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Thymic stromal lymphopoietin: a central regulator of allergic asthma

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  • Greenberger PA. 7. Immunologic lung disease. J Allergy Clin Immunol 2008;121:S393-7; quiz S418
  • Holgate ST. Pathogenesis of asthma. Clin Exp Allergy 2008;38:872-97
  • Mosmann TR, Cherwinksi H, Bond MW, et al. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348-57
  • Miazgowicz MM, Headley MB, Larson RP, Ziegler SF. Thymical stromal lymphopoietin and the pathophysiology of atopic disease. Expert Rev Clin Immunol 2009;5:547-56
  • Leonard WJ. TSLP: finally in the limelight. Nat Immunol 2002;3:605-7
  • Friend SL, Hoiser S, Nelson A, et al. A thymic stromal cell line supports in vitro development of surface IgM + B cells and produces a novel growth factor affecting B and T lineage cells. Exp Hematol 1994;22:321-8
  • Ray RJ, Furlonger C, Williams DE, et al. Characterization of thymic stromal-derived lymphopoietin (TSLP) in murine B cell development in vitro. Eur J Immunol 1996;26:10-16
  • Sim JE, Williams DE, Morrisset PJ, et al. Molecular cloning and biological characterization of a novel murine lymphoid growth factor. J Exp Med 2000;192:671-80
  • Ferreira MA, Matheson MC, Tang CS, et al. Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. J Allergy Clin Immunol 2013;6749(13):01643-6
  • Torgerson DG, Ampleford EJ, Chiu GY, et al. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet 2011;43(9):887-92
  • Liu W, Xu LS, Liu QJ, et al. Two single nucleotide polymorphisms in TSLP gene are associated with asthma susceptibility in Chinese Han population. Exp Lung Res 2012;38(8):375-82
  • Harada M, Hirota T, Jodo AI, et al. Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma. Am J Respir Cell Mol Biol 2011;44(6):787-93
  • Liu YJ, Soumelis V, Watanabe N, et al. TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. Ann Rev Immunol 2007;25:193-219
  • Ziegler SF, Artis D. Sensing the outside world: TSLP regulates barrier immunity. Nat Immunol 2010;11(4):289-93
  • Ziegler SF. The role of thymic stromal lymphopoietin in allergic disorders. Curr Opin Immunol 2010;22:795-9
  • Allakhverdi Z, Comeau MR, Jessup HK, Delespesse G. Thymic stromal lymphopoietin as a mediator of crosstalk between bronchial smooth muscle and mast cells. J Allergy Clin Immunol 2009;123:958-60; e952
  • Allakhverdi Z, Comeau MR, Jessup HK, et al. Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. J Exp Med 2007;204:253-8
  • Lee HC, Ziegler SF. Inducible expression of proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkappaB. Proc Natl Acad Sci USA 2007;104:914-19
  • Ying S, O'Connor B, Ratoff J, et al. Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease. J Immunol 2008;181:2790-8
  • Zhang K, Shan L, Rahman MS, et al. Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol 2007;293:L375-82
  • Ying S, O'Connor B, Ratoff J, et al. Thymic stromal lymphopoietin is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J Immunol 2005;174:8183-90
  • Kashyap M, Rochman Y, Spolski R, et al. Thymic stromal lymphopoietin is produced by dendritic cells. J Immunol 2011;187:13-24
  • Soumelis V, Reche PA, Kanzler H, et al. Human epithelial cells trigger dendritic cell mediator allergic inflammation by producing TSLP. Nat Immunol 2002;3:673-80
  • Watanabe N, Hannabuchi S, Soumelis V, et al. Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion. Nat Immunol 2004;5:426-34
  • Moon PD, Choi IH, Kim HM. Naringenin suppresses the production of thymic stromal lymphopoietin through the blockade of RIP2 and caspase-1 signal cascade in mast cells. Eur J Pharmacol 2011;671:128-32
