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Editorial

Neuronal nicotinic acetylcholine receptors as drug targets

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Pages 61-64 | Published online: 02 Mar 2005

Bibliography

  • ARIAS HR: Binding sites for exogenous and endogenous non-competitive inhibitors of the nicotinic acetylcholine receptor. Biochim. Biophys. Acta (1998) 1376:173–220.
  • KARLIN A: Emerging structure of the nicotinic acetylcholine receptors. Nat. Rev Neurosci. (2002) 3:102–114.
  • PATERSON D, NORDBERG A: Neuronal nicotinic receptors in the human brain. Frog. Neurobiol (2000) 61:75–111.
  • LEVIN ED, SIMON BB: Nicotinic acetylcholine involvement in cognitive function in animals. Psychopharmacology (1998) 138:217–230.
  • SACAAN Al, DUNLOP JL, LLOYD GK: Pharmacological characterization of neuronal acetylcholine gated ion channel receptor-mediated hippocampal norepinephrine and striatal dopamine release in rat brain slices. J. Phannacol Exp. Thec (1995) 274:224–230.
  • ELENES S, AUERBACH A: Densensitization of diliganded mouse muscle nicotinic acetylcholine receptor channels. J. Physiol (2002) 541:367–383.
  • HOLLADAY MW, DART MJ, LYNCH JK: Neuronal nicotinic acetylcholine receptors as targets for drug discovery. J. Med. Chem. (1997) 40:4169–4194.
  • GENTRY CL, LUKAS RJ: Regulation of nicotinic acetylcholine receptor numbers and function by chronic nicotine exposure. CUIT. Drug Target. CNS Neurol Disord (2002) 1:359–385.
  • ASTLES PC, BAKER SR, BOOT JR, BROAD LM, DELL CP, KEENAN M: Recent progress in the development of subtype selective nicotinic acetylcholine receptor ligands. Can: Drug Target. CNS Nemo]. Disord. (2002) 1:337–348.
  • •Recent review illustrating structures and progress in the area of small-molecule modulators.
  • LLOYD GK, WILLIAMS M: Neuronal nicotinic acetylcholine receptors as novel drug targets. I Pharmacol Exp. Thec (2000) 292:461–467.
  • •Review on the potential of nAChRs in drug discovery.
  • LEVIN ED, CHRISTOPHER NC: Persistence of nicotinic agonist RJR 2403-induced working memory improvement in rats. Drug Dev. Res. (2002) 55:97–103.
  • SAHAKIAN B, JONES G, KEVY R, GRAY J, WARBURTON D: The effects of nicotine on attention, information processing, and short term memory in patients with dementia of the Alzheimer type. Br: J. Psychiatry (1989) 154:797–800.
  • PICCIOTTO MR, ZOLI M, LENA C et al: Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature (1995) 374:65–67.
  • MARUBIO LM, DEL MAR ARROYO-JIMENEZ M, CORDERO-ERAUSQUIN M et al: Reduced antinociception in mice lacking neuronal nicotinic receptor subunits. Nature (1999) 398:805–810.
  • PABREZA LA, DHAWAN S, KELLAR KJ: PHIcydsine binding to nicotinic cholinergic receptors in brain. Ma Pharmacol (1991) 39:9–12.
  • WEILAND S, BERTRAND D, LEONARD S: Neuronal nicotinic acetylcholine receptors: from the gene to the disease. Behav. Brain Res. (2000) 113:43–56.
  • DECKER MW, MEYER MD, SULLIVAN JP: The therapeutic potential of nicotinic acetylcholine receptor agonists for pain control. Expert Opin. Investig. Drugs (2001) 10:1819–1830.
  • SPANDE TF, GARRAFFO HM, YEH HJ, PANNELL LK, DALY JW: A new class of alkaloids from a dendrobatid poison frog: a structure for alkaloid 251F. J. Am. Chem. Soc. (1992) 114:3475–3478.
  • BITNER RS, NIKKEL AL, CURZON P et al.: Reduced nicotinic receptor-mediated antinociception following in vivo antisense knock-down in rat. Brazil Res. (2000) 871:66–74.
  • BREJC K, VAN DIJK WJ, KLAASSEN RV et al.: Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature (2001) 411:269–276.
  • ••Publication describing the snailAChBP crystal structure, which has served as the basis for recent nAChR homology models.
  • BUNNELLE WH, DECKER MW: Neuronal nicotinic acetylcholine receptor ligands as potential analgesics. Expert Opin. The]: Patents (2003) 13:1003–1021.
  • •A review covering the use of nAChR small molecules in the treatment of pain.
  • BENCHERIF M, SCHMITT JD: Targeting neuronal nicotinic receptors: a path to new therapies. Curt: Drug Target. CNS Nemo]. Disord. (2002) 1:349–357.
  • •Recent progress on new nAChR compounds and approaches.

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