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Adiponectin in health and diseases: from metabolic syndrome to tissue regeneration

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Pages 193-206 | Published online: 17 Dec 2009

Bibliography

  • Arita Y, Kihara S, Ouchi N, Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999;257:79-83
  • Hotta K, Funahashi T, Bodkin NL, Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 2001;50:1126-33
  • Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996;271:10697-703
  • Spranger J, Kroke A, Mohlig M, Adiponectin and protection against type 2 diabetes mellitus. Lancet 2003;361:226-8
  • Kumada M, Kihara S, Sumitsuji S, Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 2003;23:85-9
  • Pischon T, Girman CJ, Hotamisligil GS, Plasma adiponectin levels and risk of myocardial infarction in men. JAMA 2004;291:1730-7
  • Adamczak M, Wiecek A, Funahashi T, Decreased plasma adiponectin concentration in patients with essential hypertension. Am J Hypertens 2003;16:72-5
  • Pischon T, Girman CJ, Rifai N, Association between dietary factors and plasma adiponectin concentrations in men. Am J Clin Nutr 2005;81:780-6
  • Kadowaki T, Yamauchi T, Kubota N, Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 2006;116:1784-92
  • Furukawa S, Fujita T, Shimabukuro M, Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004;114:1752-61
  • Swarbrick MM, Havel PJ. Physiological, pharmacological, and nutritional regulation of circulating adiponectin concentrations in humans. Metab Syndr Relat Disord 2008;6:87-102
  • Garaulet M, Hernandez-Morante JJ, de Heredia FP, Tebar FJ. Adiponectin, the controversial hormone. Public Health Nutr 2007;10:1145-50
  • Skurk T, van H, V, Lee YM, Relationship between IL-6, leptin and adiponectin and variables of fibrinolysis in overweight and obese hypertensive patients. Horm Metab Res 2002;34:659-63
  • Chandran M, Phillips SA, Ciaraldi T, Henry RR. Adiponectin: more than just another fat cell hormone? Diabetes Care 2003;26:2442-50
  • Bottner A, Kratzsch J, Muller G, Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels. J Clin Endocrinol Metab 2004;89:4053-61
  • Kadowaki T, Yamauchi T. Adiponectin and adiponectin receptors. Endocr Rev 2005;26:439-51
  • Scherer PE, Williams S, Fogliano M, A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 1995;270:26746-9
  • Berner HS, Lyngstadaas SP, Spahr A, Adiponectin and its receptors are expressed in bone-forming cells. Bone 2004;35:842-9
  • Caminos JE, Nogueiras R, Gallego R, Expression and regulation of adiponectin and receptor in human and rat placenta. J Clin Endocrinol Metab 2005;90:4276-86
  • Delaigle AM, Senou M, Guiot Y, Induction of adiponectin in skeletal muscle of type 2 diabetic mice: In vivo and in vitro studies. Diabetologia 2006;49:1311-23
  • Krause MP, Liu Y, Vu V, Adiponectin is expressed by skeletal muscle fibers and influences muscle phenotype and function. Am J Physiol Cell Physiol 2008;295:C203-12
  • Natarajan R, Salloum FN, Fisher BJ, Hypoxia inducible factor-1 upregulates adiponectin in diabetic mouse hearts and attenuates post-ischemic injury. J Cardiovasc Pharmacol 2008;51:178-87
  • Pineiro R, Iglesias MJ, Gallego R, Adiponectin is synthesized and secreted by human and murine cardiomyocytes. FEBS Lett 2005;579:5163-9
  • Rodriguez-Pacheco F, Martinez-Fuentes AJ, Tovar S, Regulation of pituitary cell function by adiponectin. Endocrinology 2007;148:401-10
  • Shinoda Y, Yamaguchi M, Ogata N, Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways. J Cell Biochem 2006;99:196-208
  • Fiaschi T, Cirelli D, Comito G, Globular adiponectin induces differentiation and fusion of skeletal muscle cells. Cell Res 2009;19:584-97
  • Pajvani UB, Du X, Combs TP, Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity. J Biol Chem 2003;278:9073-85
  • Peake PW, Kriketos AD, Campbell LV, The metabolism of isoforms of human adiponectin: studies in human subjects and in experimental animals. Eur J Endocrinol 2005;153:409-17
  • Wang Y, Lam KS, Yau MH, Xu A. Post-translational modifications of adiponectin: mechanisms and functional implications. Biochem J 2008;409:623-33
  • Pajvani UB, Hawkins M, Combs TP, Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem 2004;279:12152-62
  • Wang Y, Xu A, Knight C, Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity. J Biol Chem 2002;277:19521-9
  • Hug C, Wang J, Ahmad NS, T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci USA 2004;101:10308-13
  • Sato C, Yasukawa Z, Honda N, Identification and adipocyte differentiation-dependent expression of the unique disialic acid residue in an adipose tissue-specific glycoprotein, adipo Q. J Biol Chem 2001;276:28849-56
  • Waki H, Yamauchi T, Kamon J, Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1. Endocrinology 2005;146:790-6
