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Drug Evaluation

Infliximab therapy for pediatric Crohn's disease

, MD, , MD & , MD
Pages 1869-1880 | Published online: 22 Nov 2007

Bibliography

  • MAMULA P, MARKOWITZ JE, BALDASSANO RN: Inflammatory bowel disease in early childhood and adolescence: special considerations. Gastroenterol. Clin. North Am. (2003) 32:967-995.
  • AUVIN S, MOLINIE F, GOWER-ROUSSEAU C et al.: Incidence, clinical presentation and location at diagnosis of pediatric inflammatory bowel disease: a prospective population-based study in northern France (1988 – 1999). J. Pediatr. Gastroenterol. Nutr. (2005) 41:49-55.
  • KUGATHASAN SJ, HOFFMANN R, HEIKENEN R et al.: Epidemiologic and characteristics of children with newly diagnosed inflammatory bowel disease in Wisconsin: a statewide population-based study. J. Pediatr. (2003) 143:525-531.
  • HILDEBRAND H, FINKEL Y, GRAHNQUIST L et al.: Changing pattern of paediatric inflammatory bowel disease in northern Stockholm 1990 – 2001. Gut (2003) 52:1432-1434.
  • CUFFARI C: Inflammatory bowel disease in children: a pediatrician's perspective. Minerva Pediatr. (2006) 58:139-157.
  • GRIFFITHS A, NGUYEN P, SMITH C et al.: Growth and clinical course of children with Crohn's disease. Gut (1993) 34:939-943.
  • MARKOWITZ J, GRANCHER K, KOHN N et al.: A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn's disease. Gastroenterology (2000) 119:895-902.
  • KIRSCHNER B: Safety of azathioprine and 6-mercaptopurine in pediatric patients with inflammatory bowel disease. Gastroenterology (1998) 115:813-821.
  • RUTGEERTS P, D'HAENS G, TARGAN S et al.: Efficacy and safety of retreatment with anti-TNF antibody (infliximab) to maintain remission in Crohn's disease. Gastroenterology (1999) 117:761-769.
  • RUEMMELE FM: Infliximab: how to use it in pediatric Crohn's disease. J. Pediatr. Gastroenterol. Nutr. (2004) 39:12-14.
  • LOWENBERG M, PEPPELENBOSCH M, HOMMES D: Biological therapy in the management of recent-onset Crohn's disease: why, when and how? Drugs (2006) 66:1431-1439.
  • CAPRILLI R, ANGELUCCI E, COCCO A: Early or late guided missile in the treatment of Crohn's disease? Dig. Liver Dis. (2005) 37:973-979.
  • BALDASSANO RN: Surpassing conventional therapies: the role of biologic therapy. J. Pediatr. Gastroenterol. Nutr. (2001) 33(Suppl. 1):S19-S26.
  • RUTGEERTS P, VAN ASSCHE G, VERMEIRE S: Review article: infliximab therapy for inflammatory bowel disease – seven years on. Aliment. Pharmacol. Ther. (2006) 23:451-463.
  • TARGAN SR, HANAUER SB, VAN DEVENTER SJ et al.: A short-term study of chimeric monoclonal antibody cA2 to TNF-α for Crohn's disease. Crohn's disease cA2 study group. N. Engl. J. Med. (1997) 337:1029-1035.
  • HANAUER SB, FEAGAN BG, LICHTENSTEIN GR et al.: Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial. Lancet (2002) 359:1541-1549.
  • RUTGEERTS P, FEAGAN BG, LICHTENSTEIN GR et al.: Comparison of scheduled and episodic treatment strategies of infliximab in Crohn's disease. Gastroenterology (2004) 126:402-413.
  • DERKX B, TAMINIAU J, RADEMA S et al.: TNF antibody treatment in Crohn's disease. Lancet (1993) 342:173-174.
  • HOMAN M, BALDASSANO RN, MAMULA P: Managing complicated Crohn's disease in children and adolescents. Nat. Clin. Pract. Gastroenterol. Hepatol. (2005) 2:572-579.
  • Hyams J, Crandall W, Kugathasan S et al.: Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn's disease in children. Gastroenterology (2007) 132:863-873.
  • BAUMGART DC, SANDBORN WJ: Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet (2007) 369:1641-1657.