  • Sokol CL, Barton GM, Farr EG, et al. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol 2000;9:310-18
  • He R, Geha RS. Thymic stromal lymphopoietin. Ann NY Acad Sci 2010;1183:13-24
  • Oyoshi MK, Larson RP, Ziegler SF, Geha RS. Mechanical injury polarizes skin dendritic cells to elicit a T(H)2 response by inducing cutaneous thymic stromal lymphopoietin expression. J Allergy Clin Immunol 2010;126:976-84; e975
  • Tu HY, Chen X, Li J. Signal transduction in respiratory syncytial virus infection-induced thymic stromal lymphopoietin expression in human epithelial cells. Nan Fang Yi Ke Da Xue Xue Bao 2007;27:1581-3
  • Medoff BD, Landry AL, Wittbold KA, et al. CARMA3 mediates lysophoshatidic acid-stimulated cytokine secretion by bronchial epithelial cells. Am J Respir Cell Mol Biol 2009;40:286-94
  • Kato A, Favoreto S Jr, Avila PC, Schleimer RP. TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells. J Immunol 2007;179:1080-7
  • Bogiatzi SI, Fernandez I, Bichet JC, et al. Cutting edge: proinflammatory and Th2 cytokines synergize to induce thymic stromal lymphopoietin production by human skin keratinocytes. J Immunol 2007;178:3373-7
  • Kinoshita H, Takai T, Le TA, et al. Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA. J Allergy Clin Immunol 2009;123:179-86
  • Uller L, Leino M, Bedke N, et al. Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-beta in bronchial epithelial cells from donors with asthma. Thorax 2010;65(7):626-32
  • Brandelius A, Yudina Y, Calven J, et al. dsRNA-induced expression of thymic stromal lymphopoietin (TSLP) in asthmatic epithelial cells is inhibited by a small airway relaxant. Pulm Pharmacol Ther 2011;24(1):59-66
  • Pesci A, Foresi A, Bertorelli G, et al. Histochemical characteristics and degranulation of mast cells in epithelium and lamina propria of bronchial biopsies from asthmatic and normal subjects. Am Rev Respir Dis 1993;147(3):684-9
  • Balzar S, Fajt ML, Comhair SA, et al. Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program. Am J Respir Crit Care Med 2011;183(3):299-309
  • Okayama Y, Okumura S, Sagara H, et al. FcER1-mediated TSLP production by IL-4 primed human mast cells. Eur Respir J 2009;34:425-35
  • Shikotra A, Chov DF, Ohri CM, et al. Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma. J Allergy Clin Immunol 2010;129(1):104-11; e1-9
  • Harada M, Hirota T, Jodo AI, et al. Functional analysis of the thymic stromal lymphopoietin variants in human bronchial epithelial cells. Am J Respir Cell Mol Biol 2009;40(3):368-74
  • Liu M, Rogers L, Cheng Q, et al. Genetic variants of TSLP and asthma in an admixed urban population. PLoS One 2011;6(9):325099
  • Masuko H, Sakamoto T, Kaneko Y, et al. Lower FEV1 in non-COPD, nonasthmatic subjects: association with smoking, annual decline in FEV1, total IgE levels, and TSLP genotypes. Int J Chron Obstruct Pulmon Dis 2011;6:181-9
  • Hunninghake GM, Soto-Quiros ME, et al. TSLP polymorphisms are associated with asthma in a sex-specific fashion. Allergy 2010;65(12):1566-75
  • He JQ, Hallstrand TS, Knight D, et al. A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness. J Allergy Clin Immunol 2009;124(2):222-9
  • Lee HC, Headley MB, Iseki M, et al. Cutting edge: inhibition of NF-kappaB-mediated TSLP expression by retinoid X receptor. J Immunol 2008;181:5189-93
  • Park LS, Martin U, Garka K, et al. Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: formation of a functional heteromeric complex requires interleukin 7 receptor. J Exp Med 2000;192:659-70
  • Reche PA, Soumelis VM, Gorman DM, et al. Human thyroid stromal lymphopoietin preferentially stimulates myeloid cells. J Immunol 2001;167:336-43
