Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target

Bibliography

• Gabius H-J. editor. The sugar code. Fundamentals of glycosciences. Wiley-VCH, Weinheim, Germany; 2009
   Google Scholar
• Gabius H-J, Andre S, Jimenez-Barbero J, From lectin structure to functional glycomics: principles of the sugar code. Trends Biochem Sci 2011;36:298-313
   PubMed Web of Science ®Google Scholar
• Mitchell SW. Researches upon the venom of the rattlesnake. Smithsonian Contributions to Knowledge 1860;XII:89-90.
   Google Scholar
• Stillmark H. Ueber Ricin, ein giftiges Ferment aus den Samen von Ricinus comm. L. und einigen anderen Euphorbiaceen [Inaugural-Dissertation]. Schnakenburg's Buchdruckerei; Dorpat; 1888
   Google Scholar
• Agrawal BBL, Goldstein IJ. Specific binding of concanavalin A to cross-linked dextran gel. Biochem J 1965;96:23c
   Web of Science ®Google Scholar
• Caselitz J. Lectins and blood group substances as “tumor markers”. Curr Top Pathol 1987;77:245-77
   PubMedGoogle Scholar
• Watkins WM. A half century of blood-group antigen research: some personal recollections. Trends Glycosci Glycotechnol 1999;11:391-411
   Google Scholar
• Roth J. Lectins for histochemical demonstration of glycans. Histochem Cell Biol 2011;136:117-30
   PubMed Web of Science ®Google Scholar
• Gabius H-J, Engelhardt R, Rehm S, Biochemical characterization of endogenous carbohydrate-binding proteins from spontaneous murine rhabdomyosarcoma, mammary adenocarcinoma, and ovarian teratoma. J Natl Cancer Inst 1984;73:1349-57
   PubMed Web of Science ®Google Scholar
• Raz A, Meromsky L, Carmi P, Monoclonal antibodies to endogenous galactose-specific tumor cell lectins. EMBO J 1984;3:2979-83
   PubMed Web of Science ®Google Scholar
• Gabius H-J, Engelhardt R, Cramer F, Pattern of endogenous lectins in a human epithelial tumor. Cancer Res 1985;45:253-7
   PubMed Web of Science ®Google Scholar
• Hennet T. Diseases of glycosylation. In: Gabius H-J, editor. The sugar code. Fundamentals of glycosciences. Wiley-VCH, Weinheim, Germany; 2009. p. 365-83
   Google Scholar
• Honke K, Taniguchi N. Animal models to delineate glycan functionality. In; Gabius H-J, editor. The sugar code. Fundamentals of glycosciences. Wiley-VCH, Weinheim, Germany; 2009. p. 385-401
   Google Scholar
• Osborn HMI, Turkson A. Sugars as pharmaceuticals. In; Gabius H-J, editor. The sugar code. Fundamentals of glycosciences. Wiley-VCH, Weinheim, Germany; 2009. p. 469-83
   Google Scholar
• Gready JN, Zelensky AN. Routes in lectin evolution: case study on the C-type lectin-like domains. In; Gabius H-J, editor. The sugar code. Fundamentals of glycosciences. Wiley-VCH, Weinheim, Germany; 2009. p. 329-46
   Google Scholar
• Schwartz-Albiez R. Inflammation and glycosciences. In: Gabius H-J, editor. The sugar code. Fundamentals of glycosciences. Wiley-VCH, Weinheim, Germany; 2009. p. 447-67
   Google Scholar
• Teichberg VI, Silman I, Beitsch DD, A beta-D-galactoside-binding protein from electric organ tissue of Electrophorus electricus. Proc Natl Acad Sci USA 1975;72:1383-7
   PubMed Web of Science ®Google Scholar
• Barondes SH. Stumbling on galectins. In; Klyosov AA, Witczak ZJ, Platt D, editors. Galectins. Wiley, Hoboken; 2008. p. 1-8
   Google Scholar
• Raz A, Lotan R. Lectin-like activities associated with human and murine neoplastic cells. Cancer Res 1981;41:3642-7
   PubMed Web of Science ®Google Scholar
• De Waard A, Hickman S, Kornfeld S. Isolation and properties of beta-galactoside-binding lectins of calf heart and lung. J Biol Chem 1976;251:7581-7
   PubMedGoogle Scholar
• Lopez-Lucendo MF, Solis D, Andre S, Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding. J Mol Biol 2004;343:957-70
