Oncogenic role and therapeutic target of transient receptor potential melastatin 7 channel in malignancy

Bibliography

• Arcangeli A, Pillozzi S, Becchetti A. Targeting ion channels in leukemias: a new challenge for treatment. Curr Med Chem 2012;19:683-96
   PubMed Web of Science ®Google Scholar
• Lehen’kyi V, Shapovalov G, Skryma R, Prevarskaya N. Ion channnels and transporters in cancer. 5. Ion. channels in control of cancer and cell apoptosis. Am J Physiol Cell Physiol 2011;301:C1281-9
   Google Scholar
• Li M, Xiong ZG. Ion channels as targets for cancer therapy. Int J Physiol Pathophysiol Pharmacol 2011;3:156-66
   PubMedGoogle Scholar
• Venkatachalam K, Montell C. TRP channels. Annu Rev Biochem 2007;76:387-417
   PubMed Web of Science ®Google Scholar
• Vennekens R, Menigoz A, Nilius B. TRPs in the Brain. Rev Physiol Biochem Pharmacol 2012;27:27
   Google Scholar
• Capiod T. The need for calcium channels in cell proliferation. Recent Pat Anticancer Drug Discov 2012;23:23
   Google Scholar
• Roderick HL, Cook SJ. Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival. Nat Rev Cancer 2008;8:361-75
   PubMed Web of Science ®Google Scholar
• Montell C, Birnbaumer L, Flockerzi V, et al. A unified nomenclature for the superfamily of TRP cation channels. Mol Cell 2002;9:229-31
   PubMed Web of Science ®Google Scholar
• Clapham DE. TRP channels as cellular sensors. Nature 2003;426:517-24
   PubMed Web of Science ®Google Scholar
• Minke B. TRP channels and Ca2+ signaling. Cell Calcium 2006;40:261-75
   PubMed Web of Science ®Google Scholar
• Pedersen SF, Owsianik G, Nilius B. TRP channels: an overview. Cell Calcium 2005;38:233-52
   PubMed Web of Science ®Google Scholar
• Sumoza-Toledo A, Penner R. TRPM2: a multifunctional ion channel for calcium signalling. J Physiol 2011;589:1515-25
   PubMed Web of Science ®Google Scholar
• Toth B, Csanady L. Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel. J Biol Chem 2010;285:30091-102
   PubMedGoogle Scholar
• Middelbeek J, Clark K, Venselaar H, et al. The alpha-kinase family: an exceptional branch on the protein kinase tree. Cell Mol Life Sci 2010;67:875-90
   Google Scholar
• Runnels LW. TRPM6 and TRPM7: a Mul-TRP-PLIK-cation of channel functions. Curr Pharm Biotechnol 2011;12:42-53
   PubMedGoogle Scholar
• Bae CY, Sun HS. Current understanding of TRPM7 pharmacology and drug development for stroke. Acta Pharmacol Sin 2012;23:94
   Google Scholar
• Touyz RM. Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension. Am J Physiol Heart Circ Physiol 2008;294:H1103-18
   PubMed Web of Science ®Google Scholar
• Hermosura MC, Garruto RM. TRPM7 and TRPM2-Candidate susceptibility genes for Western Pacific ALS and PD? Biochim Biophys Acta 2007;1772:822-35
   PubMed Web of Science ®Google Scholar
• Jiang J, Li MH, Inoue K, et al. Transient receptor potential melastatin 7-like current in human head and neck carcinoma cells: role in cell proliferation. Cancer Res 2007;67:10929-38
   PubMed Web of Science ®Google Scholar
• Middelbeek J, Kuipers AJ, Henneman L, et al. TRPM7 is required for breast tumor cell metastasis. Cancer Res 2012;72:4250-61
   PubMedGoogle Scholar
• Sun Y, Selvaraj S, Varma A, et al. Increase in serum Ca2+/Mg2+ ratio promotes proliferation of prostate cancer cells by activating TRPM7 channels. J Biol Chem 2013;288:255-63
   PubMedGoogle Scholar
• Guilbert A, Gautier M, Dhennin-Duthille I, et al. Evidence that TRPM7 is required for breast cancer cell proliferation. Am J Physiol Cell Physiol 2009;297:C493-502
   PubMed Web of Science ®Google Scholar