  • Fruebis J, Tsao TS, Javorschi S, Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA 2001;98:2005-10
  • Berg AH, Combs TP, Du X, The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 2001;7:947-53
  • Yamauchi T, Kamon J, Waki H, The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001;7:941-6
  • Yamauchi T, Kamon J, Minokoshi Y, Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002;8:1288-95
  • Fiaschi T, Buricchi F, Cozzi G, Redox-dependent and ligand-independent trans-activation of insulin receptor by globular adiponectin. Hepatology 2007;46:130-9
  • Yamauchi T, Kamon J, Ito Y, Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003;423:762-9
  • Gil-Campos M, Canete RR, Gil A. Adiponectin, the missing link in insulin resistance and obesity. Clin Nutr 2004;23:963-74
  • Tsuchida A, Yamauchi T, Ito Y, Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. J Biol Chem 2004;279:30817-22
  • Hebbard LW, Garlatti M, Young LJ, T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model. Cancer Res 2008;68:1407-16
  • Mao X, Kikani CK, Riojas RA, APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol 2006;8:516-23
  • Cheng KK, Lam KS, Wang Y, Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells. Diabetes 2007;56:1387-94
  • Chandrasekar B, Boylston WH, Venkatachalam K, Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression. J Biol Chem 2008;283:24889-98
  • Coope A, Milanski M, Araujo EP, AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus. FEBS Lett 2008;582:1471-6
  • Zhou L, Deepa SS, Etzler JC, Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways. J Biol Chem 2009;284:22426-35
  • Deepa SS, Dong LQ. APPL1: role in adiponectin signaling and beyond. Am J Physiol Endocrinol Metab 2009;296:E22-36
  • Lochhead PA, Salt IP, Walker KS, 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase. Diabetes 2000;49:896-903
  • Woods A, Azzout-Marniche D, Foretz M, Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase. Mol Cell Biol 2000;20:6704-11
  • Tomas E, Tsao TS, Saha AK, Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci USA 2002;99:16309-13
  • Kubota N, Yano W, Kubota T, Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab 2007;6:55-68
  • Chen H, Montagnani M, Funahashi T, Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem 2003;278:45021-6
  • Goldstein BJ, Scalia RG, Ma XL. Protective vascular and myocardial effects of adiponectin. Nat Clin Pract Cardiovasc Med 2009;6:27-35
  • Chiarugi P, Fiaschi T. Redox signalling in anchorage-dependent cell growth. Cell Signal 2007;19:672-82
  • Reynolds AR, Tischer C, Verveer PJ, EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation. Nat Cell Biol 2003;5:447-53
  • Akifusa S, Kamio N, Shimazaki Y, Globular adiponectin-induced RAW 264 apoptosis is regulated by a reactive oxygen species-dependent pathway involving Bcl-2. Free Radic Biol Med 2009;46:1308-16
  • Weyer C, Funahashi T, Tanaka S, Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 2001;86:1930-5
  • Hara K, Boutin P, Mori Y, Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 2002;51:536-40
  • Kondo H, Shimomura I, Matsukawa Y, Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. Diabetes 2002;51:2325-8
  • Stumvoll M, Tschritter O, Fritsche A, Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes. Diabetes 2002;51:37-41
  • Menzaghi C, Trischitta V, Doria A. Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease. Diabetes 2007;56:1198-209
  • Maeda N, Shimomura I, Kishida K, Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 2002;8:731-7
  • Hara K, Horikoshi M, Yamauchi T, Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome. Diabetes Care 2006;29:1357-62
  • McAinch AJ, Steinberg GR, Mollica J, Differential regulation of adiponectin receptor gene expression by adiponectin and leptin in myotubes derived from obese and diabetic individuals. Obesity (Silver Spring) 2006;14:1898-904
  • Saltiel AR. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 2001;104:517-29
  • Yki-Jarvinen H. Thiazolidinediones. N Engl J Med 2004;351:1106-18
  • Evans RM, Barish GD, Wang YX. PPARs and the complex journey to obesity. Nat Med 2004;10:355-61
  • Kubota N, Terauchi Y, Kubota T, Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem 2006;281:8748-55
  • Shibata R, Sato K, Pimentel DR, Adiponectin protects against myocardial ischemia-reperfusion injury through. Nat Med 2005;11:1096-103
  • Shinmura K, Tamaki K, Saito K, Cardioprotective effects of short-term caloric restriction are mediated by adiponectin via activation of AMP-activated protein kinase. Circulation 2007;116:2809-17
  • Shibata R, Skurk C, Ouchi N, Adiponectin promotes endothelial progenitor cell number and function. FEBS Lett 2008;582:1607-12
  • Ikeda Y, Ohashi K, Shibata R, Cyclooxygenase-2 induction by adiponectin is regulated by a sphingosine kinase-1 dependent mechanism in cardiac myocytes. FEBS Lett 2008;582:1147-50
