Exploitation of stem cell homing for gene delivery

Bibliography

• Penn MS. Cell-based gene therapy for the prevention and treatment of cardiac dysfunction. Nat Clin Pract Cardiovasc Med 2007;4(Suppl 1):S83-S88
   PubMedGoogle Scholar
• Weisfeldt ML, Zieman SJ. Advances in the prevention and treatment of cardiovascular disease. Health Aff (Millwood) 2007;26(1):25-37
   PubMed Web of Science ®Google Scholar
• Penn MS, Zhang M, Deglurkar I, Topol EJ. Role of stem cell homing in myocardial regeneration. Int J Cardiol 2004;95(Suppl 1):S23-S25
   PubMed Web of Science ®Google Scholar
• Sailor KA, Ming GL, Song H. Neurogenesis as a potential therapeutic strategy for neurodegenerative diseases. Expert Opin Biol Ther 2006;6(9):879-90
   PubMed Web of Science ®Google Scholar
• Fiegel HC, Lange C, Kneser U, et al. Fetal and adult liver stem cells for liver regeneration and tissue engineering. J Cell Mol Med 2006;10(3):577-87
   PubMed Web of Science ®Google Scholar
• Assmus B, Fischer-Rasokat U, Honold J, et al. Transcoronary transplantation of functionally competent BMCs is associated with a decrease in natriuretic peptide serum levels and improved survival of patients with chronic postinfarction heart failure: results of the TOPCARE-CHD Registry. Circ Res 2007;100(8):1234-41
   PubMed Web of Science ®Google Scholar
• Penn MS. Patient and cellular characteristics determine efficacy of cell therapy. Circ Res 2007;100(8):1101-3
   PubMed Web of Science ®Google Scholar
• Penn MS. Stem-cell therapy after acute myocardial infarction: the focus should be on those at risk. Lancet 2006;367(9505):87-8
   PubMed Web of Science ®Google Scholar
• Tachibana K, Hirota S, Iizasa H, et al. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature 1998;393(6685):591-4
   PubMed Web of Science ®Google Scholar
• Foudi A, Jarrier P, Zhang Y, et al. Reduced retention of radioprotective hematopoietic cells within the bone marrow microenvironment in CXCR4-/- chimeric mice. Blood 2006;107(6):2243-51
   PubMed Web of Science ®Google Scholar
• Lapidot T, Dar A, Kollet O. How do stem cells find their way home? Blood 2005;106(6):1901-10
   PubMed Web of Science ®Google Scholar
• Frimberger AE, Stering AI, Quesenberry PJ. An in vitro model of hematopoietic stem cell homing demonstrates rapid homing and maintenance of engraftable stem cells. Blood 2001;98(4):1012-18
   PubMed Web of Science ®Google Scholar
• Cui J, Wahl RL, Shen T, et al. Bone marrow cell trafficking following intravenous administration. Br J Haematol 1999;107(4):895-902
   PubMed Web of Science ®Google Scholar
• Jetmore A, Plett PA, Tong X, et al. Homing efficiency, cell cycle kinetics, and survival of quiescent and cycling human CD34(+) cells transplanted into conditioned NOD/SCID recipients. Blood 2002;99(5):1585-93
   PubMed Web of Science ®Google Scholar
• Lanzkron SM, Collector MI, Sharkis SJ. Hematopoietic stem cell tracking in vivo: a comparison of short-term and long-term repopulating cells. Blood 1999;93(6):1916-21
   PubMed Web of Science ®Google Scholar
• Kim CH, Broxmeyer HE. In vitro behavior of hematopoietic progenitor cells under the influence of chemoattractants: stromal cell-derived factor-1, steel factor, and the bone marrow environment. Blood 1998;91(1):100-10
   PubMed Web of Science ®Google Scholar
• Peled A, Petit I, Kollet O, et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 1999;283(5403):845-8
   PubMed Web of Science ®Google Scholar