  • Quentmeier H, Drezler HG, Fleckenstein D, et al. Cloning of human thyroid stromal lymphopoietin (TSLP) and signalling mechanisms leading to proliferation. Leukemia 2001;15:1286-92
  • Arima K, Watanabe N, Hanabuchi S, et al. Distinct signal codes generate dendritic cell functional plasticity. Sci Signal 2010;3:ra4
  • Rochman V, Kashyap M, Robinson GW, et al. Thyroid stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling. Proc Natl Acid Sci USA 2010;107:19455-60
  • Isaksen DE, Baumann H, Zhou B, et al. Uncoupling of proliferation and Stat5 activation in thyroid stromal lymphopoietin-mediated signal transduction. J Immunol 2002;168:3288-94
  • Isaksen DE, Baumann H, Trobridge PA, et al. Requirement for stat5 in thyroid stromal lymphopoietin-mediated signal transduction. J Immunol 1999;163:5971-7
  • Pandey A, Ozaki K, Baumann H, et al. Cloning of a receptor subunit required for signaling by thyroid stromal lymphopoietin. Nat Immunol 2000;1:59-64
  • Lu N, Wang YH, Arima K, et al. TSLP and IL-7 use two different mechanisms to regulate human CD4+ T cell homeostasis. J Exp Med 2009;206:2111-19
  • Rochman Y, Leonard WJ. The role of thyroid stromal lymphopoietin in CD8+ T cell homeostasis. J Immunol 2008;181:7699-05
  • Siracusa MC, Saenz SA, Hill DA, et al. TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation. Nature 2011;477:229-33
  • Allakhverdi Z, Comeau MR, Smith DE, et al. CD34 hematopoietic progenitor cells are potent effectors of allergic inflammation. J Allergy Clin Immunol 2009;123:472-8
  • Scheeren FA, van Lent AU, Nagasawa M, et al. Thymic stromal lymphopoietin induces early human B-cell proliferation and differentiation. Eur J Immunol 2010;40(4):955-65
  • Wong CK, Hu S, Cheung PF, Lam CW. TSLP induces chemotactic and pro-survival effects in eosinophils. Am J Respir Cell Mol Biol 2010;43(3):305-15
  • Wu WH, Park CO, Oh SH, et al. Thymic stromal lymphopoietin-activated invariant natural killer T cells trigger an innate allergic immune response in atopic dermatitis. J Allergy Clin Immunol 2010;126(2):290-9
  • Kitajima M, Lee HC, Nakayama T, Ziegler SF. TSLP enhances the function of helper T cells. Eur J Immunol 2011;41(7):1862-71
  • Less JY, Lim YM, Park MJ, et al. Murine thymic stromal lymphopoietin promotes the differentiation of regulator T cells from thymic CD4(+)CD8()CD25(-) naïve cells in a dendritic cell-independent manner. Immunl Cell Biol 2008;96(2):206-13
  • Mazzucchelli R, Hixon JA, Spolski R, et al. Development of regulatory T cells requires IL-17Ralpha stimulation by IL-7 or TSLP. Blood 2008;112(8):3283-92
  • Smith SG, Kinoshito T, Campbell H, et al. Allergen-induced increased in TSLP and IL-33 receptor expression on eosinophil-lineage committed cells in dual responders. Am J Respir Crit Care 2014;186:A2063
  • Watson BM, Tang W, Oliveria JP, et al. Expression of epithelial-derived cytokine receptor on basophils following allergen inhalation challenge in subjects with mild allergic asthma. Am J Respir Crit Care 2013;187:A54348
  • Hanabuchi S, Ito T, Park W-R, et al. Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymus. J Immunol 2010;184:2999-3007
  • Liu YJ. Thymic stromal lymphopoietin: master switch for allergic inflammation. J Exp Med 2006;203:269-73
  • Ito I, Wang YH, Duramad O, et al. TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J Exp Med 2005;202(9):1213-23
  • Zhou B, Comeau MR, De Smedt T, et al. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat Immunol 2005;6:1047-53
  • Wang YH, Ito T, Wang YH, et al. Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells. Immunity 2006;24(6):827-36