   PubMed Web of Science ®Google Scholar
• Kasai K-I, Hirabayashi J. Galectins: a family of animal lectins that decipher glycocodes. J Biochem 1996;119:1-8
   PubMed Web of Science ®Google Scholar
• Cooper DNW. Galectinomics: finding themes in complexity. Biochim Biophys Acta 2002;1572:209-31
   PubMed Web of Science ®Google Scholar
• Kaltner H, Gabius H-J. A toolbox of lectins for translating the sugar code: the galectin network in phylogenesis and tumors. Histol Histopathol 2012;27:397-416
   PubMed Web of Science ®Google Scholar
• Kaltner H, Solis D, Andre S, Unique chicken tandem-repeat-type galectin: implications of alternative splicing and a distinct expression profile compared to those of the three proto-type proteins. Biochemistry 2009;48:4403-16
   PubMedGoogle Scholar
• Villalobo A, Nogales-Gonzales A, Gabius H-J. A guide to signaling pathways connecting protein-glycan interaction with the emerging versatile effector functionality of mammalian lectins. Trends Glycosci Glycotechnol 2006;18:1-37
   Web of Science ®Google Scholar
• Boscher C, Dennis JW, Nabi IR. Glycosylation, galectins and cellular signaling. Curr Opin Cell Biol 2011;23:383-92
   PubMed Web of Science ®Google Scholar
• Blasko A, Fajka-Boja R, Ion G, How does it act when soluble? Critical evaluation of mechanism of galectin-1-induced T-cell apoptosis. Acta Biol Hung 2011;62:106-11
   PubMedGoogle Scholar
• Liu F-T, Yang RY, Hsu DK. Galectins in acute and chronic inflammation. Ann NY Acad Sci 2012;1253:80-91
   PubMed Web of Science ®Google Scholar
• Gabius H-J, Brehler R, Schauer A, Localization of endogenous lectins in normal human breast, benign breast lesions and mammary carcinomas. Virch Arch [Cell Pathol] 1986;52:107-15
   Web of Science ®Google Scholar
• Lahm H, Andre S, Hoflich A, Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures. J Cancer Res Clin Oncol 2001;127:375-86
   PubMed Web of Science ®Google Scholar
• Nagy N, Legendre H, Engels O, Refined prognostic evaluation in colon cancer using immunohistochemical galectin fingerprinting. Cancer 2003;97:1849-58
   PubMedGoogle Scholar
• Remmelink M, de Leval L, Decaestecker C, Quantitative immunohistochemical fingerprinting of adhesion/growth-regulatory galectins in salivary gland tumours: divergent profiles with diagnostic potential. Histopathology 2011;58:543-56
   PubMedGoogle Scholar
• Wilson TJ, Firth MN, Powell JT, The sequence of the mouse 14 kDa beta-galactoside-binding lectin and evidence for its synthesis on free cytoplasmic ribosomes. Biochem J 1989;261:847-52
   PubMedGoogle Scholar
• Cooper DNW, Barondes SH. Evidence for export of a muscle lectin from cytosol to extracellular matrix and for a novel secretory mechanism. J Cell Biol 1990;110:1681-91
   PubMed Web of Science ®Google Scholar
• Smetana K Jr, Dvorankova B, Chovanec M, Nuclear presence of adhesion/growth-regulatory galectins in normal/malignant cells of squamous epithelial origin. Histochem Cell Biol 2006;125:171-82
   PubMed Web of Science ®Google Scholar
• Haudek KC, Patterson RJ, Wang JL. SR proteins and galectins: what's in a name? Glycobiology 2010;20:1199-207
   PubMed Web of Science ®Google Scholar
• Saussez S, Decaestecker C, Lorfevre F, Increased expression and altered intracellular distribution of adhesion/growth-regulatory lectins galectins-1 and -7 during tumour progression in hypopharyngeal and laryngeal squamous cell carcinomas. Histopathology 2008;52:483-93
   PubMed Web of Science ®Google Scholar
• Goldstone SD, Lavin MF. Isolation of a cDNA clone, encoding a human beta-galactoside-binding protein, overexpressed during glucocorticoid-induced cell death. Biochem Biophys Res Commun 1991;178:746-50