• Wright DE, Bowman EP, Wagers AJ, Butcher EC, Weissman IL. Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. J Exp Med 2002;195(9):1145-54
   PubMed Web of Science ®Google Scholar
• Peled A, Grabovsky V, Habler L, et al. The chemokine SDF-1 stimulates integrin-mediated arrest of CD34(+) cells on vascular endothelium under shear flow. J Clin Invest 1999;104(9):1199-211
   PubMed Web of Science ®Google Scholar
• Peled A, Kollet O, Ponomaryov T, et al. The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice. Blood 2000;95(11):3289-96
   PubMed Web of Science ®Google Scholar
• Naiyer AJ, Jo DY, Ahn J, et al. Stromal derived factor-1-induced chemokinesis of cord blood CD34(+) cells (long-term culture-initiating cells) through endothelial cells is mediated by E-selectin. Blood 1999;94(12):4011-19
   PubMed Web of Science ®Google Scholar
• Zanjani ED, Flake AW, Almeida-Porada G, Tran N, Papayannopoulou T. Homing of human cells in the fetal sheep model: modulation by antibodies activating or inhibiting very late activation antigen-4-dependent function. Blood 1999;94(7):2515-22
   PubMed Web of Science ®Google Scholar
• Van Buul JD, Voermans C, Van Den Berg V, et al. Migration of human hematopoietic progenitor cells across bone marrow endothelium is regulated by vascular endothelial cadherin. J Immunol 2002;168(2):588-96
   PubMed Web of Science ®Google Scholar
• Imbert AM, Belaaloui G, Bardin F, et al. CD99 expressed on human mobilized peripheral blood CD34+ cells is involved in transendothelial migration. Blood 2006;108(8):2578-86
   PubMed Web of Science ®Google Scholar
• Jacenko O, Roberts DW, Campbell MR, et al. Linking hematopoiesis to endochondral skeletogenesis through analysis of mice transgenic for collagen X. Am J Pathol 2002;160(6):2019-34
   PubMed Web of Science ®Google Scholar
• Adams GB, Chabner KT, Alley IR, et al. Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature 2006;439(7076):599-603
   PubMed Web of Science ®Google Scholar
• Zhang J, Niu C, Ye L, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 2003;425(6960):836-41
   PubMed Web of Science ®Google Scholar
• Wagner W, Saffrich R, Wirkner U, et al. Hematopoietic progenitor cells and cellular microenvironment: behavioral and molecular changes upon interaction. Stem Cells 2005;23(8):1180-91
   PubMed Web of Science ®Google Scholar
• Sugiyama T, Kohara H, Noda M, Nagasawa T. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 2006;25(6):977-88
   PubMed Web of Science ®Google Scholar
• De Becker A, Van Hummelen P, Bakkus M, et al. Migration of culture-expanded human mesenchymal stem cells through bone marrow endothelium is regulated by matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-3. Haematologica 2007;92(4):440-9
   PubMed Web of Science ®Google Scholar
• Honczarenko M, Le Y, Swierkowski M, et al. Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors. Stem Cells 2006;24:1030-101
   PubMed Web of Science ®Google Scholar
• Viswanathan A, Painter RG Jr, Nal, Wang G. Functional expression of N-Formyl peptide receptors in human bone marrow-derived mesenchymal stem cells. Stem Cells 2007;25:1263-9
   PubMed Web of Science ®Google Scholar
• Wynn RF, Hart CA, Corradi-Perini C, et al. A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow. Blood 2004;104(9):2643-5
   PubMed Web of Science ®Google Scholar
• Li Y, Yu X, Lin S, et al. Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells. Biochem Biophys Res Commun 2007;356(3):780-4
   PubMed Web of Science ®Google Scholar
