Brain-derived neurotrophic factor as a drug target for CNS disorders

Bibliography

• BARDE YA, EDGAR D, THOENEN H: Purification of a new neurotrophic factor from mammalian brain. EMBO (1982) 1:549–553.
   PubMed Web of Science ®Google Scholar
• ERNFORS P, IBANEZ CF, EBENDAL T, OLSON L, PERSSON H: Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain. Proc. Natl. Acad. Sd. USA (1990) 87:5454–5458.
   PubMed Web of Science ®Google Scholar
• HOHN A, LEIBROCK J, BAILEY K, BARDE YA: Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature (1990) 344:339–341.
   PubMed Web of Science ®Google Scholar
• HAMBURGER V, LEVI-MONTALCINI R: Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions. J. Exp. Zool. (1949) 111:457–501.
   PubMedGoogle Scholar
• JONES KR, REICHARDT LF: Molecular cloning of a human gene that is a member of the nerve growth factor family. Proc. Nati Acad. Sd. USA (1990) 87:8060–8064.
   PubMed Web of Science ®Google Scholar
• MAISONPIERRE PC, LE BEAU MM, ESPINOSA R III et al: Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. Cenomics (1991) 10:558–568.
   Google Scholar
• ULLRICH A, SCHLESSINGER J: Signal transduction by receptors with tyrosine kinase activity. Cell (1990) 61:203–212.
   PubMed Web of Science ®Google Scholar
• COWLEY S, PATERSON H, KEMP P, MARSHALL CJ: Activation of MAPK kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. CO (1994) 77:841–852.
   Google Scholar
• KNUSEL B, RABIN SJ, HEFTI F, KAPLAN DR: Regulated neurotrophin receptor responsiveness during neuronal migrationand early differentiation. Neurosci. (1994) 14:1542–1554.
   Web of Science ®Google Scholar
• VETTER ML, MARTIN-ZANCA D, PARADA LF, BISHOP JM, KAPLAN DR: Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-7 1 by a kinase activity associated with the product of the trk proto-oncogene. Proc. Natl. Acad. Sci. USA (1991) 88:5650–5654.
   PubMed Web of Science ®Google Scholar
• OBERMEIER A, HALFTER H, WIESMULLER KH, JUNG G, SCHLESSINGER J, ULLRICH A: Tyrosine 785 is a major determinant of Trk-substrate interaction. EMBO J. (1993) 12:933–941.
   PubMed Web of Science ®Google Scholar
• YUEN EC, MOBLEY WC: Early BDNF, NT-3, and NT-4 signalling events. Exp. Neurol (1999) 159:297–308.
   PubMed Web of Science ®Google Scholar
• OBERMEIER A, LAMMERS R, WIESMULLER KH, JUNG G, SCHLESSINGER J, ULLRICH A: Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signalling complex. J. Biol. Chem. (1993) 268:22963–22966.
   PubMed Web of Science ®Google Scholar
• OHMICHI M, DECKER SJ, SALTIEL AR: Activation of phosphatidylinosito1-3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains. Neuron (1992) 9:769–777.
   PubMed Web of Science ®Google Scholar
• HANSEN MR, ZHA XM, BOK J, GREEN SH: Multiple distinct signal pathways, including an autocrine neurotrophic mechanism, contribute to the survival-promoting effect of depolarization on spiral ganglion neurons M vitro. J. Neurosci. (2001) 21:2256–2267.
   PubMed Web of Science ®Google Scholar
• MASTERS CL, SIMMS G, WEINMAN NA, MULTHAUP G, MCDONALD BL, BEYREUTHER K: Amyloid plaque core protein in Alzheimer's disease and Down's syndrome. Proc. Natl. Acad. Sci. USA (1985) 82:4245–4249.
   PubMed Web of Science ®Google Scholar
• ALZHEIMER A: Uber eine eigenartige Erkrankung der Hirnrinde. Allgemeine Zeitschrift fur Psychiatric. und Psychisch-Cerichtliche Medezin. (1907) E. Schultze, O. Sne11:146–148.
   Google Scholar
• HOLSINGER RM, SCHNARR J, HENRY P, CASTELO VT, FAHNESTOCK M: Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease. Brain Res. Ma Brain Res. (2000) 76:347–354.
   PubMedGoogle Scholar
• GARZON D, YU G, FAHNESTOCK M: A new brain-derived neurotrophic factor transcript and decrease in brain-derived neurotrophic factor transcripts 1, 2 and 3 in Alzheimer's disease parietal cortex. Neurochem. (2002) 82:1058–1064.
   PubMed Web of Science ®Google Scholar
• MICHALSKI B, FAHNESTOCK M: Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease. Brain Res. Ma Brain Res. (2003) 111:148–154.
   PubMedGoogle Scholar
• NARISAWA-SAITO M, WAKABAYASHI K, TSUJI S, TAKAHASHI H, NAWA H: Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease. Neuroreport (1996) 7:2925–2928.