  • MULLBERG J, ALTHOFF K, JOSTOCK T et al.: The importance of shedding of membrane proteins for cytokine biology. Eur. Cytokine Netw. (2000) 11:27-38.
  • BRYNSKOV J, FOEGH P, PEDERSEN G et al.: TNF-α converting enzyme (TACE) activity in the colonic mucosa of patients with inflammatory bowel disease. Gut (2002) 51:37-43.
  • LOUIS E, RIBBENS C, GODON A et al.: Increased production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 by inflamed mucosa in inflammatory bowel disease. Clin. Exp. Immunol. (2000) 120:241-246.
  • BREESE EJ, MICHIE CA, NICHOLLS SW et al.: TNF-α-producing cells in the intestinal mucosa of children with inflammatory bowel disease. Gastroenterology (1994) 106:1455-1466.
  • NICHOLLS S, STEPHENS S, BRAEGGER CP et al.: Cytokines in stools of children with inflammatory bowel disease or infective diarrhoea. J. Clin. Pathol. (1993) 46:757-760.
  • ARDIZZONE S, BIANCHI PORRO G: Inflammatory bowel disease: new insights into pathogenesis and treatment. J. Intern. Med. (2002) 252:475-496.
  • CORNILLIE F, SHEALY D, D'HAENS G et al.: Infliximab induces potent anti-inflammatory and local immunomodulatory activity but no systemic immune suppression in patients with crohn's disease. Aliment. Pharmacol. Ther. (2001) 15:463-473.
  • RUTGEERTS P, VAN ASSCHE G, VERMEIRE S: Optimizing anti-TNF treatment in inflammatory bowel disease. Gastroenterology (2004) 126:1593-1610.
  • ZEISSIG S, BOJARSKI C, BUERGEL N et al.: Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by TNF-α antibody treatment. Gut (2004) 53:1295-1302.
  • BEGUE B, WAJANT H, BAMBOU JC et al.: Implication of TNF-related apoptosis-inducing ligand in inflammatory intestinal epithelial lesions. Gastroenterology (2006) 130:1962-1974.
  • VAN DEN BRANDE JM, BRAAT H, VAN DEN BRINK GR et al.: Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease. Gastroenterology (2003) 124:1774-1785.
  • DI SABATINO A, CICCOCIOPPO R, CINQUE B et al.: Defective mucosal T cell death is sustainably reverted by infliximab in a caspase dependent pathway in Crohn's disease. Gut (2004) 53:70-77.
  • VAN DEN BRANDE JM, KOEHLER TC, ZELINKOVA Z et al.: Prediction of anti-TNF clinical efficacy by real-time visualisation of apoptosis in patients with Crohn's disease. Gut (2007) 56:509-517.
  • ARDIZZONE S, BIANCHI PORRO G: Biologic therapy for inflammatory bowel disease. Drugs (2005) 65:2253-2286.
  • MAMULA P, COHEN SA, FERRY GD et al.: CDP571, a humanized anti-TNF-α monoclonal antibody in pediatric Crohn's disease. Inflamm. Bowel Dis. (2004) 10:723-730.
  • SANDBORN WJ, FEAGAN BG, HANAUER SB et al.: An engineered human antibody to TNF (CDP571) for active Crohn's disease: a randomized double-blind placebo-controlled trial. Gastroenterology (2001) 120:1330-1338.
  • NESBITT A, FOSSATI G, BERGIN M et al.: Mechanism of action of certolizumab pegol (CDP870): in vitro comparison with other anti-TNF-α agents. Inflamm. Bowel Dis. (2007) 13:1323-1332.
  • PAPADAKIS KA, TARGAN SR: TNF: biology and therapeutic inhibitors. Gastroenterology (2000) 119:1148-1157.
  • DANESE S, SANS M, SCALDAFERRI F et al.: TNF-α blockade down-regulates the CD40/CD40L pathway in the mucosal microcirculation: a novel anti-inflammatory mechanism of infliximab in Crohn's disease. J. Immunol. (2006) 176:2617-2624.
  • BALDASSANO R, BRAEGGER CP, ESCHER JC et al.: Infliximab (REMICADE) therapy in the treatment of pediatric Crohn's disease. Am. J. Gastroenterol. (2003) 98:833-838.
