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Toll-like receptors: a novel target for therapeutic intervention in intestinal and hepatic ischemia–reperfusion injury?

, MD, , MD, , MD, , MD, , MD & , MD
Pages 839-853 | Published online: 23 Jun 2010

Bibliography

  • West AP, Koblansky AA, Ghosh S. Recognition and signaling by Toll-like receptors. Annu Rev Cell Dev Biol 2006;22:409-37
  • Kawai T, Akira S. Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med 2007;13:460-9
  • Kawai T, Akira S. TLR signaling. Semin Immunol 2007;19:24-32
  • Schnare M, Rollinghoff M, Qureshi S. Toll-like receptors: sentinels of host defence against bacterial infection. Int Arch Allergy Immunol 2006;139:75-85
  • Zhong B, Tien P, Shu HB. Innate immune responses: crosstalk of signaling and regulation of gene transcription. Virology 2006;352:14-21
  • Johnson GB, Brunn GJ, Platt JL. Activation of mammalian Toll-like receptors by endogenous agonists. Crit Rev Immunol 2003;23:15-44
  • Kaczorowski DJ, Mollen KP, Edmonds R, Billiar TR. Early events in the recognition of danger signals after tissue injury. J Leukoc Biol 2008;83:546-52
  • Boley SJ, Brandt LJ, Sammartano RJ. History of mesenteric ischemia. The evolution of a diagnosis and management. Surg Clin North Am 1997;77:275-88
  • Levine JS, Jacobson ED. Intestinal ischemic disorders. Dig Dis 1995;13:3-24
  • Ghosh S, Roberts N, Firmin RK, Risk factors for intestinal ischaemia in cardiac surgical patients. Eur J Cardiothorac Surg 2002;21:411-6
  • Reber PU, Peter M, Patel AG, Ischaemia/reperfusion contributes to colonic injury following experimental aortic surgery. Eur J Vasc Endovasc Surg 2001;21:35-9
  • Kimizuka K, Nakao A, Nalesnik MA, Exogenous IL-6 inhibits acute inflammatory responses and prevents ischemia/reperfusion injury after intestinal transplantation. Am J Transplant 2004;4:482-94
  • Arumugam TV, Okun E, Tang SC, Toll-like receptors in ischemia-reperfusion injury. Shock 2009;32:4-16
  • Nagy LE. Recent insights into the role of the innate immune system in the development of alcoholic liver disease. Exp Biol Med (Maywood) 2003;228:882-90
  • Gregory SH, Wing EJ. Neutrophil-Kupffer cell interaction: a critical component of host defenses to systemic bacterial infections. J Leukoc Biol 2002;72:239-48
  • Decker K. Biologically active products of stimulated liver macrophages (Kupffer cells). Eur J Biochem 1990;192:245-61
  • Rivera CA, Adegboyega P, van Rooijen N, Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J Hepatol 2007;47:571-9
  • Tsung A, Hoffman RA, Izuishi K, Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells. J Immunol 2005;175:7661-8
  • Hashimoto C, Hudson KL, Anderson KV. The Toll gene of drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein. Cell 1988;52:269-79
  • Chuang T, Ulevitch RJ. Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. Biochim Biophys Acta 2001;1518:157-61
  • Du X, Poltorak A, Wei Y, Beutler B. Three novel mammalian Toll-like receptors: gene structure, expression, and evolution. Eur Cytokine Netw 2000;11:362-71
  • Rock FL, Hardiman G, Timans JC, A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci USA 1998;95:588-93
  • Takeuchi O, Kawai T, Sanjo H, TLR6: a novel member of an expanding toll-like receptor family. Gene 1999;231:59-65
  • Chuang TH, Ulevitch RJ. Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur Cytokine Netw 2000;11:372-8
  • Poltorak A, He X, Smirnova I, Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998;282:2085-8
  • Di Muzio M, Spoletini L, Strizzi L, Prognostic significance of presence and reduplication of basal lamina in malignant pleural mesothelioma. Hum Pathol 2000;31:1341-5
  • Krug A, Towarowski A, Britsch S, Toll-like receptor expression reveals CPG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur J Immunol 2001;31:3026-37
  • Jarrossay D, Napolitani G, Colonna M, Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur J Immunol 2001;31:3388-93
