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Human models of aging and longevity

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Pages 1393-1405 | Published online: 11 Aug 2008

Bibliography

  • Candore G, Balistreri CR, Listì F, et al. Immunogenetics, gender, and longevity. Ann NY Acad Sci 2006;1089:516-37
  • Fraga MF, Ballestar E, Paz MF, et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA 2005;102(30):10604-9
  • Franceschi C, Monti D, Barbieri D, et al. Immunosenescence in humans: deterioration or remodelling? Int Rev Immunol 1995;12(1):57-74
  • De Benedictis G, Tan Q, Jeune B, et al. Recent advances in human gene–longevity association studies. Mech Ageing Dev 2001;122(9):909-20
  • Franceschi C, Bonafè M. Centenarians as a model for healthy aging. Biochem Soc Trans 2003;31(2):457-61
  • Leroi AM, Bartke A, De Benedictis G, et al. What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? Mech Ageing Dev 2005;126(3):421-9
  • Franceschi C, Olivieri F, Marchegiani F, et al. Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mech Ageing Dev 2005;126(2):351-61
  • Deiana L, Ferrucci L, Pes GM, et al. AKEntAnnos. The Sardinia study of extreme longevity. Aging (Milano) 1999;11(3):142-9
  • Gueresi P, Troiano L, Minicuci N, et al. The MALVA (MAntova LongeVA) study: an investigation on people 98 years of age and over in a province of Northern Italy. Exp Gerontol 2003;38(10):1189-97
  • Franceschi C, Monti D, Sansoni P, et al. The immunology of exceptional individuals: the lesson of centenarians. Immunol Today 1995;16(1):12-6
  • Sansoni P, Vescovini R, Fagnoni F, et al. The immune system in extreme longevity. Exp Gerontol 2008;43(2):61-5
  • Salvioli S, Olivieri F, Marchegiani F, et al. Genes, ageing and longevity in humans: problems, advantages and perspectives. Free Radic Res 2006;40(12):1303-23
  • Capri M, Salvioli S, Monti D, et al. Human longevity within an evolutionary perspective: The peculiar paradigm of a post-reproductive genetics. Exp Gerontol 2008;43(2):53-60
  • Atzmon G, Schechter C, Greiner W, et al. Clinical phenotype of families with longevity. J Am Geriatr Soc 2004;52(2):274-7
  • Erls TT, Wilmoth J, Levenson R, et al. Life-long sustained mortality advantage of siblings of centenarians. Proc Natl Acad Sci USA 2002;99(12):8442-7
  • Willcox BJ, Willcox DC, He Q, et al. Siblings of Okinawan centenarians share lifelong mortality advantages. J Gerontol A Biol Sci Med Sci 2006;61(4):345-54
  • Schoenmaker M, De Craen AJ, De Meijer PH, et al. Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study. Eur J Hum Genet 2006;14(1):79-84
  • Puca AA, Daly MJ, Brewster SJ, et al. A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. Proc Natl Acad Sci USA 2001;98(18):10505-8
  • Beekman M, Blauw GJ, Houwing-Duistermaat JJ, et al. Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies. J Gerontol A Biol Sci Med Sci 2006;61(4):355-62
  • Vb Hjelmborg J, Iachine I, Skytthe A, et al. Genetic influence on human lifespan and longevity. Hum Genet 2006;119(3):312-21
  • Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56-62
  • Gsell OR. Longitudinal gerontological research over 10 years (Basel Studies, 1955 – 1965). Gerontol Clin 1967;9(2):67-80
  • Folstein MF, Folstein SE, McHugh PR. ‘Mini-mental state’ a practical method for grading the cognitive state of patients for the clinician. J Psychiatry Res 1975;12(3):189-98
  • Lagaay AM, D'Amaro J, Ligthart GJ, et al. Longevity and heredity in humans. Association with the human leucocyte antigen phenotype. Ann NY Acad Sci 1991;621:78-89
  • Bootsma-Van Der Wiel A, Gussekloo J, De Craen AJ, et al. Disability in the oldest old: “can do” or “do do”? J Am Geriatr Soc 2001;49(7):909-14
  • Nybo H, Gaist D, Jeune B, et al. Functional status and self-rated health in 2,262 nonagenarians: the Danish 1905 Cohort Survey. J Am Geriatr Soc 2001;49(5):601-9