• Kim BJ, Park EJ, Lee JH, et al. Suppression of transient receptor potential melastatin 7 channel induces cell death in gastric cancer. Cancer Sci 2008;99:2502-9
   PubMed Web of Science ®Google Scholar
• Kim BJ, Nah SY, Jeon JH, et al. Transient receptor potential melastatin 7 channels are involved in ginsenoside Rg3-induced apoptosis in gastric cancer cells. Basic Clin Pharmacol Toxicol 2011;109:233-9
   PubMedGoogle Scholar
• Jiang J, Lei WB, Shi JB, et al. [Transient receptor potential melastatin 7 channel protein in human head and neck carcinoma cells and role in cell proliferation]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2008;43:451-5
   PubMedGoogle Scholar
• Chen JP, Luan Y, You CX, et al. TRPM7 regulates the migration of human nasopharyngeal carcinoma cell by mediating Ca(2+) influx. Cell Calcium 2010;47:425-32
   PubMed Web of Science ®Google Scholar
• Yee NS, Zhou W, Liang IC. Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer. Dis Model Mech 2011;4:240-54
   PubMed Web of Science ®Google Scholar
• Rybarczyk P, Gautier M, Hague F, et al. Transient receptor potential melastatin-related 7 channel is overexpressed in human pancreatic ductal adenocarcinomas and regulates human pancreatic cancer cell migration. Int J Cancer 2012;131:E851-61
   Google Scholar
• Sun Y, Selvaraj S, Varma A, et al. Increase in serum Ca2+/Mg2+ ratio promote proliferation of prostate cancer cells by activating TRPM7 channel. J Biol Chem 2013;288(1):255-63
   PubMedGoogle Scholar
• Hanano T, Hara Y, Shi J, et al. Involvement of TRPM7 in cell growth as a spontaneously activated Ca2+ entry pathway in human retinoblastoma cells. J Pharmacol Sci 2004;95:403-19
   PubMedGoogle Scholar
• Zierler S, Yao G, Zhang Z, et al. Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels. J Biol Chem 2011;286:39328-35
   PubMedGoogle Scholar
• Sahni J, Tamura R, Sweet IR, Scharenberg AM. TRPM7 regulates quiescent/proliferative metabolic transitions in lymphocytes. Cell Cycle 2010;9:3565-74
   PubMed Web of Science ®Google Scholar
• Dhennin-Duthille I, Gautier M, Faouzi M, et al. High expression of transient receptor potential channels in human breast cancer epithelial cells and tissues: correlation with pathological parameters. Cell Physiol Biochem 2011;28:813-22
   PubMedGoogle Scholar
• Trapani V, Arduini D, Cittadini A, Wolf FI. From magnesium to magnesium transporters in cancer: TRPM7, a novel signature in tumour development. Magnes Res 2013;26:149-55
   PubMedGoogle Scholar
• Yee NS, Chan AS, Yee JD, Yee RK. TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets. Scientifica (Cairo) 2012;2012:415158
   PubMedGoogle Scholar
• Holzer P. Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system. Pharmacol Ther 2011;131:142-70
   PubMed Web of Science ®Google Scholar
• Ouadid-Ahidouch H, Dhennin-Duthille I, Gautier M, et al. [TRP calcium channel and breast cancer: expression, role and correlation with clinical parameters]. Bull Cancer 2012;99:655-64
   PubMedGoogle Scholar
• Chubanov V, Waldegger S, Mederos y Schnitzler M, et al. Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia. Proc Natl Acad Sci USA 2004;101:2894-9
   PubMedGoogle Scholar
• Li M, Jiang J, Yue L. Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7. J Gen Physiol 2006;127:525-37
   PubMed Web of Science ®Google Scholar
• Schmitz C, Dorovkov MV, Zhao X, et al. The channel kinases TRPM6 and TRPM7 are functionally nonredundant. J Biol Chem 2005;280:37763-71
   Google Scholar
• Farooqi AA, Javeed MK, Javed Z, et al. TRPM channels: same ballpark, different players, and different rules in immunogenetics. Immunogenetics 2011;63:773-87
   PubMedGoogle Scholar