   PubMedGoogle Scholar
• Sugimoto N, Oida T, Hirota K, Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis. Int Immunol 2006;18:1197-209
   PubMed Web of Science ®Google Scholar
• Garin MI, Chu CC, Golshayan D, Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. Blood 2007;109:2058-65
   PubMed Web of Science ®Google Scholar
• Lotan R, Lotan D, Carralero DM. Modulation of galactoside-binding lectins in tumor cells by differentiation-inducing agents. Cancer Lett 1989;48:115-22
   PubMed Web of Science ®Google Scholar
• Lu Y, Lotan R. Transcriptional regulation by butyrate of mouse galectin-1 gene in embryonal carcinoma cells. Biochim Biophys Acta 1999;1444:85-91
   PubMedGoogle Scholar
• Chiariotti L, Benvenuto G, Zarrilli R, Activation of the galectin-1 (L-14-I) gene from nonexpressing differentiated cells by fusion with undifferentiated and tumorigenic cells. Cell Growth Differ 1994;5:769-75
   PubMedGoogle Scholar
• Li X, Ohannesian DW, Yoshida M, Induction of galectin-1 expression in human colon carcinoma cells by histone deacetylase inhibitors. Mol Cell Diff 1996;4:149-65
   Google Scholar
• Poirier F, Bourin P, Bladier D, Effect of 5-azacytidine and galectin-1 on growth and differentiation of the human b lymphoma cell line bl36. Cancer Cell Int 2001;1:2
   PubMedGoogle Scholar
• Whitney PL, Powell JT, Sanford GL. Oxidation and chemical modification of lung beta-galactoside-specific lectin. Biochem J 1986;238:683-9
   PubMedGoogle Scholar
• Hirabayashi J, Kasai K-i. Effect of amino acid substitution by sited-directed mutagenesis on the carbohydrate recognition and stability of human 14-kDa beta-galactoside-binding lectin. J Biol Chem 1991;266:23648-53
   PubMed Web of Science ®Google Scholar
• Gohler A, Buchner C, Andre S, Analysis of homodimeric avian and human galectins by two methods based on fluorescence spectroscopy: different structural alterations upon oxidation and ligand binding. Biochimie 2012;94:2649-55
   PubMedGoogle Scholar
• Wells V, Mallucci L. Identification of an autocrine negative growth factor: mouse beta-galactoside-binding protein is a cytostatic factor and cell growth regulator. Cell 1991;64:91-7
   PubMedGoogle Scholar
• Yamaoka K, Ohno S, Kawasaki H, Overexpression of a beta-galactoside binding protein causes transformation of BALB3T3 fibroblast cells. Biochem Biophys Res Commun 1991;179:272-9
   PubMedGoogle Scholar
• Kadoya T, Horie H. Structural and functional studies of galectin-1: a novel axonal regeneration-promoting activity for oxidized galectin-1. Curr Drug Targets 2005;6:375-83
   PubMed Web of Science ®Google Scholar
• Lopez-Lucendo MF, Solis D, Saiz JL, Homodimeric chicken galectin CG-1B (C-14): crystal structure and detection of unique redox-dependent shape changes involving inter- and intrasubunit disulfide bridges by gel filtration, ultracentrifugation, site-directed mutagenesis, and peptide mass fingerprinting. J Mol Biol 2009;386:366-78
   PubMedGoogle Scholar
• Siebert H-C, Andre S, Lu S-Y, Unique conformer selection of human growth-regulatory lectin galectin-1 for ganglioside GM1 versus bacterial toxins. Biochemistry 2003;42:14762-73
   PubMed Web of Science ®Google Scholar
• Kopitz J, Bergmann M, Gabius H-J. How adhesion/growth-regulatory galectins-1 and -3 attain cell specificity: case study defining their target on neuroblastoma cells (SK-N-MC) and marked affinity regulation by affecting microdomain organization of the membrane. IUBMB Life 2010;62:624-8
   PubMedGoogle Scholar