  • Ferrucci L, Bandinelli S, Benvenuti E, et al. Subsystems contributing to the decline in ability to walk: bridging the gap between epidemiology and geriatric practice in the InCHIANTI study. JAGS 2000;48(12):1618-25
  • Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 2003;33(Suppl):245-54
  • Bjornsson HT, Fallin MD, Feinberg AP. An integrated epigenetic and genetic approach to common human disease. Trends Genet 2004;20(8):350-8
  • Capri M, Salvioli S, Sevini F, et al. The genetics of human longevity. Ann NY Acad Sci 2006;1067:252-63
  • Santoro A, Salvioli S, Raule N, et al. Mitochondrial DNA involvement in human longevity. Biochim Biophys Acta 2006;1757(9-10):1388-99
  • Jeune B, Skytthe A, Cournil A, et al. Handgrip strength among nonagenarians and centenarians in three European regions. J Gerontol A Biol Sci Med Sci 2006;61(7):707-12
  • De Benedictis G, Franceschi C. The unusual genetics of human longevity. Sci Aging Knowledge Environ 2006;10:pe20
  • Paolisso G, Tagliamonte MR, Rizzo MR, et al. Oxidative stress and advancing age: results in healthy centenarians. J Am Geriatr Soc 1998;46(7):833-8
  • Baggio G, Donazzan S, Monti D, et al. Lipoprotein(a) and lipoprotein profile in healthy centenarians: a reappraisal of vascular risk factors. FASEB J 1998;12(6):433-7
  • Barbagallo CM, Averna MR, Fradà G, et al. Plasma lipid, apolipoprotein and Lp(a) levels in elderly normolipidemic women: relationships with coronary heart disease and longevity. Gerontology 1995;41(5):260-6
  • Effros RB, Boucher N, Porter V, et al. Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence. Exp Gerontol 1994;29(6):601-9
  • Silver M, Newell K, Hyman B, et al. Unraveling the mystery of cognitive changes in old age: correlation of neuropsychological evaluation with neuropathological findings in the extreme old. Int Psychogeriatr 1998;10(1):25-41
  • Hagberg B, Bauer Alfredson B, Poon LW, et al. Cognitive functioning in centenarians: a coordinated analysis of results from three countries. J Gerontol B Psychol Sci Soc Sci 2001;56(3):141-51
  • Andersen-Ranberg K, Vasegaard L, Jeune B. Dementia is not inevitable: a population-based study of Danish centenarians. J Gerontol B Psychol Sci Soc Sci 2001;56(3):152-9
  • Franceschi C, Motta L, Valensin S, et al. Do men and women follow different trajectories to reach estreme longevity? Italian Multicenter Study on Centenarians (IMUSCE). Aging 2000;12(2):77-84
  • Passarino G, Calignano C, Vallone A, et al. Male/female ratio in centenarians: a possible role played by population genetic structure. Exp Gerontol 2002;37(11-12):1283-9
  • Barzilai N, Atzmon G, Schechter C, et al. Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA 2003;290(15):2030-40
  • Poulain M, Pes GM, Grasland C, et al. Identification of a geographic area characterized by extreme longevity in the Sardinia island: the AKEA study. Exp Gerontol 2004;39(9):1423-9
  • Caselli G, Lipsi RM. Survival differences among the oldest old in Sardinia: who, what, where, and why? Demogr Res 2006;14:267-94
  • Robine JM, Caselli G, Rasulo D, et al. Differentials in the femininity ratio among centenarians: variations between northern and southern Italy from 1870. Popul Stud (Camb) 2006;60(1):99-113
  • Rigby JE, Dorling D. Mortality in relation to sex in the affluent world. J Epidemiol Community Health 2007;61(2):159-64
  • Passeri G, Pini G, Troiano L, et al. Low vitamin D status, high bone turnover, and bone fractures in centenarians. J Clin Endocrinol Metab 2003;88(11):5109-15
  • Barbieri M, Gambardella A, Paolisso G, et al. Metabolic aspects of the extreme longevity. Exp Gerontol 2008;43(2):74-8
  • Paolisso G, Barbieri M, Bonafè M, et al. Metabolic age modelling: the lesson from centenarians. Eur J Clin Invest 2000;30(10):888-94
  • Fletcher AE, Breeze E, Shetty PS. Antioxidant vitamins and mortality in older persons: findings from the nutrition add-on study to the Medical Research Council Trial of Assessment and Management of Older People in the Community. Am J Clin Nutr 2003;78(5):999-1010