  • Nguyen KD, Vanichsarn C, Nadeau KC. TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway. Allergy Asthma Clin Immunol 2010;6(1):4
  • Spadoni I, Iliev ID, Rossi G, Rescigno M. Dendritic cells produce TSLP that limits the differentiation of Th17 cells, fosters Treg development, and protects against colitis. Mucosal Immunol 2012;5(2):184-93
  • Omori M, Ziegler S. Induction of IL-4 expression in CD4(+) T cells by thymic stromal lymphopoietin. J Immunol 2007;178(3):1396-404
  • Rochman I, Watanabe N, Arima K, et al. Cutting edge: direct action of thymic stromal lymphopoietin on activated human CD4+ T cells. J Immunol 2007;178(11):6720-4
  • Nagata Y, Kamijuku H, Taniguchi M, et al. Differential role of thymic stromal lymphopoietin in the induction of airway hyperreactivity and Th2 immune responses in antigen-induced asthma with respect to natural killer T cell function. Int Arch Allergy Immunol 2007;144(4):305-14
  • Friend SL, Hoiser S, Nelson A, et al. A thymic stromal cell line supports in vitro development of surface IgM + B cells and produces a novel growth factor affecting B and T lineage cells. Exp Hematol 1994;22:321-8
  • Levin SD, Koelling RM, Friend SL, et al. Thymic stromal lymphopoietin: a cytokine that promotes the development of IgM+ B cells in vitro and signals via a novel mechanism. J Immunol 1999;162:667-83
  • Vosshenrich CA, Cumano A, Muller W, et al. Thymic stromal lymphopoietin distinguishes fetal from adult B cell development. Nat Immunol 2003;4:773-9
  • Galli SJ, Naka S, Tsai M. Mast cells in the development of adaptive immune responses. Nat Immunol 2005;6:135-42
  • Gilfillan AM. TkazcykC. Integrated signalling pathways for mast cell activation. Nat Rev Immunol 2006;6:218-30
  • Jessup HK, Allakhverdi Z, Comeau MR, et al. Thymic stromal lymphopoietin (TSLPR) is a potent activator of human mast cells. J Immunol 2007;178:S23
  • Miyata M, Hatsushika K, Ando T, et al. Mast cell regulation of epithelial TSLP expression players an important role in the development of allergic rhinitis. Eur J Immunol 2008;38(6):1487-92
  • Cameron L, Christodoulopoulos P, Lavigne F, et al. Evidence for local eosinophil differentiation within allergic nasal mucosa: inhibition with soluble IL-5 receptor. J Immunol 2000;164(3):1538-45
  • Imaoka H, Campbell H, Babirad I, et al. TPI ASM8 reduces eosinophil progenitors in sputum after allergen challenge. Clin Exp Allergy 2011;41(12):1740-6
  • Dorman SC, Efthimiadis A, Babirad I, et al. Sputum CD34+IL-5Ralpha+ cells increase after allergen: evidence for in situ eosinophilopoiesis. Am J Respir Crit Care Med 2004;169(5):573-7
  • Hui CCK, Asher I, Heroux D, et al. Effect of thymic stromal lymphopoietin on cord blood progenitor cell differentiation and hemopoietic cytokine receptor expression. Allergy Asthma Clin Immunol 2011;7(2):A24
  • Voehringer D. Basophil modulation by cytokine instruction. Eur J Immunol 2012;42(10):2544-50
  • Giacomin PR, Siracusa MC, Walsh KP, et al. Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal helminth infection. J Immunol 2012;189:4371-8
  • Watson BM, Tang W, Oliveria JP, et al. Effect of epithelial-derived cytokines on human basophil function in vitro. Am J Respir Crit Care 2014;187:A54355
  • Noti M, Woino ED, Kim BS, et al. Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis. Nat Med 2013;19(8):1005-13
  • Cook EB, Stahl JL, Schwantes EA, et al. IL-3 and TNFα increase Thymic Stromal Lymphopoietin Receptor (TSLPR) expression on eosinophils and enhance TSLP-stimulated degranulation. Clin Mol Allergy 2012;10(1):8
  • Morshed M, Yousefi S, Stöckle C, et al. Thymic stromal lymphopoietin stimulates the formation of eosinophil extracellular traps. Allergy 2012;67(9):1127-37
