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Protein arginine methyltransferases (PRMTs) as therapeutic targets

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Pages 651-664 | Published online: 24 May 2012

Bibliography

  • Paik WK, Paik DC, Kim S. Historical review: the field of protein methylation. Trends Biochem Sci 2007;32:146-52
  • McBride AE, Silver PA. State of the arg: protein methylation at arginine comes of age. Cell 2001;106:5-8
  • Bedford MT, Clarke SG. Protein arginine methylation in mammals: who, what, and why. Mol Cell 2009;33:1-13
  • Boisvert FM, Chenard CA, Richard S. Protein interfaces in signaling regulated by arginine methylation. Sci STKE 2005;2005:re2
  • Chang B, Chen Y, Zhao Y, JMJD6 is a histone arginine demethylase. Science 2007;318:444-7
  • Hong X, Zang J, White J, Interaction of JMJD6 with single-stranded RNA. Proc Natl Acad Sci USA 2010;107:14568-72
  • Cook JR, Lee JH, Yang ZH, FBXO11/PRMT9, a new protein arginine methyltransferase, symmetrically dimethylates arginine residues. Biochem Biophys Res Commun 2006;342:472-81
  • Miranda TB, Miranda M, Frankel A, PRMT7 is a member of the protein arginine methyltransferase family with a distinct substrate specificity. J Biol Chem 2004;279:22902-7
  • Zurita-Lopez CI, Sandberg T, Kelly R, Human Protein Arginine Methyltransferase 7 (PRMT7) Is a Type III enzyme forming omega-NG-Monomethylated arginine residues. J Biol Chem 2012;287:7859-70
  • Sun L, Wang M, Lv Z, Structural insights into protein arginine symmetric dimethylation by PRMT5. Proc Natl Acad Sci USA 2011;108:20538-43
  • Zhang X, Cheng X. Structure of the predominant protein arginine methyltransferase PRMT1 and analysis of its binding to substrate peptides. Structure 2003;11:509-20
  • Yue WW, Hassler M, Roe SM, Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase. EMBO J 2007;26:4402-12
  • Troffer-Charlier N, Cura V, Hassenboehler P, Functional insights from structures of coactivator-associated arginine methyltransferase 1 domains. EMBO J 2007;26:4391-401
  • Ubersax JA, Ferrell JE Jr. Mechanisms of specificity in protein phosphorylation. Nat Rev Mol Cell Biol 2007;8:530-41
  • Wooderchak WL, Zang T, Zhou ZS, Substrate profiling of PRMT1 reveals amino acid sequences that extend beyond the "RGG" paradigm. Biochemistry 2008;47:9456-66
  • Osborne TC, Obianyo O, Zhang X, Protein arginine methyltransferase 1: positively charged residues in substrate peptides distal to the site of methylation are important for substrate binding and catalysis. Biochemistry 2007;46:13370-81
  • Cheng D, Cote J, Shaaban S, The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing. Mol Cell 2007;25:71-83
  • Pahlich S, Zakaryan RP, Gehring H. Protein arginine methylation: cellular functions and methods of analysis. Biochim Biophys Acta 2006;1764:1890-903
  • Lin WJ, Gary JD, Yang MC, The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase. J Biol Chem 1996;271:15034-44
  • Robin-Lespinasse Y, Sentis S, Kolytcheff C, hCAF1, a new regulator of PRMT1-dependent arginine methylation. J Cell Sci 2007;120:638-47
  • Singh V, Miranda TB, Jiang W, DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo. Oncogene 2004;23:7761-71
  • Friesen WJ, Wyce A, Paushkin S, A novel WD repeat protein component of the methylosome binds Sm proteins. J Biol Chem 2002;277:8243-7
  • Aggarwal P, Vaites LP, Kim JK, Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. Cancer Cell 2010;18:329-40
  • Liu F, Zhao X, Perna F, JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation. Cancer Cell 2011;19:283-94