• Perraud AL, Knowles HM, Schmitz C. Novel aspects of signaling and ion-homeostasis regulation in immunocytes. The TRPM ion channels and their potential role in modulating the immune response. Mol Immunol 2004;41:657-73
   PubMedGoogle Scholar
• Drennan D, Ryazanov AG. Alpha-kinases: analysis of the family and comparison with conventional protein kinases. Prog Biophys Mol Biol 2004;85:1-32
   PubMed Web of Science ®Google Scholar
• Nilius B, Prenen J, Tang J, et al. Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4. J Biol Chem 2005;280:6423-33
   PubMed Web of Science ®Google Scholar
• Perraud AL, Fleig A, Dunn CA, et al. ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature 2001;411:595-9
   PubMed Web of Science ®Google Scholar
• Chokshi R, Matsushita M, Kozak JA. Detailed examination of Mg2+ and pH sensitivity of human TRPM7 channels. Am J Physiol Cell Physiol 2012;302:C1004-11
   Google Scholar
• Matsushita M, Kozak JA, Shimizu Y, et al. Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1. J Biol Chem 2005;280:20793-803
   Google Scholar
• Schlingmann KP, Weber S, Peters M, et al. Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. Nat Genet 2002;31:166-70
   PubMed Web of Science ®Google Scholar
• Walder RY, Landau D, Meyer P, et al. Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia. Nat Genet 2002;31:171-4
   PubMed Web of Science ®Google Scholar
• Nadler MJ, Hermosura MC, Inabe K, et al. LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. Nature 2001;411:590-5
   PubMed Web of Science ®Google Scholar
• Runnels LW, Yue L, Clapham DE. TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science 2001;291:1043-7
   PubMed Web of Science ®Google Scholar
• Langeslag M, Clark K, Moolenaar WH, et al. Activation of TRPM7 channels by phospholipase C-coupled receptor agonists. J Biol Chem 2007;282:232-9
   Google Scholar
• Wolf FI, Trapani V. Cell (patho)physiology of magnesium. Clin Sci (Lond) 2008;114:27-35
   PubMed Web of Science ®Google Scholar
• Wolf FI, Trapani V. Magnesium and its transporters in cancer: a novel paradigm in tumour development. Clin Sci (Lond) 2012;123:417-27
   PubMedGoogle Scholar
• Schmitz C, Perraud AL, Johnson CO, et al. Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7. Cell 2003;114:191-200
   PubMed Web of Science ®Google Scholar
• Desai BN, Krapivinsky G, Navarro B, et al. Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. Dev Cell 2012;22:1149-62
   PubMedGoogle Scholar
• Aarts M, Iihara K, Wei WL, et al. A key role for TRPM7 channels in anoxic neuronal death. Cell 2003;115:863-77
   PubMed Web of Science ®Google Scholar
• Levitan IB, Cibulsky SM. Biochemistry. TRP ion channels – two proteins in one. Science 2001;293:1270-1
   PubMedGoogle Scholar
• Jin J, Desai BN, Navarro B, et al. Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science 2008;322:756-60
   PubMed Web of Science ®Google Scholar
• Berridge MJ, Lipp P, Bootman MD. The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol 2000;1:11-21
   PubMed Web of Science ®Google Scholar
• Kaul G, Pattan G, Rafeequi T. Eukaryotic elongation factor-2 (eEF2): its regulation and peptide chain elongation. Cell Biochem Funct 2011;29:227-34
   PubMed Web of Science ®Google Scholar
• Elizondo MR, Arduini BL, Paulsen J, et al. Defective skeletogenesis with kidney stone formation in dwarf zebrafish mutant for trpm7. Curr Biol 2005;15:667-71
   PubMedGoogle Scholar
• Clark K, Langeslag M, van Leeuwen B, et al. TRPM7, a novel regulator of actomyosin contractility and cell adhesion. Embo J 2006;25:290-301
   PubMed Web of Science ®Google Scholar