  • KUGATHASAN S, WERLIN SL, MARTINEZ A et al.: Prolonged duration of response to infliximab in early but not late pediatric Crohn's disease. Am. J. Gastroenterol. (2000) 95:3189-3194.
  • HYAMS JS, MARKOWITZ J, WYLLIE R: Use of infliximab in the treatment of Crohn's disease in children and adolescents. J. Pediatr. (2000) 137:192-196.
  • CEZARD JP, NOUAILI N, TALBOTEC C et al.: A prospective study of the efficacy and tolerance of a chimeric antibody to TNF (remicade) in severe pediatric Crohn disease. J. Pediatr. Gastroenterol. Nutr. (2003) 36:632-636.
  • BORRELLI O, BASCIETTO C, VIOLA F et al.: Infliximab heals intestinal inflammatory lesions and restores growth in children with Crohn's disease. Dig. Liver Dis. (2004) 36:342-347.
  • HOMMES D, BAERT F, VAN ASSCHE G et al.: The ideal management of Crohn's disease: top down versus step up strategies, a randomized controlled trial. Gastroenterology (2006) 130(Suppl. II):A749.
  • ROMEO E, VIOLA F, DEANGELIS G et al.: Infliximab as a first choice therapy in children with newly diagnosed Crohn's disease promotes long-term sustained remission and alters the course of the disease. Gastroenterology (2007) 130(Suppl. II):A56.
  • DE RIDDER L, ESCHER JC, BOUQUET J et al.: Infliximab therapy in 30 patients with refractory pediatric Crohn disease with and without fistulas in The Netherlands. J. Pediatr. Gastroenterol. Nutr. (2004) 39:46-52.
  • LIONETTI P, BRONZINI F, SALVESTRINI C et al.: Response to infliximab is related to disease duration in paediatric Crohn's disease. Aliment. Pharmacol. Ther. (2003) 18:425-431.
  • LAMIREAU T, CEZARD JP, DABADIE A et al.: Efficacy and tolerance of infliximab in children and adolescents with Crohn's disease. Inflamm. Bowel Dis. (2004) 10:745-750.
  • CANDON S, MOSCA A, RUEMMELE F et al.: Clinical and biological consequences of immunization to infliximab in pediatric Crohn's disease. Clin. Immunol. (2006) 118:11-19.
  • WEWER V, RIIS L, VIND I et al.: Infliximab dependency in a national cohort of children with Crohn's disease. J. Pediatr. Gastroenterol. Nutr. (2006) 42:40-45.
  • CONDINO AA, FIDANZA S, HOFFENBERG EJ: A home infliximab infusion program. J. Pediatr. Gastroenterol. Nutr. (2005) 40:67-69.
  • PARK SH, JEEN YT, CHUN HR et al.: A case of refractory pediatric Crohn's disease with a successful treatment by infliximab therapy. Korean J. Gastroenterol. (2005) 46:297-301.
  • TEITELBAUM JE, SAEED S, TRIANTAFYLLOPOULOU M et al.: Infliximab in pediatric Crohn disease patients with enterovesicular fistulas. J. Pediatr. Gastroenterol. Nutr. (2007) 44:279-282.
  • BARABINO A, CASTELLANO E, GANDULLIA P et al.: A girl with severe fistulizing Crohn's disease. Dig. Liver Dis. (2000) 32:792-794.
  • REGUEIRO M, MARDINI H: Treatment of perianal fistulizing Crohn's disease with infliximab alone or as an adjunct to exam under anesthesia with seton placement. Inflamm. Bowel Dis. (2003) 9:98-103.
  • KOOROS K, KATZ AJ: Infliximab therapy in pediatric Crohn's pouchitis. Inflamm. Bowel Dis. (2004) 10:417-420.
  • KUGATHASAN S, MIRANDA A, NOCTON J et al.: Dermatologic manifestations of Crohn disease in children: response to infliximab. J. Pediatr. Gastroenterol. Nutr. (2003) 37:150-154.
  • BATRES LA, MAMULA P, BALDASSANO RN: Resolution of severe peristomal pyoderma gangrenosum with infliximab in a child with Crohn disease. J. Pediatr. Gastroenterol. Nutr. (2002) 34:558-560.