  • Frankel A, Yadav N, Lee J, The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. J Biol Chem 2002;277:3537-43
  • Sayegh J, Webb K, Cheng D, Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain. J Biol Chem 2007;282:36444-53
  • Kuhn P, Xu Q, Cline E, Delineating Anopheles gambiae coactivator associated arginine methyltransferase 1 automethylation using top-down high resolution tandem mass spectrometry. Protein Sci 2009;18:1272-80
  • Kuhn P, Chumanov R, Wang Y, Automethylation of CARM1 allows coupling of transcription and mRNA splicing. Nucleic Acids Res 2011;39:2717-26
  • Higashimoto K, Kuhn P, Desai D, Phosphorylation-mediated inactivation of coactivator-associated arginine methyltransferase 1. Proc Natl Acad Sci USA 2007;104:12318-23
  • Feng Q, He B, Jung SY, Biochemical control of CARM1 enzymatic activity by phosphorylation. J Biol Chem 2009;284:36167-74
  • Avila MA, Garcia-Trevijano ER, Lu SC, Methylthioadenosine. Int J Biochem Cell Biol 2004;36:2125-30
  • Zheng YG, Wu J, Chen Z, Chemical regulation of epigenetic modifications: opportunities for new cancer therapy. Med Res Rev 2008;28:645-87
  • Cheng D, Yadav N, King RW, Small molecule regulators of protein arginine methyltransferases. J Biol Chem 2004;279:23892-9
  • Mai A, Valente S, Cheng D, Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors. ChemMedChem 2007;2:987-91
  • Ragno R, Simeoni S, Castellano S, Small molecule inhibitors of histone arginine methyltransferases: homology modeling, molecular docking, binding mode analysis, and biological evaluations. J Med Chem 2007;50:1241-53
  • Spannhoff A, Heinke R, Bauer I, Target-based approach to inhibitors of histone arginine methyltransferases. J Med Chem 2007;50:2319-25
  • Heinke R, Spannhoff A, Meier R, Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors. ChemMedChem 2009;4:69-77
  • Purandare AV, Chen Z, Huynh T, Pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1). Bioorg Med Chem Lett 2008;18:4438-41
  • Huynh T, Chen Z, Pang S, Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1). Bioorg Med Chem Lett 2009;19:2924-7
  • Allan M, Manku S, Therrien E, N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1). Bioorg Med Chem Lett 2009;19:1218-23
  • Therrien E, Larouche G, Manku S, 1,2-Diamines as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1). Bioorg Med Chem Lett 2009;19:6725-32
  • Pawlak MR, Scherer CA, Chen J, Arginine N-methyltransferase 1 is required for early postimplantation mouse development, but cells deficient in the enzyme are viable. Mol Cell Biol 2000;20:4859-69
  • Yu Z, Chen T, Hebert J, A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation. Mol Cell Biol 2009;29:2982-96
  • Yoshimoto T, Boehm M, Olive M, The arginine methyltransferase PRMT2 binds RB and regulates E2F function. Exp Cell Res 2006;312:2040-53
  • Ganesh L, Yoshimoto T, Moorthy NC, Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis. Mol Cell Biol 2006;26:3864-74
  • Iwasaki H, Kovacic JC, Olive M, Disruption of protein arginine N-methyltransferase 2 regulates leptin signaling and produces leanness in vivo through loss of STAT3 methylation. Circ Res 2010;107:992-1001
  • Swiercz R, Cheng D, Kim D, Ribosomal protein rpS2 is hypomethylated in PRMT3-deficient mice. J Biol Chem 2007;282:16917-23
  • Kongsuwan K, Yu Q, Vincent A, A drosophila minute gene encodes a ribosomal protein. Nature 1985;317:555-8
  • Choi S, Jung CR, Kim JY, PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex. Biochim Biophys Acta 2008;1780:1062-9
  • Yadav N, Lee J, Kim J, Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Proc Natl Acad Sci USA 2003;100:6464-8