  • Ito T, Amakawa R, Kaisho T, Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets. J Exp Med 2002;195:1507-12
  • Supajatura V, Ushio H, Nakao A, Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4. J Immunol 2001;167:2250-6
  • McCurdy JD, Lin TJ, Marshall JS. Toll-like receptor 4-mediated activation of murine mast cells. J Leukoc Biol 2001;70:977-84
  • Gewirtz AT, Navas TA, Lyons S, Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J Immunol 2001;167:1882-5
  • Abreu MT, Vora P, Faure E, Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide. J Immunol 2001;167:1609-16
  • Breslin JW, Wu MH, Guo M, Toll-like receptor 4 contributes to microvascular inflammation and barrier dysfunction in thermal injury. Shock 2008;29:349-55
  • Frantz S, Kelly RA, Bourcier T. Role of TLR-2 in the activation of nuclear factor κB by oxidative stress in cardiac myocytes. J Biol Chem 2001;276:5197-203
  • Tang SC, Arumugam TV, Xu X, Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci USA 2007;104:13798-803
  • Miettinen M, Sareneva T, Julkunen I, Matikainen S. IFNs activate toll-like receptor gene expression in viral infections. Genes Immun 2001;2:349-55
  • Wang T, Lafuse WP, Zwilling BS. Regulation of Toll-like receptor 2 expression by macrophages following Mycobacterium avium infection. J Immunol 2000;165:6308-13
  • Matsuguchi T, Musikacharoen T, Ogawa T, Yoshikai Y. Gene expressions of Toll-like receptor 2, but not Toll-like receptor 4, is induced by LPS and inflammatory cytokines in mouse macrophages. J Immunol 2000;165:5767-72
  • Lin Y, Lee H, Berg AH, The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J Biol Chem 2000;275:24255-63
  • Nomura F, Akashi S, Sakao Y, Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface Toll-like receptor 4 expression. J Immunol 2000;164:3476-9
  • Sweet MJ, Campbell CC, Sester DP, Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of Toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages. J Immunol 2002;168:392-9
  • Sweet MJ, Leung BP, Kang D, A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression. J Immunol 2001;166:6633-9
  • Bosisio D, Polentarutti N, Sironi M, Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma: a molecular basis for priming and synergism with bacterial lipopolysaccharide. Blood 2002;99:3427-31
  • Bozza M, Satoskar AR, Lin G, Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis. J Exp Med 1999;189:341-6
  • Roger T, David J, Glauser MP, Calandra T. MIF regulates innate immune responses through modulation of Toll-like receptor 4. Nature 2001;414:920-4
  • Tsujimoto H, Ono S, Efron PA, Role of Toll-like receptors in the development of sepsis. Shock 2008;29:315-21
  • Smith KD, Ozinsky A. Toll-like receptor-5 and the innate immune response to bacterial flagellin. Curr Top Microbiol Immunol 2002;270:93-108
  • Chen CJ, Kono H, Golenbock D, Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med 2007;13:851-6
  • Yarovinsky F, Zhang D, Andersen JF, TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science 2005;308:1626-9
  • Doughty LA, Carlton S, Galen B, Activation of common antiviral pathways can potentiate inflammatory responses to septic shock. Shock 2006;26:187-94
  • Hornung V, Barchet W, Schlee M, Hartmann G. RNA recognition via TLR7 and TLR8. Handb Exp Pharmacol 2008;183:71-86
  • Krieg AM, Vollmer J. Toll-like receptors 7, 8, and 9: linking innate immunity to autoimmunity. Immunol Rev 2007;220:251-69
  • Foldes G, von Haehling S, Anker SD. Toll-like receptor modulation in cardiovascular disease: a target for intervention? Expert Opin Investig Drugs 2006;15:857-71
  • Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006;124:783-801
  • Kaisho T, Akira S. Toll-like receptor function and signaling. J Allergy Clin Immunol 2006;117:979-987; quiz 988
  • Frantz S, Ertl G, Bauersachs J. Mechanisms of disease: Toll-like receptors in cardiovascular disease. Nat Clin Pract Cardiovasc Med 2007;4:444-54
