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Expert Opinion on Biological Therapy Volume 8, 2008 - Issue 9
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Reviews

Gene therapy of arthritis and orthopaedic disorders: current experimental approaches in China and in Canada

Ke-Rong Dai Shanghai Jiao Tong University, Insititue of Health Sciences, School of Medicine and Shanghai Institutes for the Biological Sciences, Chinese Academy of Sciences, 225 South Chongqing Road, Shanghai 200025, China; Shanghai Jiao Tong University, Department of Orthopaedics, Ninth People's Hospital, School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China
,
Xiao-Ling Zhang Shanghai Jiao Tong University, Insititue of Health Sciences, School of Medicine and Shanghai Institutes for the Biological Sciences, Chinese Academy of Sciences, 225 South Chongqing Road, Shanghai 200025, China; Shanghai Jiao Tong University, Department of Orthopaedics, Ninth People's Hospital, School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China
,
Qin Shi University of Montreal, Orthopaedics Research Laboratory, Research Center, Sacré-Coeur Hospital, 5400 Gouin Blvd.West, Montreal, Quebec, H4J 1C5, Canada +1 514 338 2222, ext. 3043; +1 514 338 2694; [email protected]
&
Julio C Fernandes University of Montreal, Orthopaedics Research Laboratory, Research Center, Sacré-Coeur Hospital, 5400 Gouin Blvd.West, Montreal, Quebec, H4J 1C5, Canada +1 514 338 2222, ext. 3043; +1 514 338 2694; [email protected]
Pages 1337-1346 | Published online: 11 Aug 2008

Bibliography

  • Muirden KD. Community oriented program for the control of rheumatic diseases: studies of rheumatic diseases in the developing world. Curr Opin Rheumatol 2005;17:153-6
  • Evans CH, Ghivizzani SC, Robbins PD. The 2003 Nicolas Andry Award. Orthopaedic gene therapy. Clin Orthop Relat Res 2004;429:316-29
  • Evans CH, Ghivizzani SC, Herndon JH, et al. Clinical trials in the gene therapy of arthritis. Clin Orthop Relat Res 2000;379(Suppl):S300-7
  • Romero NB, Braun S, Benveniste O, et al. Phase I study of dystrophin plasmid-based gene therapy in Duchenne/Becker muscular dystrophy. Hum Gene Ther 2004;15:1065-76
  • Seiler MP, Cerullo V, Lee B. Immune response to helper dependent adenoviral mediated liver gene therapy: challenges and prospects. Curr Gene Ther 2007;7:297-305
  • Vandenberghe LH, Wilson JM. AAV as an immunogen. Curr Gene Ther 2007;7:325-33
  • Mingozzi F, High KA. Immune responses to AAV in clinical trials. Curr Gene Ther 2007;7:316-24
  • Hacein-Bey-Abina S, von KC, Schmidt M, et al. A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 2003;348:255-6
  • Kaiser J. Clinical research. Death prompts a review of gene therapy vector. Science 2007;317:580
  • Romano G. Current development of nonviral-mediated gene transfer. Drug News Perspect 2007;20:227-31
  • Gao X, Kim KS, Liu D. Nonviral gene delivery: what we know and what is next. AAPS J 2007;9:E92-104
  • Sakurai H, Kawabata K, Sakurai F, et al. Innate immune response induced by gene delivery vectors. Int J Pharm 2008;354:9-15
  • Hyde SC, Southern KW, Gileadi U, et al. Repeat administration of DNA/liposomes to the nasal epithelium of patients with cystic fibrosis. Gene Ther 2000;7:1156-65
  • Ramesh R, Saeki T, Templeton NS, et al. Successful treatment of primary and disseminated human lung cancers by systemic delivery of tumor suppressor genes using an improved liposome vector. Mol Ther 2001;3:337-50
  • Fernandes J, Tardif G, Martel-Pelletier J, et al. In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression. Am J Pathol 1999;154:1159-69
  • Wolff JA, Malone RW, Williams P, et al. Direct gene transfer into mouse muscle in vivo. Science 1990;247:1465-8