  • O'Brien KB, Alberich-Jorda M, Yadav N, CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development 2010;137:2147-56
  • Yadav N, Cheng D, Richard S, CARM1 promotes adipocyte differentiation by coactivating PPARgamma. EMBO Rep 2008;9:193-8
  • Kim J, Lee J, Yadav N, Loss of CARM1 results in hypomethylation of thymocyte cyclic AMP-regulated phosphoprotein and deregulated early T cell development. J Biol Chem 2004;279:25339-44
  • Tee WW, Pardo M, Theunissen TW, Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency. Genes Dev 2010;24:2772-7
  • Thomson JA, Itskovitz-Eldor J, Shapiro SS, Embryonic stem cell lines derived from human blastocysts. Science 1998;282:1145-7
  • Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981;292:154-6
  • Young RA. Control of the embryonic stem cell state. Cell 2011;144:940-54
  • Boiani M, Scholer HR. Regulatory networks in embryo-derived pluripotent stem cells. Nat Rev Mol Cell Biol 2005;6:872-84
  • Yamanaka S. A fresh look at iPS cells. Cell 2009;137:13-17
  • Bannister AJ, Kouzarides T. Reversing histone methylation. Nature 2005;436:1103-6
  • Schurter BT, Koh SS, Chen D, Methylation of histone H3 by coactivator-associated arginine methyltransferase 1. Biochemistry 2001;40:5747-56
  • Torres-Padilla ME, Parfitt DE, Kouzarides T, Histone arginine methylation regulates pluripotency in the early mouse embryo. Nature 2007;445:214-18
  • Parfitt DE, Zernicka-Goetz M. Epigenetic modification affecting expression of cell polarity and cell fate genes to regulate lineage specification in the early mouse embryo. Mol Biol Cell 2010;21:2649-60
  • Wu Q, Bruce AW, Jedrusik A, CARM1 is required in embryonic stem cells to maintain pluripotency and resist differentiation. Stem Cells 2009;27:2637-45
  • Calvanese V, Lara E, Suarez-Alvarez B, Sirtuin 1 regulation of developmental genes during differentiation of stem cells. Proc Natl Acad Sci USA 2010;107:13736-41
  • Pollack BP, Kotenko SV, He W, The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity. J Biol Chem 1999;274:31531-42
  • Lee DY, Teyssier C, Strahl BD, Role of protein methylation in regulation of transcription. Endocr Rev 2005;26:147-70
  • Ancelin K, Lange UC, Hajkova P, Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells. Nat Cell Biol 2006;8:623-30
  • Wang J, Rao S, Chu J, A protein interaction network for pluripotency of embryonic stem cells. Nature 2006;444:364-8
  • Kim J, Chu J, Shen X, An extended transcriptional network for pluripotency of embryonic stem cells. Cell 2008;132:1049-61
  • Matsuda H, Shi YB. An essential and evolutionarily conserved role of protein arginine methyltransferase 1 for adult intestinal stem cells during postembryonic development. Stem Cells 2010;28:2073-83
  • Yamanaka S. Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell 2007;1:39-49
  • Saha K, Jaenisch R. Technical challenges in using human induced pluripotent stem cells to model disease. Cell Stem Cell 2009;5:584-95
  • Yuan X, Wan H, Zhao X, Brief report: combined chemical treatment enables oct4-induced reprogramming from mouse embryonic fibroblasts. Stem Cells 2011;29:549-53
  • Teyssier C, Le Romancer M, Sentis S, Protein arginine methylation in estrogen signaling and estrogen-related cancers. Trends Endocrinol Metab 2010;21:181-9
  • Cha B, Kim W, Kim YK, Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling. Oncogene 2011;30:2379-89
  • Blythe SA, Cha SW, Tadjuidje E, Beta-Catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2. Dev Cell 2010;19:220-31
  • Cadigan KM, Nusse R. Wnt signaling: a common theme in animal development. Genes Dev 1997;11:3286-305