  • Medzhitov R, Preston-Hurlburt P, Kopp E, MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell 1998;2:253-8
  • Frantz S, Kobzik L, Kim YD, Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. J Clin Invest 1999;104:271-80
  • Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2001;2:675-80
  • Cook DN, Pisetsky DS, Schwartz DA. Toll-like receptors in the pathogenesis of human disease. Nat Immunol 2004;5:975-9
  • Yamamoto M, Sato S, Hemmi H, TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol 2003;4:1144-50
  • Bin LH, Xu LG, Shu HB. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. J Biol Chem 2003;278:24526-32
  • Harari OA, Alcaide P, Ahl D, Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway. Circ Res 2006;98:1134-40
  • Parks DA, Granger DN. Contributions of ischemia and reperfusion to mucosal lesion formation. Am J Physiol 1986;250:G749-753
  • Collard CD, Gelman S. Pathophysiology, clinical manifestations, and prevention of ischemia-reperfusion injury. Anesthesiology 2001;94:1133-8
  • Levonen AL, Vahakangas E, Koponen JK, Yla-Herttuala S. Antioxidant gene therapy for cardiovascular disease: current status and future perspectives. Circulation 2008;117:2142-50
  • Thurman JM. Triggers of inflammation after renal ischemia/reperfusion. Clin Immunol 2007;123:7-13
  • Arumugam TV, Magnus T, Woodruff TM, Complement mediators in ischemia-reperfusion injury. Clin Chim Acta 2006;374:33-45
  • Arumugam TV, Granger DN, Mattson MP. Stroke and T-cells. Neuromolecular Med 2005;7:229-42
  • Chen CH, Liu K, Chan JY. Anesthetic preconditioning confers acute cardioprotection via up-regulation of manganese superoxide dismutase and preservation of mitochondrial respiratory enzyme activity. Shock 2008;29:300-8
  • Yeh CH, Chen TP, Lee CH, Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators. Shock 2006;26:262-70
  • Toyokuni S. Reactive oxygen species-induced molecular damage and its application in pathology. Pathol Int 1999;49:91-102
  • Panes J, Perry M, Granger DN. Leukocyte-endothelial cell adhesion: avenues for therapeutic intervention. Br J Pharmacol 1999;126:537-50
  • Vanlangenakker N, Berghe TV, Krysko DV, Molecular mechanisms and pathophysiology of necrotic cell death. Curr Mol Med 2008;8:207-20
  • Liu P, Xu B, Cavalieri TA, Hock CE. Pifithrin-alpha attenuates p53-mediated apoptosis and improves cardiac function in response to myocardial ischemia/reperfusion in aged rats. Shock 2006;26:608-14
  • Nakano H, Nakajima A, Sakon-Komazawa S, Reactive oxygen species mediate crosstalk between NF-kappaB and JNK. Cell Death Differ 2006;13:730-7
  • Collard CD, Lekowski R, Jordan JE, Complement activation following oxidative stress. Mol Immunol 1999;36:941-8
  • Kruger B, Krick S, Dhillon N, Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation. Proc Natl Acad Sci USA 2009;106:3390-5
  • Chao W. Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart. Am J Physiol Heart Circ Physiol 2009;296:H1-12
  • Feng Y, Zhao H, Xu X, Innate immune adaptor MyD88 mediates neutrophil recruitment and myocardial injury after ischemia-reperfusion in mice. Am J Physiol Heart Circ Physiol 2008;295:H1311-8
  • Kilic U, Kilic E, Matter CM, TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration. Neurobiol Dis 2008;31:33-40
  • Mura M, Andrade CF, Han B, Intestinal ischemia-reperfusion-induced acute lung injury and oncotic cell death in multiple organs. Shock 2007;28:227-38
  • Daudel F, Freise H, Westphal M, Continuous thoracic epidural anesthesia improves gut mucosal microcirculation in rats with sepsis. Shock 2007;28:610-4
  • Stefanutti G, Pierro A, Vinardi S, Moderate hypothermia protects against systemic oxidative stress in a rat model of intestinal ischemia and reperfusion injury. Shock 2005;24:159-64
  • Arumugam TV, Shiels IA, Woodruff TM, The role of the complement system in ischemia-reperfusion injury. Shock 2004;21:401-9