  • Yu BP, Chung HY. Oxidative stress and vascular aging. Diabetes Res Clin Pract 2001;54(Suppl l2):S73-80
  • Fagiolo U, Cossarizza A, Scala E, et al. Increased cytokine production in mononuclear cells of healthy elderly people. Eur J Immunol 1993;23(9):2375-8
  • Mari D, Coppola R, Provenzano R. Hemostasis factors and aging. Exp Gerontol 2008;43(2):66-73
  • Ferrari E, Cravello L, Falvo F, et al. Neuroendocrine features in extreme longevity. Exp Gerontol 2008;43(2):88-94
  • Franceschi C, Bonafè M, Valensin S. Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine 2000;18(16):1717-20
  • De Martinis M, Franceschi C, Monti D, et al. Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. FEBS Lett 2005;579(10):2035-9
  • Pawelec G, Akbar A, Caruso C, et al. Is immunosenescence infectious? Trends Immunol 2004;25(8):406-10
  • Franceschi C, Bonafè M, Valensin S, et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann NY Acad Sci 2000;908:244-54
  • Licastro F, Candore G, Lio D, et al. Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun Ageing 2005;18:2-8
  • Ikeda A, Iso H, Toyoshima H, et al. Parental longevity and mortality amongst Japanese men and women: the JACC Study. J Intern Med 2006;259(3):285-95
  • Karasik D, Hannan MT, Cupples LA, et al. Genetic contribution to biological aging: the Framingham Study. J Gerontol A Biol Sci Med Sci 2004;59(3):218-26
  • Terry DF, Wilcox MA, McCormick MA, et al. Lower all-cause, cardiovascular, and cancer mortality in centenarians' offspring. J Am Geriatr Soc 2004;52(12):2074-6
  • Terry DF, McCormick M, Andersen S, et al. Cardiovascular disease delay in centenarian offspring: role of heat shock proteins. Ann NY Acad Sci 2004;1019:502-5
  • Atzmon G, Rincon M, Schechter CB, et al. Lipoprotein genotype and conserved pathway for exceptional longevity in humans. PLoS Biol 2006;4(4):e113. Published online 4 April 2006, doi:10.1371/journal.pbio.0040113
  • Heijmans BT, Beekman M, Houwing-Duistermaat JJ, et al. Lipoprotein particle profiles mark familial and sporadic human longevity. PLoS Med 2006;3(12):e495. Published online 26 December 2006, doi:10.1371/journal.pmed.0030495
  • Cellini E, Nacmias B, Olivieri F, et al. Cholesteryl ester transfer protein (CETP) I405V polymorphism and longevity in Italian centenarians. Mech Ageing Dev 2005;126(6-7):826-8
  • Finch CE, Tanzi RE. Genet Aging Sci 1997;278(5337):407-11
  • Herskind AM, Mcgue M, Holm NV, et al. The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870 – 1900. Hum Genet 1996;97(3):319-23
  • Ljungquist B, Berg S, Lanke J, et al. The effect of genetic factors for longevity: a comparison of identical and fraternal twins in the Swedish Twin Registry. J Gerontol A Biol Sci Med Sci 1998;53(6):M441-6
  • Mousseau TA, Roff DA. Natural selection and the heritability of fitness components. Heredity 1987;59(Pt 2):181-97
  • Poulsen P, Kyvik KO, Vaag A, Beck-Nielsen H. Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance – a population-based twin study. Diabetologia 1999;42(2):139-45
  • Gatz M, Reynolds CA, Fratiglioni L, et al. Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry 2006;63(2):168-74
  • Mack TM, Hamilton AS, Press MF, et al. Heritable breast cancer in twins. Br J Cancer 2002;87(3):294-300
  • Page WF, Braun MM, Partin AW, et al. Heredity and prostate cancer: a study of World War II veteran twins. Prostate 1997;33(4):240-5
  • Cardno AG, Rijsdijk FV, Sham PC, et al. A twin study of genetic relationships between psychotic symptoms. Am J Psychiatry 2002;159(4):539-45
  • Gringras P, Chen W. Mechanisms for differences in monozygous twins. Early Hum Dev 2001;64(2):105-17
  • Singh SM, Murphy B. O'reilly R Epigenetic contributors to the discordance of monozygotic twins. Clin Genet 2002;62(2):97-103
