Role of pulmonary adenosine during hypoxia: extracellular generation, signaling and metabolism by surface adenosine deaminase/CD26

Bibliography

• GRENZ A, ZHANG H, ECKLE T et al.: Protective role of ecto-5′-nucleotidase (CD73) in renal ischemia. J. Am. Soc. Nephrol. (2007).
   PubMedGoogle Scholar
• GRENZ A, ECKLE T, ZHANG H et al.: Use of a hanging-weight system for isolated renal artery occlusion during ischemic preconditioning in mice. Am. J. Physiol. Renal Physiol. (2007) 292(1):F475-F485.
   PubMed Web of Science ®Google Scholar
• ECKLE T, KRAHN T, GRENZ A et al.: Cardioprotection by ecto-5′-nucleotidase (CD73) and A2B adenosine receptors. Circulation (2007).
   Google Scholar
• ECKLE T, GRENZ A, KOHLER D et al.: Systematic evaluation of a novel model for cardiac ischemic preconditioning in mice. Am. J. Physiol. Heart Circ. Physiol. (2006) 291(5):H2533-H2540.
   PubMed Web of Science ®Google Scholar
• GOLDHABER SZ: Pulmonary embolism. N. Engl. J. Med. (1998) 339(2):93-104.
   PubMed Web of Science ®Google Scholar
• WARE LB, MATTHAY MA: The acute respiratory distress syndrome. N. Engl. J. Med. (2000) 342(18):1334-1349.
   PubMed Web of Science ®Google Scholar
• ELTZSCHIG HK, IBLA JC, FURUTA GT et al.: Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors. J. Exp. Med. (2003) 198(5):783-796.
   PubMed Web of Science ®Google Scholar
• THOMPSON LF, ELTZSCHIG HK, IBLA JC et al.: Crucial role for ecto-5′-nucleotidase (CD73) in vascular leakage during hypoxia. J. Exp. Med. (2004) 200(11):1395-1405.
   PubMed Web of Science ®Google Scholar
• ELTZSCHIG HK, THOMPSON LF, KARHAUSEN J et al.: Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood (2004) 104(13):3986-3992.
   PubMed Web of Science ®Google Scholar
• COLGAN SP, DZUS AL, PARKOS CA: Epithelial exposure to hypoxia modulates neutrophil transepithelial migration. J. Exp. Med. (1996) 184(3):1003-1015.
   PubMed Web of Science ®Google Scholar
• KARAKURUM M, SHREENIWAS R, CHEN J et al.: Hypoxic induction of interleukin-8 gene expression in human endothelial cells. J. Clin. Invest. (1994) 93(4):1564-1570.
   PubMed Web of Science ®Google Scholar
• YAN SF, OGAWA S, STERN DM, PINSKY DJ: Hypoxia-induced modulation of endothelial cell properties: regulation of barrier function and expression of interleukin-6. Kidney Int. (1997) 51(2):419-425.
   PubMed Web of Science ®Google Scholar
• ZUND G, UEZONO S, STAHL GL et al.: Hypoxia enhances induction of endothelial ICAM-1: role for metabolic acidosis and proteasomes. Am. J. Physiol. (1997) 273(5 Part 1):C1571-C1580.
   PubMed Web of Science ®Google Scholar
• KONG T, ELTZSCHIG HK, KARHAUSEN J, COLGAN SP, SHELLEY CS: Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of {β}2 integrin gene expression. Proc. Natl. Acad. Sci. USA (2004) 101(28):10440-10445.
   PubMed Web of Science ®Google Scholar
• WEISSMULLER T, ELTZSCHIG HK, COLGAN SP: Dynamic purine signaling and metabolism during neutrophil-endothelial interactions. Purinergic Signal. (2005) 1(3):229-239.
   PubMedGoogle Scholar
• ELTZSCHIG HK, ABDULLA P, HOFFMAN E et al.: HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia. J. Exp. Med. (2005) 202(11):1493-1505.
   PubMed Web of Science ®Google Scholar
• COLGAN SP, ELTZSCHIG HK, ECKLE T, THOMPSON LF: Physiological roles of 5′-ectonucleotidase (CD73). Purinergic Signal. (2006) 2(2):351-360.