• Wei C, Wang X, Chen M, et al. Calcium flickers steer cell migration. Nature 2009;457:901-5
   PubMedGoogle Scholar
• Su LT, Agapito MA, Li M, et al. TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain. J Biol Chem 2006;281:11260-70
   PubMedGoogle Scholar
• Dorovkov MV, Ryazanov AG. Phosphorylation of annexin I by TRPM7 channel-kinase. J Biol Chem 2004;279:50643-6
   Google Scholar
• Clark K, Middelbeek J, Lasonder E, et al. TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation. J Mol Biol 2008;378:790-803
   Google Scholar
• Perraud AL, Zhao X, Ryazanov AG, Schmitz C. The channel-kinase TRPM7 regulates phosphorylation of the translational factor eEF2 via eEF2-k. Cell Signal 2011;23:586-93
   Google Scholar
• Wei WL, Sun HS, Olah ME, et al. TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations. Proc Natl Acad Sci USA 2007;104:16323-8
   PubMedGoogle Scholar
• Inoue K, Branigan D, Xiong ZG. Zinc-induced neurotoxicity mediated by transient receptor potential melastatin 7 channels. J Biol Chem 2010;285:7430-9
   PubMedGoogle Scholar
• Monteilh-Zoller MK, Hermosura MC, Nadler MJ, et al. TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions. J Gen Physiol 2003;121:49-60
   PubMed Web of Science ®Google Scholar
• Wolf FI. TRPM7: channeling the future of cellular magnesium homeostasis? Sci STKE 2004;2004:pe23
   PubMedGoogle Scholar
• Kozak JA, Cahalan MD. MIC channels are inhibited by internal divalent cations but not ATP. Biophys J 2003;84:922-7
   PubMedGoogle Scholar
• Takezawa R, Schmitz C, Demeuse P, et al. Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain. Proc Natl Acad Sci USA 2004;101:6009-14
   PubMedGoogle Scholar
• Corey DP. New TRP channels in hearing and mechanosensation. Neuron 2003;39:585-8
   PubMed Web of Science ®Google Scholar
• Ramsey IS, Delling M, Clapham DE. An introduction to TRP channels. Annu Rev Physiol 2006;68:619-47
   PubMed Web of Science ®Google Scholar
• Aarts MM, Tymianski M. TRPM7 and ischemic CNS injury. Neuroscientist 2005;11:116-23
   Google Scholar
• He Y, Yao G, Savoia C, Touyz RM. Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells: role of angiotensin II. Circ Res 2005;96:207-15
   PubMedGoogle Scholar
• Oancea E, Wolfe JT, Clapham DE. Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow. Circ Res 2006;98:245-53
   PubMedGoogle Scholar
• Kozak JA, Matsushita M, Nairn AC, Cahalan MD. Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition, and rundown of TRPM7/MIC channels. J Gen Physiol 2005;126:499-514
   Google Scholar
• Jiang J, Li M, Yue L. Potentiation of TRPM7 inward currents by protons. J Gen Physiol 2005;126:137-50
   PubMedGoogle Scholar
• Li M, Du J, Jiang J, et al. Molecular determinants of Mg2+ and Ca2+ permeability and pH sensitivity in TRPM6 and TRPM7. J Biol Chem 2007;282:25817-30
   PubMed Web of Science ®Google Scholar
• Runnels LW, Yue L, Clapham DE. The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nat Cell Biol 2002;4:329-36
   PubMedGoogle Scholar
• Gerke V, Moss SE. Annexins: from structure to function. Physiol Rev 2002;82:331-71
   PubMed Web of Science ®Google Scholar
• Rescher U, Gerke V. Annexins – unique membrane binding proteins with diverse functions. J Cell Sci 2004;117:2631-9
   PubMed Web of Science ®Google Scholar
• Rothhut B. Participation of annexins in protein phosphorylation. Cell Mol Life Sci 1997;53:522-6
   PubMedGoogle Scholar
• Dorovkov MV, Kostyukova AS, Ryazanov AG. Phosphorylation of annexin A1 by TRPM7 kinase: a switch regulating the induction of an alpha-helix. Biochemistry 2011;50:2187-93
   PubMedGoogle Scholar