• Broxmeyer HE, Hangoc G, Cooper S, et al. AMD3100 and CD26 modulate mobilization, engraftment, and survival of hematopoietic stem and progenitor cells mediated by the SDF-1/CXCL12-CXCR4 axis. Ann NY Acad Sci 2007;1106:1-19
   PubMed Web of Science ®Google Scholar
• Christopherson KW II, Hangoc G, Mantel CR, Broxmeyer HE. Modulation of hematopoietic stem cell homing and engraftment by CD26. Science 2004;305(5686):1000-3
   PubMed Web of Science ®Google Scholar
• Tian C, Bagley J, Forman D, Iacomini J. Inhibition of CD26 peptidase activity significantly improves engraftment of retrovirally transduced hematopoietic progenitors. Gene Ther 2006;13(7):652-8
   PubMed Web of Science ®Google Scholar
• Chute JP. Stem cell homing. Curr Opin Hematol 2006;13(6):399-406
   PubMed Web of Science ®Google Scholar
• Desponts C, Hazen AL, Paraiso Kh, Kerr WG. SHIP deficiency enhances HSC proliferation and survival but compromises homing and repopulation. Blood 2006;107(11):4338-45
   PubMed Web of Science ®Google Scholar
• Broxmeyer HE, Hangoc G, Cooper S, et al. AMD3100 and CD26 modulate mobilization, engraftment, and survival of hematopoietic stem and progenitor cells mediated by the SDF-1/CXCL12-CXCR4 axis. Ann NY Acad Sci 2007;1106:1-19
   PubMed Web of Science ®Google Scholar
• Benveniste P, Cantin C, Hyam D, Iscove NN. Hematopoietic stem cells engraft in mice with absolute efficiency. Nat Immunol 2003;4(7):708-13
   PubMed Web of Science ®Google Scholar
• Camargo FD, Chambers SM, Drew E, Mcnagny KM, Goodell MA. Hematopoietic stem cells do not engraft with absolute efficiencies. Blood 2006;107(2):501-7
   PubMed Web of Science ®Google Scholar
• Matsuzaki Y, Kinjo K, Mulligan RC, Okano H. Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells. Immunity 2004;20(1):87-93
   PubMed Web of Science ®Google Scholar
• Uchida N, Dykstra B, Lyons KJ, Leung FY, Eaves CJ. Different in vivo repopulating activities of purified hematopoietic stem cells before and after being stimulated to divide in vitro with the same kinetics. Exp Hematol 2003;31(12):1338-47
   PubMed Web of Science ®Google Scholar
• Wagers AJ, Sherwood RI, Christensen JL, Weissman IL. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 2002;297(5590):2256-9
   PubMed Web of Science ®Google Scholar
• Cerny J, Dooner M, Mcauliffe C, et al. Homing of purified murine lymphohematopoietic stem cells: a cytokine-induced defect. J Hematother Stem Cell Res 2002;11(6):913-22
   PubMedGoogle Scholar
• Gilner JB, Walton WG, Gush K, Kirby SL. Antibodies to stem cell marker antigens reduce engraftment of hematopoietic stem cells. Stem Cells 2007;25(2):279-88
   PubMed Web of Science ®Google Scholar
• Balazs AB, Fabian AJ, Esmon CT, Mulligan RC. Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow. Blood 2006;107(6):2317-21
   PubMed Web of Science ®Google Scholar
• Castello S, Podesta M, Menditto VG, et al. Intra-bone marrow injection of bone marrow and cord blood cells: an alternative way of transplantation associated with a higher seeding efficiency. Exp Hematol 2004;32(8):782-7
   PubMed Web of Science ®Google Scholar
• Hagglund H, Ringden O, Agren B, et al. Intraosseous compared to intravenous infusion of allogeneic bone marrow. Bone Marrow Transplant 1998;21(4):331-5
   PubMed Web of Science ®Google Scholar
• Askari AT, Unzek S, Popovic ZB, et al. Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy. Lancet 2003;362(9385):697-703
   PubMed Web of Science ®Google Scholar
• Abbott JD, Huang Y, Liu D, et al. Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury. Circulation 2004;110(21):3300-5
