Bibliography
- GOLDSTEIN LB: Medical therapy for acute ischemic stroke. Carr: Atherosclec Rep. (2001) 3:299–306.
- DIRNAGL H, IADECOLA C, MOSKOWITZ MA: Pathobiology of ischemic stroke: an integrated view. Trends Neurosci (1999) 22:391–397.
- WHITE BC, SULLIVAN JM, DEGRACIA DJ et al.: Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. Neurol Sci (2000) 179(S1-2):1–33.
- NEUMAR RW: Molecular mechanisms of ischemic neuronal injury. Ann. Emerg. Med. (2000) 36:483–506.
- CONN PJ, PIN JP: Pharmacology and functions of metabotropic glutamate receptors. Anna. Rev Pharmacol Toxicol (1997) 37:205–237.
- BOCKAERT J, PIN JP: Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J. (1999) 18:1723–1729.
- PARMENTIER ML, PIN JP, BOCKAERTJ, GRAU Y: Cloning and functional expression of a Drosophila metabotropic glutamate receptor expressed in the embryonic CNS. Neurosci. (1996) 16:6687–6694.
- ALBANI-TORREGROSSA S, ATTUCCI S, MARINOZZI M, PELLICCIARI R, MORONI F, PELLEGRINI-GIAMPIETRO DE: Antagonist pharmacology of metabotropic glutamate receptors coupled to phospholipase D activation in adult rat hippocampus: focus on (2R,1'S,2'R,3'S)-2-(2'-carboxy-3'-phenylcyclopropyflglycine versus 2,3-dihydroxyphenylglycine. Mol. Pharmacol (1999) 55:699–707.
- BOSS VK, CONN PJ: Metabotropic excitatory amino acid receptor activation stimulates phospholipase D in hippocampal slices. Neurochem. (1992) 59:2340–2343.
- BOSS VK, NUTT M, CONN PJ: L-cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to phospholipase D activity. Ma Phannacol (1994) 45:1177–1182.
- MASU M, TANABE Y, TSUCHIDA K, SHIGEMOTO R, NAKANISHI S: Sequence and expression of a metabotropic glutamate receptor. Nature (1991) 349:760–765.
- NAKANISHI S: Molecular diversity of glutamate receptors and implications for brain function. Science (1992) 258:597–603.
- ROMANO C, YANG WL, O'MALLEY K:Metabotropic glutamate receptor 5 is a disulfide-linked dimer. I Biol. Chem. (1996) 271:28612–28616.
- O'HARA PJ, SHEPPARD PO, THOGERSEN H et al: The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins. Neuron (1993) 11:41–52.
- TAKAHASHI K, TSUCHIDA K, TANABE Y, MASU M, NAKANISHI S: Role of the large extracellular domain of metabotropic glutamate receptors in agonist selectivity determination. J. Biol. Chem. (1993) 268:19341–19345.
- SHIGEMOTO R, ABET, NOMURA S, NAKANISHI S, HIRANO T: Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells. Neuron (1994) 12:1245–1255.
- OKAMOTO T, SEKIYAMA N, OTSU M et al.: Expression and purification of the extracellular ligand binding region of metabotropic glutamate receptor subtype 1. J. Biol. Chem. (1998) 273:13089–13096.
- MAO B, PEAR MR, MCCAMMON JA, QUIOCHO FA: Hinge-bending in L-arabinose-binding protein. The "Venus's-flytrap" model. J. Biol. Chem. (1982) 257:1131–1133.
- GALVEZ T, PARMENTIER ML, JOLY Cet al.: Mutagenesis and modeling of the GABAB receptor extracellular domain support a venus flytrap mechanism for ligand binding. J. Biol. Chem. (1999) 274:13362–13369.
- COSTANTINO G, PELLICCIARI R: Homology modeling of metabotropic glutamate receptors. (mGluRs) structural motifs affecting binding modes and pharmacological profile of mGluR1 agonists and competitive antagonists. J. Med. Chem (1996) 39:3998–4006.
- COSTANTINO G, MACCHIARULO A, PELLICCIARI R: Modeling of amino-terminal domains of group I metabotropic glutamate receptors: structural motifs affecting ligand selectivity. Med. Chem (1999) 42:5390–5401.
- COSTANTINO G, MACCHIARULO A, PELLICCIARI R: Homology model of the closed, functionally active, form of the amino terminal domain of mGluRl. Bioorg. Med. Chem. (2001) 9:847–852.
