Targeting the thyrotropin receptor in thyroid disease

Bibliography

• Weetman AP. Graves' disease. N Engl J Med 2000;343:1236-48
   PubMed Web of Science ®Google Scholar
• Parmentier M, Libert F, Maenhaut C, Molecular cloning of the thyrotropin receptor. Science 1989;246:1620-2
   PubMed Web of Science ®Google Scholar
• El-Kaissi S, Frauman AG, Wall JR. Thyroid-associated ophthalmopathy: a practical guide to classification, natural history and management. Intern Med J 2004;34:482-91
   PubMed Web of Science ®Google Scholar
• Eckstein AK, Johnson KT, Thanos M, Current insights into the pathogenesis of Graves' orbitopathy. Horm Metab Res 2009;41:456-64
   PubMed Web of Science ®Google Scholar
• Gross B, Misrahi M, Sar S, Composite structure of the human thyrotropin receptor gene. Biochem Biophys Res Commun 1991;177:679-87
   PubMedGoogle Scholar
• Rousseau-Merck MF, Misrahi M, Loosfelt H, Assignment of the human thyroid stimulating hormone receptor (TSHR) gene to chromosome 14q31. Genomics 1990;8:233-6
   Google Scholar
• Latif R, Morshed SA, Zaidi M, The thyroid-stimulating hormone receptor: impact of thyroid-stimulating hormone and thyroid-stimulating hormone receptor antibodies on multimerization, cleavage, and signaling. Endocrinol Metab Clin North Am 2009;38:319-41. viii
   PubMed Web of Science ®Google Scholar
• Chazenbalk GD, Nagayama Y, Russo D, Functional analysis of the cytoplasmic domains of the human thyrotropin receptor by site-directed mutagenesis. J Biol Chem 1990;265:20970-5
   Web of Science ®Google Scholar
• Rapoport B, Chazenbalk GD, Jaume JC, The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies. Endocr Rev 1998;19:673-716
   PubMed Web of Science ®Google Scholar
• Jeffreys J, Depraetere H, Sanders J, Characterization of the thyrotropin binding pocket. Thyroid 2002;12:1051-61
   PubMed Web of Science ®Google Scholar
• Nagayama Y, Wadsworth HL, Russo D, Binding domains of stimulatory and inhibitory thyrotropin (TSH) receptor autoantibodies determined with chimeric TSH-lutropin/chorionic gonadotropin receptors. J Clin Invest 1991;88:336-40
   PubMed Web of Science ®Google Scholar
• Wadsworth HL, Russo D, Nagayama Y, Studies on the role of amino acids 38-45 in the expression of a functional thyrotropin receptor. Mol Endocrinol 1992;6:394-8
   PubMedGoogle Scholar
• Mizutori Y, Chen CR, McLachlan SM, The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction. Mol Endocrinol 2008;22:1171-82
   PubMedGoogle Scholar
• Mueller S, Kleinau G, Jaeschke H, Extended hormone binding site of the human thyroid stimulating hormone receptor: distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation. J Biol Chem 2008;283:18048-55
   Google Scholar
• Kleinau G, Krause G. Thyrotropin and homologous glycoprotein hormone receptors: structural and functional aspects of extracellular signaling mechanisms. Endocr Rev 2009;30:133-51
   PubMed Web of Science ®Google Scholar
• Chazenbalk GD, Jaume JC, McLachlan SM, Engineering the human thyrotropin receptor ectodomain from a non-secreted form to a secreted, highly immunoreactive glycoprotein that neutralizes autoantibodies in Graves' patients' sera. J Biol Chem 1997;272:18959-65
   Google Scholar
• Loosfelt H, Pichon C, Jolivet A, Two-subunit structure of the human thyrotropin receptor. Proc Natl Acad Sci USA 1992;89:3765-9
   Google Scholar
• Kaczur V, Puskas LG, Nagy ZU, Cleavage of the human thyrotropin receptor by ADAM10 is regulated by thyrotropin. J Mol Recognit 2007;20:392-404
   PubMed Web of Science ®Google Scholar
• Couet J, de Bernard S, Loosfelt H, Cell surface protein disulfide-isomerase is involved in the shedding of human thyrotropin receptor ectodomain. Biochemistry 1996;35:14800-5
   Google Scholar
• Couet J, Sar S, Jolivet A, Shedding of human thyrotropin receptor ectodomain. Involvement of a matrix metalloprotease. J Biol Chem 1996;271:4545-52