   PubMedGoogle Scholar
• BLACKBURN MR: Too much of a good thing: adenosine overload in adenosine-deaminase-deficient mice. Trends Pharmacol. Sci. (2003) 24(2):66-70.
   PubMed Web of Science ®Google Scholar
• DRIVER AG, KUKOLY CA, ALI S, MUSTAFA SJ: Adenosine in bronchoalveolar lavage fluid in asthma. Am. Rev. Respir. Dis. (1993) 148(1):91-97.
   PubMed Web of Science ®Google Scholar
• HUSZAR E, VASS G, VIZI E et al.: Adenosine in exhaled breath condensate in healthy volunteers and in patients with asthma. Eur. Respir. J. (2002) 20(6):1393-1398.
   PubMed Web of Science ®Google Scholar
• MUSTAFA SJ, NADEEM A, FAN M et al.: Effect of a specific and selective A(2B) adenosine receptor antagonist on adenosine agonist AMP and allergen-induced airway responsiveness and cellular influx in a mouse model of asthma. J. Pharmacol. Exp. Ther. (2007) 320(3):1246-1251.
   PubMed Web of Science ®Google Scholar
• NADEEM A, FAN M, ANSARI HR, LEDENT C, MUSTAFA SJ: Enhanced airway reactivity and inflammation in A2A adenosine receptor deficient allergic mice. Am. J. Physiol. Lung Cell Mol. Physiol. (2007) 292(6):L1335-L1344.
   PubMed Web of Science ®Google Scholar
• FOZARD JR, HANNON JP: Adenosine receptor ligands: potential as therapeutic agents in asthma and COPD. Pulm. Pharmacol. Ther. (1999) 12(2):111-114.
   PubMed Web of Science ®Google Scholar
• BLACKBURN MR, VOLMER JB, THRASHER JL et al.: Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction. J. Exp. Med. (2000) 192(2):159-170.
   PubMed Web of Science ®Google Scholar
• SUN C-X, YOUNG HW, MOLINA JG et al.: A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury. J. Clin. Invest. (2005) 115(1):35-43.
   PubMed Web of Science ®Google Scholar
• CHUNN JL, MOLINA JG, MI T et al.: Adenosine-dependent pulmonary fibrosis in adenosine deaminase-deficient mice. J. Immunol. (2005) 175(3):1937-1946.
   PubMed Web of Science ®Google Scholar
• ELTZSCHIG HK, FAIGLE M, KNAPP S et al.: Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26. Blood (2006) 108(5):1602-1610.
   PubMed Web of Science ®Google Scholar
• LINDEN J: Ups and downs of adenosine. Blood (2006) 108(5):1430.
   Web of Science ®Google Scholar
• KUZMIN AI, LAKOMKIN VL, KAPELKO VI, VASSORT G: Interstitial ATP level and degradation in control and postmyocardial infarcted rats. Am. J. Physiol. (1998) 275(3 Part 1):C766-C771.
   PubMed Web of Science ®Google Scholar
• ECKLE T, FULLBIER L, WEHRMANN M et al.: Identification of ecto-nucleotidases CD39 and CD73 in innate protection during acute lung injury. J. Immunol. (2007) (In Press).
   PubMedGoogle Scholar
• KHOURY J, IBLA JC, NEISH AS, COLGAN SP: Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation. J. Clin. Invest. (2007) 117(3):703-711.
   PubMed Web of Science ®Google Scholar
• ENJYOJI K, SEVIGNY J, LIN Y et al.: Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Nat. Med. (1999) 5(9):1010-1017.
   PubMed Web of Science ®Google Scholar
• NOVAK I: ATP as a signaling molecule: the exocrine focus. News Physiol. Sci. (2003) 18(1):12-17.
   PubMedGoogle Scholar
• GERASIMOVSKAYA EV, AHMAD S, WHITE CW et al.: Extracellular ATP is an autocrine/paracrine regulator of hypoxia-induced adventitial fibroblast growth. Signaling through extracellular signal-regulated kinase-1/2 and the Egr-1 transcription factor. J. Biol. Chem. (2002) 277(47):44638-44650.
   PubMed Web of Science ®Google Scholar
• AHMAD S, AHMAD A, GHOSH M, LESLIE CC, WHITE CW: Extracellular ATP-mediated signaling for survival in hyperoxia-induced oxidative stress. J. Biol. Chem. (2004) 279(16):16317-16325.