• Nakasawa T, Takahashi M, Matsuzawa F, et al. Critical regions for assembly of vertebrate nonmuscle myosin II. Biochemistry 2005;44:174-83
   PubMed Web of Science ®Google Scholar
• Abed E, Moreau R. Importance of melastatin-like transient receptor potential 7 and magnesium in the stimulation of osteoblast proliferation and migration by platelet-derived growth factor. Am J Physiol Cell Physiol 2009;297:C360-8
   Web of Science ®Google Scholar
• Gao H, Chen X, Du X, et al. EGF enhances the migration of cancer cells by up-regulation of TRPM7. Cell Calcium 2011;50:559-68
   PubMedGoogle Scholar
• Sahni J, Scharenberg AM. TRPM7 ion channels are required for sustained phosphoinositide 3-kinase signaling in lymphocytes. Cell Metab 2008;8:84-93
   PubMed Web of Science ®Google Scholar
• Zhao L, Wang Y, Sun N, et al. Electroacupuncture regulates TRPM7 expression through the trkA/PI3K pathway after cerebral ischemia-reperfusion in rats. Life Sci 2007;81:1211-22
   PubMed Web of Science ®Google Scholar
• Inoue K, Xiong ZG. Silencing TRPM7 promotes growth/proliferation and nitric oxide production of vascular endothelial cells via the ERK pathway. Cardiovasc Res 2009;83:547-57
   PubMedGoogle Scholar
• Meng X, Cai C, Wu J, et al. TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway. Cancer Lett 2013;333:96-102
   PubMedGoogle Scholar
• Su LT, Chen HC, Gonzalez-Pagan O, et al. TRPM7 activates m-calpain by stress-dependent stimulation of p38 MAPK and c-Jun N-terminal kinase. J Mol Biol 2010;396:858-69
   Google Scholar
• Davis FM, Azimi I, Faville RA, et al. Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent. Oncogene 2014;33(18):2307-16
   PubMed Web of Science ®Google Scholar
• Davis FM, Azimi I, Faville RA, et al. Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent. Oncogene 2014;33:2307-16
   PubMed Web of Science ®Google Scholar
• Choe G, Horvath S, Cloughesy TF, et al. Analysis of the phosphatidylinositol 3’-kinase signaling pathway in glioblastoma patients in vivo. Cancer Res 2003;63:2742-6
   PubMed Web of Science ®Google Scholar
• de la Iglesia N, Konopka G, Puram SV, et al. Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes Dev 2008;22:449-62
   PubMed Web of Science ®Google Scholar
• Mellinghoff IK, Wang MY, Vivanco I, et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med 2005;353:2012-24
   PubMed Web of Science ®Google Scholar
• Stockhausen MT, Kristoffersen K, Poulsen HS. Notch signaling and brain tumors. Adv Exp Med Biol 2012;727:289-304
   PubMedGoogle Scholar
• Qiang L, Wu T, Zhang HW, et al. HIF-1alpha is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway. Cell Death Differ 2012;19:284-94
   PubMed Web of Science ®Google Scholar
• Hovinga KE, Shimizu F, Wang R, et al. Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediate. Stem Cells 2010;28:1019-29
   PubMed Web of Science ®Google Scholar
• Chigurupati S, Venkataraman R, Barrera D, et al. Receptor channel TRPC6 is a key mediator of Notch-driven glioblastoma growth and invasiveness. Cancer Res 2010;70:418-27
   PubMedGoogle Scholar
• Liu M, Inoue K, Leng T, et al. TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways [abstract #3237]. Proceedings of the 105th Annual Meeting of the American Association for Cancer Research, 5-9 April 2014, San Diego
   Google Scholar
• Chen HC, Su LT, Gonzalez-Pagan O, et al. A key role for Mg(2+) in TRPM7’s control of ROS levels during cell stress. Biochem J 2012;445:441-8
   PubMedGoogle Scholar
• Browne GJ, Proud CG. A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin. Mol Cell Biol 2004;24:2986-97
   PubMed Web of Science ®Google Scholar