  • Bloquel C, Bessis N, Boissier MC, et al. Gene therapy of collagen-induced arthritis by electrotransfer of human tumor necrosis factor-α soluble receptor I variants. Hum Gene Ther 2004;15:189-201
  • Hagstrom JE, Hegge J, Zhang G, et al. A facile nonviral method for delivering genes and siRNAs to skeletal muscle of mammalian limbs. Mol Ther 2004;10:386-98
  • Li SD, Huang L. Gene therapy progress and prospects: non-viral gene therapy by systemic delivery. Gene Ther 2006;13:1313-9
  • Suda T, Liu D. Hydrodynamic gene delivery: its principles and applications. Mol Ther 2007;15:2063-9
  • Nakajima A. Application of cellular gene therapy for rheumatoid arthritis. Mod Rheumatol 2006;16:269-75
  • Bandara G, Mueller GM, Galea-Lauri J, et al. Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer. Proc Natl Acad Sci USA 1993;90:10764-8
  • Smith P, Shuler FD, Georgescu HI, et al. Genetic enhancement of matrix synthesis by articular chondrocytes: comparison of different growth factor genes in the presence and absence of interleukin-1. Arthritis Rheum 2000;43:1156-64
  • Bessis N, Lemeiter D, Laroche L, et al. Engraftment of cutaneous fibroblasts within synovial membrane in a nonhuman primate: short-term results. Joint Bone Spine 2007;74:48-51
  • Lieberman JR, Daluiski A, Stevenson S, et al. The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats. J Bone Joint Surg Am 1999;81:905-17
  • Peng H, Wright V, Usas A, et al. Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4. J Clin Invest 2002;110:751-9
  • Rutherford RB, Moalli M, Franceschi RT, et al. Bone morphogenetic protein-transduced human fibroblasts convert to osteoblasts and form bone in vivo. Tissue Eng 2002;8:441-52
  • Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002;13:4279-95
  • Goto H, Shuler FD, Niyibizi C, et al. Gene therapy for meniscal injury: enhanced synthesis of proteoglycan and collagen by meniscal cells transduced with a TGFβ(1)gene. Osteoarthritis. Cartilage 2000;8:266-71
  • Egermann M, Schneider E, Evans CH, Baltzer AW. The potential of gene therapy for fracture healing in osteoporosis. Osteoporos Int 2005;16(Suppl 2):S120-8
  • Evans CH, Robbins PD, Ghivizzani SC, et al. Gene transfer to human joints: progress toward a gene therapy of arthritis1. Proc Natl Acad Sci USA 2005;102:8698-703
  • Evans CH. Gene therapies for osteoarthritis. Curr Rheumatol Rep 2004;6:31-40
  • Gouze JN, Ghivizzani SC, Gouze E, et al. Gene therapy for rheumatoid arthritis. Hand Surg 2001;6:211-9
  • Giannoudis PV, Tzioupis CC, Tsiridis E. Gene therapy in orthopaedics. Injury 2006;37(Suppl 1):S30-40
  • Adriaansen J, Vervoordeldonk MJ, Tak PP. Gene therapy as a therapeutic approach for the treatment of rheumatoid arthritis: innovative vectors and therapeutic genes. Rheumatology (Oxford) 2006;45:656-68
  • Woods JM, Katschke KJ, Volin MV, et al. IL-4 adenoviral gene therapy reduces inflammation, proinflammatory cytokines, vascularization, and bony destruction in rat adjuvant-induced arthritis. J Immunol 2001;166:1214-22
  • Woods JM, Amin MA, Katschke KJ, et al. Interleukin-13 gene therapy reduces inflammation, vascularization, and bony destruction in rat adjuvant-induced arthritis. Hum Gene Ther 2002;13:381-93
  • Khoury M, Louis-Plence P, Escriou V, et al. Efficient new cationic liposome formulation for systemic delivery of small interfering RNA silencing tumor necrosis factor α in experimental arthritis. Arthritis Rheum 2006;54:1867-77
  • Lind M, Bunger C. Orthopaedic applications of gene therapy. Int Orthop 2005;29:205-9
  • Ulrich-Vinther M. Gene therapy methods in bone and joint disorders. Evaluation of the adeno-associated virus vector in experimental models of articular cartilage disorders, periprosthetic osteolysis and bone healing. Acta Orthop Suppl 2007;78:1-64