   PubMed Web of Science ®Google Scholar
• Ma J, Ge J, Zhang S, et al. Time course of myocardial stromal cell-derived factor 1 expression and beneficial effects of intravenously administered bone marrow stem cells in rats with experimental myocardial infarction. Basic Res Cardiol 2005;100(3):217-23
   PubMed Web of Science ®Google Scholar
• Kocher AA, Schuster MD, Bonaros N, et al. Myocardial homing and neovascularization by human bone marrow angioblasts is regulated by IL-8/Gro CXC chemokines. J Mol Cell Cardiol 2006;40(4):455-64
   PubMed Web of Science ®Google Scholar
• Schenk S, Mal N, Finan A, et al. Monocyte chemotactic protein-3 is a myocardial mesenchymal stem cell homing factor. Stem Cells 2007;25(1):245-51
   PubMed Web of Science ®Google Scholar
• Hill WD, Hess DC, Martin-Studdard A, et al. SDF-1 (CXCL12) is upregulated in the ischemic penumbra following stroke: association with bone marrow cell homing to injury. J Neuropathol Exp Neurol 2004;63(1):84-96
   PubMed Web of Science ®Google Scholar
• Bartley J, Soltau T, Wimborne H, et al. BrdU-positive cells in the neonatal mouse hippocampus following hypoxic-ischemic brain injury. BMC Neurosci 2005;6(1):15
   PubMed Web of Science ®Google Scholar
• Kokovay E, Li L, Cunningham LA. Angiogenic recruitment of pericytes from bone marrow after stroke. J Cereb Blood Flow Metab 2006;26(4):545-55
   PubMed Web of Science ®Google Scholar
• Shen LH, Li Y, Chen J, et al. Therapeutic benefit of bone marrow stromal cells administered 1 month after stroke. J Cereb Blood Flow Metab 2007;27(1):6-13
   PubMed Web of Science ®Google Scholar
• Chen J, Li Y, Wang L, et al. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 2001;32(4):1005-11
   PubMed Web of Science ®Google Scholar
• Togel F, Isaac J, Hu Z, Weiss K, Westenfelder C. Renal SDF-1 signals mobilization and homing of CXCR4-positive cells to the kidney after ischemic injury. Kidney Int 2005;67(5):1772-84
   PubMed Web of Science ®Google Scholar
• Dekel B, Shezen E, Even-Tov-Friedman S, et al. Transplantation of human hematopoietic stem cells into ischemic and growing kidneys suggests a role in vasculogenesis but not tubulogenesis. Stem Cells 2006;24(5):1185-93
   PubMed Web of Science ®Google Scholar
• Togel F, Hu Z, Weiss K, et al. Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am J Physiol Renal Physiol 2005;289(1):F31-42
   PubMed Web of Science ®Google Scholar
• Woo LL, Hijaz A, Kuang M, et al. Over expression of stem cell homing cytokines in urogenital organs following vaginal distention. J Urol 2007;177(4):1568-72
   PubMed Web of Science ®Google Scholar
• Zufferey R, Nagy D, Mandel RJ, Naldini L, Trono D. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat Biotechnol 1997;15(9):871-5
   PubMed Web of Science ®Google Scholar
• Lu ZZ, Ni F, Hu ZB, et al. Efficient gene transfer into hematopoietic cells by a retargeting adenoviral vector system with a chimeric fiber of adenovirus serotype 5 and 11p. Exp Hematol 2006;34(9):1171-82
   PubMed Web of Science ®Google Scholar
• Kutschka I, Kofidis T, Chen IY, et al. Adenoviral human BCL-2 transgene expression attenuates early donor cell death after cardiomyoblast transplantation into ischemic rat hearts. Circulation 2006;114(1 Suppl):I174-80
   PubMed Web of Science ®Google Scholar
• Chen Z, Mok H, Pflugfelder SC, Li DQ, Barry MA. Improved transduction of human corneal epithelial progenitor cells with cell-targeting adenoviral vectors. Exp Eye Res 2006;83(4):798-806
   PubMed Web of Science ®Google Scholar
