Targeting ubiquilin-1 in Alzheimer's disease

Bibliography

• Wortmann M. Dementia: a global health priority – highlights from an ADI and world health organization report. Alzheimers Res Ther 2012;4(5):40
   PubMed Web of Science ®Google Scholar
• Tanzi RE. The genetics of Alzheimer disease. Cold Spring Harb Perspect Med 2012;2(10): 10.1101/cshperspect.a006296
   PubMed Web of Science ®Google Scholar
• Bertram L, McQueen MB, Mullin K, et al. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet 2007;39(1):17-23
   PubMed Web of Science ®Google Scholar
• Goate A, Chartier-Harlin MC, Mullan M, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991;349(6311):704-6
   PubMed Web of Science ®Google Scholar
• Sherrington R, Rogaev EI, Liang Y, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 1995;375(6534):754-60
   PubMed Web of Science ®Google Scholar
• Levy-Lahad E, Wasco W, Poorkaj P, et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 1995;269(5226):973-7
   PubMed Web of Science ®Google Scholar
• Selkoe DJ. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 1999;399(6738 Suppl):A23-31
   PubMed Web of Science ®Google Scholar
• Haass C, Kaether C, Thinakaran G, Sisodia S. Trafficking and proteolytic processing of APP. Cold Spring Harb Perspect Med 2012;2(5):a006270
   PubMed Web of Science ®Google Scholar
• Jonsson T, Atwal JK, Steinberg S, et al. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 2012;488(7409):96-9
   PubMed Web of Science ®Google Scholar
• Morris M, Maeda S, Vossel K, Mucke L. The many faces of tau. Neuron 2011;70(3):410-26
   PubMed Web of Science ®Google Scholar
• Jin M, Shepardson N, Yang T, et al. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce tau hyperphosphorylation and neuritic degeneration. Proc Natl Acad Sci USA 2011;108(14):5819-24
   PubMed Web of Science ®Google Scholar
• Lambert JC, Heath S, Even G, et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet 2009;41(10):1094-9
   PubMed Web of Science ®Google Scholar
• Hollingworth P, Harold D, Sims R, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet 2011;43(5):429-35
   PubMed Web of Science ®Google Scholar
• Lambert JC, Grenier-Boley B, Harold D, et al. Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease. Mol Psychiatry 2012, doi: 10.1038/mp.2012.75. [Epub ahead of print]
   Google Scholar
• Bertram L, Hiltunen M, Parkinson M, et al. Family-based association between Alzheimer's disease and variants in UBQLN1. N Engl J Med 2005;352(9):884-94
   PubMedGoogle Scholar
• Slifer MA, Martin ER, Haines JL, Pericak-Vance MA. The ubiquilin 1 gene and Alzheimer's disease. N Engl J Med 2005;352(26):2752; 3; author reply 2752-3
   PubMedGoogle Scholar
• Kamboh MI, Minster RL, Feingold E, DeKosky ST. Genetic association of ubiquilin with Alzheimer's disease and related quantitative measures. Mol Psychiatry 2006;11(3):273-9
   PubMedGoogle Scholar
• Golan MP, Melquist S, Safranow K, et al. Analysis of UBQLN1 variants in a Polish Alzheimer's disease patient: control series. Dement Geriatr Cogn Disord 2008;25(4):366-71
   PubMedGoogle Scholar
• Hiltunen M, Lu A, Thomas AV, et al. Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J Biol Chem 2006;281(43):32240-53
   PubMedGoogle Scholar
• Stieren ES, El Ayadi A, Xiao Y, et al. Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein. J Biol Chem 2011;286(41):35689-98
   PubMed Web of Science ®Google Scholar
• El Ayadi A, Stieren ES, Barral JM, Boehning D. Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688. Proc Natl Acad Sci USA 2012;109(33):13416-21
   PubMedGoogle Scholar
• Mah AL, Perry G, Smith MA, Monteiro MJ. Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation. J Cell Biol 2000;151(4):847-62
   PubMedGoogle Scholar
• Viswanathan J, Haapasalo A, Bottcher C, et al. Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic 2011;12(3):330-48
   PubMedGoogle Scholar
• Massey LK, Mah AL, Ford DL, et al. Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins. J Alzheimers Dis 2004;6(1):79-92
   PubMedGoogle Scholar
• Kleijnen MF, Shih AH, Zhou P, et al. The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. Mol Cell 2000;6(2):409-19
   PubMed Web of Science ®Google Scholar
• Ko HS, Uehara T, Tsuruma K, Nomura Y. Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains. FEBS Lett 2004;566(1-3):110-14
   PubMed Web of Science ®Google Scholar