  • RAJARAMAN RT, KIMURA Y, LI S et al.: Retrospective case review of pediatric patients with uveitis treated with infliximab. Ophthalmology (2006) 113:308-314.
  • QUARTA L, CORRADO A, MELILLO N et al.: Juvenile idiopathic arthritis: an update on clinical and therapeutic approaches. Ann. Ital. Med. Int. (2005) 20:211-217.
  • RICHARDS JC, TAY-KEARNEY ML, MURRAY K et al.: Infliximab for juvenile idiopathic arthritis-associated uveitis. Clin. Exp. Ophthalmol. (2005) 33:461-468.
  • SILBERMINTZ A, KRISHNAN S, BANQUET A et al.: Granulomatous pneumonitis, sclerosing cholangitis, and pancreatitis in a child with Crohn disease: response to infliximab. J. Pediatr. Gastroenterol. Nutr. (2006) 42:324-326.
  • MIELE E, MARKOWITZ JE, MAMULA P et al.: Human antichimeric antibody in children and young adults with inflammatory bowel disease receiving infliximab. J. Pediatr. Gastroenterol. Nutr. (2004) 38:502-508.
  • FARRELL RJ, ALSAHLI M, JEEN YT et al.: Intravenous hydrocortisone premedication reduces antibodies to infliximab in Crohn's disease: a randomized controlled trial. Gastroenterology (2003) 124:917-924.
  • BAERT F, NOMAN M, VERMEIRE S et al.: Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease. N. Engl. J. Med. (2003) 348:601-608.
  • SANDBORN WJ: Preventing antibodies to infliximab in patients with Crohn's disease: optimize not immunize. Gastroenterology (2003) 124:1140-1145.
  • VERMEIRE S, NOMAN M, VAN ASSCHE G et al.: Autoimmunity associated with anti-TNF-α treatment in Crohn's disease: a prospective cohort study. Gastroenterology (2003) 125:32-39.
  • HANAUER SB: Risks and benefits of combining immunosuppressives and biological agents in inflammatory bowel disease: is the synergy worth the risk? Gut (2007) 56:1181-1183.
  • VERMEIRE S, NOMAN M, VAN ASSCHE G et al.: Effectiveness of concomitant immunosuppressive therapy in suppressing the formation of antibodies to infliximab in Crohn's disease. Gut (2007) 56:1226-1231.
  • COHEN RD, TSANG JF, HANAUER SB: Infliximab in Crohn's disease: first anniversary clinical experience. Am. J. Gastroenterol. (2000) 95:3469-3477.
  • COHEN RD: Efficacy and safety of repeated infliximab infusions for Crohn's disease: 1-year clinical experience. Inflamm. Bowel Dis. (2001) 7(Suppl. 1):S17-S22.
  • JACOBSTEIN DA, MARKOWITZ JE, KIRSCHNER BS et al.: Premedication and infusion reactions with infliximab: results from a pediatric inflammatory bowel disease consortium. Inflamm. Bowel Dis. (2005) 11:442-446.
  • STEPHENS MC, SHEPANSKI MA, MAMULA P et al.: Safety and steroid-sparing experience using infliximab for Crohn's disease at a pediatric inflammatory bowel disease center. Am. J. Gastroenterol. (2003) 98:104-111.
  • FRIESEN CA, CALABRO C, CHRISTENSON K et al.: Safety of infliximab treatment in pediatric patients with inflammatory bowel disease. J. Pediatr. Gastroenterol. Nutr. (2004) 39:265-269.
  • CRANDALL WV, MACKNER LM: Infusion reactions to infliximab in children and adolescents: frequency, outcome and a predictive model. Aliment. Pharmacol. Ther. (2003) 17:75-84.
  • KUGATHASAN S, LEVY MB, SAEIAN K et al.: Infliximab retreatment in adults and children with Crohn's disease: risk factors for the development of delayed severe systemic reaction. Am. J. Gastroenterol. (2002) 97:1408-1414.
  • PUCHNER TC, KUGATHASAN S, KELLY KJ et al.: Successful desensitization and therapeutic use of infliximab in adult and pediatric Crohn's disease patients with prior anaphylactic reaction. Inflamm. Bowel Dis. (2001) 7:34-37.