  • Evans CH, Ghivizzani SC, Smith P, et al. Using gene therapy to protect and restore cartilage. Clin Orthop Relat Res 2000;379(Suppl):S214-9
  • Evans CH, Robbins PD. Genetically augmented tissue engineering of the musculoskeletal system. Clin Orthop Relat Res 1999;S410-8
  • Einhorn TA. Clinical applications of recombinant human BMPs: early experience and future development. J Bone Joint Surg Am 2003;85-A (Suppl 3):82-8
  • Betz OB, Betz VM, Nazarian A, et al. Delayed administration of adenoviral BMP-2 vector improves the formation of bone in osseous defects. Gene Ther 2007;14:1039-44
  • Nishida K, Kang JD, Gilbertson LG, et al. Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: an in vivo study of adenovirus-mediated transfer of the human transforming growth factor β1 encoding gene. Spine 1999;24:2419-25
  • Goodrich LR, Hidaka C, Robbins PD, et al. Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model. J Bone Joint Surg Br 2007;89:672-85
  • Ulrich-Vinther M, Carmody EE, Goater JJ, et al. Recombinant adeno-associated virus-mediated osteoprotegerin gene therapy inhibits wear debris-induced osteolysis. J Bone Joint Surg Am 2002;84-A:1405-12
  • Lamoureux F, Richard P, Wittrant Y, et al. Therapeutic relevance of osteoprotegerin gene therapy in osteosarcoma: blockade of the vicious cycle between tumor cell proliferation and bone resorption. Cancer Res 2007;67:7308-18
  • Bolon B, Carter C, Daris M, et al. Adenoviral delivery of osteoprotegerin ameliorates bone resorption in a mouse ovariectomy model of osteoporosis. Mol Ther 2001;3:197-205
  • Dai KR, Xu XL, Tang TT, et al. Repairing of goat tibial bone defects with BMP-2 gene-modified tissue-engineered bone. Calcif Tissue Int 2005;77:55-61
  • Li H, Dai K, Tang T, et al. Bone regeneration by implantation of adipose-derived stromal cells expressing BMP-2. Biochem Biophys Res Commun 2007;356:836-42
  • Yue B, Lu B, Dai KR, et al. BMP2 gene therapy on the repair of bone defects of aged rats. Calcif Tissue Int 2005;77:395-403
  • Ding HF, Liu R, Li BG, et al. Biologic effect and immunoisolating behavior of BMP-2 gene-transfected bone marrow-derived mesenchymal stem cells in APA microcapsules. Biochem Biophys Res Commun 2007;362:923-7
  • Zhang Y, Song J, Shi B, et al. Combination of scaffold and adenovirus vectors expressing bone morphogenetic protein-7 for alveolar bone regeneration at dental implant defects. Biomaterials 2007;28:4635-42
  • Jiang J, Fan CY, Zeng BF. Osteogenic differentiation effects on rat bone marrow-derived mesenchymal stromal cells by lentivirus-mediated co-transfection of human BMP2 gene and VEGF165 gene. Biotechnol Lett 2008;30:197-203
  • Zhang X, Yu C, Xushi, et al. Direct chitosan-mediated gene delivery to the rabbit knee joints in vitro and in vivo. Biochem Biophys Res Commun 2006;341:202-8
  • Wilson JM. Regulation of gene therapy in china. Hum Gene Ther 2006;7:969
  • Guo J, Xin H. Chinese gene therapy. Splicing out the West? Science 2006;314:1232-5
  • Hu X, Ma Q, Zhang S. Biopharmaceuticals in China. Biotechnol J 2006;1:1215-24
  • Leong-Poi H, Kuliszewski MA, Lekas M, et al. Therapeutic arteriogenesis by ultrasound-mediated VEGF165 plasmid gene delivery to chronically ischemic skeletal muscle. Circ Res 2007;101:295-303
  • Doherty PJ, Zhang H, Manolopoulos V, et al. Adhesion of transplanted chondrocytes onto cartilage in vitro and in vivo. J Rheumatol 2000;27:1725-31
  • Corsi K, Chellat F, Yahia L, Fernandes JC. Mesenchymal stem cells, MG63 and HEK293 transfection using chitosan-DNA nanoparticles. Biomaterials 2003;24:1255-64