   Google Scholar
• Chen CR, Chazenbalk GD, Wawrowsky KA, Evidence that human thyroid cells express uncleaved, single-chain thyrotropin receptors on their surface. Endocrinology 2006;147:3107-13
   Google Scholar
• Misrahi M, Milgrom E. Cleavage and shedding of the TSH receptor. Eur J Endocrinol 1997;137:599-602
   Google Scholar
• Vassart G, Costagliola S. A physiological role for the posttranslational cleavage of the thyrotropin receptor? Endocrinology 2004;145:1-3
   Google Scholar
• Latif R, Ando T, Davies TF. Monomerization as a prerequisite for intramolecular cleavage and shedding of the thyrotropin receptor. Endocrinology 2004;145:5580-8
   Google Scholar
• Zhang M, Tong KP, Fremont V, The extracellular domain suppresses constitutive activity of the transmembrane domain of the human TSH receptor: implications for hormone-receptor interaction and antagonist design. Endocrinology 2000;141:3514-17
   PubMedGoogle Scholar
• Ciullo I, Latif R, Graves P, Functional assessment of the thyrotropin receptor-beta subunit. Endocrinology 2003;144:3176-81
   Google Scholar
• Barbesino G, Sluss PM, Caturegli P. Central hypothyroidism in a patient with pituitary autoimmunity: evidence for TSH-independent thyroid hormone synthesis. J Clin Endocrinol Metab 2012;97:345-50
   Google Scholar
• Graves PN, Vlase H, Bobovnikova Y, Multimeric complex formation by the thyrotropin receptor in solubilized thyroid membranes. Endocrinology 1996;137:3915-20
   PubMed Web of Science ®Google Scholar
• Latif R, Ando T, Davies TF. Lipid rafts are triage centers for multimeric and monomeric thyrotropin receptor regulation. Endocrinology 2007;148:3164-75
   PubMedGoogle Scholar
• Latif R, Graves P, Davies TF. Oligomerization of the human thyrotropin receptor: fluorescent protein-tagged hTSHR reveals post-translational complexes. J Biol Chem 2001;276:45217-24
   PubMed Web of Science ®Google Scholar
• Kursawe R, Paschke R. Modulation of TSHR signaling by posttranslational modifications. Trends Endocrinol Metab 2007;18:199-207
   Google Scholar
• Bonomi M, Busnelli M, Persani L, Structural differences in the hinge region of the glycoprotein hormone receptors: evidence from the sulfated tyrosine residues. Mol Endocrinol 2006;20:3351-63
   PubMedGoogle Scholar
• Russo D, Chazenbalk GD, Nagayama Y, Site-directed mutagenesis of the human thyrotropin receptor: role of asparagine-linked oligosaccharides in the expression of a functional receptor. Mol Endocrinol 1991;5:29-33
   PubMedGoogle Scholar
• Nagayama Y, Nishihara E, Namba H, Identification of the sites of asparagine-linked glycosylation on the human thyrotropin receptor and studies on their role in receptor function and expression. J Pharmacol Exp Ther 2000;295:404-9
   Google Scholar
• Vlaeminck-Guillem V, Ho SC, Rodien P, Activation of the cAMP pathway by the TSH receptor involves switching of the ectodomain from a tethered inverse agonist to an agonist. Mol Endocrinol 2002;16:736-46
   PubMedGoogle Scholar
• Allgeier A, Offermanns S, Van Sande J, The human thyrotropin receptor activates G-proteins Gs and Gq/11. J Biol Chem 1994;269:13733-5
   PubMed Web of Science ®Google Scholar
• Dumont JE, Lamy F, Roger P, Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors. Physiol Rev 1992;72:667-97
   PubMed Web of Science ®Google Scholar
• Van Sande J, Swillens S, Gerard C, In Chinese hamster ovary K1 cells dog and human thyrotropin receptors activate both the cyclic AMP and the phosphatidylinositol 4,5-bisphosphate cascades in the presence of thyrotropin and the cyclic AMP cascade in its absence. Eur J Biochem 1995;229:338-43
   Google Scholar
• Neumann S, Krause G, Claus M, Structural determinants for g protein activation and selectivity in the second intracellular loop of the thyrotropin receptor. Endocrinology 2005;146:477-85
   PubMed Web of Science ®Google Scholar