• Park JW, Voss PG, Grabski S, Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein. Nucleic Acids Res 2001;29:3595-602
   PubMed Web of Science ®Google Scholar
• Rotblat B, Niv H, Andre S, Galectin-1(L11A) predicted from a computed galectin-1 farnesyl-binding pocket selectively inhibits Ras-GTP. Cancer Res 2004;64:3112-8
   PubMed Web of Science ®Google Scholar
• Gabius H-J, Springer WR, Barondes SH. Receptor for the cell binding site of discoidin I. Cell 1985;42:449-56
   PubMed Web of Science ®Google Scholar
• Jeffery CJ. Multifunctional proteins: examples of gene sharing. Ann Med 2003;35:28-35
   PubMed Web of Science ®Google Scholar
• Copley SD. Moonlighting is mainstream: paradigm adjustment required. BioEssays 2012;34:578-88
   PubMed Web of Science ®Google Scholar
• Andre S, Sanchez-Ruderisch H, Nakagawa H, Tumor suppressor p16INK4a: modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells. FEBS J 2007;274:3233-56
   PubMed Web of Science ®Google Scholar
• Sanchez-Ruderisch H, Fischer C, Detjen KM, Tumor suppressor p16INK4a: downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model. FEBS J 2010;277:3552-63
   PubMed Web of Science ®Google Scholar
• Amano M, Eriksson H, Manning JC, Tumor suppressor p16INK4a: anoikis-favoring decrease in N/O-glycan/cell surface sialylation by downregulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model. FEBS J 2012;279:4062-80
   PubMed Web of Science ®Google Scholar
• Fischer C, Sanchez-Ruderisch H, Welzel M, Galectin-1 interacts with the alpha5beta1 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27. J Biol Chem 2005;280:37266-77
   PubMed Web of Science ®Google Scholar
• Sanchez-Ruderisch H, Detjen KM, Welzel M, Galectin-1 sensitizes carcinoma cells to anoikis via the fibronectin receptor alpha5beta1-integrin. Cell Death Differ 2011;18:806-16
   PubMedGoogle Scholar
• Pace KE, Baum LG. Induction of T lymphocyte apoptosis: a novel function for galectin-1. Trends Glycosci Glycotechnol 1997;9:21-9
   Google Scholar
• Amano M, Galvan M, He J, The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death. J Biol Chem 2003;278:7469-75
   PubMed Web of Science ®Google Scholar
• Patsos G, Corfield A. O-Glycosylation: structural diversity and function. In: Gabius H-J, editor. The sugar code. Fundamentals of glycosciences. Wiley-VCH, Weinheim, Germany; 2009. p. 111-37
   Google Scholar
• Nguyen JT, Evans DP, Galvan M, CD45 modulates galectin-1-induced T cell death: regulation by expression of core 2 O-glycans. J Immunol 2001;167:5697-707
   PubMed Web of Science ®Google Scholar
• Valenzuela HF, Pace KE, Cabrera PV, O-glycosylation regulates LNCaP prostate cancer cell susceptibility to apoptosis induced by galectin-1. Cancer Res 2007;67:6155-62
   PubMed Web of Science ®Google Scholar
• Kopitz J, von Reitzenstein C, Burchert M, Galectin-1 is a major receptor for ganglioside GM1, a product of the growth-controlling activity of a cell surface ganglioside sialidase, on human neuroblastoma cells in culture. J Biol Chem 1998;273:11205-11
   PubMed Web of Science ®Google Scholar
• Ledeen RW, Wu G, Andre S, Beyond glycoproteins as galectin counterreceptors: tumor/effector T cell growth control via ganglioside GM1. Ann NY Acad Sci 2012;1253:206-21
   PubMedGoogle Scholar
• Wang J, Lu ZH, Gabius H-J, Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: possible role in suppressing experimental autoimmune encephalomyelitis. J Immunol 2009;182:4036-45
   PubMed Web of Science ®Google Scholar
• Wu G, Lu ZH, Gabius H-J, Ganglioside GM1 deficiency in effector T cells from NOD mice induces resistance to regulatory T cell suppression. Diabetes 2011;60:2341-9
   PubMed Web of Science ®Google Scholar