  • Mansouri S, Lavigne P, Corsi K, et al. Chitosan-DNA nanoparticles as non-viral vectors in gene therapy: strategies to improve transfection efficacy. Eur J Pharm Biopharm 2004;57:1-8
  • Mansouri S, Cuie Y, Winnik F, et al. Characterization of folate-chitosan-DNA nanoparticles for gene therapy. Biomaterials 2006;27:2060-5
  • Edelstein ML, Abedi MR, Wixon J. Gene therapy clinical trials worldwide to 2007 – an update. J Gene Med 2007;9:833-42
  • Wu J, Sun TS, Ren JX, Wang XZ. Ex vivo non-viral vector-mediated neurotrophin-3 to olfactory ensheating glia: effects on axonal regeneration and functional recovery after implantation in rats with spinal cord injury. Neurosci Bull 2008;24:57-65
  • Lin L, Fu X, Zhang X, et al. Rat adipose-derived stromal cells expressing BMP4 induce ectopic bone formation in vitro and in vivo. Acta Pharmacol Sin 2006;27:1608-15
  • Lin L, Chen L, Wang H, et al. Adenovirus-mediated transfer of siRNA against Runx2/Cbfa1 inhibits the formation of heterotopic ossification in animal model. Biochem Biophys Res Commun 2006;349:564-72
  • Wang HJ, Yu CL, Kishi H, et al. Suppression of experimental osteoarthritis by adenovirus-mediated double gene transfer. Chin Med J 2006;19:1365-73
  • He J, Yao LH, Chen AJ, et al. Expression of sTNF-IgGFc fusion gene in endothelial cell and its application in gene therapy for rheumatoid arthritis. Sheng Wu Gong Geng Xue Bao 2006;22:378-83
  • Chen LX, Lin L, Wang HJ, et al. Suppression of early experimented osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-κBp65-specific siRNA. Osteoarthritis Cartilage 2008;16:174-84
  • Lin L, Fu X, Zhang X, et al. Rat adipose-derived stromal cells expressing BMP4 induce ectopic bone formation in vitro and in vivo. Acta Pharmacol Sin 2006;27:1608-15
  • Wang XD, Tang JG, Xie XL, et al. A comprehensive study of optimal conditions for naked plasmid DNA transfer into skeletal muscle by electroporation. J Gene Med 2005;7:1235-45
  • Li A, Zhang Q, Jiang J, et al. Co-transplantation of bone marrow stromal cells tranduced with IL-17 gene enhances immune reconstitution after allogeneic bone marrow transplantation in mice. Gene Ther 2006;13:1178-87
  • Kang Y, Liao WM, Sheng PY, et al. Construction and identification of human bone morphogenetic protein-7 recombinant adeno-associated virus type-2 vector and its expression in bone mesenchymal stem cells. Zhonghua Wai Ke Za Zhi 2007;45:1279-83
  • Zhang SK, Liu Y, Song ZM, et al. Green fluorescent protein as marker in chondrocytes overexpressing human insulin-like growth factor for repair of articular cartilage defects in rabbits. Chin J Traumatol 2007;10:10-7
  • Yang S, Laumonier, Menetrey J. Heat shock pre-treatment enhances pocine myoblasts survival after autotransplantation in intact skeletal muscle. Sci China C Life Sci 2007;50:438-46
  • Leng J, Yao H, Shen J, et al. Co-expression of IL-18 binding protein and IL-4 regulates Th1/Th2 cytokine response in murine collagen-induced arthritis. Acta Biochem Biophys Sin (Shanghai) 2008;40:116-24
  • Zhang LQ, Shen JG. Experimental treatment of collagen-induced arthritis in rats with recombinant plasmid containing vasoactive intestinal peptide gene. Zhejiang Da Xue Xue Bao Yi Xue Ban 2006;35:403-10
  • Guo T, Zeng X, Hong H, et al. Gene-activated matrices for cartilage defect reparation. Int J Artif Organs 2006;29:612-21
  • Zhang X, Zhang C, Tang T, et al. Immunomodulatory and osteogenic differentiation effects of mesenchymal stem cells by adenovirus-mediated coexpression of CTLA4Ig and BMP2. J Orthop Res 2008;26:314-21
  • Zhang L, Gu S, Zhao C, Wen T. Combined treatment of neurotrophin-3 gene and neural stem cells is propitious to functional recovery after spinal cord injury. Cell Transplant 2007;16:475-81