- BESSIS AS, BERTRAND HO, GALVEZ T, DE COLLE C, PIN JP, ACHER F: Three-dimensional model of the extracellular domain of the type 4a metabotropic glutamate receptor: new insights into the activation process. Protein Sci (2000) 9:2200–2209.
- JENSEN AA, SHEPPARD PO, O'HARA PJ, KROGSGAARD-LARSEN P, BRAUNER-OSBORNE H: The role of Arg(78) in the metabotropic glutamate receptor mG1u(1) for agonist binding and selectivity. Eur: J Pharmacol (2000) 397:247–253.
- HAMPSON R, HUANG XP, PEKHLETSKI et al: Probing the ligand-binding domain of the mGluR4 subtype of metabotropic glutamate receptor. J. Biol. Chem. (1999) 274:33488–33495.
- COSTANTINO G, NATALINI B, PELLICCIARI R, MORONI F, LOMBARDI G: Definition of a pharmacophore for the metabotropic glutamate receptors negatively linked to adenylyl cyclase. Bioorg. Med. Chem. (1993) 1:259–265.
- COSTANTINO G, MACCHIARULO A, PELLICCIARI R: Pharmacophore models of group I and group II metabotropic glutamate receptor agonists. Analysis of conformational, steric, and topological parameters affecting potency and selectivity. J. Med. Chem. (1999) 42:2816–2827.
- JULLIAN N, BRABET I, PIN F, ACHER FC: Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation. J. Med. Chem. (1999) 42:1546–1555.
- BESSIS AS, JULLIAN N, COUDERT E,PIN JP, ACHER F: Extended glutamate activates metabotropic receptor types 1, 2 and 4: selective features at mGluR4 binding site. Neuropharmacology (1999) 38:1543–1551.
- KUNISHIMA N, SHIMADA Y, TSUJI Y et al: Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature (2000) 407:971–977.
- ROMANO C, MILLER JK, HYRC K et al.: Covalent and noncovalent interactions mediate metabotropic glutamate receptor mG1u5 dimerization. MM. Pharmacoi (2001) 59:46–53.
- DE BLASI A, CONN PJ, PIN J, NICOLETTI F: Molecular determinants of metabotropic glutamate receptor signaling. Trends Pharmacol Sci (2001) 22:114–120.
- ANGO F, PREZEAU L, MULLER T et al: Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein homer. Nature (2001) 411:962–965.
- CHOI DW: Calcium: still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci. (1995) 18:58–60.
- LUTSEP HL, CLARK WM: Neuroprotection in acute ischaemic stroke. Current status and future potential. Drugs R &D. (1999) 1:3–8.
- NICOLETTI F, BRUNO V, COPANI A,CASABONA G, KNOPFEL T: Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? Trends Neurosci. (1996) 19:267–271.
- BRUNO V, BATTAGLIA G, KINGSTON A et al.: Neuroprotective activity of the potent and selective mGlul a metabotropic glutamate receptor antagonist, (+)-2-methy1-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlul a and mG1u5 receptors. Neuropharmacology(1999) 38:199–207.
- FERRAGUTI F, PIETRA C, VALERIO E, CORTI C, CHIAMULERA C, CONQUET F: Evidence against a permissive role of the metabotropic glutamate receptor 1 in acute excitotoxicity. Neuroscience (1997) 79:1–5.
- PIZZI M, BORONI F, BIANCHETTI KM, MEMO M, SPANO P: Reversal of glutamate excitotoxicity by activation of PKC-associated metabotropic glutamate receptors in cerebellar granule cells relies on NR2C subunit expression. Eut: I Neurosci. (1999) 11:2489–2496.
- CHAVIS P, FAGNI L, LANSMAN JB, BOCKAERT J: Functional coupling between ryanodine receptors and L-type calcium channels in neurons. Nature (1996) 382:719–722.
- STRASSER U, LOBNER D, BEHRENS MM, CANZONIERO LM, CHOI DW: Antagonists for group I mGluRs attenuate excitotoxic neuronal death in cortical cultures. Eut: Neurosci (1998) 10:2848–2855.
- MORISHITA W, KIROV SA, ALGER BE: Evidence for metabotropic glutamate receptor activation in the induction of depolarization-induced suppression of inhibition in hippocampal CA 1. I Neurosci (1998) 18:4870–4882.