• Yee NS, Zhou W, Lee M, Yee RK. Targeted silencing of TRPM7 ion channel induces replicative senescence and produces enhanced cytotoxicity with gemcitabine in pancreatic adenocarcinoma. Cancer Lett 2012;318:99-105
   PubMedGoogle Scholar
• Cheng H, Feng JM, Figueiredo ML, et al. Transient receptor potential melastatin type 7 channel is critical for the survival of bone marrow derived mesenchymal stem cells. Stem Cells Dev 2010;19:1393-403
   PubMed Web of Science ®Google Scholar
• Jin J, Wu LJ, Jun J, et al. The channel kinase, TRPM7, is required for early embryonic development. Proc Natl Acad Sci USA 2012;109:E225-33
   Google Scholar
• Cui L, Xu SM, Ma DD, Wu BL. The effect of TRPM7 suppression on the proliferation, migration and osteogenic differentiation of human dental pulp stem cells. Int Endod J 2013;10:12193
   Google Scholar
• Kakarala M, Wicha MS. Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy. J Clin Oncol 2008;26:2813-20
   PubMed Web of Science ®Google Scholar
• Pang LY, Argyle DJ. Using naturally occurring tumours in dogs and cats to study telomerase and cancer stem cell biology. Biochim Biophys Acta 2009;1792:380-91
   PubMed Web of Science ®Google Scholar
• Clarke MF. Self-renewal and solid-tumor stem cells. Biol Blood Marrow Transplant 2005;11:14-16
   PubMed Web of Science ®Google Scholar
• Clevers H. The cancer stem cell: premises, promises and challenges. Nat Med 2011;17:313-19
   PubMed Web of Science ®Google Scholar
• Guilbert A, Gautier M, Dhennin-Duthille I, et al. Transient receptor potential melastatin 7 is involved in oestrogen receptor-negative metastatic breast cancer cells migration through its kinase domain. Eur J Cancer 2013;49:3694-707
   PubMedGoogle Scholar
• Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007;114:97-109
   PubMed Web of Science ®Google Scholar
• Chen HC, Xie J, Zhang Z, et al. Blockade of TRPM7 channel activity and cell death by inhibitors of 5-lipoxygenase. PLoS One 2010;5:e11161
   Google Scholar
• Kim BJ, Kim SY, Lee S, et al. The role of transient receptor potential channel blockers in human gastric cancer cell viability. Can J Physiol Pharmacol 2012;90:175-86
   Google Scholar
• Lam DH, Grant CE, Hill CE. Differential expression of TRPM7 in rat hepatoma and embryonic and adult hepatocytes. Can J Physiol Pharmacol 2012;90:435-44
   PubMedGoogle Scholar
• Wolf FI, Cittadini A. Magnesium in cell proliferation and differentiation. Front Biosci 1999;4:D607-17
   PubMedGoogle Scholar
• French PJ, Swagemakers SM, Nagel JH, et al. Gene expression profiles associated with treatment response in oligodendrogliomas. Cancer Res 2005;65:11335-44
   PubMedGoogle Scholar
• Finak G, Bertos N, Pepin F, et al. Stromal gene expression predicts clinical outcome in breast cancer. Nat Med 2008;14:518-27
   PubMed Web of Science ®Google Scholar
• Radvanyi L, Singh-Sandhu D, Gallichan S, et al. The gene associated with trichorhinophalangeal syndrome in humans is overexpressed in breast cancer. Proc Natl Acad Sci USA 2005;102:11005-10
   PubMed Web of Science ®Google Scholar
• Richardson AL, Wang ZC, De Nicolo A, et al. X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell 2006;9:121-32
   PubMed Web of Science ®Google Scholar
• Sun L, Hui AM, Su Q, et al. Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. Cancer Cell 2006;9:287-300
   PubMed Web of Science ®Google Scholar
• Turashvili G, Bouchal J, Baumforth K, et al. Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis. BMC Cancer 2007;7:55
   PubMed Web of Science ®Google Scholar
• Compagno M, Lim WK, Grunn A, et al. Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Nature 2009;459:717-21
