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Miscellaneous

Connective tissue growth factor: an attractive therapeutic target in fibrotic renal disease

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Pages 519-530 | Published online: 25 Feb 2005

Bibliography

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  • ••First study of the expression of CTGF inthe diseased kidney.
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  • •Key paper establishing the role of TGF-in diabetes.
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  • ••A key paper demonstrating that targetingTGF- p could be a therapeutic strategy.
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  • •First isolation of human CTGE
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  • ••Important paper establishing that CTGFexpression is at least partly under the control of a TGF- p response element in the CTGF promoter.
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  • •A nice review of the role of integrins as receptors for the CCN family.
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  • •Paper establishing CTGF as a marker in fibrotic skin disease and identifying it as a putative therapeutic target.
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  • WENGER C, ELLENRIEDER V, ALBER B et al.: Expression and differential regulation of connective tissue growth factor in pancreatic cancer cells. Oricogerie (1999) 18(4):1073–1080.
  • DI MOLA FF, FRIESS H, MARTIGNONI ME et al: Connective tissue growth factor is a regulator for fibrosis in human chronic pancreatitis. Ann. Surg. (1999) 230(1):63–71.
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  • ITO Y, GOLDS CHMEDING R, BENDE R et al: Kinetics of connective tissue growth factor expression during experimental proliferative glomerulonephritis. I Am. Soc. Nephrol (2001) 12(3):472–84.
  • ••Another excellent paper looking at thekinetics of CTGF expression in an animal model of glomerulonephritis.
  • FRAZIER KS, PAREDES A, DUBE P, STYER E: Connective tissue growth factor expression in the rat remnant kidney model and association with tubular epithelial cells undergoing transdifferentiation. Vet. Pathol (2000) 37(4):328–335.
  • RISER BL, DENICHILO M, CORTES P et al.: Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis. Am. Soc. Nephrol. (2000) 11(1):25–38.
  • HISHIKAWA K, OEMAR BS, NAKAKI T: Static pressure regulates connective tissue growth factor expression in human mesangial cells. I Biol. Chem. (2001) fepub ahead of print I.
  • HAHN A, HEUSINGER-RIBEIRO J, LANZ T, ZENKEL S, GOPPELT-STREUBE M: Induction of connective tissue growth factor by activation of heptahelical receptors; modulation by Rho proteins and the actin cytoskeleton. _J. Biol. Chem. (2000) 275(48):37429–37435.
  • SHAKUNAGA T, OZAKI T, OHARA N et al.: Expression of connective tissue growth factor in cartilaginous tumors. Cancer (2000) 89(7):1466–1473.
  • DUNCAN MR, FRAZIER KS, ABRAMSON S et al.: Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP. FASEBI (1999) 13(13):1774–1786.
  • NAKANISHI T, NISHIDA T, SHIMO T et al: Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture. Endocrinology (2000) 141(1):264–273.

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