Connexins as therapeutic targets in lung disease

Bibliography

• Johnson LN, Koval M. Cross-talk between pulmonary injury, oxidant stress, and gap junctional communication. Antioxid Redox Signal 2009;11:355-67
   PubMed Web of Science ®Google Scholar
• Sohl G, Willecke K. Gap junctions and the connexin protein family. Cardiovasc Res 2004;62:228-32
   PubMed Web of Science ®Google Scholar
• Harris A, Locke D. Connexins: a guide. Humana Press, New York; 2009
   Google Scholar
• Wiszniewski L, Sanz J, Scerri I, Functional expression of connexin30 and connexin31 in the polarized human airway epithelium. Differentiation 2007;75:382-92
   PubMed Web of Science ®Google Scholar
• Albright CD, Grimley PM, Jones RT, Resau JH. Differential effects of TPA and retinoic acid on cell-cell communication in human bronchial epithelial cells. Exp Mol Pathol 2002;72:62-7
   PubMed Web of Science ®Google Scholar
• Jinn Y, Ichioka M, Marumo F. Expression of connexin32 and connexin43 gap junction proteins and E-cadherin in human lung cancer. Cancer Lett 1998;127:161-9
   PubMed Web of Science ®Google Scholar
• Carson JL, Reed W, Moats-Staats BM, Connexin 26 expression in human and ferret airways and lung during development. Am J Respir Cell Mol Biol 1998;18:111-19
   PubMed Web of Science ®Google Scholar
• Chen Y, Huhn D, Knosel T, Downregulation of connexin 26 in human lung cancer is related to promoter methylation. Int J Cancer 2005;113:14-21
   PubMed Web of Science ®Google Scholar
• Cesen-Cummings K, Fernstrom MJ, Malkinson AM, Ruch RJ. Frequent reduction of gap junctional intercellular communication and connexin43 expression in human and mouse lung carcinoma cells. Carcinogenesis 1998;19:61-7
   PubMed Web of Science ®Google Scholar
• Park SJ, Lee KS, Kim SR, Change of connexin 37 in allergen-induced airway inflammation. Exp Mol Med 2007;39:629-40
   PubMed Web of Science ®Google Scholar
• Traub O, Hertlein B, Kasper M, Characterization of the gap junction protein connexin37 in murine endothelium, respiratory epithelium, and after transfection in human HeLa cells. Eur J Cell Biol 1998;77:313-22
   PubMed Web of Science ®Google Scholar
• Udaka N, Miyagi Y, Ito T. Connexin expression in mouse lung tumor. Cancer Lett 2007;246:224-9
   PubMed Web of Science ®Google Scholar
• Lee YC, Yellowley CE, Li Z, Expression of functional gap junctions in cultured pulmonary alveolar epithelial cells. Am J Physiol 1997;272:L1105-14
   PubMed Web of Science ®Google Scholar
• Abraham V, Chou ML, George P, Heterocellular gap junctional communication between alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 2001;280:L1085-93
   Web of Science ®Google Scholar
• Avanzo JL, Mesnil M, Hernandez-Blazquez FJ, Altered expression of connexins in urethane-induced mouse lung adenomas. Life Sci 2006;79:2202-8
   PubMed Web of Science ®Google Scholar
• Saez JC, Berthoud VM, Branes MC, Plasma membrane channels formed by connexins: their regulation and functions. Physiol Rev 2003;83:1359-400
   PubMed Web of Science ®Google Scholar
• Jiang JX, Gu S. Gap junction- and hemichannel-independent actions of connexins. Biochim Biophys Acta 2005;1711:208-14
   Google Scholar
• Spray DC, Ye ZC, Ransom BR. Functional connexin "hemichannels": a critical appraisal. Glia 2006;54:758-73
   PubMed Web of Science ®Google Scholar
• Scemes E, Suadicani SO, Dahl G, Spray DC. Connexin and pannexin mediated cell-cell communication. Neuron Glia Biol 2007;3:199-208
   Google Scholar
• Bruzzone R, Hormuzdi SG, Barbe MT, Pannexins, a family of gap junction proteins expressed in brain. Proc Natl Acad Sci USA 2003;100:13644-9
   PubMed Web of Science ®Google Scholar
• Ransford GA, Fregien N, Qiu F, Pannexin 1 contributes to ATP release in airway epithelia. Am J Respir Cell Mol Biol 2009;41:525-34
   Google Scholar
• Fahy JV, Dickey BF. Airway mucus function and dysfunction. N Engl J Med 2010;363:2233-47
   PubMed Web of Science ®Google Scholar
• Sanderson MJ, Chow I, Dirksen ER. Intercellular communication between ciliated cells in culture. Am J Physiol 1988;254:C63-74