• Lu A, Hiltunen M, Romano DM, et al. Effects of ubiquilin 1 on the unfolded protein response. J Mol Neurosci 2009;38(1):19-30
   PubMed Web of Science ®Google Scholar
• Brouwers N, Sleegers K, Engelborghs S, et al. The UBQLN1 polymorphism, UBQ-8i, at 9q22 is not associated with Alzheimer's disease with onset before 70 years. Neurosci Lett 2006;392(1-2):72-4
   PubMedGoogle Scholar
• Bensemain F, Chapuis J, Tian J, et al. Association study of the ubiquilin gene with Alzheimer's disease. Neurobiol Dis 2006;22(3):691-3
   PubMedGoogle Scholar
• Slifer MA, Martin ER, Bronson PG, et al. Lack of association between UBQLN1 and Alzheimer disease. Am J Med Genet B Neuropsychiatr Genet 2006;141B(3):208-13
   PubMedGoogle Scholar
• Arias-Vasquez A, de Lau L, Pardo L, et al. Relationship of the ubiquilin 1 gene with Alzheimer's and Parkinson's disease and cognitive function. Neurosci Lett 2007;424(1):1-5
   PubMedGoogle Scholar
• Giedraitis V, Kilander L, Degerman-Gunnarsson M, et al. Genetic analysis of Alzheimer's disease in the Uppsala longitudinal study of adult men. Dement Geriatr Cogn Disord 2009;27(1):59-68
   PubMedGoogle Scholar
• Gross GG, Feldman RM, Ganguly A, et al. Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in Drosophila. PLoS One 2008;3(6):e2495
   Google Scholar
• Ganguly A, Feldman RM, Guo M. Ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila. Hum Mol Genet 2008;17(2):293-302
   PubMedGoogle Scholar
• Deng HX, Chen W, Hong ST, et al. Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Nature 2011;477(7363):211-15
   PubMed Web of Science ®Google Scholar
• N'Diaye EN, Hanyaloglu AC, Kajihara KK, et al. The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis. Mol Biol Cell 2008;19(3):1252-60
   PubMedGoogle Scholar
• Edbauer D, Winkler E, Regula JT, et al. Reconstitution of gamma-secretase activity. Nat Cell Biol 2003;5(5):486-8
   PubMed Web of Science ®Google Scholar
• Massey LK, Mah AL, Monteiro MJ. Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, pen-2 and nicastrin. Biochem J 2005;391(Pt 3):513-25
   PubMedGoogle Scholar
• Zhang C, Khandelwal PJ, Chakraborty R, et al. An AICD-based functional screen to identify APP metabolism regulators. Mol Neurodegener 2007;2:15
   PubMed Web of Science ®Google Scholar
• Li A, Xie Z, Dong Y, et al. Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes. Hum Mol Genet 2007;16(21):2626-39
   PubMedGoogle Scholar
• Kopito RR. Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol 2000;10(12):524-30
   PubMed Web of Science ®Google Scholar
• Heir R, Ablasou C, Dumontier E, et al. The UBL domain of PLIC-1 regulates aggresome formation. EMBO Rep 2006;7(12):1252-8
   PubMedGoogle Scholar
• Ko HS, Uehara T, Nomura Y. Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death. J Biol Chem 2002;277(38):35386-92
   PubMedGoogle Scholar
• Lim PJ, Danner R, Liang J, et al. Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. J Cell Biol 2009;187(2):201-17
   PubMed Web of Science ®Google Scholar
• Wang S, Kaufman RJ. The impact of the unfolded protein response on human disease. J Cell Biol 2012;197(7):857-67
   PubMed Web of Science ®Google Scholar
• Kim TY, Kim E, Yoon SK, Yoon JB. Herp enhances ER-associated protein degradation by recruiting ubiquilins. Biochem Biophys Res Commun 2008;369(2):741-6
   PubMed Web of Science ®Google Scholar
• N'Diaye EN, Kajihara KK, Hsieh I, et al. PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation. EMBO Rep 2009;10(2):173-9
   PubMed Web of Science ®Google Scholar
• Rothenberg C, Srinivasan D, Mah L, et al. Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy. Hum Mol Genet 2010;19(16):3219-32
   PubMed Web of Science ®Google Scholar
• Kundu M, Thompson CB. Autophagy: basic principles and relevance to disease. Annu Rev Pathol 2008;3:427-55
   PubMed Web of Science ®Google Scholar
• Wu S, Mikhailov A, Kallo-Hosein H, et al. Characterization of ubiquilin 1, an mTOR-interacting protein. Biochim Biophys Acta 2002;1542(1-3):41-56
   PubMed Web of Science ®Google Scholar
• Doi H, Mitsui K, Kurosawa M, et al. Identification of ubiquitin-interacting proteins in purified polyglutamine aggregates. FEBS Lett 2004;571(1-3):171-6
   PubMed Web of Science ®Google Scholar
• Wang H, Lim PJ, Yin C, et al. Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington's disease by ubiquilin. Hum Mol Genet 2006;15(6):1025-41