• Kopp P. The TSH receptor and its role in thyroid disease. Cell Mol Life Sci 2001;58:1301-22
   Google Scholar
• Balendran A, Hare GR, Kieloch A, Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms. FEBS Lett 2000;484:217-23
   PubMed Web of Science ®Google Scholar
• Brewer C, Yeager N, Di Cristofano A. Thyroid-stimulating hormone initiated proliferative signals converge in vivo on the mTOR kinase without activating AKT. Cancer Res 2007;67:8002-6
   PubMed Web of Science ®Google Scholar
• Kim WB, Chung HK, Park YJ, The prevalence and clinical significance of blocking thyrotropin receptor antibodies in untreated hyperthyroid Graves' disease. Thyroid 2000;10:579-86
   PubMed Web of Science ®Google Scholar
• Tahara K, Ban T, Minegishi T, Immunoglobulins from Graves' disease patients interact with different sites on TSH receptor/LH-CG receptor chimeras than either TSH or immunoglobulins from idiopathic myxedema patients. Biochem Biophys Res Commun 1991;179:70-7
   PubMed Web of Science ®Google Scholar
• Kim WB, Cho BY, Park HY, Epitopes for thyroid-stimulating antibodies in Graves' sera: a possible link of heterogeneity to differences in response to antithyroid drug treatment. J Clin Endocrinol Metab 1996;81:1758-67
   PubMed Web of Science ®Google Scholar
• Cho BY. Clinical applications of TSH receptor antibodies in thyroid diseases. J Korean Med Sci 2002;17:293-301
   Google Scholar
• Kim WB, Chung HK, Lee HK, Changes in epitopes for thyroid-stimulating antibodies in Graves' disease sera during treatment of hyperthyroidism: therapeutic implications. J Clin Endocrinol Metab 1997;82:1953-9
   PubMed Web of Science ®Google Scholar
• Ando T, Latif R, Davies TF. Antibody-induced modulation of TSH receptor post-translational processing. J Endocrinol 2007;195:179-86
   Google Scholar
• Ilicki A, Gamstedt A, Karlsson FA. Hyperthyroid Graves' disease without detectable thyrotropin receptor antibodies. J Clin Endocrinol Metab 1992;74:1090-4
   PubMedGoogle Scholar
• Orgiazzi J. Anti-TSH receptor antibodies in clinical practice. Endocrinol Metab Clin North Am 2000;29:339-55. vii
   PubMed Web of Science ®Google Scholar
• Tamaki H, Amino N, Kimura M, Low prevalence of thyrotropin receptor antibody in primary hypothyroidism in Japan. J Clin Endocrinol Metab 1990;71:1382-6
   PubMedGoogle Scholar
• Kraiem Z, Lahat N, Glaser B, Thyrotrophin receptor blocking antibodies: incidence, characterization and in-vitro synthesis. Clin Endocrinol (Oxf) 1987;27:409-21
   PubMedGoogle Scholar
• Cho BY, Kim WB, Chung JH, High prevalence and little change in TSH receptor blocking antibody titres with thyroxine and antithyroid drug therapy in patients with non-goitrous autoimmune thyroiditis. Clin Endocrinol (Oxf) 1995;43:465-71
   Google Scholar
• Zimmerman D. Fetal and neonatal hyperthyroidism. Thyroid 1999;9:727-33
   PubMed Web of Science ®Google Scholar
• Brown RS, Bellisario RL, Botero D, Incidence of transient congenital hypothyroidism due to maternal thyrotropin receptor-blocking antibodies in over one million babies. J Clin Endocrinol Metab 1996;81:1147-51
   PubMed Web of Science ®Google Scholar
• Gozu HI, Lublinghoff J, Bircan R, Genetics and phenomics of inherited and sporadic non-autoimmune hyperthyroidism. Mol Cell Endocrinol 2010;322:125-34
   Google Scholar
• Burek CL, Hoffman WH, Rose NR. The presence of thyroid autoantibodies in children and adolescents with autoimmune thyroid disease and in their siblings and parents. Clin Immunol Immunopathol 1982;25:395-404
   PubMedGoogle Scholar
• Brix TH, Kyvik KO, Christensen K, Evidence for a major role of heredity in Graves' disease: a population-based study of two Danish twin cohorts. J Clin Endocrinol Metab 2001;86:930-4
   PubMed Web of Science ®Google Scholar
• Brand OJ, Gough SC. Genetics of thyroid autoimmunity and the role of the TSHR. Mol Cell Endocrinol 2010;322:135-43