   PubMed Web of Science ®Google Scholar
• Pyeon D, Newton MA, Lambert PF, et al. Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers. Cancer Res 2007;67:4605-19
   PubMed Web of Science ®Google Scholar
• Sengupta S, den Boon JA, Chen IH, et al. Genome-wide expression profiling reveals EBV-associated inhibition of MHC class I expression in nasopharyngeal carcinoma. Cancer Res 2006;66:7999-8006
   PubMed Web of Science ®Google Scholar
• Skotheim RI, Lind GE, Monni O, et al. Differentiation of human embryonal carcinomas in vitro and in vivo reveals expression profiles relevant to normal development. Cancer Res 2005;65:5588-98
   PubMed Web of Science ®Google Scholar
• Zhan F, Barlogie B, Arzoumanian V, et al. Gene-expression signature of benign monoclonal gammopathy evident in multiple myeloma is linked to good prognosis. Blood 2007;109:1692-700
   PubMed Web of Science ®Google Scholar
• Blaveri E, Simko JP, Korkola JE, et al. Bladder cancer outcome and subtype classification by gene expression. Clin Cancer Res 2005;11:4044-55
   PubMed Web of Science ®Google Scholar
• Grutzmann R, Pilarsky C, Ammerpohl O, et al. Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays. Neoplasia 2004;6:611-22
   PubMed Web of Science ®Google Scholar
• Hong Y, Downey T, Eu KW, et al. A ’metastasis-prone’ signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics. Clin Exp Metastasis 2010;27:83-90
   PubMedGoogle Scholar
• Kaiser S, Park YK, Franklin JL, et al. Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol 2007;8:R131
   PubMed Web of Science ®Google Scholar
• Korkola JE, Houldsworth J, Chadalavada RS, et al. Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors. Cancer Res 2006;66:820-7
   PubMed Web of Science ®Google Scholar
• Sperger JM, Chen X, Draper JS, et al. Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc Natl Acad Sci USA 2003;100:13350-5
   PubMed Web of Science ®Google Scholar
• Yusenko MV, Kuiper RP, Boethe T, et al. High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomas. BMC Cancer 2009;9:152
   PubMed Web of Science ®Google Scholar
• Qin X, Yue Z, Sun B, et al. Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels. Br J Pharmacol 2013;168:1294-312
   PubMedGoogle Scholar
• Gong YZ, Ding WG, Wu J, et al. Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase. Eur J Pharmacol 2008;600:18-25
   PubMedGoogle Scholar
• Hatton CJ, Peers C. Multiple effects of nordihydroguaiaretic acid on ionic currents in rat isolated type I carotid body cells. Br J Pharmacol 1997;122:923-9
   PubMedGoogle Scholar
• Korn SJ, Horn R. Nordihydroguaiaretic acid inhibits voltage-activated Ca2+ currents independently of lipoxygenase inhibition. Mol Pharmacol 1990;38:524-30
   PubMed Web of Science ®Google Scholar
• Mastrocola T, De Luca M, Rugolo M. Characterization of chloride transport pathways in cultured human keratinocytes. Biochim Biophys Acta 1991;1097:275-82
   PubMedGoogle Scholar
• Parnas M, Peters M, Dadon D, et al. Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels. Cell Calcium 2009;45:300-9
   PubMed Web of Science ®Google Scholar
• Chubanov V, Mederos y Schnitzler M, Meissner M, et al. Natural and synthetic modulators of SK (K(ca)2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7. Br J Pharmacol 2012;166:1357-76
   PubMedGoogle Scholar
• TCGA (The Cancer Genome Atlas). Available from: http://tcga-data.nci.nih.gov/tcga/
   Google Scholar
• Rohacs T, Lopes CM, Michailidis I, Logothetis DE. PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain. Nat Neurosci 2005;8:626-34
   PubMed Web of Science ®Google Scholar