   PubMed Web of Science ®Google Scholar
• Wang H, Monteiro MJ. Ubiquilin overexpression reduces GFP-polyalanine-induced protein aggregates and toxicity. Exp Cell Res 2007;313(13):2810-20
   PubMedGoogle Scholar
• Wang H, Monteiro MJ. Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins. Biochem Biophys Res Commun 2007;360(2):423-7
   PubMedGoogle Scholar
• Kim SH, Shi Y, Hanson KA, et al. Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1. J Biol Chem 2009;284(12):8083-92
   PubMed Web of Science ®Google Scholar
• Hanson KA, Kim SH, Wassarman DA, Tibbetts RS. Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS). J Biol Chem 2010;285(15):11068-72
   PubMed Web of Science ®Google Scholar
• Saliba RS, Pangalos M, Moss SJ. The ubiquitin-like protein Plic-1 enhances the membrane insertion of GABAA receptors by increasing their stability within the endoplasmic reticulum. J Biol Chem 2008;283(27):18538-44
   PubMedGoogle Scholar
• Bedford FK, Kittler JT, Muller E, et al. GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1. Nat Neurosci 2001;4(9):908-16
   PubMedGoogle Scholar
• Ficklin MB, Zhao S, Feng G. Ubiquilin-1 regulates nicotine-induced up-regulation of neuronal nicotinic acetylcholine receptors. J Biol Chem 2005;280(40):34088-95
   PubMedGoogle Scholar
• Lee JE, Jeon IS, Han NE, et al. Ubiquilin 1 interacts with Orai1 to regulate calcium mobilization. Mol Cells 2013;35(1):41-6
   PubMed Web of Science ®Google Scholar
• Hochrainer K, Kroismayr R, Baranyi U, et al. Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B. Cell Mol Life Sci 2008;65(13):2105-17
   PubMedGoogle Scholar
• Hitt B, Riordan SM, Kukreja L, et al. beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects. J Biol Chem 2012;287(46):38408-25
   PubMed Web of Science ®Google Scholar
• Cai J, Qi X, Kociok N, et al. beta-secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment. EMBO Mol Med 2012;4(9):980-91
   PubMed Web of Science ®Google Scholar
• Thathiah A, Horre K, Snellinx A, et al. beta-arrestin 2 regulates Abeta generation and gamma-secretase activity in Alzheimer's disease. Nat Med 2013;19(1):43-9
   PubMed Web of Science ®Google Scholar
• Espinoza I, Miele L. Notch inhibitors for cancer treatment. Pharmacol Ther 2013; doi:pii: S0163-7258(13)00044-2. 10.1016/j.pharmthera.2013.02.003. [Epub ahead of print]
   PubMedGoogle Scholar
• Roussel BD, Kruppa AJ, Miranda E, et al. Endoplasmic reticulum dysfunction in neurological disease. Lancet Neurol 2013;12(1):105-18
   PubMed Web of Science ®Google Scholar
• Beverly LJ, Lockwood WW, Shah PP, et al. Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1. Proc Natl Acad Sci USA 2012;109(3):E119-26
   Web of Science ®Google Scholar
• Persson P, Stockhausen MT, Pahlman S, Axelson H. Ubiquilin-1 is a novel HASH-1-complexing protein that regulates levels of neuronal bHLH transcription factors in human neuroblastoma cells. Int J Oncol 2004;25(5):1213-21
   PubMedGoogle Scholar
• Wu AL, Wang J, Zheleznyak A, Brown EJ. Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane. Mol Cell 1999;4(4):619-25
   PubMedGoogle Scholar
• Regan-Klapisz E, Sorokina I, Voortman J, et al. Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction. J Cell Sci 2005;118(Pt 19):4437-50
   PubMedGoogle Scholar
• Gao L, Tu H, Shi ST, et al. Interaction with a ubiquitin-like protein enhances the ubiquitination and degradation of hepatitis C virus RNA-dependent RNA polymerase. J Virol 2003;77(7):4149-59
   PubMedGoogle Scholar
• N'Diaye EN, Brown EJ. The ubiquitin-related protein PLIC-1 regulates heterotrimeric G protein function through association with Gbeta. J Cell Biol 2003;163(5):1157-65
   PubMedGoogle Scholar
• Feng P, Scott CW, Cho NH, et al. Kaposi's sarcoma-associated herpesvirus K7 protein targets a ubiquitin-like/ubiquitin-associated domain-containing protein to promote protein degradation. Mol Cell Biol 2004;24(9):3938-48
   PubMedGoogle Scholar
• Thomas AV, Herl L, Spoelgen R, et al. Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader. J Biol Chem 2006;281(36):26400-7
   PubMedGoogle Scholar
• Bao J, Zhang J, Zheng H, et al. UBQLN1 interacts with SPEM1 and participates in spermiogenesis. Mol Cell Endocrinol 2010;327(1-2):89-97
   PubMedGoogle Scholar
• Biswas N, Liu S, Ronni T, et al. The ubiquitin-like protein PLIC-1 or ubiquilin 1 inhibits TLR3-trif signaling. PLoS One 2011;6(6):e21153
   Google Scholar