   PubMed Web of Science ®Google Scholar
• FERRER I, MARIN C, REY MJ et al: BDNF and full-length and truncated TrkB expression in Alzheimer's disease. Implications in therapeutic strategies. Neuropathol Exp. Neurol (1999) 58:729–739.
   PubMed Web of Science ®Google Scholar
• CONNOR B, YOUNG D, YAN Q, FAULL RL, SYNEK B, DRAGUNOW M: Brain-derived neurotrophic factor is reduced in Alzheimer's disease. Brain Res. MM. Brain Res. (1997) 49:71–81.
   PubMedGoogle Scholar
• HOCK C, HEESE K, HULETTE C, ROSENBERG C, OTTEN U: Region-specific neurotrophin imbalances in Alzheimer's disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas. Arch. Neurol (2000) 57:846–851.
   PubMed Web of Science ®Google Scholar
• MURER MG, BOISSIERE F, YAN Q et al.: An immunohistochemical study of the distribution of brain-derived neurotrophic factor in the adult human brain, with particular reference to Alzheimer's disease. Neuroscience (1999) 88:1015–1032.
   PubMed Web of Science ®Google Scholar
• VENTRIGLIA M, BOCCHIO CL, BENUSSI L et al: Association between the BDNF 196 A/G polymorphism and sporadic Alzheimer's disease. Mol. Psychiatry (2002) 7:136–137.
   PubMed Web of Science ®Google Scholar
• KUNUGI H, UEKI A, OTSUKA M et al.:A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease. Mol. Psychiatry (2001) 6:83–86.
   PubMed Web of Science ®Google Scholar
• BAGNOLI S, NACMIAS B, TEDDE A et al.: Brain-derived neurotrophic factor genetic variants are not susceptibility factors to Alzheimer's disease in Italy. Ann. Neurol (2004) 55:447–448.
   PubMed Web of Science ®Google Scholar
• TSAI SJ, HONG CJ, LIU HC, LIU TY, HSU LE, LIN CH: Association analysis of brain-derived neurotrophic factor Va166Met polymorphisms with Alzheimer's disease and age of onset. Neuropsychobiology (2004) 49:10–12.
   PubMed Web of Science ®Google Scholar
• SALEHI A, VERHAAGEN J, DIJKHUIZEN PA, SWAAB DF: Co-localization of high-affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease. Neuroscience (1996) 75:373–387.
   PubMed Web of Science ®Google Scholar
• ALLEN SJ, DAWBARN D, ECKFORD SD et al.: Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain. Neuroscience (1994) 60:825–834.
   PubMed Web of Science ®Google Scholar
• CONNOR B, YOUNG D, LAWLOR P et al.: Trk receptor alterations in Alzheimer's disease. Brain Res. Mol. Braila Res. (1996) 42:1–17.
   PubMed Web of Science ®Google Scholar
• MURER MG, YAN Q, RAISMAN-VOZARI R: Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease. Frog. Neurobiol. (2001) 63:71–124.
   Google Scholar
• ••Outstanding review summarisingmolecular and cellular biology of BDNF, and the pathophysiological changes of BDNF and its receptor in AD and PD.
   Google Scholar
• MCALLISTER AK, KATZ LC, LO DC: Neurotrophins and synaptic plasticity. Anna. Rev Neurosci. (1999) 22:295–318.
   PubMed Web of Science ®Google Scholar
• •Interesting review reporting the effect of neurotrophins in the modulation of synaptic activity.
   Google Scholar
• TYLER WJ, ALONSO M, BRAMHAM CR, POZZO-MILLER LD: From acquisition to consolidation: on the role of brain-derived neurotrophic factor signalling in hippocampal-dependent learning. Learn. Mem. (2002) 9:224–237.
   PubMed Web of Science ®Google Scholar
• HORCH HW, KRUTTGEN A, PORTBURY SD, KATZ LC: Destabilization of cortical dendrites and spines by BDNF. Neuron (1999) 23:353–364.
   PubMed Web of Science ®Google Scholar
• •Interesting review reporting the cellular and molecular mechanism involved in BDNF modulation of synaptic activity in the hippocarnpus and learning.
   Google Scholar
• LU B, CHOW A: Neurotrophins and hippocampal synaptic transmission and plasticity. Neurosci. Res. (1999) 58:76–87.
   Web of Science ®Google Scholar
• JANKOWSKY JL, PATTERSON PH: Cytokine and growth factor involvement in long-term potentiation. Mol. Cell. Neurosci. (1999) 14:273–286.
   Web of Science ®Google Scholar
• FISCHER W, SIREVAAG A, WIEGAND SJ, LINDSAY PM, BJORKLUND A: Reversal of spatial memory impairments in aged rats by nerve growth factor and neurotrophins 3 and 4/5 but not by brain-derived neurotrophic factor. Proc. Nati Acad. Sci. USA (1994) 91:8607–8611.