- BRUNO V, BATTAGLIA G, COPANI A etal.: An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors. Eut: Neurosci. (2001) 13:1469–1478.
- EATON SA, JANE DE, JONES PL et al:Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methy1-4-carboxyphenylglycine. Eut: Pharmacol (1993) 244:195–197.
- PELLICCIARI R, LUNEIA R, COSTANTINO G et al.: 1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors. Med. Chem. (1995) 38:3717–3719.
- PELLICCIARI R, RAIMONDO M, MARINOZZI M, NATALINI B, COSTANTINO G, THOMSEN C: (5)-(-0-2- (3'-carboxybicyclo [1.1.11penty1)-glycine, a structurally new group I metabotropic glutamate receptor antagonist. Med. Chem. (1996) 39:2874–2876.
- CLARK BP, BAKER SR, GOLDSWOTHYJ, HARRIS JR, KINGSTON AE: (+)-2-Methyl-4-carboxyphenylglycine (LY367385) selectively antagonises metabotropic glutamate receptors. Bioorg. Med. Chem. Lett. (1997) 7:2777–2780.
- DOHERTY AJ, PALMER MJ, HENLEY JM, COLLINGRIDGE GL, JANE DE: (RS)-2-chloro-5 hydroxyphenylglycine (CHPG) activates mG1u5, but no mGlul, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology (1997) 36 :265–267.
- LITSCHIG S, GASPARINI F, RUEEGG D et al.: CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding. MM. Pharmacol (1999) 55:453–461.
- GASPARINI F, LINGENHOHL K, STOEHR N et al.: 2-Methy1-6-(phenylethyny1)-pyridine (MPEP), a potent, selective and systemically active mG1u5 receptor antagonist. Neuropharmacology (1999) 38:1493–1503.
- VARNEY MA, COSFORD ND, JACHEC C et al: SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5. J. Pharmacol Exp. Ther. (1999) 290:170–181.
- CARROLL FY, STOLLE A, BEART PM etal.: BAY36-7620: a potent non-competitive mGlul receptor antagonist with inverse agonist activity. Mot. Pharmacol (2001) 59:965–973.
- PAGANO A, RUEGG D, LITSCHIG S et al.: The non-competitive antagonists 2-methyl-6- (phenylethynyOpyridine and 7-hydroxyimino cyc lopropa n [b] c hro m e n- 1 a - carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate receptors. j. Biol. Chem. (2000) 275:33750–33758.
- OTT D, FLOERSHEIM P, INDERBITZIN W et al.: Chiral resolution, pharmacological characterization, and receptor docking of the noncompetitive mGlul receptor antagonist (+1-) 2 hydroxyimino-1a, 2-dihydro-1H-7- oxacyclopropa [b] naphthalene-7a-carboxylic acid ethyl ester. Med. Chem. (2000) 43:4428–4436.
- PELLEGRINI-GIAMPIETRO DE, COZZI A, PERUGINELLI F et al.: 1-Aminoindan-1, 5-dicarboxylic acid and (S)-(+)-2-(3'-carboxybicyclo [1 .1.11 penty1)-glycine, two mGlul receptor-preferring antagonists, reduce neuronal death in vitro and in vivo models of cerebral ischaemia. Eur: I Neurosci. (1999) 11:3637–3647.
- KINGSTON AE, O'NEILL MJ, BOND A et al.: Neuroprotective actions of novel and potent ligands of group I and group II metabotropic glutamate receptors. Ann. NY Acad. ScL (1999) 890:438–449.
- RAO AM, HATCHER JF, DEMPSEY RJ: Neuroprotection by group I metabotropic glutamate receptor antagonists in forebrain ischemia of gerbil. NeuroscL Lett. (2000) 293:1–4
- BATTAGLIA G, BRUNO V, PISANI A et al.: Selective blockade of type-1 metabotropic glutamate receptors induces neuroprotection by enhancing gabaergic transmission. MM. Cell Neurosci. (2001) 17:1071–1083.
- ALLEN JW, VICINI S, FADEN Al: Exacerbation of neuronal cell death by activation of group I metabotropic glutamate receptors: role of NMDA receptors and arachidonic acid release. Exp. Neurol (2001) 169:449–460.