   PubMed Web of Science ®Google Scholar
• Watson PF, French A, Pickerill AP, Lack of association between a polymorphism in the coding region of the thyrotropin receptor gene and Graves' disease. J Clin Endocrinol Metab 1995;80:1032-5
   Google Scholar
• Barbesino G, Chiovato L. The genetics of Hashimoto's disease. Endocrinol Metab Clin North Am 2000;29:357-74
   Google Scholar
• Roman SH, Greenberg D, Rubinstein P, Genetics of autoimmune thyroid disease: lack of evidence for linkage to HLA within families. J Clin Endocrinol Metab 1992;74:496-503
   PubMed Web of Science ®Google Scholar
• Tomer Y, Barbesino G, Keddache M, Mapping of a major susceptibility locus for Graves' disease (GD-1) to chromosome 14q31. J Clin Endocrinol Metab 1997;82:1645-8
   PubMed Web of Science ®Google Scholar
• Tomer Y, Barbesino G, Greenberg DA, Linkage analysis of candidate genes in autoimmune thyroid disease. III. Detailed analysis of chromosome 14 localizes Graves' disease-1 (GD-1) close to multinodular goiter-1 (MNG-1). International Consortium for the Genetics of Autoimmune Thyroid Disease. J Clin Endocrinol Metab 1998;83:4321-7
   Google Scholar
• Tomer Y, Barbesino G, Greenberg DA, Mapping the major susceptibility loci for familial Graves' and Hashimoto's diseases: evidence for genetic heterogeneity and gene interactions. J Clin Endocrinol Metab 1999;84:4656-64
   PubMed Web of Science ®Google Scholar
• Dechairo BM, Zabaneh D, Collins J, Association of the TSHR gene with Graves' disease: the first disease specific locus. Eur J Hum Genet 2005;13:1223-30
   PubMed Web of Science ®Google Scholar
• Hiratani H, Bowden DW, Ikegami S, Multiple SNPs in intron 7 of thyrotropin receptor are associated with Graves' disease. J Clin Endocrinol Metab 2005;90:2898-903
   PubMed Web of Science ®Google Scholar
• Ho SC, Goh SS, Khoo DH. Association of Graves' disease with intragenic polymorphism of the thyrotropin receptor gene in a cohort of Singapore patients of multi-ethnic origins. Thyroid 2003;13:523-8
   Google Scholar
• Davies TF, Yin X, Latif R. The genetics of the thyroid stimulating hormone receptor: history and relevance. Thyroid 2010;20:727-36
   Google Scholar
• Glinoer D. Thyroid hyperfunction during pregnancy. Thyroid 1998;8:859-64
   PubMed Web of Science ®Google Scholar
• Rodien P, Bremont C, Sanson ML, Familial gestational hyperthyroidism caused by a mutant thyrotropin receptor hypersensitive to human chorionic gonadotropin. N Engl J Med 1998;339:1823-6
   PubMed Web of Science ®Google Scholar
• Hebrant A, van Staveren WC, Maenhaut C, Genetic hyperthyroidism: hyperthyroidism due to activating TSHR mutations. Eur J Endocrinol 2011;164:1-9
   Google Scholar
• Al-Khafaji F, Wiltshire M, Fuhrer D, Biological activity of activating thyrotrophin receptor mutants: modulation by iodide. J Mol Endocrinol 2005;34:209-20
   Google Scholar
• Parma J, Van Sande J, Swillens S, Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas: identification of additional mutations activating both the cyclic adenosine 3',5'-monophosphate and inositol phosphate-Ca2+ cascades. Mol Endocrinol 1995;9:725-33
   PubMedGoogle Scholar
• Van Sande J, Parma J, Tonacchera M, Somatic and germline mutations of the TSH receptor gene in thyroid diseases. J Clin Endocrinol Metab 1995;80:2577-85
   PubMed Web of Science ®Google Scholar
• Arseven OK, Wilkes WP, Jameson JL, Substitutions of tyrosine 601 in the human thyrotropin receptor result in increase or loss of basal activation of the cyclic adenosine monophosphate pathway and disrupt coupling to Gq/11. Thyroid 2000;10:3-10
   Google Scholar
• Russo D, Arturi F, Chiefari E, Thyrotropin receptor: a role for thyroid tumourigenesis? Forum (Genova) 1999;9:166-75
   Google Scholar
• Garcia-Jimenez C, Santisteban P. TSH signalling and cancer. Arq Bras Endocrinol Metabol 2007;51:654-71
   PubMedGoogle Scholar