• Weissinger F, Reimer P, Waessa T, et al. Gene transfer in purified human hematopoietic peripheral-blood stem cells by means of electroporation without prestimulation. J Lab Clin Med 2003;141(2):138-49
   PubMedGoogle Scholar
• Worsham DN, Schuesler T, Von Kalle C, Pan D. In vivo gene transfer into adult stem cells in unconditioned mice by in situ delivery of a lentiviral vector. Mol Ther 2006;14(4):514-24
   PubMed Web of Science ®Google Scholar
• Li S, Kimura E, Fall BM, et al. Stable transduction of myogenic cells with lentiviral vectors expressing a minidystrophin. Gene Ther 2005;12(14):1099-108
   PubMed Web of Science ®Google Scholar
• Bemelmans AP, Bonnel S, Houhou L, et al. Retinal cell type expression specificity of HIV-1-derived gene transfer vectors upon subretinal injection in the adult rat: influence of pseudotyping and promoter. J Gene Med 2005;7(10):1367-74
   PubMed Web of Science ®Google Scholar
• Hioki H, Kameda H, Nakamura H, et al. Efficient gene transduction of neurons by lentivirus with enhanced neuron-specific promoters. Gene Ther 2007;14(11):872-82
   PubMed Web of Science ®Google Scholar
• Nguyen TH, Birraux J, Wildhaber B, et al. Ex vivo lentivirus transduction and immediate transplantation of uncultured hepatocytes for treating hyperbilirubinemic Gunn rat. Transplantation 2006;82(6):794-803
   PubMed Web of Science ®Google Scholar
• Li LH, Biagi E, Allen C, et al. Rapid and efficient nonviral gene delivery of CD154 to primary chronic lymphocytic leukemia cells. Cancer Gene Ther 2006;13(2):215-24
   PubMed Web of Science ®Google Scholar
• Nakashima M, Mizunuma K, Murakami T, Akamine A. Induction of dental pulp stem cell differentiation into odontoblasts by electroporation-mediated gene delivery of growth/differentiation factor 11 (Gdf11). Gene Ther 2002;9(12):814-18
   PubMed Web of Science ®Google Scholar
• Potapova I, Plotnikov A, Lu Z, et al. Human mesenchymal stem cells as a gene delivery system to create cardiac pacemakers. Circ Res 2004;94(7):952-9
   PubMed Web of Science ®Google Scholar
• Sadelain M. Globin gene transfer for the treatment of severe hemoglobinopathies: a paradigm for stem cell-based gene therapy. J Gene Med 2002;4(2):113-21
   PubMed Web of Science ®Google Scholar
• Imren S, Fabry ME, Westerman KA, et al. High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells. J Clin Invest 2004;114(7):953-62
   PubMed Web of Science ®Google Scholar
• Richard E, Robert E, Cario-Andre M, et al. Hematopoietic stem cell gene therapy of murine protoporphyria by methylguanine-DNA-methyltransferase-mediated in vivo drug selection. Gene Ther 2004;11(22):1638-47
   PubMed Web of Science ®Google Scholar
• Richard E, Geronimi F, Lalanne M, et al. A bicistronic SIN-lentiviral vector containing G156A MGMT allows selection and metabolic correction of hematopoietic protoporphyric cell lines. J Gene Med 2003;5(9):737-47
   PubMed Web of Science ®Google Scholar
• Zielske SP, Lingas KT, Li Y, Gerson SL. Limited lentiviral transgene expression with increasing copy number in an MGMT selection model: lack of copy number selection by drug treatment. Mol Ther 2004;9(6):923-31
   PubMed Web of Science ®Google Scholar
• Zhang M, Mal N, Kiedrowski M, et al. SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction. FASEB J 2007;21:3197-207
   PubMed Web of Science ®Google Scholar
• Lataillade JJ, Clay D, Bourin P, et al. Stromal cell-derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G(0)/G(1) transition in CD34(+) cells: evidence for an autocrine/paracrine mechanism. Blood 2002;99(4):1117-29