  • Kato T, Iwamoto K, Kakiuchi C, et al. Genetic or epigenetic difference causing discordance between monozygotic twins as a clue to molecular basis of mental disorders. Mol Psychiatry 2005;10(7):622-30
  • Oates NA, Van Vliet J, Duffy DL, et al. Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly. Am J Hum Genet 2006;79(1):155-62
  • Petronis A, Gottesman II, Kan P, et al. Monozygotic twins exhibit numerous epigenetic differences: clues to twin discordance? Schizophr Bull 2003;29(1):169-78
  • Mill J, Dempster E, Caspi A, et al. Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene. Am J Med Genet B Neuropsychiatr Genet 2006;141(4):421-5
  • Heijmans BT, Kremer D, Tobi EW, et al. Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus. Hum Mol Genet 2007;16(5):547-54
  • Bjornsson HT, Fallin MD, Feinberg AP. An integrated epigenetic and genetic approach to common human disease. Trends Genet 2004;20(8):350-8
  • Wong AH, Gottesman II, Petronis A. Phenotypic differences in genetically identical organisms: the epigenetic perspective. Hum Mol Genet 2005;14(SpecNo 1):R11-8
  • Cooney CA. Are somatic cells inherently deficient in methylation metabolism? A proposed mechanism for DNA methylation loss, senescence and aging. Growth Dev Aging 1993;57(4):261-73
  • Bennett-Baker PE, Wilkowski J, Burke DT. Age-associated activation of epigenetically repressed genes in the mouse. Genetics 2003;165(4):2055-62
  • De Benedictis G, Carotenuto L, Carrieri G, et al. Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2). Eur J Hum Genet 1998;6:534-41
  • Cardelli M, Marchegiani F, Cavallone L, et al. A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity. J Gerontol A Biol Sci Med Sci 2006;61:547-56
  • De Benedictis G, Rose G, Carrieri G, et al. Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans. FASEB J 1999;13:1532-6
  • Zhang J, Asin-Cayuela J, Fish J, et al. Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes. Proc Natl Acad Sci USA 2003;100:1116-21
  • Rose G, Passarino G, Scornaienchi V, et al. The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring. BMC Genomics 2007;29(8):293
  • Gavrilov LA, Gavrilova NS. Early-life programming of aging and longevity: the idea of high initial damage load (the HIDL hypothesis). Ann NY Acad Sci 2004;1019:496-501
  • Gavrilov LA, Gavrilova NS. The reliability-engineering approach to the problem of biological aging. Ann NY Acad Sci 2004;1019:509-12
  • Csete M, Doyle J. Bow ties, metabolism and disease. Trends Biotechnol 2004;22(9):446-50
  • Rabini RA, Moretti N, Staffolani R, et al. Reduced susceptibility to peroxidation of erythrocyte plasma membranes from centenarians. Exp Gerontol 2002;37(5):657-63
  • Caprari P, Scuteri A, Salvati AM, et al. Aging and red blood cell membrane: a study of centenarians. Exp Gerontol 1999;34(1):47-57
  • Chondrogianni N, Petropoulos I, Franceschi C, et al. Fibroblast cultures from healthy centenarians have an active proteasome. Exp Gerontol 2000;35(6-7):721-8
  • Mishto M, Santoro A, Bellavista E, et al. Immunoproteasomes and immunosenescence. Ageing Res Rev 2003;2(4):419-32
  • Mondello C, Petropoulou C, Monti D, et al. Telomere length in fibroblasts and blood cells from healthy centenarians. Exp Cell Res 1999;248(1):234-42
  • Bagnara GP, Bonsi L, Strippoli P, et al. Hemopoiesis in healthy old people and centenarians: well-maintained responsiveness of CD34+ cells to hemopoietic growth factors and remodeling of cytokine network. J Gerontol A Biol Sci Med Sci 2000;55(2):B61-6
  • Bellavia D, Fradà G, Di Franco P, et al. C4, BF, C3 allele distribution and complement activity in healthy aged people and centenarians. J Gerontol A Biol Sci Med Sci 1999;54(4):B150-3
  • Sansoni P, Cossarizza A, Brianti V, et al. Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians. Blood 1993;82(9):2767-73
  • Tesco G, Vergelli M, Grassilli E, et al. Growth properties and growth factor responsiveness in skin fibroblasts from centenarians. Biochem Biophys Res Commun 1998;244(3):912-6