  • Shibata R, Ouchi N, Murohara T. Adiponectin and cardiovascular disease. Circ J 2009;73:608-14
  • Dore DD, Trivedi AN, Mor V, Lapane KL. Association between extent of thiazolidinedione exposure and risk of acute myocardial infarction. Pharmacotherapy 2009;29:775-83
  • Ouedraogo R, Wu X, Xu SQ, Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway. Diabetes 2006;55:1840-6
  • Lautamaki R, Ronnemaa T, Huupponen R, Low serum adiponectin is associated with high circulating oxidized low-density lipoprotein in patients with type 2 diabetes mellitus and coronary artery disease. Metabolism 2007;56:881-6
  • Motoshima H, Wu X, Mahadev K, Goldstein BJ. Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL. Biochem Biophys Res Commun 2004;315:264-71
  • Bruun JM, Lihn AS, Verdich C, Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. Am J Physiol Endocrinol Metab 2003;285:E527-33
  • Komai N, Morita Y, Sakuta T, Anti-tumor necrosis factor therapy increases serum adiponectin levels with the improvement of endothelial dysfunction in patients with rheumatoid arthritis. Mod Rheumatol 2007;17:385-90
  • Rovin BH, Song H, Hebert LA, Plasma, urine, and renal expression of adiponectin in human systemic lupus erythematosus. Kidney Int 2005;68:1825-33
  • Yamamoto K, Kiyohara T, Murayama Y, Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease. Gut 2005;54:789-96
  • Fayad R, Pini M, Sennello JA, Adiponectin deficiency protects mice from chemically induced colonic inflammation. Gastroenterology 2007;132:601-14
  • Ouedraogo R, Gong Y, Berzins B, Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. J Clin Invest 2007;117:1718-26
  • Ouchi N, Kihara S, Arita Y, Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 1999;100:2473-6
  • Xu SQ, Mahadev K, Wu X, Adiponectin protects against angiotensin II or tumor necrosis factor alpha-induced endothelial cell monolayer hyperpermeability: role of cAMP/PKA signaling. Arterioscler Thromb Vasc Biol 2008;28:899-905
  • Kobayashi H, Ouchi N, Kihara S, Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circ Res 2004;94:e27-31
  • Ouchi N, Kobayashi H, Kihara S, Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem 2004;279:1304-9
  • Ouchi N, Kihara S, Arita Y, Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-κB signaling through a cAMP-dependent pathway. Circulation 2000;102:1296-301
  • Collins SP, Reoma JL, Gamm DM, Uhler MD. LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. Biochem J 2000;345(Pt 3):673-80
  • Date H, Imamura T, Ideguchi T, Adiponectin produced in coronary circulation regulates coronary flow reserve in nondiabetic patients with angiographically normal coronary arteries. Clin Cardiol 2006;29:211-4
  • Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 2006;6:772-83
  • Conejo R, Valverde AM, Benito M, Lorenzo M. Insulin produces myogenesis in C2C12 myoblasts by induction of NF-κB and downregulation of AP-1 activities. J Cell Physiol 2001;186:82-94
  • DiMascio L, Voermans C, Uqoezwa M, Identification of adiponectin as a novel hemopoietic stem cell growth factor. J Immunol 2007;178:3511-20
  • Lee HW, Kim SY, Kim AY, Adiponectin stimulates osteoblast differentiation through induction of COX2 in mesenchymal progenitor cells. Stem Cells 2009;27:2254-62
  • Shu RZ, Zhang F, Wang F, Adiponectin deficiency impairs liver regeneration through attenuating STAT3 phosphorylation in mice. Lab Invest 2009;89:1043-52
  • Vu V, Riddell MC, Sweeney G. Circulating adiponectin and adiponectin receptor expression in skeletal muscle: effects of exercise. Diabetes Metab Res Rev 2007;23:600-11
  • Jones NC, Tyner KJ, Nibarger L, The p38alpha/beta MAPK functions as a molecular switch to activate the quiescent satellite cell. J Cell Biol 2005;169:105-16
  • Sampaolesi M, Blot S, D'Antona G, Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs. Nature 2006;444:574-9
  • Williams T, Brenman JE. LKB1 and AMPK in cell polarity and division. Trends Cell Biol 2008;18:193-8
  • Ando Y, Inaba M, Sakaguchi Y, Subcutaneous adipose tissue-derived stem cells facilitate colonic mucosal recovery from 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. Inflamm Bowel Dis 2008;14:826-38
  • Kase H, Hattori Y, Jojima T, Globular adiponectin induces adhesion molecule expression through the sphingosine kinase pathway in vascular endothelial cells. Life Sci 2007;81:939-43
  • Nagata Y, Partridge TA, Matsuda R, Zammit PS. Entry of muscle satellite cells into the cell cycle requires sphingolipid signaling. J Cell Biol 2006;174:245-53
  • Donati C, Cencetti F, Nincheri P, Sphingosine 1-phosphate mediates proliferation and survival of mesoangioblasts. Stem Cells 2007;25:1713-9
  • Chiarugi P, Giannoni E. Anoikis: a necessary death program for anchorage-dependent cells. Biochem Pharmacol 2008;76:1352-64

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