   PubMed Web of Science ®Google Scholar
• Ting-De Ravin SS, Kennedy DR, Naumann N, et al. Correction of canine X-linked severe combined immunodeficiency by in vivo retroviral gene therapy. Blood 2006;107(8):3091-7
   PubMed Web of Science ®Google Scholar
• Gaspar HB, Parsley KL, Howe S, et al. Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector. Lancet 2004;364(9452):2181-7
   PubMed Web of Science ®Google Scholar
• Chinen J, Davis J, De Ravin SS, et al. Gene therapy improves immune function in pre-adolescents with X-linked severe combined immunodeficiency. Blood 2007;110(1):67-73
   PubMed Web of Science ®Google Scholar
• Persons DA, Allay ER, Sabatino DE, et al. Functional requirements for phenotypic correction of murine beta-thalassemia: implications for human gene therapy. Blood 2001;97(10):3275-82
   PubMed Web of Science ®Google Scholar
• Puthenveetil G, Scholes J, Carbonell D, et al. Successful correction of the human beta-thalassemia major phenotype using a lentiviral vector. Blood 2004;104(12):3445-53
   PubMed Web of Science ®Google Scholar
• May C, Rivella S, Chadburn A, Sadelain M. Successful treatment of murine beta-thalassemia intermedia by transfer of the human beta-globin gene. Blood 2002;99(6):1902-8
   PubMed Web of Science ®Google Scholar
• Goebel WS, Pech NK, Dinauer MC. Stable long-term gene correction with low-dose radiation conditioning in murine X-linked chronic granulomatous disease. Blood Cells Mol Dis 2004;33(3):365-71
   PubMed Web of Science ®Google Scholar
• Pawliuk R, Westerman KA, Fabry ME, et al. Correction of sickle cell disease in transgenic mouse models by gene therapy. Science 2001;294(5550):2368-71
   PubMed Web of Science ®Google Scholar
• Yamada K, Ramezani A, Hawley RG, et al. Phenotype correction of Fanconi anemia group A hematopoietic stem cells using lentiviral vector. Mol Ther 2003;8(4):600-10
   PubMed Web of Science ®Google Scholar
• Moayeri M, Hawley TS, Hawley RG. Correction of murine hemophilia A by hematopoietic stem cell gene therapy. Mol Ther 2005;12(6):1034-42
   PubMed Web of Science ®Google Scholar
• Braun SE, Wong FE, Connole M, et al. Inhibition of simian/human immunodeficiency virus replication in CD4+ T cells derived from lentiviral-transduced CD34+ hematopoietic cells. Mol Ther 2005;12(6):1157-67
   PubMed Web of Science ®Google Scholar
• Banerjea A, Li MJ, Bauer G, et al. Inhibition of HIV-1 by lentiviral vector-transduced siRNAs in T lymphocytes differentiated in SCID-hu mice and CD34+ progenitor cell-derived macrophages. Mol Ther 2003;8(1):62-71
   PubMed Web of Science ®Google Scholar
• Tian C, Bagley J, Cretin N, et al. Prevention of type 1 diabetes by gene therapy. J Clin Invest 2004;114(7):969-78
   PubMed Web of Science ®Google Scholar
• Chan J, Clements W, Field J, et al. Transplantation of bone marrow genetically engineered to express proinsulin II protects against autoimmune insulitis in NOD mice. J Gene Med 2006;8(11):1281-90
   PubMed Web of Science ®Google Scholar
• Hao X, Silva EA, Mansson-Broberg A, et al. Angiogenic effects of sequential release of VEGF-A165 and PDGF-BB with alginate hydrogels after myocardial infarction. Cardiovasc Res 2007;75(1):178-85
   PubMed Web of Science ®Google Scholar
• Lu H, Xu X, Zhang M, et al. Combinatorial protein therapy of angiogenic and arteriogenic factors remarkably improves collaterogenesis and cardiac function in pigs. Proc Natl Acad Sci USA 2007;104(29):12140-5
   PubMed Web of Science ®Google Scholar