   PubMed Web of Science ®Google Scholar
• AHMAD S, AHMAD A, MCCONVILLE G et al.: Lung epithelial cells release ATP during ozone exposure: signaling for cell survival. Free Radic. Biol. Med. (2005) 39(2):213-226.
   PubMed Web of Science ®Google Scholar
• GORDON JL: Extracellular ATP: effects, sources and fate. Biochem. J. (1986) 233(2):309-319.
   PubMed Web of Science ®Google Scholar
• LINDEN J: Purinergic chemotaxis. Science (2006) 314(5806):1689-1690.
   PubMed Web of Science ®Google Scholar
• CHEN Y, CORRIDEN R, INOUE Y et al.: ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science (2006) 314(5806):1792-1795.
   PubMed Web of Science ®Google Scholar
• ELTZSCHIG HK, ECKLE T, MAGER A et al.: ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function. Circ. Res. (2006) 99(10):1100-1108.
   PubMed Web of Science ®Google Scholar
• ROBSON SC, WU Y, SUN X et al.: Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation. Semin. Thromb. Hemost. (2005) 31(2):217-233.
   PubMed Web of Science ®Google Scholar
• GUCKELBERGER O, SUN XF, SEVIGNY J et al.: Beneficial effects of CD39/ecto-nucleoside triphosphate diphosphohydrolase-1 in murine intestinal ischemia–reperfusion injury. Thromb. Haemost. (2004) 91(3):576-586.
   PubMed Web of Science ®Google Scholar
• SYNNESTVEDT K, FURUTA GT, COMERFORD KM et al.: Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. J. Clin. Invest. (2002) 110(7):993-1002.
   PubMed Web of Science ®Google Scholar
• HUANG LE, GU J, SCHAU M, BUNN HF: Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci. USA (1998) 95(14):7987-7992.
   PubMed Web of Science ®Google Scholar
• IYER NV, KOTCH LE, AGANI F et al.: Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1a. Genes Dev. (1998) 12(2):149-162.
   PubMed Web of Science ®Google Scholar
• SEMENZA GL: HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell (2001) 107(1):1-3.
   PubMed Web of Science ®Google Scholar
• SEMENZA GL: HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J. Appl. Physiol. (2000) 88(4):1474-1480.
   PubMed Web of Science ®Google Scholar
• HENTTINEN T, JALKANEN S, YEGUTKIN GG: Adherent leukocytes prevent adenosine formation and impair endothelial barrier function by ecto-5′-nucleotidase/CD73-dependent mechanism. J. Biol. Chem. (2003) 278(27):24888-24895.
   PubMed Web of Science ®Google Scholar
• KONG T, WESTERMAN KA, FAIGLE M, ELTZSCHIG HK, COLGAN SP: HIF-dependent induction of adenosine A2B receptor in hypoxia. FASEB J. (2006) 20(13):2242-2250.
   PubMed Web of Science ®Google Scholar
• DELACRETAZ E: Clinical practice. Supraventricular tachycardia. N. Engl. J. Med. (2006) 354(10):1039-1051.
   PubMed Web of Science ®Google Scholar
• LOFFLER M, MOROTE-GARCIA JC, ELTZSCHIG SA, COE IR, ELTZSCHIG HK: Physiological roles of vascular nucleoside transporters. Arterioscler. Thromb. Vasc. Biol. (2007) 27(5):1004-1013.
   PubMed Web of Science ®Google Scholar
• SAITO H, NISHIMURA M, SHINANO H et al.: Plasma concentration of adenosine during normoxia and moderate hypoxia in humans. Am. J. Respir. Crit. Care Med. (1999) 159(3):1014-1018.
   PubMed Web of Science ®Google Scholar
• ARCHER RG, PITELKA V, HAMMOND JR: Nucleoside transporter subtype expression and function in rat skeletal muscle microvascular endothelial cells. Br. J. Pharmacol. (2004) 143(1):202-214.
   PubMed Web of Science ®Google Scholar
• CASANELLO P, TORRES A, SANHUEZA F et al.: Equilibrative nucleoside transporter 1 expression is downregulated by hypoxia in human umbilical vein endothelium. Circ. Res. (2005) 97(1):16-24.