  • Mariotti S, Sansoni P, Barbesino G, et al. Thyroid and other organ-specific autoantibodies in healthy centenarians. Lancet 1992;339(8808):1506-8
  • Candore G, Di Lorenzo G, Mansueto P, et al. Prevalence of organ-specific and non organ-specific autoantibodies in healthy centenarians. Mech Ageing Dev 1997;94(1-3):183-90
  • Paolisso G, Barbieri M, Rizzo MR, et al. Low insulin resistance and preserved β-cell function contribute to human longevity but are not associated with TH-INS genes. Exp Gerontol 2001;37(1):149-56
  • Monti D, Salvioli S, Capri M, et al. Decreased susceptibility to oxidative stress-induced apoptosis of peripheral blood mononuclear cells from healthy elderly and centenarians. Mech Ageing Dev 2000;121(1-3):239-50
  • Cardelli M, Cavallone L, Marchegiani F, et al. A genetic-demographic approach reveals male-specific association between survival and TNF(A/G)-308 polymorphism. J Gerontol A Biol Sci Med Sci 2008;63(5):454-60
  • Wang XY, Hurme M, Jylhä M, Hervonen A. Lack of association between human longevity and polymorphisms of IL-1 cluster, IL-6, IL-10 and TNF-α genes in Finnish nonagenarians. Mech Ageing Dev 2001;123(1):29-38
  • Balistreri CR, Candore G, Colonna-Romano G, et al. Role of Toll-like receptor 4 in acute myocardial infarction and longevity. JAMA 2004;292(19):2339-40
  • Nebel A, Flachsbart F, Schäfer A, et al. Role of the toll-like receptor 4 polymorphism Asp299Gly in longevity and myocardial infarction in German men. Mech Ageing Dev 2007;128(5-6):409-11
  • Carrieri G, Marzi E, Olivieri F, et al. The G/C915 polymorphism of transforming growth factor β1 is associated with human longevity: a study in Italian centenarians. Aging Cell 2004;3(6):443-8
  • Lio D, Scola L, Crivello A, et al. Allele frequencies of +874T→A single nucleotide polymorphism at the first intron of interferon-γ gene in a group of Italian centenarians. Exp Gerontol 2002;37(2-3):315-9
  • Smith JD. Apolipoprotein E4: an allele associated with many diseases. Ann Med 2000;32:118-27
  • De Benedictis G, Falcone E, Rose G, et al. DNA multiallelic systems reveal gene/longevity associations not detected by diallelic systems. The APOB locus. Hum Genet 1997;99:312-8
  • Marchegiani F, Marra M, Olivieri F, et al. Paraoxonase 1: genetics and activities during aging. Rejuvenation Res 2008;111:113-27
  • Rose G, Dato S, Altomare K, et al. Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. Exp Gerontol 2003;38:1065-70
  • Bonafe M, Barbieri M, Marchegiani F, et al. Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. J Clin Endocrinol Metab 2003;88:3299-304
  • Tanaka M, Gong JS, Zhang J, et al. Mitochondrial genotype associated with longevity. Lancet 1998;351:185-6
  • Dato S, Passarino G, Rose G, et al. Association of the mitochondrial DNA haplogroup J with longevity is population specific. Eur J Hum Genet 2004;12:1080-2
  • Niemi AK, Moilanen JS, Tanaka M, et al. A combination of three common inherited mitochondrial DNA polymorphisms promotes longevity in Finnish and Japanese subjects. Eur J Hum Genet 2005;13(2):166-70
  • Iwata N, Zhang J, Atzmon G, et al. Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmic mtDNA mutation adjacent to replication origin frequently remodeled in Italian centenarians. Mitochondrion 2007;7:267-72
  • Van Heemst D, Mooijaart SP, Beekman M, et al.; Long Life study group. Variation in the human TP53 gene affects old age survival and cancer mortality. Exp Gerontol 2005;40(1-2):11-5
  • Bojesen SE, Nordestgaard BG. The common germline Arg72Pro polymorphism of p53 and increased longevity in humans. Cell Cycle 2008;7(2):158-63
  • Bonafè M, Barbi C, Storci G, et al. What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenarians. Exp Gerontol 2002;37:1263-71
  • Bonafè M, Olivieri F, Mari D, et al. p53 variants predisposing to cancer are present in healthy centenarians. Am J Hum Genet 1999;64:292-5

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