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Review

HIV-1 entry inhibitors: closing the front door

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Pages 65-78 | Published online: 02 Mar 2005

Bibliography

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  • •The above two papers proved an excellent review of the challenges involved in developing antibodies that neutralise HIV-1 and/or block gp120 interactions with the entry receptor complex.
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  • •Evidence for some limited efficacy of CXCR4 blocking in vivo, which highlights the importance of viral phenotyping in selecting co-receptor antagonists.
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  • ••Evidence that CXCR4 blocking has majoreffects on the haematopoietic system, which highlights potential new uses for blocking agents, and offers a caution regarding chronic use in infected individuals.
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  • ••First demonstration that entry inhibition,by a peptide that blocks gp41 structural reorganisation required for fusion, has antiretroviral efficacy in vivo.
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  • •The above two papers demonstrate in two large Phase III studies of individuals with drug-resistant viruses, that the fusion inhibitor T-20 improves viral control when added to an otherwise optimal HAART regimen.
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  • •An excellent discussion of the complex factors that determine sensitivity to entry inhibitor agents.
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