   PubMed Web of Science ®Google Scholar
• NARRAVULA S, COLGAN SP: Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor α expression during hypoxia. J. Immunol. (2001) 166(12):7543-7548.
   PubMed Web of Science ®Google Scholar
• MANALO DJ, ROWAN A, LAVOIE T et al.: Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood (2005) 105(2):659-669.
   PubMed Web of Science ®Google Scholar
• FACTOR P, MUTLU GM, CHEN L et al.: Adenosine regulation of alveolar fluid clearance. Proc. Natl. Acad. Sci. USA (2007) 104(10):4083-4088.
   PubMed Web of Science ®Google Scholar
• KREINDLER JL, SHAPIRO SD: Lung turns to AA (adenosine analogues) to dry out. Nat. Med. (2007) 13(4):406-408.
   PubMed Web of Science ®Google Scholar
• IBLA JC, KHOURY J, KONG T, ROBINSON A, COLGAN SP: Transcriptional repression of Na-K-2Cl cotransporter NKCC1 by hypoxia-inducible factor-1. Am. J. Physiol. Cell Physiol. (2006) 291(2):C282-C289.
   PubMed Web of Science ®Google Scholar
• HASHIKAWA T, HOOKER SW, MAJ JG et al.: Regulation of adenosine receptor engagement by ecto-adenosine deaminase. FASEB J. (2004) 18(1):131-133.
   PubMed Web of Science ®Google Scholar
• VALENZUELA A, BLANCO J, CALLEBAUT C et al.: Adenosine deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles. J. Immunol. (1997) 158(8):3721-3729.
   PubMed Web of Science ®Google Scholar
• LAW WR, VALLI VE, CONLON BA: Therapeutic potential for transient inhibition of adenosine deaminase in systemic inflammatory response syndrome. Crit. Care Med. (2003) 31(5):1475-1481.
   PubMed Web of Science ®Google Scholar
• COHEN ES, LAW WR, EASINGTON CR et al.: Adenosine deaminase inhibition attenuates microvascular dysfunction and improves survival in sepsis. Am. J. Respir. Crit. Care Med. (2002) 166(1):16-20.
   PubMed Web of Science ®Google Scholar
• ADANIN S, YALOVETSKIY IV, NARDULLI BA et al.: Inhibiting adenosine deaminase modulates the systemic inflammatory response syndrome in endotoxemia and sepsis. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2002) 282(5):R1324-R1332.
   PubMed Web of Science ®Google Scholar
• BUCKLEY RH: Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution. Annu. Rev. Immunol. (2004) 22:625-655.
   PubMed Web of Science ®Google Scholar
• JIN X, SHEPHERD RK, DULING BR, LINDEN J: Inosine binds to A3 adenosine receptors and stimulates mast cell degranulation. J. Clin. Invest. (1997) 100(11):2849-2857.
   PubMed Web of Science ®Google Scholar
• HASKO G, SITKOVSKY MV, SZABO C: Immunomodulatory and neuroprotective effects of inosine. Trends Pharmacol. Sci. (2004) 25(3):152-157.
   PubMed Web of Science ®Google Scholar
• HASKO G, KUHEL DG, NEMETH ZH et al.: Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock. J. Immunol. (2000) 164(2):1013-1019.
   PubMed Web of Science ®Google Scholar
• GRENZ A, ZHANG H, HERMES M et al.: Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury. FASEB J. (2007) [Epub ahead of print].
   PubMedGoogle Scholar
• CHAUDARY N, NAYDENOVA Z, SHURALYOVA I, COE IR: The adenosine transporter, mENT1, is a target for adenosine receptor signaling and PKC{ϵ} in hypoxic and pharmacological preconditioning in the mouse cardiomyocyte cell line, HL-1. J. Pharmacol. Exp. Ther. (2004) 310(3):1190-1198.
   PubMed Web of Science ®Google Scholar
• CHAUDARY N, NAYDENOVA Z, SHURALYOVA I, COE IR: Hypoxia regulates the adenosine transporter, mENT1, in the murine cardiomyocyte cell line, HL-1. Cardiovasc. Res. (2004) 61(4):780-788.
   PubMed Web of Science ®Google Scholar