   Google Scholar
• Boitano S, Dirksen ER, Sanderson MJ. Intercellular propagation of calcium waves mediated by inositol trisphosphate. Science 1992;258:292-5
   PubMed Web of Science ®Google Scholar
• Homolya L, Steinberg TH, Boucher RC. Cell to cell communication in response to mechanical stress via bilateral release of ATP and UTP in polarized epithelia. J Cell Biol 2000;150:1349-60
   PubMed Web of Science ®Google Scholar
• Scheckenbach KE, Losa D, Dudez T, PGE2 regulation of CFTR activity and air surface liquid volume requires gap junctional communication. Am J Respir Cell Mol Biol 2011;44:74-82
   PubMed Web of Science ®Google Scholar
• Lazarowski ER, Boucher RC. Purinergic receptors in airway epithelia. Curr Opin Pharmacol 2009;9:262-7
   PubMed Web of Science ®Google Scholar
• Andreeva AV, Kutuzov MA, Voyno-Yasenetskaya TA. Regulation of surfactant secretion in alveolar type II cells. Am J Physiol Lung Cell Mol Physiol 2007;293:L259-71
   PubMed Web of Science ®Google Scholar
• Ichimura H, Parthasarathi K, Lindert J, Bhattacharya J. Lung surfactant secretion by interalveolar Ca2+ signaling. Am J Physiol Lung Cell Mol Physiol 2006;291:L596-601
   Web of Science ®Google Scholar
• Isakson BE, Evans WH, Boitano S. Intercellular Ca2+ signaling in alveolar epithelial cell through gap junctions and by extracellular ATP. Am J Physiol Lung Cell Mol Physiol 2001;280:L221-8
   PubMed Web of Science ®Google Scholar
• Patel AS, Reigada D, Mitchell CH, Paracrine stimulation of surfactant secretion by extracellular ATP in response to mechanical deformation. Am J Physiol Lung Cell Mol Physiol 2005;289:L489-96
   PubMed Web of Science ®Google Scholar
• Ashino Y, Ying X, Dobbs LG, Bhattacharya J. [Ca2+]i oscillations regulate type II cell exocytosis in the pulmonary alveolus. Am J Physiol Lung Cell Mol Physiol 2000;279:L5-L13
   Web of Science ®Google Scholar
• Wang PM, Fujita E, Bhattacharya J. Vascular regulation of type II cell exocytosis. Am J Physiol Lung Cell Mol Physiol 2002;282:L912-16
   Web of Science ®Google Scholar
• Seminario-Vidal L, Kreda S, Jones L, Thrombin promotes release of ATP from lung epithelial cells through coordinated activation of rho- and Ca2+-dependent signaling pathways. J Biol Chem 2009;284:20638-48
   Google Scholar
• Kreda SM, Seminario-Vidal L, van Heusden CA, Receptor-promoted exocytosis of airway epithelial mucin granules containing a spectrum of adenine nucleotides. J Physiol 2010;588:2255-67
   PubMed Web of Science ®Google Scholar
• Chanson M, Derouette JP, Roth I, Gap junctional communication in tissue inflammation and repair. Biochim Biophys Acta 2005;1711:197-207
   PubMed Web of Science ®Google Scholar
• Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000;342:1334-49
   PubMed Web of Science ®Google Scholar
• Parthasarathi K, Ichimura H, Monma E, Connexin 43 mediates spread of Ca2+-dependent proinflammatory responses in lung capillaries. J Clin Invest 2006;116:2193-200
   PubMed Web of Science ®Google Scholar
• Kasper M, Traub O, Reimann T, Upregulation of gap junction protein connexin43 in alveolar epithelial cells of rats with radiation-induced pulmonary fibrosis. Histochem Cell Biol 1996;106:419-24
   PubMed Web of Science ®Google Scholar
• Sarieddine MZ, Scheckenbach KE, Foglia B, Connexin43 modulates neutrophil recruitment to the lung. J Cell Mol Med 2009;13:4560-70
   PubMed Web of Science ®Google Scholar
• Moreno AP, Chanson M, Elenes S, Role of the carboxyl terminal of connexin43 in transjunctional fast voltage gating. Circ Res 2002;90:450-7
   Google Scholar
• Rignault S, Haefliger JA, Waeber B, Acute inflammation decreases the expression of connexin 40 in mouse lung. Shock 2007;28:78-85
   PubMed Web of Science ®Google Scholar
• Zhang J, Wang W, Sun J, Gap junction channel modulates pulmonary vascular permeability through calcium in acute lung injury: an experimental study. Respiration 2010;80:236-45
   PubMed Web of Science ®Google Scholar