  • Kong SE, Blennerhassett LR, Heel KA, Ischaemia-reperfusion injury to the intestine. Aust NZ J Surg 1998;68:554-61
  • Andoh A, Fujiyama Y, Araki Y, Role of complement activation and mast cell degranulation in the pathogenesis of rapid intestinal ischemia/reperfusion injury in rats. Digestion 2001;63(Suppl 1):103-7
  • Chen Y, Lui VC, Rooijen NV, Tam PK. Depletion of intestinal resident macrophages prevents ischaemia reperfusion injury in gut. Gut 2004;53:1772-80
  • Sonnenburg JL, Angenent LT, Gordon JI. Getting a grip on things: how do communities of bacterial symbionts become established in our intestine? Nat Immunol 2004;5:569-73
  • Kelly D, Conway S, Aminov R. Commensal gut bacteria: mechanisms of immune modulation. Trends Immunol 2005;26:326-33
  • Finck C. Enteral versus parenteral nutrition in the critically ill. Nutrition 2000;16:393-4
  • Abrams GD, Schneider H, Formal SB, Sprinz H. Cellular renewal and mucosal morphology in experimental enteritis. Infection with Salmonella typhimurium in the mouse. Lab Invest 1963;12:1241-8
  • Hooper LV, Gordon JI. Commensal host-bacterial relationships in the gut. Science 2001;292:1115-8
  • Sonnenburg JL, Xu J, Leip DD, Glycan foraging in vivo by an intestine-adapted bacterial symbiont. Science 2005;307:1955-9
  • Cario E, Podolsky DK. Differential alteration in intestinal epithelial cell expression of Toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun 2000;68:7010-7
  • Melmed G, Thomas LS, Lee N, Human intestinal epithelial cells are broadly unresponsive to Toll-like receptor 2-dependent bacterial ligands: implications for host-microbial interactions in the gut. J Immunol 2003;170:1406-15
  • Fukata M, Michelsen KS, Eri R, Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Am J Physiol Gastrointest Liver Physiol 2005;288:G1055-1065
  • Hart AL, Al-Hassi HO, Rigby RJ, Characteristics of intestinal dendritic cells in inflammatory bowel diseases. Gastroenterology 2005;129:50-65
  • Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 2004;118:229-41
  • Fukata M, Chen A, Klepper A, Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: role in proliferation and apoptosis in the intestine. Gastroenterology 2006;131:862-77
  • Rhee SH, Im E, Riegler M, Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc Natl Acad Sci USA 2005;102:13610-5
  • Kono H, Rock KL. How dying cells alert the immune system to danger. Nat Rev Immunol 2008;8:279-89
  • Victoni T, Coelho FR, Soares AL, Local and remote tissue injury upon intestinal ischemia and reperfusion depends on the TLR/MyD88 signaling pathway. Med Microbiol Immunol 2010;199:35-42
  • Grotz MR, Deitch EA, Ding J, Intestinal cytokine response after gut ischemia: role of gut barrier failure. Ann Surg 1999;229:478-86
  • Chen LW, Chang WJ, Chen PH, TLR ligand decreases mesenteric ischemia and reperfusion injury-induced gut damage through TNF-alpha signaling. Shock 2008;30:563-70
  • Baldwin AS Jr. Series introduction: the transcription factor NF-kappaB and human disease. J Clin Invest 2001;107:3-6
  • Kaufmann T, Schinzel A, Borner C. Bcl-w(edding) with mitochondria. Trends Cell Biol 2004;14:8-12
  • Baumler MD, Nelson DW, Ney DM, Groblewski GE. Loss of exocrine pancreatic stimulation during parenteral feeding suppresses digestive enzyme expression and induces Hsp70 expression. Am J Physiol Gastrointest Liver Physiol 2007;292:G857-866
  • Brown MA, Jones WK. NF-kappaB action in sepsis: the innate immune system and the heart. Front Biosci 2004;9:1201-17
  • Aprahamian CJ, Lorenz RG, Harmon CM, Dimmit RA. Toll-like receptor 2 is protective of ischemia-reperfusion-mediated small-bowel injury in a murine model. Pediatr Crit Care Med 2008;9:105-9
  • Jilling T, Lu J, Jackson M, Caplan MS. Intestinal epithelial apoptosis initiates gross bowel necrosis in an experimental rat model of neonatal necrotizing enterocolitis. Pediatr Res 2004;55:622-9