  • Moon RT, Brown JD, Torres M. WNTs modulate cell fate and behavior during vertebrate development. Trends Genet 1997;13:157-62
  • Polakis P. Wnt signaling and cancer. Genes Dev 2000;14:1837-51
  • Bienz M, Clevers H. Linking colorectal cancer to Wnt signaling. Cell 2000;103:311-20
  • MacDonald BT, Tamai K, He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 2009;17:9-26
  • Mosimann C, Hausmann G, Basler K. Beta-catenin hits chromatin: regulation of Wnt target gene activation. Nat Rev Mol Cell Biol 2009;10:276-86
  • Koh SS, Li H, Lee YH, Synergistic coactivator function by coactivator-associated arginine methyltransferase (CARM) 1 and beta-catenin with two different classes of DNA-binding transcriptional activators. J Biol Chem 2002;277:26031-5
  • Xu W, Chen H, Du K, A transcriptional switch mediated by cofactor methylation. Science 2001;294:2507-11
  • Chevillard-Briet M, Trouche D, Vandel L. Control of CBP co-activating activity by arginine methylation. EMBO J 2002;21:5457-66
  • Ou CY, Labonte MJ, Manegold PC, A coactivator role of CARM1 in the Dysregulation of {beta}-Catenin activity in colorectal cancer cell growth and gene expression. Mol Cancer Res 2011;9:660-70
  • Bikkavilli RK, Malbon CC. Arginine methylation of G3BP1 in response to Wnt3a regulates {beta}-catenin mRNA. J Cell Sci 2011;124:2310-20
  • Seligson DB, Horvath S, Shi T, Global histone modification patterns predict risk of prostate cancer recurrence. Nature 2005;435:1262-6
  • Mathioudaki K, Papadokostopoulou A, Scorilas A, The PRMT1 gene expression pattern in colon cancer. Br J Cancer 2008;99:2094-9
  • Mathioudaki K, Scorilas A, Ardavanis A, Clinical evaluation of PRMT1 gene expression in breast cancer. Tumour Biol 2011;32:575-82
  • Yoshimatsu M, Toyokawa G, Hayami S, Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers. Int J Cancer 2011;128:562-73
  • Daser A, Rabbitts TH. The versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis. Semin Cancer Biol 2005;15:175-88
  • Cheung N, Chan LC, Thompson A, Protein arginine-methyltransferase-dependent oncogenesis. Nat Cell Biol 2007;9:1208-15
  • Le Romancer M, Treilleux I, Leconte N, Regulation of estrogen rapid signaling through arginine methylation by PRMT1. Mol Cell 2008;31:212-21
  • Majumder S, Liu Y, Ford OH III, Involvement of arginine methyltransferase CARM1 in androgen receptor function and prostate cancer cell viability. Prostate 2006;66:1292-301
  • Hong H, Kao C, Jeng MH, Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status. Cancer 2004;101:83-9
  • El Messaoudi S, Fabbrizio E, Rodriguez C, Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene. Proc Natl Acad Sci USA 2006;103:13351-6
  • Kim YR, Lee BK, Park RY, Differential CARM1 expression in prostate and colorectal cancers. BMC Cancer 2010;10:197
  • Metivier R, Penot G, Hubner MR, Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell 2003;115:751-63
  • Chen D, Huang SM, Stallcup MR. Synergistic, p160 coactivator-dependent enhancement of estrogen receptor function by CARM1 and p300. J Biol Chem 2000;275:40810-16
  • Frietze S, Lupien M, Silver PA, CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1. Cancer Res 2008;68:301-6
  • Al-Dhaheri M, Wu J, Skliris GP, CARM1 is an important determinant of ERalpha-dependent breast cancer cell differentiation and proliferation in breast cancer cells. Cancer Res 2011;71:2118-28
  • Pal S, Baiocchi RA, Byrd JC, Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma. EMBO J 2007;26:3558-69
  • Pal S, Vishwanath SN, Erdjument-Bromage H, Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes. Mol Cell Biol 2004;24:9630-45

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