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Original Research

Decrease of phosphorylated proto-oncogene CREB at Ser 133 site inhibits growth and metastatic activity of renal cell cancer

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Bibliography

  • Rini B I, Campbell SC, Escudier B. Renal cell carcinoma. Lancet 2009;373(9669):1119-32
  • Cheung C W, Vesey D A, Nicol D L, et al. The roles of IGF-I and IGFBP-3 in the regulation of proximal tubule, and renal cell carcinoma cell proliferation. Kidney Int 2004;65(4):1272-9
  • Sun M, Lughezzani G, Perrotte P, et al. Treatment of metastatic renal cell carcinoma. Nat Rev Urol 2010;7(6):327-38
  • Gonzalez GA, Montminy MR. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 1989;59(4):675-80
  • Sakamoto KM, Frank DA. CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy. Clin Cancer Res 2009;15(8):2583-7
  • Shaywitz AJ, Greenberg ME. CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 1999;68:821-61
  • Abramovitch R, Tavor E, Jacob-Hirsch J, et al. A pivotal role of cyclic AMP-responsive element binding protein in tumor progression. Cancer Res 2004;64(4):1338-46
  • Son J, Lee JH, Kim HN, et al. cAMP-response-element-binding protein positively regulates breast cancer metastasis and subsequent bone destruction. Biochem Biophys Res Commun 2010;398(2):309-14
  • Seo H S, Liu D D, Bekele B N, et al. Cyclic AMP response element-binding protein overexpression: a feature associated with negative prognosis in never smokers with non-small cell lung cancer. Cancer Res 2008;68(15):6065-73
  • Shankar D B, Cheng J C, Kinjo K, et al. The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia. Cancer Cell 2005;7(4):351-62
  • Kinjo K, Sandoval S, Sakamoto K M, et al. The role of CREB as a proto-oncogene in hematopoiesis. Cell Cycle 2005;4(9):1134-5
  • Kovach S J, Price J A, Shaw C M, et al. Role of cyclic-AMP responsive element binding (CREB) proteins in cell proliferation in a rat model of hepatocellular carcinoma. J Cell Physiol 2006;206(2):411-19
  • Chin K T, Zhou H J, Wong C M, et al. The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma. Nucleic Acids Res 2005;33(6):1859-73
  • Tan X, Wang S, Zhu L, et al. cAMP response element-binding protein promotes gliomagenesis by modulating the expression of oncogenic microRNA-23a. Proc Natl Acad Sci USA 2012;109(39):15805-10
  • Tan X, Wang S, Yang B, et al. The CREB-miR-9 negative feedback minicircuitry coordinates the migration and proliferation of glioma cells. PLoS ONE 2012;7(11):e49570
  • Jean D, Bar-Eli M. Regulation of tumor growth and metastasis of human melanoma by the CREB transcription factor family. Mol Cell Biochem 2000;212(1-2):19-28
  • Jean D, Bar-Eli M. Targeting the ATF-1/CREB transcription factors by single chain Fv fragment in human melanoma: potential modality for cancer therapy. Crit Rev Immunol 2001;21(1-3):275-86
  • Wang P, Xu J, Zhang C. CREB, a possible upstream regulator of Bcl-2 in trichosanthin-induced HeLa cell apoptosis. Mol Biol Rep 2010;37(4):1891-6
  • Wang P, Yan H, Li JC. CREB-mediated Bcl-2 expression in trichosanthin-induced Hela cell apoptosis. Biochem Biophys Res Commun 2007;363(1):101-5
  • Wang P, Huang S, Wang F, et al. Cyclic AMP-response element regulated cell cycle arrests in cancer cells. PLoS One 2013;8(6):e65661
  • Lai C Y, Pan B, Luo Y, et al. Engrailed-2 is down-regulated but also ectopically expressed in clear cell renal cell carcinoma. Mol Biol Rep 2014;41(6):3651-7
  • Richards J P, Bachinger H P, Goodman R H, et al. Analysis of the structural properties of cAMP-responsive element-binding protein (CREB) and phosphorylated CREB. J Biol Chem 1996;271(23):13716-23
  • Huang S, Ren Y, Wang P, et al. Transcription factor CREB is involved in CaSR-mediated cytoskeleton gene expression. Anat Rec (Hoboken), 2015;298(3):501-12
  • Pfeifer A, Kessler T, Silletti S, et al. Suppression of angiogenesis by lentiviral delivery of PEX, a noncatalytic fragment of matrix metalloproteinase 2. Proc Natl Acad Sci USA 2000;97(22):12227-32