  • Fondevila C, Busuttil RW, Kupiec-Weglinski JW. Hepatic ischemia/reperfusion injury–a fresh look. Exp Mol Pathol 2003;74:86-93
  • Katsargyris A, Klonaris C, Alexandrou A, Toll-like receptors in liver ischemia reperfusion injury: a novel target for therapeutic modulation? Expert Opin Ther Targets 2009;13:427-42
  • Kupiec-Weglinski JW, Busuttil RW. Ischemia and reperfusion injury in liver transplantation. Transplant Proc 2005;37:1653-6
  • Matsumura T, Ito A, Takii T, Endotoxin and cytokine regulation of toll-like receptor (TLR) 2 and TLR4 gene expression in murine liver and hepatocytes. J Interferon Cytokine Res 2000;20:915-21
  • Liu S, Gallo DJ, Green AM, Role of Toll-like receptors in changes in gene expression and NF-kappaB activation in mouse hepatocytes stimulated with lipopolysaccharide. Infect Immun 2002;70:3433-42
  • Su GL, Klein RD, Aminlari A, Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and Toll-like receptor 4. Hepatology 2000;31:932-6
  • Zhai Y, Shen XD, O'Connell R, Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway. J Immunol 2004;173:7115-9
  • Wang L, Xu JB, Wu HS, The relationship between activation of TLR4 and partial hepatic ischemia/reperfusion injury in mice. Hepatobiliary Pancreat Dis Int 2006;5:101-4
  • Tsung A, Klune JR, Zhang X, HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling. J Exp Med 2007;204:2913-23
  • Shen XD, Ke B, Zhai Y, Absence of Toll-like receptor 4 (TLR4) signaling in the donor organ reduces ischemia and reperfusion injury in a murine liver transplantation model. Liver Transpl 2007;13:1435-43
  • Dhillon N, Walsh L, Kruger B, A single nucleotide polymorphism of Toll-like receptor 4 identifies the risk of developing graft failure after liver transplantation. J Hepatol 2010;53:67-72
  • Prince JM, Levy RM, Yang R, Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock. J Am Coll Surg 2006;202:407-17
  • Frink M, Hsieh YC, Thobe BM, TLR4 regulates Kupffer cell chemokine production, systemic inflammation and lung neutrophil infiltration following trauma-hemorrhage. Mol Immunol 2007;44:2625-30
  • Hsieh YC, Frink M, Hsieh CH, Downregulation of migration inhibitory factor is critical for estrogen-mediated attenuation of lung tissue damage following trauma-hemorrhage. Am J Physiol Lung Cell Mol Physiol 2007;292:L1227-1232
  • Thobe BM, Frink M, Hildebrand F, The role of MAPK in Kupffer cell toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhage. J Cell Physiol 2007;210:667-75
  • Zhang JX, Wu HS, Wang H, Protection against hepatic ischemia/reperfusion injury via downregulation of toll-like receptor 2 expression by inhibition of Kupffer cell function. World J Gastroenterol 2005;11:4423-6
  • Zhai Y, Qiao B, Shen XD, Evidence for the pivotal role of endogenous Toll-like receptor 4 ligands in liver ischemia and reperfusion injury. Transplantation 2008;85:1016-22
  • Wang H, Li ZY, Wu HS, Endogenous danger signals trigger hepatic ischemia/reperfusion injury through toll-like receptor 4/nuclear factor-kappa B pathway. Chin Med J (Engl) 2007;120:509-14
  • Jin X, Wang L, Wu HS, N-acetylcysteine inhibits activation of toll-like receptor 2 and 4 gene expression in the liver and lung after partial hepatic ischemia-reperfusion injury in mice. Hepatobiliary Pancreat Dis Int 2007;6:284-9
  • Ke B, Shen XD, Tsuchihashi S, Viral interleukin-10 gene transfer prevents liver ischemia-reperfusion injury: Toll-like receptor-4 and heme oxygenase-1 signaling in innate and adaptive immunity. Hum Gene Ther 2007;18:355-66
  • Katsargyris A, Klonaris C, Bastounis E, Theocharis S. Toll-like receptor modulation: a novel therapeutic strategy in cardiovascular disease? Expert Opin Ther Targets 2008;12:1329-46
  • Tsung A, Zheng N, Jeyabalan G, Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury. J Leukoc Biol 2007;81:119-28

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