  • Smelter DF, Sathish V, Thompson MA, et al. Thymic stromal lymphopoietin in cigarette smoke-exposed human airway smooth muscle. J Immunol 2010;185(5):3035-40
  • Redhu NS, Shan L, Movassagh H, Gounni AS. Thymic stromal lymphopoietin induces migration in human airway smooth muscle cells. Scientific Rep 2013;2301(3):3035-40
  • Kaur D, et al. Mast cell-airway smooth muscle crosstalk: the role of thymic stromal lymphopoietin. Chest 2012;142:76-85
  • Hallstrand TS, Hackett TL, Altemeier WA, et al. Airway epithelial regulation of pulmonary immune homeostasis and inflammation. Clin Immunol 2014;151(1):1-15
  • Kang CM, Jang AS, Ahn MH, et al. Interleukin-25 and interleukin-13 production by alveolar macrophages in response to particles. Am J Respir Cell Mol Biol 2005;33:290-6
  • Dolgachev V, Petersen BC, Budelsky AL, et al. Pulmonary IL-17E (IL-25) production and IL-17RB+ myeloid cell-derived Th2 cytokine production are dependent upon stem cell factor-induced responses during chronic allergic pulmonary disease. J Immunol 2009;183:5705-15
  • Wang YH, Angkasekwinai P, Lu N, et al. IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. J Exp Med 2007;204:1837-47
  • Angkasekwinai P, Park H, Wang Y-H, et al. Interleukin 25 promotes the initiation of proallergic tpye 2 responses. J Exp Med 2007;204(7):1509-17
  • Fort MM, Cheung J, Yen D, et al. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity 2001;15:985-95
  • Kim MR, Manoukian R, Yeh SM, et al. Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production. Blood 2002;100:2330-234
  • Hurst SD, Muchamuel DM, Gorman JM, et al. New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25. J Immunol 2002;169:443-53
  • Busse W, Holgate S, Kerwin E, et al. Randomized, double-blind, placebo-controlled study of Brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma. Am J Respir Crit Care Med 2013;188(11):1294-302
  • Akdis M, Burgler S, Crameri R, et al. Interleukins, from 1 to 37, and interferon-y: receptors, functions and roles in diseases. J Allergy Clin Immunol 2011;127:701-21; e1-70
  • Mjosberg JM, Trifari S, Crellin NK, et al. Human IL-25 and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161. Nat Immunol 2011;12:1055-62
  • Pushparaj PN, Tay HK, H'ng SC, et al. The cytokine interleukin-33 mediates anaphylactic shock. Proc Natl Acad Sci USA 2009;106:9773-8
  • Prefontaine D, Lajoie-Kadoch S, Foley S, et al. Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells. J Immunol 2009;183:5094-103
  • Prefontaine D, Nadigel J, Chouiali F, et al. Increased IL-33 expression by epithelial cells in bronchial asthma. J Allergy Clin Immunol 2010;125:752-4
  • Sakashita M, Yoshimoto T, Hirota T, et al. Association of serum interleukin-33 level and the interleukin-33 genetic variant with Japanese cedar pollinosis. Clin Exp Allergy 2008;38:1875-81
  • Kamekura R, Kojima T, Takano K, et al. The role of IL-33 and its receptor ST2 in human nasal epithelium with allergic rhinitis. Clin Exp Allergy 2012;42:218-28
  • Asaka D, Yoshikawa M, Nakayama T, et al. Elevated levels of interleukin-33 in the nasal secretions of patients with allergic rhinitis. Int Arch Allergy Immunol 2012;158(Suppl 1):47-50
  • Gordon E, Lachowicz-Scroggins ME, Woodruff PG, et al. Characterization of IL-33 and St2 expression in human asthma. Am J Respir Crit Care Med 2013;187:A1003
  • Magat JL, Thomas JL, Dumouchel JP, Bigby TD. Interleukin-33 plays an important role in modulating the innate and adaptive immune responses in a mouse asthma-like model. Am J Respir Crit Care Med 2013;187:A1006