  • VERES G, BALDASSANO RN, MAMULA P: Infliximab therapy in children and adolescents with inflammatory bowel disease. Drugs (2007) 67:1703-1723.
  • COLOMBEL JF, LOFTUS EV Jr, TREMAINE WJ et al.: The safety profile of infliximab in patients with Crohn's disease: the Mayo clinic experience in 500 patients. Gastroenterology (2004) 126:19-31.
  • KAMATH BM, MAMULA P, BALDASSANO RN et al.: Listeria meningitis after treatment with infliximab. J. Pediatr. Gastroenterol. Nutr. (2002) 34:410-412.
  • BEHNAM SM, BEHNAM SE, KOO JY: TNF-α inhibitors and congestive heart failure. Skinmed (2005) 4:363-368.
  • REICHARDT P, DAHNERT I, TILLER G et al.: Possible activation of an intramyocardial inflammatory process (Staphylococcus aureus) after treatment with infliximab in a boy with Crohn disease. Eur. J. Pediatr. (2002) 161:281-283.
  • ARMBRUST W, KAMPHUIS SS, WOLFS TW et al.: Tuberculosis in a nine-year-old girl treated with infliximab for systemic juvenile idiopathic arthritis. Rheumatology (2004) 43:527-529.
  • MYERS A, CLARK J, FOSTER H: Tuberculosis and treatment with infliximab. N. Engl. J. Med. (2002) 346:623-626.
  • KEANE J, GERSHON S, WISE RP et al.: Tuberculosis associated with infliximab, a TNF-α-neutralizing agent. N. Engl. J. Med. (2001) 345:1098-1104.
  • MOW WS, ABREU-MARTIN MT, PAPADAKIS KA et al.: High incidence of anergy in inflammatory bowel disease patients limits the usefulness of PPD screening before infliximab therapy. Clin. Gastroenterol. Hepatol. (2004) 2:309-313.
  • HATEMI G, MELIKOGLU M, FRESKO I et al.: Infliximab does not suppress the tuberculin skin test (purified protein derivative). J. Rheumatol. (2007) 34:474-480.
  • HOMIK J, SUAREZ-ALMAZOR ME, SHEA B et al.: Calcium and vitamin D for corticosteroid-induced osteoporosis. Cochrane Database Syst. Rev. (2000) 2:CD000952.
  • LICHTENSTEIN GR, FEAGAN BG, COHEN RD et al.: Serious infections and mortality in association with therapies for Crohn's disease: TREAT registry. Clin. Gastroenterol. Hepatol. (2006) 4:621-630.
  • BIANCONE L, ORLANDO A, KOHN A et al.: Infliximab and newly diagnosed neoplasia in Crohn's disease: a multicentre matched pair study. Gut (2006) 55:228-233.
  • BONGARTZ T, SUTTON AJ, SWEETING MJ et al.: Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA (2006) 295:2275-2285.
  • SIEGEL CA, HUR C, KORZENIK JR et al.: Risks and benefits of infliximab for the treatment of Crohn's disease. Clin. Gastroenterol. Hepatol. (2006) 4:1017-1024.
  • THAYU M, MARKOWITZ JE, MAMULA P et al.: Hepatosplenic T-cell lymphoma in an adolescent patient after immunomodulator and biologic therapy for Crohn disease. J. Pediatr. Gastroenterol. Nutr. (2005) 40:220-222.
  • MACKEY AC, GREEN L, LIANG LC et al.: Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease. J. Pediatr. Gastroenterol. Nutr. (2007) 44:265-267.
  • ROSH JR, GROSS T, MAMULA P et al.: Hepatosplenic T-cell lymphoma in adolescents and young adults with Crohn's disease: a cautionary tale? Inflamm. Bowel Dis. (2007) 13:1024-1030.
  • NAVARRO JT, RIBERA JM, MATE JL et al.: Hepatosplenic T-γδ lymphoma in a patient with Crohn's disease treated with azathioprine. Leuk. Lymphoma (2003) 44:531-533.
  • VEGA F, MEDEIROS LJ, GAULARD P: Hepatosplenic and other γδ T-cell lymphomas. Am. J. Clin. Pathol. (2007) 127:869-880.

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