• Wu H, Chen P, Liao R, Overexpression of galectin-1 is associated with poor prognosis in human hepatocellular carcinoma following resection. J Gastroenterol Hepatol 2012;27:1312-9
   PubMedGoogle Scholar
• Kuo PL, Huang MS, Cheng DE, Lung cancer-derived galectin-1 enhances tumorigenic potentiation of tumor-associated dendritic cells by expressing heparin-binding EGF-like growth factor. J Biol Chem 2012;287:9753-64
   PubMedGoogle Scholar
• Dvorankova B, Szabo P, Lacina L, Human galectins induce conversion of dermal fibroblasts into myofibroblasts and production of extracellular matrix: potential application in tissue engineering and wound repair. Cells Tissues Organs 2011;194:469-80
   PubMed Web of Science ®Google Scholar
• Valach J, Fik Z, Strnad H, Smooth muscle actin-expressing stromal fibroblasts in head and neck squamous cell carcinoma: increased expression of galectin-1 and induction of poor-prognosis factors. Int J Cancer 2012;131:2499-508
   PubMed Web of Science ®Google Scholar
• Szebeni GJ, Kriston-Pal E, Blazso P, Identification of galectin-1 as a critical factor in function of mouse mesenchymal stromal cell-mediated tumor promotion. PLoS ONE 2012;7:e41372
   Google Scholar
• Roda O, Ortiz-Zapater E, Martinez-Bosch N, Galectin-1 is a novel functional receptor for tissue plasminogen activator in pancreatic cancer. Gastroenterology 2009;136:1379-90
   Google Scholar
• Sanford GL, Harris-Hooker S. Stimulation of vascular cell proliferation by beta-galactoside specific lectins. FASEB J 1990;4:2912-8
   PubMed Web of Science ®Google Scholar
• Adams L, Scott GK, Weinberg CS. Biphasic modulation of cell growth by recombinant human galectin-1. Biochim Biophys Acta 1996;1312:137-44
   PubMed Web of Science ®Google Scholar
• Scott K, Weinberg C. Galectin-1: a bifunctional regulator of cellular proliferation. Glycoconj J 2004;19:467-77
   Google Scholar
• Levi G, Tarrab-Hazdai R, Teichberg VI. Prevention and therapy with electrolectin of experimental autoimmune myasthenia gravis in rabbits. Eur J Immunol 1983;13:500-7
   PubMed Web of Science ®Google Scholar
• Offner H, Celnik B, Bringman TS, Recombinant human beta-galactoside-binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis. J Neuroimmunol 1990;28:177-84
   PubMed Web of Science ®Google Scholar
• Perone MJ, Bertera S, Shufesky WJ, Suppression of autoimmune diabetes by soluble galectin-1. J Immunol 2009;182:2641-53
   PubMed Web of Science ®Google Scholar
• Liu SD, Lee S, La Cava A, Galectin-1-induced down-regulation of T lymphocyte activation protects (NZB x NZW) F1 mice from lupus-like disease. Lupus 2011;20:473-84
   PubMedGoogle Scholar
• Ellerhorst J, Nguyen T, Cooper DNW, Induction of differentiation and apoptosis in the prostate cancer cell line LNCaP by sodium butyrate and galectin-1. Int J Oncol 1999;14:225-32
   PubMedGoogle Scholar
• Satelli A, Rao US. Galectin-1 is silenced by promoter hypermethylation and its re-expression induces apoptosis in human colorectal cancer cells. Cancer Lett 2011;301:38-46
   PubMedGoogle Scholar
• Rorive S, Belot N, Decaestecker C, Galectin-1 is highly expressed in human gliomas with relevance for modulation of invasion of tumor astrocytes into the brain parenchyma. Glia 2001;33:241-55
   PubMed Web of Science ®Google Scholar
• Camby I, Decaestecker C, Lefranc F, Galectin-1 knocking down in human U87 glioblastoma cells alters their gene expression pattern. Biochem Biophys Res Commun 2005;335:27-35
   PubMed Web of Science ®Google Scholar
• Moise A, Andre S, Eggers F, Toward bioinspired galectin mimetics: identification of ligand-contacting peptides by proteolytic-excision mass spectrometry. J Am Chem Soc 2011;133:14844-7