  • Kim YH, Park C, Lim DH, et al. Beneficial effect of anti-interleukin-33 on the murine model of allergic inflammation of the lower airway. J Asthma 2012;49:738-43
  • Kim YH, Yang TY, Park C, et al. Anti-IL-33 antibody has a therapeutic effect in a murine model of allergic rhinitis. Allergy 2012;67:183-90
  • Al-Shami A, Spolski R, Kelly J, et al. A role for TSLP in the development of inflammation in an asthma model. J Exp Med 2005;202(6):829-39
  • Shi L, Leu SW, Xu F, et al. Local blockade of TSLP receptor alleviated allergic disease by regulating airway dendritic cells. Clin Immunol 2008;129:202-10
  • Headley MB, Zhou B, Shih WX, et al. TSLP conditions the lung immune environment for the generation of pathogenic innate and antigen-specific adaptive immune responses. J Immunol 2009;182(3):1641-7
  • Chen ZG, Zhang TT, Li HT, et al. Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite. PLoS One 2013;8(1):e51268
  • Ishii N, Takahashi T, Soroosh P, Sugamura K. OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathology. Adv Immunol 2010;105:63-98
  • Seshsayee D, Zhou M, Shu J, et al. Blocking OX40L function inhibits TSLP-induced atopic disease in lung and skin. J Immunol 2007;178:S20
  • Seshsayee D, Lee WP, Zhou M, et al. In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation. J Clin Invest 2007;117(12):3868-78
  • Cheng DT, Ma C, Niewoehner J, et al. TSLP receptor blockage reduces allergic inflammation in a cynomolgus monkey model of asthma. J Allergen Clin Immunol 2013;132(2):455-62
  • Gauvreau GM, Boulet LP, Cockcroft DW, et al. OX40L blockade and allergen-induced airway responses in subjects with mild asthma. Clin Exp Allergy 2014;44(1):29-37
  • Li YL, Li HJ, Ji F, et al. Thymic stromal lymphopoietin promotes lung inflammation through activation of dendritic cells. J Asthma 2010;47(2):117-23
  • Gilliet M, Soumelis V, Watanabe N, et al. Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells. J Exp Med 2003;197(8):1059-63
  • Nair P, Pizzichini MM, Kjarsgaard M, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 2009;360:985-93
  • Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009;360:973-84
  • Gauvreau GM, Boulet LP, Cockcroft DW, et al. The effects of IL-13 blockade on allergen-induced airway responses in mild atopic asthma. Am J Respir Crit Care Med 2011;183(8):1007-14
  • Corren J, Lemanske RF, Hanania NA, et al. Lebrikizumab treatment in adults with asthma. N Engl J Med 2011;365:1088-98
  • Wenzel S, Ford L, Pearlman D, et al. Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med 2013;368:2455-66
  • Akamatsu T, Watanabe N, Kido M, et al. Human TSLP directly enhances expansion of CD8+ T cells. Clin Exp Immunol 2008;154(1):98-106
  • Lee JY, Lim YM, Park MJ, et al. Murine thymic stromal lymphopoietin promotes the differentiation of regulatory T cells from thymic CD4(+)CD8(-)CD25(-) naïve cells in a dendritic cell-independent manner. Immunol Cell Biol 2008;86(2):206-13
  • Hirano R, Hasegawa S, Hashimoto K, et al. Human thymic stromal lymphopoietin enhances expression of CD80 in human CD14+ monocytes/macrophages. Inflamm Res 2011;60(6):605-10
  • Lei L, Zhang Y, Yao W, et al. Thymic stromal lymphopoietin interferes with airway tolerance by suppressing the generation of antigen-specific regulatory T cells. J Immunol 2011;186(4):2254-61
  • Watanabe N, Wang YH, Lee HK, et al. Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus. Nature 2005;436(7054):1181-5
  • Zhang F, Huang G, Hu B, et al. A soluble thymic stromal lymphopoietin (TSLP) antagonist, TSLPR-immunoglobulin, reduces the severity of allergic disease by regulating pulmonary dendritic cells. Clin Exp Immunol 2011;164(2):256-64

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