• O'Sullivan C, Barton CM, Staddon SL, Activating point mutations of the gsp oncogene in human thyroid adenomas. Mol Carcinog 1991;4:345-9
   PubMed Web of Science ®Google Scholar
• Suarez HG, du Villard JA, Caillou B, gsp mutations in human thyroid tumours. Oncogene 1991;6:677-9
   PubMed Web of Science ®Google Scholar
• Alberti L, Proverbio MC, Costagliola S, Germline mutations of TSH receptor gene as cause of nonautoimmune subclinical hypothyroidism. J Clin Endocrinol Metab 2002;87:2549-55
   Google Scholar
• Abramowicz MJ, Duprez L, Parma J, Familial congenital hypothyroidism due to inactivating mutation of the thyrotropin receptor causing profound hypoplasia of the thyroid gland. J Clin Invest 1997;99:3018-24
   Google Scholar
• Sunthornthepvarakui T, Gottschalk ME, Hayashi Y, Brief report: resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene. N Engl J Med 1995;332:155-60
   Google Scholar
• Persani L, Calebiro D, Cordella D, Genetics and phenomics of hypothyroidism due to TSH resistance. Mol Cell Endocrinol 2010;322:72-82
   Web of Science ®Google Scholar
• Russo D, Betterle C, Arturi F, A novel mutation in the thyrotropin (TSH) receptor gene causing loss of TSH binding but constitutive receptor activation in a family with resistance to TSH. J Clin Endocrinol Metab 2000;85:4238-42
   Google Scholar
• Lazar V, Bidart JM, Caillou B, Expression of the Na+/I- symporter gene in human thyroid tumors: a comparison study with other thyroid-specific genes. J Clin Endocrinol Metab 1999;84:3228-34
   PubMed Web of Science ®Google Scholar
• Duntas LH, Cooper DS. Review on the occasion of a decade of recombinant human TSH: prospects and novel uses. Thyroid 2008;18:509-16
   PubMed Web of Science ®Google Scholar
• Rees Smith B, Sanders J, Evans M, TSH receptor - autoantibody interactions. Horm Metab Res 2009;41:448-55
   PubMed Web of Science ®Google Scholar
• Allen MD, Neumann S, Gershengorn MC. Small-molecule thyrotropin receptor agonist activates naturally occurring thyrotropin-insensitive mutants and reveals their distinct cyclic adenosine monophosphate signal persistence. Thyroid 2011;21:907-12
   Google Scholar
• Neumann S, Huang W, Titus S, Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci USA 2009;106:12471-6
   PubMed Web of Science ®Google Scholar
• Neumann S, Kleinau G, Costanzi S, A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism. Endocrinology 2008;149:5945-50
   PubMed Web of Science ®Google Scholar
• Neumann S, Huang W, Eliseeva E, A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. Endocrinology 2010;151:3454-9
   PubMed Web of Science ®Google Scholar
• Emerson CH. When will thyrotropin receptor antagonists and inverse thyrotropin receptor agonists become available for clinical use? Thyroid 2011;21:817-19
   PubMed Web of Science ®Google Scholar
• Neumann S, Raaka BM, Gershengorn MC. Human TSH receptor ligands as pharmacological probes with potential clinical application. Expert Rev Endocrinol Metab 2009;4:669
   Google Scholar
• Neumann S, Eliseeva E, McCoy JG, A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor. J Clin Endocrinol Metab 2011;96:548-54
   PubMed Web of Science ®Google Scholar
• Prummel MF, Brokken LJ, Meduri G, Expression of the thyroid-stimulating hormone receptor in the folliculo-stellate cells of the human anterior pituitary. J Clin Endocrinol Metab 2000;85:4347-53
   PubMed Web of Science ®Google Scholar
• El-Kaissi S, Wall J. Determinants of extraocular muscle volume in patients with Graves' disease. J Thyroid Res 2012; doi:10.1155/2012/368536
   Google Scholar
• Chen CR, Pichurin P, Nagayama Y, The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim. J Clin Invest 2003;111:1897-904
   PubMed Web of Science ®Google Scholar
• Brand OJ, Barrett JC, Simmonds MJ, Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Hum Mol Genet 2009;18:1704-13
   PubMed Web of Science ®Google Scholar