• Chadjichristos CE, Scheckenbach KE, van Veen TA, Endothelial-specific deletion of connexin40 promotes atherosclerosis by increasing CD73-dependent leukocyte adhesion. Circulation 2010;121:123-31
   PubMed Web of Science ®Google Scholar
• Thompson LF, Eltzschig HK, Ibla JC, Crucial role for ecto-5′-nucleotidase (CD73) in vascular leakage during hypoxia. J Exp Med 2004;200:1395-405
   PubMed Web of Science ®Google Scholar
• Volmer JB, Thomson LF, Blackburn MR. Ecto-5′-nucleotidase (CD73)-mediated adenosine production is tissue protective in a model of bleomycin-incuded lung injury. J Immunol 2006;176:4449-58
   PubMed Web of Science ®Google Scholar
• Eckle T, Fulbier L, Wehrmann M, Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injury. J Immunol 2007;178:8127-37
   PubMed Web of Science ®Google Scholar
• Boucher RC. Cystic fibrosis: a disease of vulnerability to airway surface dehydration. Trends Mol Med 2007;13:231-40
   PubMed Web of Science ®Google Scholar
• Chanson M, Scerri I, Suter S. Defective regulation of gap junctional coupling in cystic fibrosis pancreatic duct cells. J Clin Invest 1999;103:1677-84
   PubMed Web of Science ®Google Scholar
• Martin FJ, Prince AS. TLR2 regulates gap junction intercellular communication in airway cells. J Immunol 2008;180:4986-93
   PubMed Web of Science ®Google Scholar
• Chanson M, Berclaz PY, Scerri I, Regulation of gap junctional communication by a pro-inflammatory cytokine in cystic fibrosis transmembrane conductance regulator-expressing but not cystic fibrosis airway cells. Am J Pathol 2001;158:1775-84
   PubMed Web of Science ®Google Scholar
• Huang S, Dudez T, Scerri I, Defective activation of c-Src in cystic fibrosis airway epithelial cells results in loss of tumor necrosis factor-alpha-induced gap junction regulation. J Biol Chem. 2003;278:8326-32
   PubMed Web of Science ®Google Scholar
• Huang S, Jornot L, Wiszniewski L, Src signaling links mediators of inflammation to Cx43 gap junction channels in primary and transformed CFTR-expressing airway cells. Cell Commun Adhes 2003;10:279-85
   PubMed Web of Science ®Google Scholar
• Jacquot J, Tabary O, Clement A. Hyperinflammation in airways of cystic fibrosis patients: what's new? Expert Rev Mol Diagn 2008;8:359-63
   PubMed Web of Science ®Google Scholar
• Murphy DM, O'Byrne PM. Recent advances in the pathophysiology of asthma. Chest 2010;137:1417-26
   PubMed Web of Science ®Google Scholar
• Herve JC, Sarrouilhe D. Connexin-made channels as pharmacological targets. Curr Pharm Des 2005;11:1941-58
   PubMed Web of Science ®Google Scholar
• Ram A, Singh SK, Singh VP, Inhaled carbenoxolone prevents allergic airway inflammation and airway hyperreactivity in a mouse model of asthma. Int Arch Allergy Immunol 2009;149:38-46
   PubMed Web of Science ®Google Scholar
• Oviedo-Orta E, Errington RJ, Evans WH. Gap junction intercellular communication during lymphocyte transendothelial migration. Cell Biol Int 2002;26:253-63
   Google Scholar
• Eugenin EA, Branes MC, Berman JW, Saez JC. TNF-alpha plus IFN-gamma induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses. J Immunol 2003;170:1320-8
   PubMed Web of Science ®Google Scholar
• Zahler S, Hoffmann A, Gloe T, Pohl U. Gap-junctional coupling between neutrophils and endothelial cells: a novel modulator of transendothelial migration. J Leukoc Biol 2003;73:118-26
   PubMed Web of Science ®Google Scholar
• Scerri I, Tabary O, Dudez T, Gap junctional communication does not contribute to the interaction between neutrophils and airway epithelial cells. Cell Commun Adhes 2006;13:1-12
   PubMed Web of Science ®Google Scholar
• Wong CW, Christen T, Roth I, Connexin37 protects against atherosclerosis by regulating monocyte adhesion. Nat Med 2006;12:950-4
   PubMed Web of Science ®Google Scholar
• Eltzschig HK, Eckle T, Mager A, ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function. Circ Res. 2006;99:1100-8
   PubMed Web of Science ®Google Scholar
• Kolliputi N, Shaik RS, Waxman AB. The inflammasome mediates hyperoxia-induced alveolar cell permeability. J Immunol 2010;184:5819-26