  • Keshamouni VG, Reddy RC, Arenberg DA, et al. Peroxisome proliferator-activated receptor-gamma activation inhibits tumor progression in non-small-cell lung cancer. Oncogene 2004;23(1):100-8
  • Zhong Z, Yeow W S, Zou C, et al. Cyclin D1/cyclin-dependent kinase 4 interacts with filamin A and affects the migration and invasion potential of breast cancer cells. Cancer Res 2010;70(5):2105-14
  • Zhao K, Wang W, Guan C, et al. Inhibition of gap junction channel attenuates the migration of breast cancer cells. Mol Biol Rep 2012;39(3):2607-13
  • Wang P, Li JC. Trichosanthin-induced specific changes of cytoskeleton configuration were associated with the decreased expression level of actin and tubulin genes in apoptotic Hela cells. Life Sci 2007;81(14):1130-40
  • Cheng J C, Kinjo K, Judelson D R, et al. CREB is a critical regulator of normal hematopoiesis and leukemogenesis. Blood 2008;111(3):1182-92
  • Aggarwal S, Kim S W, Ryu S H, et al. Growth suppression of lung cancer cells by targeting cyclic AMP response element-binding protein. Cancer Res 2008;68(4):981-8
  • Yoon S O, Park S J, Yun C H, et al. Roles of matrix metalloproteinases in tumor metastasis and angiogenesis. J Biochem Mol Biol 2003;36(1):128-37
  • John A, Tuszynski G. The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis. Pathol Oncol Res 2001;7(1):14-23
  • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009;119(6):1420-8
  • Zong H, Yin B, Zhou H, et al. Inhibition of mTOR pathway attenuates migration and invasion of gallbladder cancer via EMT inhibition. Mol Biol Rep 2014;41(7):4507-12
  • Chang L, Goldman RD. Intermediate filaments mediate cytoskeletal crosstalk. Nat Rev Mol Cell Biol 2004;5(8):601-13
  • Tarin D, Thompson EW, Newgreen DF. The fallacy of epithelial mesenchymal transition in neoplasia. Cancer Res 2005;65(14):5996-6000; discussion 6000-5991
  • Hu L, Lau S H, Tzang C H, et al. Association of Vimentin overexpression and hepatocellular carcinoma metastasis. Oncogene 2004;23(1):298-302
  • Huang J F, Guo Y J, Zhao C X, et al. Hepatitis B virus X protein (HBx)-related long noncoding RNA (lncRNA) down-regulated expression by HBx (Dreh) inhibits hepatocellular carcinoma metastasis by targeting the intermediate filament protein vimentin. Hepatology 2013;57(5):1882-92
  • Kong W Q, Bai R, Liu T, et al. MicroRNA-182 targets cAMP-responsive element-binding protein 1 and suppresses cell growth in human gastric adenocarcinoma. FEBS J 2012;279(7):1252-60
  • Li L, Gao Y, Zhang L L, et al. Concomitant activation of the JAK/STAT3 and ERK1/2 signaling is involved in leptin-mediated proliferation of renal cell carcinoma Caki-2 cells. Cancer Biol Ther 2008;7(11):1787-92
  • Arany I, Megyesi J K, Reusch J E, et al. CREB mediates ERK-induced survival of mouse renal tubular cells after oxidant stress. Kidney Int 2005;68(4):1573-82
  • Yamaguchi H, Wyckoff J, Condeelis J. Cell migration in tumors. Curr Opin Cell Biol 2005;17(5):559-64
  • Mattila PK, Lappalainen P. Filopodia: molecular architecture and cellular functions. Nat Rev Mol Cell Biol 2008;9(6):446-54
  • Agarwal N, Adhikari A S, Iyer S V, et al. MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4. Oncogene 2013;32(4):462-70
  • Wood W, Martin P. Structures in focus-filopodia. Int J Biochem Cell Biol 2002;34(7):726-30
  • Wolff K, Barrett-Freeman C, Evans M R, et al. Modelling the effect of myosin X motors on filopodia growth. Phys Biol 2014;11(1):016005
  • Dasgupta S, Cushman I, Kpetemey M, et al. Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis. J Biol Chem 2011;286(29):25935-46
  • Schafer C, Borm B, Born S, et al. One step ahead: role of filopodia in adhesion formation during cell migration of keratinocytes. Exp Cell Res 2009;315(7):1212-24
  • Xue F, Janzen DM, Knecht DA. Contribution of filopodia to cell migration: a mechanical link between protrusion and contraction. Int J Cell Biol 2010;2010:507821
  • Micalizzi D S, Farabaugh SM, Ford HL. Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia 2010;15(2):117-34
  • Sakamoto K, Huang B W, Iwasaki K, et al. Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271. Mol Biol Cell 2010;21(16):2966-74

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