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Expert Opinion on Therapeutic Targets Volume 17, 2013 - Issue 8
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Editorial

Targeting RNA polymerase I transcription and the nucleolus for cancer therapy

Ross D HannanPeter MacCallum Cancer Centre, Division of Cancer Research, Locked Bag 1, Melbourne, 8006, Victoria, Australia;The University of Melbourne, Sir Peter MacCallum Department of Oncology, Parkville, 3010, Australia;University of Melbourne, Department of Biochemistry and Molecular Biology, Parkville, 3010, Victoria, Australia;Monash University, Department of Biochemistry and Molecular Biology, Clayton, 3800, Victoria, Australia;University of Queensland, School of Biomedical Sciences, St Lucia, Brisbane, 4072, Queensland, Australia;The University of Melbourne, Sir Peter MacCallum Department of Oncology, Parkville, 3010, Australia, Australia+61 3 9656 1747;+61 3 9656 1411;[email protected]
,
Denis DryginCylene Pharmaceuticals, Inc., 5935 Cornerstone Ct, Suite 100, San Diego, CA 92121, USA
&
Richard B PearsonPeter MacCallum Cancer Centre, Division of Cancer Research, Locked Bag 1, Melbourne, 8006, Victoria, Australia;The University of Melbourne, Sir Peter MacCallum Department of Oncology, Parkville, 3010, Australia;University of Melbourne, Department of Biochemistry and Molecular Biology, Parkville, 3010, Victoria, Australia;Monash University, Department of Biochemistry and Molecular Biology, Clayton, 3800, Victoria, Australia
Pages 873-878 | Published online: 17 Jul 2013

Bibliography

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  • Bywater MJ, Poortinga G, Sanij E, et al. Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53. Cancer Cell 2012;51-65
  • Tovar C, Graves B, Packman K, et al. MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancer models. Cancer Res 2013;2587-97
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