Bibliography
- Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144(5):646-74.
- Kiesslich T, Berr F, Alinger B, Current status of therapeutic targeting of developmental signalling pathways in oncology. Curr Pharm Biotechnol 2011; In press.
- Li Y, Maitah MY, Ahmad A, Targeting the hedgehog signalling pathway in cancer therapy. Expert Opin Ther Targets 2012; In press.
- Ingham PW, Nakano Y, Seger C. Mechanisms and functions of hedgehog signalling across the metazoa. Nat Rev Genet 2011;12(6):393-406
- Teglund S, Toftgard R. Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim Biophys Acta 2010;1805(2):181-208.
- Evangelista M, Tian H, de Sauvage FJ. The hedgehog signaling pathway in cancer. Clin Cancer Res 2006;12(20 Pt 1):5924-8
- Jabari S, Meissnitzer M, Quint K, Cellular plasticity of trans- and dedifferentiation markers in human hepatoma cells in vitro and in vivo. Int J Oncol 2009;35(1):69-80
- Neureiter D, Zopf S, Dimmler A, Different capabilities of morphological pattern formation and its association with the expression of differentiation markers in a xenograft model of human pancreatic cancer cell lines. Pancreatology 2005;5(4-5):387-97
- Desch P, Asslaber D, Kern D, Inhibition of GLI, but not smoothened, induces apoptosis in chronic lymphocytic leukemia cells. Oncogene 2010;29(35):4885-95
- Quint K, Stintzing S, Alinger B, The expression pattern of PDX-1, SHH, patched and Gli-1 is associated with pathological and clinical features in human pancreatic cancer. Pancreatology 2009;9(1-2):116-26
- Ng JM, Curran T. The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer 2011;11(7):493-501.
- Von Hoff DD, LoRusso PM, Rudin CM, Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med 2009;361(12):1164-72.
- Rudin CM, Hann CL, Laterra J, Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med 2009;361(12):1173-8.
- Yauch RL, Dijkgraaf GJ, Alicke B, Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma. Science 2009;326(5952):572-4
- Lorusso PM, Jimeno A, Dy G, Pharmacokinetic dose-scheduling study of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with locally advanced or metastatic solid tumors. Clin Cancer Res 2011;17(17):5774-82
- Lauth M, Bergstrom A, Shimokawa T, Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci USA 2007;104(20):8455-60
- Hyman JM, Firestone AJ, Heine VM, Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc Natl Acad Sci USA 2009;106(33):14132-7
- Weiss GJ, Von Hoff DD. Hunting the hedgehog pathway. Clin Pharmacol Ther 2010;87(6):743-7
- Metcalfe C, de Sauvage FJ. Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists. Cancer Res 2011;71(15):5057-61.