   PubMed Web of Science ®Google Scholar
• Chen Y, Yao Y, Sumi Y, Purinergic signaling: a fundamental mechanism in neutrophil activation. Sci Signal 2010;3(125):ra45
   PubMed Web of Science ®Google Scholar
• Bara I, Ozier A, Tunon de Lara JM, Pathophysiology of bronchial smooth muscle remodelling in asthma. Eur Respir J 2010;36:1174-84
   PubMed Web of Science ®Google Scholar
• Vliagoftis H, Hutson AM, Mahmudi-Azer S, Mast cells express connexins on their cytoplasmic membrane. J Allergy Clin Immunol 1999;103:656-62
   PubMed Web of Science ®Google Scholar
• Humbert Sitbon O, Simonneau G. Treatment of pulmonary arterial hypertension. N Engl J Med 2004;351:1425-36
   PubMed Web of Science ®Google Scholar
• Girgis RE. Emerging drugs for pulmonary hypertension. Expert Opin Emerg Drugs 2010;15:71-85
   PubMed Web of Science ®Google Scholar
• Yen CH, Leu S, Lin YC, Sildenafil limits monocrotaline-induced pulmonary hypertension in rats through suppression of pulmonary vascular remodeling. J Cardiovasc Pharmacol 2010;55:574-84
   PubMed Web of Science ®Google Scholar
• Billaud M, Dahan D, Marthan R, Role of the gap junctions in the contractile response to agonists in pulmonary artery from two rat models of pulmonary hypertension. Respir Res 2011;12:30
   PubMed Web of Science ®Google Scholar
• Polontchouk L, Ebelt B, Jackels M, Dhein S. Chronic effects of endothelin 1 and angiotensin II on gap junctions and intercellular communication in cardiac cells. FASEB J 2002;16:87-9
   PubMedGoogle Scholar
• Trosko JE, Ruch RJ. Gap junctions as targets for cancer chemoprevention and chemotherapy. Curr. Drug Targets 2002;3:465-82
   PubMed Web of Science ®Google Scholar
• Ale-Agha N, Albrecht C, Klotz LO. Loss of gap junctional intercellular communication in rat lung epithelial cells exposed to quartz particles. Biochem Biophys Res Commun 2009;390:44-7
   PubMed Web of Science ®Google Scholar
• King TJ, Gurley KE, Prunty J, Deficiency in the gap junction protein connexin32 alters p27Kip1 tumor suppression and MAPK activation in a tissue-specific manner. Oncogene 2005;24:1718-26
   PubMed Web of Science ®Google Scholar
• King TJ, Lampe PD. The gap junction protein connexin32 is a mouse lung tumor suppressor. Cancer Res 2004;64:7191-6
   PubMed Web of Science ®Google Scholar
• Chen Y, Pacyna-Gengelbach M, Deutschmann N, 5-Bromodeoxyuridine induced differentiation of a human small cell lung cancer cell line is associated with alteration of gene expression. Biochem Biophys Res Commun 2007;353:559-64
   PubMed Web of Science ®Google Scholar
• Cronier L, Crespin S, Strale PO, Gap junctions and cancer: new functions for an old story. Antioxid Redox Signal 2009;11:323-38
   PubMed Web of Science ®Google Scholar
• Ito A, Koma Y, Uchino K, Increased expression of connexin 26 in the invasive component of lung squamous cell carcinoma: significant correlation with poor prognosis. Cancer Lett 2006;234:239-48
   PubMed Web of Science ®Google Scholar
• Colombo BM, Benedetti S, Ottolenghi S, The "bystander effect": association of U-87 cell death with ganciclovir-mediated apoptosis of nearby cells and lack of effect in athymic mice. Hum Gene Ther 1995;6:763-72
   PubMed Web of Science ®Google Scholar
• Kurdow R, Boehle AS, Haye S, Ganciclovir prodrug therapy is effective in a murine xenotransplant model of human lung cancer. Ann Thorac Surg 2002;73:905-10
   PubMed Web of Science ®Google Scholar
• Zhang L, Sharma S, Hershman JM, Iodide sensitizes genetically modified non-small cell lung cancer cells to ionizing radiation. Cancer Gene Ther 2006;13:74-81
   PubMed Web of Science ®Google Scholar
• Van Dillen IJ, Mulder NH, Sluiter WJ, Consequences of chemoresistance for the herpes simplex virus thymidine kinase/ganciclovir-induced bystander effect in a human small cell lung cancer cell line model. Anticancer Res 2005;25:255-61
   PubMed Web of Science ®Google Scholar
