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Editorial

Recent findings into the potential of gene therapy to reverse heart failure

, MD, , MD & , PhD
Pages 1781-1784 | Published online: 22 Nov 2007

Bibliography

  • Heart Disease and Stroke Statistics. American Heart Association, Dallas, TX, USA (2007).
  • FELDMAN DS, CARNES CA, ABRAHAM WT, BRISTOW MR: Mechanisms of disease: β-adrenergic receptors-alterations in signal transduction and pharmacogenetics in heart failure. Nat. Clin. Pract. Cardiovasc. Med. (2005) 2:475-483.
  • HASENFUSS G, PIESKE B: Calcium cycling in congestive heart failure. J. Mol. Cell. Cardiol. (2002) 34:951-969.
  • WILLIAMS M-L, HATA J-A, SCHRODER J et al.: Targeted β-adrenergic receptor kinase (bARK1) inhibition by gene transfer in failing human hearts. Circulation (2004) 109:1590-1593.
  • WHITE D-C, HATA J-A, SHAH A-S et al.: Preservation of myocardial β-adrenergic receptor signaling delays the development of heart failure after myocardial infarction. Proc. Natl. Acad. Sci. USA (2000) 97:5428-5433.
  • DEL MONTE F, HARDING S-E, DEC G-W, GWATHMEY J-K, HAJJAR R-J: Targeting phospholamban by gene transfer in human heart failure. Circulation (2002) 105:904-907.
  • MIYAMOTO M-I, DEL MONTE F, SCHMIDT U et al.: Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure. Proc. Natl. Acad. Sci. USA (2000) 97:793-798.
  • IWANAGA Y, HOSHIJIMA M, GU Y et al.: Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats. J. Clin. Invest. (2004) 113:727-736.
  • BRAZ J-C, GREGORY K, PATHAK A et al.: PKC-α regulates cardiac contractility and propensity toward heart failure. Nat. Med. (2004) 10:248-254.
  • PRESTLE J, JANSSEN P-M, JANSSEN A-P et al.: Overexpression of FK506-binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca(2+) leak from the sarcoplasmic reticulum and increases contractility. Circ. Res. (2001) 88:188-194.
  • MOST P, BERNOTAT J, EHLERMANN P et al.: S100A1: a regulator of myocardial contractility. Proc. Natl. Acad. Sci. USA (2001) 98:13889-13894.
  • MOST P, REMPPIS A, PLEGER S-T et al.: Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance. J. Biol. Chem. (2003) 278:33809-33817.
  • MOST P, PLEGER S-T, VOLKERS M et al.: Cardiac adenoviral S100A1 gene delivery rescues failing myocardium. J. Clin. Invest. (2004) 114:1550-1563.
  • DONSANTE A, MILLER D-G, LI Y et al.: AAV vector integration sites in mouse hepatocellular carcinoma. Science (2007) 317:477.
  • PLEGER S-T, MOST P, BOUCHER M et al.: Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue. Circulation (2007) 115:2506-2515.
  • KATZ A: Potential deleterious effects of inotropic reagents in the therapy of chronic heart failure. Circulation (1986) 73:III-184-III-190 (Abstract).
  • JANOSI A, GHALI J-K, HERLITZ J et al.; FOR THE MERIT-HF STUDY GROUP: Metoprolol CR/XL in postmyocardial infarction patients with chronic heart failure: experiences from MERIT-HF. Am. Heart J. (2003) 146:721-728.
  • CHEN Y, ESCOUBET B, PRUNIER F et al.: Constitutive cardiac overexpression of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase delays myocardial failure after myocardial infarction in rats at a cost of increased acute arrhythmias. Circulation (2004) 109:1898-1903.
  • SASANO T, KIKUCHI K, MC DONALD A-D, LAI S, DONAHUE J-K: Targeted high-efficiency, homogeneous myocardial gene transfer. J. Mol. Cell. Cardiol. (2007) 42:954-961.

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