   PubMed Web of Science ®Google Scholar
• Kopitz J, von Reitzenstein C, Andre S, Negative regulation of neuroblastoma cell growth by carbohydrate-dependent surface binding of galectin-1 and functional divergence from galectin-3. J Biol Chem 2001;276:35917-23
   PubMed Web of Science ®Google Scholar
• Andre S, Grandjean C, Gautier FM, Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes. Chem Commun (Camb) 2011;47:6126-8
   PubMed Web of Science ®Google Scholar
• Shah S, Lance P, Smith TJ, n-Butyrate reduces the expression of beta-galactoside alpha2,6-sialyltransferase in HepG2 cells. J Biol Chem 1992;267:10652-8
   PubMedGoogle Scholar
• Patsos G, Andre S, Roeckel N, Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile. Glycobiology 2009;19:726-34
   PubMedGoogle Scholar
• Rappl G, Abken H, Muche JM, CD4+CD7- leukemic T cells from patients with Sezary syndrome are protected from galectin-1-triggered T cell death. Leukemia 2002;16:840-5
   PubMed Web of Science ®Google Scholar
• Krzeminski M, Singh T, Andre S, Human galectin-3 (Mac-2 antigen): defining molecular switches of affinity to natural glycoproteins, structural and dynamic aspects of glycan binding by flexible ligand docking and putative regulatory sequences in the proximal promoter region. Biochim Biophys Acta 2011;1810:150-61
   PubMedGoogle Scholar
• Gabius H-J. Glycobiomarkers by glycoproteomics and glycan profiling (glycomics): emergence of functionality. Biochem Soc Trans 2011;39:399-405
   PubMedGoogle Scholar
• Plzak J, Betka J, Smetana K Jr, Galectin-3 - an emerging prognostic indicator in advanced head and neck carcinoma. Eur J Cancer 2004;40:2324-30
   PubMed Web of Science ®Google Scholar
• Szoke T, Kayser K, Baumhakel J-D, Prognostic significance of endogenous adhesion/growth-regulatory lectins in lung cancer. Oncology 2005;69:167-74
   PubMed Web of Science ®Google Scholar
• Gebert J, Kloor M, Lee J, Colonic carcinogenesis along different genetic routes: glycophenotyping of tumor cases separated by microsatellite instability/stability. Histochem Cell Biol 2012;138:339-50
   PubMedGoogle Scholar
• Antonopoulos A, North SJ, Haslam SM, Glycosylation of mouse and human immune cells: insights emerging from N-glycomics analyses. Biochem Soc Trans 2011;39:1334-40
   PubMedGoogle Scholar
• Amano M, Hashimoto R, Nishimura S-I. Effects of single genetic damage in carbohydrate-recognizing proteins in mouse serum N-glycan profile revealed by simple glycotyping analysis. ChemBioChem 2012;13:451-64
   PubMed Web of Science ®Google Scholar
• Onami TM, Lin MY, Page DM, Generation of mice deficient for macrophage galactose- and N-acetylgalactosamine-specific lectin: limited role in lymphoid and erythroid homeostasis and evidence for multiple lectins. Mol Cell Biol 2002;22:5173-81
   PubMedGoogle Scholar
• Tsuiji M, Fujimori M, Ohashi Y, Molecular cloning and characterization of a novel mouse macrophage C-type lectin, mMGL2, which has a distinct carbohydrate specificity from mMGL1. J Biol Chem 2002;277:28892-901
   PubMedGoogle Scholar
• Park EI, Baenziger JU. Closely related mammals have distinct asialoglycoprotein receptor carbohydrate specificities. J Biol Chem 2004;279:40954-9
   PubMed Web of Science ®Google Scholar
• Houzelstein D, Goncalves IR, Orth A, Lgals6, a 2-million-year-old gene in mice: a case of positive Darwinian selection and presence/absence polymorphism. Genetics 2008;178:1533-45
   PubMedGoogle Scholar
• Zuber C, Cormier JH, Guhl B, EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites. Proc Natl Acad Sci USA 2007;104:4407-12
   Google Scholar
