephen J Tuft UCL Institute of Ophthalmology, Cells for Sight Transplantation and Research Programme, Ocular Repair and Regeneration Biology Unit, Division of Pathology, 11 – 43 Bath Street, London, EC1V 9EL, UK. [email protected]; Moorfields Eye Hospital NHS Foundation Trust, External Diseases Department, City Road, London, EC1V 2PD, UK
Pages 1-3 | Published online: 06 Dec 2006

Bibliography

  • DANIELS JT, DART JKG, TUFT S, KHAW PT: Corneal stem cells in review. Wound Rep. Regener. (2001) 9(6):483-494.
  • RHEINWALD JG, GREEN H: Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell (1975) 6(3):331-343.
  • PELLEGRINI G, TRAVERSO CE, FRANZI AT et al.: Long-term restoration of damaged corneal surfaces with autologous cultivated human epithelium. Lancet (1997) 349:990-993.
  • TSAI RJ, LI LM, CHEN JK: Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells. N. Engl. J. Med. (2000) 343:86-93.
  • GRUETERICH M, ESPANA EM, TOUHAMI A, TI SE, TSENG SC: Phenotypic study of a case with successful transplantation of ex vivo expanded human limbal epithelium for unilateral total limbal stem cell deficiency. Ophthalmology (2002) 109(8):1547-1552.
  • LAVKER RM, SUN TT: Epidermal stem cells: properties, markers and location. Proc. Natl. Acad. Sci. USA (2000) 97(25):13473-13475.
  • COTSARELIS SZ, CHENG G, DONG G, SUN TT, LAVKER RM: Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell (1989) 57:201-209.
  • ROMANO AC, ESPANA EM, YOO SH et al.: Different cell sized in human limbal and central corneal basal epithelia measured by confocal microscopy and flow cytometry. Invest. Ophthalmol. Vis. Sci. (2003) 44:5125-5129.
  • WATANABE K, NISHIDA K, YAMATO M et al.: Human limbal epithelium contains side population cells expressing the ATP-binding cassette transporter ABCG2. FEBS Lett. (2004) 565:6-10.
  • PELLEGRINI G, DELLAMBRA E, GOLISANO O et al.: p63 identifies keratinocyte stem cells. Proc. Natl. Acad. Sci. USA (2001) 98(6):3156-3161.
  • DI IORIO E, BARBARO V, RUZZA A et al.: Isoforms of DeltaNp63 and the migration of ocular limbal cells in human corneal regeneration. Proc. Natl. Acad. Sci. USA (2005) 102(27):9523-9528.
  • KENYON KR, TSENG SC: Limbal autograft transplantation for ocular surface disorders. Ophthalmology (1989) 96:709-722.
  • DAYA SM, WATSON A, SHAROE JR et al.: Outcomes and DNA analysis of ex vivo expanded stem cell allograft for ocular surface reconstruction. Ophthalmology (2005) 112(3):470-477.
  • DJALILIAN AR, MAHESH SP, KOCH CA et al.: Survival of donor epithelial cells after limbal stem cell transplantation. Invest. Ophthalmol. Vis. Sci. (2005) 46(3):803-807.
  • COBBOLD SP, ADAMS E, GRACA L et al.: Immune privilege induced by regulatory T cells in transplantation tolerance. Immunol. Rev. (2006) 213:239-255.
  • TORENS S, BERGER E, STAVE J, GUTHOFF R: Imaging of the microarchitecture and dynamics of the break-up phenomena of the preocular tear film with the aid of laser scanning microscopy. Ophthalmologe (2000) 97(9):635-639.
  • GLASER T, WALTON DS, MAAS RL: Genomic struture, evolutionary conservation and aniridia mutations in the human PAX6 gene. Nat. Genet. (1992) 2:232-239.
  • HILL RE, FAVOR J, HOGAN BL et al.: Mouse small eye results from mutations in a paired-like homeobox-containing gene. Nature (1991) 354(6354):522-525.

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