• Sato H, Fukumoto K, Hada S, Enhancing effect of connexin 32 gene on vinorelbine-induced cytotoxicity in A549 lung adenocarcinoma cells. Cancer Chemother Pharmacol 2007;60:449-57
   PubMed Web of Science ®Google Scholar
• Kuebler WM, Ying X, Bhattacharya J. Pressure-induced endothelial Ca2+ oscillations in lung capillaries. Am J Physiol Lung Cell Mol Physiol 2002;282:L917-23
   Web of Science ®Google Scholar
• Dahl G, Nonner W, Werner R. Attempts to define functional domains of gap junction proteins with synthetic peptides. Biophys J 1994;67:1816-22
   PubMed Web of Science ®Google Scholar
• Warner A, Clements DK, Parikh S, Specific motifs in the external loops of connexin proteins can determine gap junction formation between chick heart myocytes. J Physiol 1995;488:721-8
   PubMed Web of Science ®Google Scholar
• Chaytor AT, Evans WH, Griffith TM. Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries. J Physiol 1997;503:99-110
   PubMed Web of Science ®Google Scholar
• Chaytor AT, Evans WH, Griffith TM. Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. J Physiol 1998;508:561-73
   PubMed Web of Science ®Google Scholar
• Kwak BR, Jongsma HJ. Selective inhibition of gap junction channel activity by synthetic peptides. J Physiol 1999;516:679-85
   PubMed Web of Science ®Google Scholar
• Boitano S, Evans WH. Connexin mimetic peptides reversibly inhibit Ca2+ signaling through gap junctions in airway cells. Am J Physiol Lung Cell Mol Physiol 2000;279:L623-30
   PubMed Web of Science ®Google Scholar
• Herve JC, Dhein S. Peptides targeting gap junctional structures. Curr Pharm Des 2010;16:3056-70
   PubMed Web of Science ®Google Scholar
• Braet K, Vandamme W, Martin PE, Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium 2003;33:37-48
   PubMed Web of Science ®Google Scholar
• Gomes P, Srinivas SP, Van Driessche W, ATP release through connexin hemichannels in corneal endothelial cells. Invest Ophthalmol Vis Sci 2005;46:1208-18
   PubMed Web of Science ®Google Scholar
• Evans WH, Leybaert L. Mimetic peptides as blockers of connexin channel-facilitated intercellular communication. Cell Commun Adhes 2007;14:265-73
   PubMed Web of Science ®Google Scholar
• Wang J, Ma M, Locovei S, Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am J Physiol Cell Physiol 2007;293:C1112-19
   PubMed Web of Science ®Google Scholar
• Dahl G. Gap junction-mimetic peptides do work, but in unexpected ways. Cell Commun Adhes 2007;14:259-64
   PubMed Web of Science ®Google Scholar
• Riteau N, Gasse P, Fauconnier L, Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis. Am J Respir Crit Care Med 2010;182:774-83
   PubMed Web of Science ®Google Scholar
• Bodendiek SB, Raman G. Connexin modulators and their potential targets under the magnifying glass. Curr Med Chem 2010;17:4191-230
   PubMed Web of Science ®Google Scholar
• Cronin M, Anderson PN, Cook JE, Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury. Mol Cell Neurosci 2008;39:152-60
   PubMed Web of Science ®Google Scholar
• de Souza N. Zinc-finger nucleases. Nat Methods 2011;8(1):43
   Web of Science ®Google Scholar
• Nakamura K, Kuraoka A, Kawabuchi M, Shibata Y. Specific localization of gap junction protein, connexin45, in the deep muscular plexus of dog and rat small intestine. Cell Tissue Res 1998;292:487-94
   PubMed Web of Science ®Google Scholar
• von Maltzahn J, Kreuzberg MM, Matern G, C-terminal tagging with eGFP yields new insights into expression of connexin45 but prevents rescue of embryonic lethal connexin45-deficient mice. Eur J Cell Biol 2009;88:481-94
   PubMed Web of Science ®Google Scholar
• Zhang ZQ, Hu Y, Wang BJ, Effective asymmetry in gap junctional intercellular communication between populations of human normal lung fibroblasts and lung carcinoma cells. Carcinogenesis 2004;25:473-82
   PubMed Web of Science ®Google Scholar
• Trovato-Salinaro A, Trovato-Salinaro E, Failla M, Altered intercellular communication in lung fibroblast cultures from patients with idiopathic pulmonary fibrosis. Respir Res 2006;7:122
   PubMed Web of Science ®Google Scholar