• Heja D, Kocsis A, Dobo J, Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2. Proc Natl Acad Sci USA 2012;109:10498-503
   PubMedGoogle Scholar
• Eude-Le Parco I, Gendronneau G, Dang T, Genetic assessment of the importance of galectin-3 in cancer initiation, progression, and dissemination in mice. Glycobiology 2009;19:68-75
   PubMed Web of Science ®Google Scholar
• Luhn K, Wild MK. Human deficiencies of fucosylation and sialylation affecting selectin ligands. Semin Immunopathol 2012;34:383-99
   Google Scholar
• Gabius H-J, van de Wouwer M, Andre S, Down-regulation of the epidermal growth factor receptor by altering N-glycosylation: emerging role of beta1,4-galactosyltransferases. Anticancer Res 2012;32:1565-72
   PubMed Web of Science ®Google Scholar
• Tsuboi S, Hatakeyama S, Ohyama C, Two opposing roles of O-glycans in tumor metastasis. Trends Mol Med 2012;18:224-32
   PubMedGoogle Scholar
• Camby I, Belot N, Lefranc F, Galectin-1 modulates human glioblastoma cell migration into the brain through modifications to the actin cytoskeleton and levels of expression of small GTPases. J Neuropathol Exp Neurol 2002;61:585-96
   PubMed Web of Science ®Google Scholar
• Belisle JA, Horibata S, Jennifer GAA, Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes. Mol Cancer 2010;9:118
   PubMed Web of Science ®Google Scholar
• Begley CG, Ellis LM. Drug development: raise standards for preclinical cancer research. Nature 2012;483:531-3
   PubMed Web of Science ®Google Scholar
• Gan HK, You B, Pond GR, Assumptions of expected benefits in randomized phase III trials evaluating systemic treatments for cancer. J Natl Cancer Inst 2012;104:590-8
   PubMedGoogle Scholar
• Matsuda Y, Yamagiwa Y, Fukushima K, Expression of galectin-3 involved in prognosis of patients with hepatocellular carcinoma. Hepatol Res 2008;38:1098-111
   PubMed Web of Science ®Google Scholar
• Zhang Z-Y, Dong J-H, Chen Y-W, Galectin-9 acts as a prognostic factor with antimetastatic potential in hepatocellular carcinoma. Asian Pac J Cancer Prev 2012;13:2503-9
   PubMedGoogle Scholar
• Langbein S, Brade J, Badawi JK, Gene-expression signature of adhesion/growth-regulatory tissue lectins (galectins) in transitional cell cancer and its prognostic relevance. Histopathology 2007;51:681-90
   PubMed Web of Science ®Google Scholar
• Kayser K, Hoft D, Hufnagl P, Combined analysis of tumor growth pattern and expression of endogenous lectins as a prognostic tool in primary testicular cancer and its lung metastases. Histol Histopathol 2003;18:771-9
   PubMed Web of Science ®Google Scholar
• Nakagawa H. Analytical aspects: analysis of protein-bound glycans. In: Gabius H-J, editor. The sugar code. Fundamentals of glycosciences. Wiley-VCH, Weinheim, Germany; 2009. p. 71-83
   Google Scholar
• Nishimura S-I. Toward automated glycan analysis. Adv Carbohydr Chem Biochem 2011;65:219-71
   PubMedGoogle Scholar
• Heitzeneder S, Seidel M, Forster-Waldl E, Mannan-binding lectin deficiency: good news, bad news, doesn't matter? Clin Immunol 2012;143:22-38
   PubMed Web of Science ®Google Scholar
• Rabien A, Sanchez-Ruderisch H, Schulz P, Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells. Cancer Sci 2012;103:169-75
   PubMedGoogle Scholar
• Song S, Ji B, Ramachandran V, Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding ras and activating ras signaling. PLoS ONE 2012;7:e42699
   Google Scholar
• Andre S, Giguere D, Dam TK, Synthesis and screening of a small glycomimetic library for inhibitory activity on medically relevant galactoside-specific lectins in assays of increasing biorelevance. New J Chem 2010;34:2229-40
   Web of Science ®Google Scholar