  • Tang TT, Lu B, Yue B, et al. Treatment of osteonecrosis of the femoral head with hBMP-2-gene-modified tissue-engineered bone in goats. J Bone Joint Surg Br 2007;89:127-9
  • Jiang X, Gittens SA, Chang Q, et al. The use of tissue-engineered bone with human bone morphogenetic protein-4-modified bone-marrow stromal cells in repairing mandibular defects in rabbits. Int J Maxillofac Surg 2006;35:1133-9
  • Liu XY, Yang SH, Liang CY, et al. Construction of recombinant baculovirus Ac-CMV-hSox9 for gene therapy of intervertebral disc degeneration. Chin J Traumatol 2007;10:94-100
  • Hart DA, Nakamura N, Marchuk L, et al. Complexity of determining cause and effect in vivo after antisense gene therapy. Clin Orthop Relat Res 2000;379(Suppl):S242-51
  • Nakamura N, Hart DA, Boorman RS, et al. Decorin antisense gene therapy improves functional healing of early rabbit ligament scar with enhanced collagen fibrillogenesis in vivo. J Orthop Res 2000;18:517-23
  • Incani V, Tunis E, Clements BA, et al. Palmitic acid substitution on cationic polymers for effective delivery of plasmid DNA to bone marrow stromal cells. J Biomed Mater Res A 2007;81:493-504
  • Farrell LL, Pepin J, Kucharski C, et al. A comparison of the effectiveness of cationic polymers poly-L-lysine (PLL) and polyethylenimine (PEI) for non-viral delivery of plasmid DNA to bone marrow stromal cells (BMSC). Eur J Pharm Biopharm 2007;65:388-97
  • Clements BA, Incani V, Kucharski C, et al. A comparative evaluation of poly-L-lysine-palmitic acid and Lipofectamine 2000 for plasmid delivery to bone marrow stromal cells. Biomaterials 2007;28:4693-704
  • Wazen RM, Moffatt P, Zalzal SF, et al. Local gene transfer to calcified tissue cells using prolonged infusion of a lentiviral vector. Gene Ther 2006;13:1595-602
  • Danialou G, Comtois AS, Matecki S, et al. Optimization of regional intraarterial naked DNA-mediated transgene delivery to skeletal muscles in a large animal model. Mol Ther 2005;11:257-66
  • Matecki S, Dudley RW, Divangahi M, et al. Therapeutic gene transfer to dystrophic diaphragm by an adenoviral vector deleted of all viral genes. Am J Physiol Lung Cell Mol Physiol 2004;287:L569-76
  • Danialou G, Comtois AS, Dudley RW, et al. Ultrasound increases plasmid-mediated gene transfer to dystrophic muscles without collateral damage. Mol Ther 2002;6:687-93
  • Anderson CL, De RY, Cifelli C, et al. The mouse dystrophin muscle promoter/enhancer drives expression of mini-dystrophin in transgenic mdx mice and rescues the dystrophy in these mice. Mol Ther 2006;14:724-34
  • DiDonato CJ, Parks RJ, Kothary R. Development of a gene therapy strategy for the restoration of survival motor neuron protein expression: implications for spinal muscular atrophy therapy. Hum Gene Ther 2003;14:179-88
  • Quenneville SP, Chapdelaine P, Skuk D, et al. Autologous transplantation of muscle precursor cells modified with a lentivirus for muscular dystrophy: human cells and primate models. Mol Ther 2007;5:431-8
  • Huang N, Khan A, Ashrafpour H, et al. Efficacy and mechanism of adenovirus-mediated VEGF-165 gene therapy for augmentation of skin flap viability. Am J Physiol Heart Circ Physiol 2006;291:H127-37
  • Kong J, Anderson JE. Dynamic restoration of dystrophin to dystrophin-deficient myotubes. Muscle Nerve 2001;24:77-88
  • Kwon BK, Liu J, Lam C, et al. Brain-derived neurotrophic factor gene transfer with adeno-associated viral and lentiviral vectors prevents rubrospinal neuronal atrophy and stimulates regeneration-associated gene expression after acute cervical spinal cord injury. Spine 2007;32:1164-73

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