- COZZI A, ATTUCCI S, PERUGINELLI F et al.: Type 2 metabotropic glutamate (mG1u) receptors tonically inhibit transmitter release in rat caudate nucleus: in vivo studies with (2S,l'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a new potent and selective antagonist. Eur: NeuroscL (1997) 9:1350–1355.
- ISHIDA M, SAITOH T, SHIMAMOTO K, OHFUNE Y, SHINOZAKI H: A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the new-born rat isolated spinal cord. ELI Pharmacol (1993) 109:1169–1177.
- PELLICCIARI R, MARINOZZI M, NATALINI B et al: Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,l'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist. Med. Chem. (1996) 39: 2259–2269.
- KOZIKOWSKI AP, STEENSMA D, ARALDI GL et al: Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist. Med. Chem. (1998) 41:1641–1650.
- MONN JA, VALLI MJ, MASSEY SM et al.: Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo [3.1.01hexane- 2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties. Med. Chem. (1997) 40:528–537.
- MONN JA, VALLI MJ, MASSEY SM et al.: Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+) -2 -aminobicyclo [3.1.01hexane- 2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors. Med. Chem. (1999) 42:1027–1040.
- ORNSTEIN PL, BLEISCH TJ, ARNOLD MB, WRIGHT RA, JOHNSON BG, SCHOEPP DD: 2-Substituted (2512)-2-amino-2-((1SR,25R)-2-carboxycycloprop-1-yOglycines as potent and selective antagonists of group II metabotropic glutamate receptors. 1. Effects of alkyl, arylalkyl, and diarylalkyl substitution. Med. Chem. (1998) 41:346–357.
- WROBLEWSKA B, WROBLEWSKI JT, SAAB OH, NEALE JH: N-acetylaspartylglutamate inhibits forskolin-stimulated cyclic AMP levels via a metabotropic glutamate receptor in cultured cerebellar granule cells. Neurochem. (1993) 61:943–948.
- BOND A, O'NEILL MJ, HICKS CA, MONN JA, LODGE D: Neuroprotective effects of a systemically active group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischaemia. Neuroreport (1998) 9:1191–1193.
- LAM AG, SORIANO MA, MONN JA,SCHOEPP DD, LODGE D, MCCULLOCH J: Effects of the selective metabotropic glutamate agonist LY354740 in a rat model of permanent ischaemia. NeuroscL Lett. (1998) 254:121–123.
- BOND A, RAGUMOORTHY N, MONN JA et al: LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia. NeuroscL Lett. (1999) 273:191–194.
- KINGSTON AE, O'NEILL MJ, LAM A, BALES KR, MONN JA, SCHOEPP DD: Neuroprotection by metabotropic glutamate receptor glutamate receptor agonists: LY354740, LY379268 and LY389795. Eur: Pharmacol (1999) 377:155–165.
- BRUNO V, BATTAGLIA G, CASABONA G, COPANI A, CACIAGLI F, NICOLETTI F: Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta. NeuroscL (1998) 18:9594–9600.
- BOND A, JONES NM, HICKS CA et Neuroprotective effects of LY379268, a selective mG1u2/3 receptor agonist: investigations into possible mechanism of action in vivo. Pharmacol Exp. The]: (2000) 294:800–809.
- JACKSON PF, SLUSHER BS: Design of naaladase inhibitors: a novel neuroprotective strategy. Curr: Med. Chem. (2001) 8:949–957.
- SLUSHER BS, VORNOV JJ, THOMAS AG et al: Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury. Nat. Med. (1999) 5:1396–1402.
- LU XM, TANG Z, LIU W, LIN Q, SLUSHER BS: N-acetylaspartylglutamate protects against transient focal cerebral ischemia in rats. Eur: Pharmacol (2000) 408:233–239.
- DE COLLE C, BESSIS AS, BOCKAERT J, ACHER F, PIN JP: Pharmacological characterization of the rat metabotropic glutamate receptor type 8a revealed strong similarities and slight differences with the type 4a receptor. Eur: Pharmacol. (2000) 394:17–26.
- GERLAI R, RODER JC, HAMPSON DR: Altered spatial learning and memory in mice lacking the mGluR4 subtype of metabotropic glutamate receptor. Behav. Neurosci. (1998) 112:525–532.
- LI H, OHISHI H, KINOSHITA A, SHIGEMOTO R, NOMURA S, MIZUNO N: Localization of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive, primary afferent fibers in the superficial layers of the spinal dorsal horn: an electron microscope study in the rat. Neurosci. Lett. (1997) 223:153–156.
- ACHER FC, TELLIER FJ, AZERAD R, BRABET IN, FAGNI L, PIN JP: Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes.J. Med. Chem. (1997) 40:3119–3129.
- AMORI L, COSTANTINO G, MARINOZZI M et al.: Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene- 1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III. Bioorg. Med. Chem. Lett. (2000) 10:1447–1450.
- TOMS NJ, JANE DE, KEMP MC, BEDINGFIELD JS, ROBERTS PJ: The effects of (RS)-alpha cyclopropy1-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist. Br. J. PharmacoL 119: 851–854.
- GASPARINI F, INDERBITZIN W, FRANCOTTE E et al: (+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist. Bioorg. Med. Chem. Lett. (2000) 10:1241–1244.
- THOMAS NK, WRIGHT RA, HOWSON PA, KINGSTON AE, SCHOEPP DD, JANE DE: (S)-3,4-DCPG, a potent and selective mG1u8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology (2001) 40:311–318.
- BRUNO V, COPANI A, BONANNO L et al.: Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures. Ear: Pharmacol (1996) 310:61–66.
- BRUNO V, BATTAGLIA G, KSIAZEK I et al: Selective activation of mG1u4 metabotropic glutamate receptors is protective against excitotoxic neuronal death. " Neurosci. (2000) 20:6413–6420.
- SABELHAUS CF, SCHRODER UH, BREDER J, HENRICH-NOACK P, REYMANN KG: Neuroprotection against hypoxic/hypoglycaemic injury after the insult by the group III metabotropic glutamate receptor agonist (R, 5)-4-phosphonophenylglycine. Br. J. PharmacoL (2000) 131:655–658.
- BHAVE G, KARIM F, CARLTON SM, GEREAU RW, 4th: Peripheral group I metabotropic glutamate receptors modulate nociception in mice. Nat. Neurosci. (2001) 4:417–423.
- KARIM F, WANG CC, GEREAU RW, 4th: Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice. J. Neurosci. (2001) 21:3771–3779.
- FUNDYTUS ME, YASHPAL K, CHABOT JG et al: Knockdown of spinal metabotropic glutamate receptor 1 (mGluR(1)) alleviates pain and restores opioid efficacy after nerve injury in rats. Br: J. Pharmacol (2001) 132:354–367.
- WALKER K, BOWES M, PANESAR M et al: Metabotropic glutamate receptor subtype 5 (mG1u5) and nociceptive function. I. Selective blockade of mG1u5 receptors in models of acute, persistent and chronic pain. Neuropharmacology (2001) 40:1–9.
- WALKER K, REEVE A, BOWES M et mG1u5 receptors and nociceptive function II. mG1u5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia. Neuropharmacology (2001) 40:10–19.
- BORDI F, UGOLINI A: Involvement of mGluR(5) on acute nociceptive transmission. Brain Res. (2000) 871:223–233.
- HELTON DR, TIZZANO JP, MONN JA, SCHOEPP DD, KALLMAN MJ: Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors. " Pharmacol Exp. Ther. (1998) 284: 651–660.
- MOGHADDAM B, ADAMS BW: Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science (1998) 281:1349–1352.
- WONG CG, SCHERER SW, SNEAD OC 3, HAMPSON DR: Localization of the human mGluR4 gene within an epilepsy susceptibility locus (1). Brain Res. MoL Brain Res. (2001) 87:109–116.
- LIE AA, BECKER A, BEHLE K et al: Up-regulation of the metabotropic glutamate receptor mGluR4 in hippocampal neurons with reduced seizure vulnerability. Ann. Neural. (2000) 47:26–35.
- MOLDRICH RX, TALEBI A, BEART PM, CHAPMAN AG, MELDRUM BS: The mG1u(2/3) agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate, is anti-and proconvulsant in DBA/2 mice. Neurosci. Lett. (2001) 299:125–129.
- YIP PK, MELDRUM BS, RATTRAY M: Elevated levels of group-III metabotropic glutamate receptors in the inferior colliculus of genetically epilepsy-prone rats following intracollicular administration of L-serine-0-phosphate. J. Neurochem. (2001) 78:13–23.
Websites
- www.strokecenter.org A web resource for information about stroke care and research.
- www.stroke.org National stroke association.
- www.strokecenter.orgitrials Stroke trials directory.