   PubMed Web of Science ®Google Scholar
• PELLEYMOUNTER MA, CULLEN MJ, BAKER MB, GOLLUB M, WELLMAN C: The effects of intrahippocampal BDNF and NGF on spatial learning in aged Long Evans rats. Mol. Chem. Neuropathol. (1996) 29:211–226.
   PubMedGoogle Scholar
• MA YL, CHEN KY, WEI CL, LEE EH: Corticotropin-releasing factor enhances brain-derived neurotrophic factor gene expression to facilitate memory retention in rats. Chin. J. Physiol. (1999) 42:73–81.
   PubMed Web of Science ®Google Scholar
• CROLL SD, SURI C, COMPTON DL et al.: Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex. Neuroscience (1999) 93:1491–1506.
   PubMed Web of Science ®Google Scholar
• SCHARFMAN HE, GOODMAN JH, SOLLAS AL, CROLL SD: Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor. Exp. Neurol. (2002) 174:201–214.
   PubMed Web of Science ®Google Scholar
• ANDO S, KOBAYASHI S, WAKI H et al.:Animal model of dementia induced by entorhinal synaptic damage and partial restoration of cognitive deficits by BDNF and carnitine.f Neurosci. Res. (2002) 70:519–527.
   PubMed Web of Science ®Google Scholar
• •New model of dementia showing the beneficial effect of chronically administered adenovirus-mediated BDNF on learning and memory tasks and LTP.
   Google Scholar
• PARAIN K, MURER MG, YAN Q et al.:Reduced expression of brain-derived neurotrophic factor protein in Parkinson's disease substantia nigra. Neuroreport (1999) 10:557–561.
   PubMed Web of Science ®Google Scholar
• MOGI M, TOGARI A, KONDO T et al.:Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease. Neurosci. Lett. (1999) 270:45–48.
   PubMed Web of Science ®Google Scholar
• BENISTY S, BOISSIERE F, FAUCHEUX B, AGID Y, HIRSCH EC: trkB messenger RNA expression in normal human brain and in the substantia nigra of parkinsonian patients: an in situ hybridization study. Neuroscience (1998) 86:813–826.
   PubMed Web of Science ®Google Scholar
• TODA T, MOMOSE Y, MURATA M et al.: Toward identification of susceptibility genes for sporadic Parkinson's disease. Neurol. (2003) 250\(Suppl. 3):11140–11143.
   Google Scholar
• HONG CJ, LIU HC, LIU TY, LIN CH,CHENG CY, TSAI SJ: Brain-derived neurotrophic factor (BDNF) Va166Met polymorphisms in Parkinson's disease and age of onset. Neurosci. Lett. (2003) 353:75–77.
   PubMed Web of Science ®Google Scholar
• HAKANSSON A, MELKE J, WESTBERG L et al.: Lack of association between the BDNF Va166Met polymorphism and Parkinson's disease in a Swedish population. Ann. New-a (2003) 53:823.
   Google Scholar
• WIRDEFELDT K, BURGESS CE, WESTERBERG L, PAYAMI H, SCHALLING M: A linkage study of candidate loci in familial Parkinson's disease. BMC Nemo]. (2003) 3:6.
   PubMedGoogle Scholar
• HAGG T: Neurotrophins prevent death and differentially affect tyrosine hydroxylase of adult rat nigrostriatal neurons in vivo. Exp. Neurol. (1998) 149:183–192.
   PubMed Web of Science ®Google Scholar
• LAPCHAK PA, BECK KD, ARAUJO DM, IRWIN I, LANGSTON JW, HEFTI F: Chronic intranigral administration of brain-derived neurotrophic factor produces striatal dopaminergic hypofunction in unlesioned adult rats and fails to attenuate the decline of striatal dopaminergic function following medial forebrain bundle transection. Neuroscience (1993) 53:639–650.
   PubMed Web of Science ®Google Scholar
• SHULTS CW, KIMBER T, ALTAR CA: BDNF attenuates the effects of intrastriatal injection of 6-hydroxydopamine. Neuroreport (1995) 6:1109–1112.
   PubMed Web of Science ®Google Scholar
• HUNG HC, LEE EH: The mesolimbic dopaminergic pathway is more resistant than the nigrostriatal dopaminergic pathway to MPTP and MPP+ toxicity: role of BDNF gene expression. Braila Res. Mol. Brain Res. (1996) 41:14–26.
   PubMed Web of Science ®Google Scholar
• TSUKAHARA T, TAKEDA M, SHIM OHAMA S, OHARA O, HASHIMOTO N: Effects of brain-derived neurotrophic factor on 1-methy1-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in monkeys. Neurosurgery (1995) 37:733–739.
   PubMed Web of Science ®Google Scholar
• LEVIVIER M, PRZEDBORSKI S, BENCSICS C, KANG UJ: Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease. .1. Neurosci. (1995) 15:7810–7820.
   PubMed Web of Science ®Google Scholar
• FRIM DM, UHLER TA, GALPERN WR, BEAL ME BREAKEFIELD XO, ISACSON O: Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methy1-4-phenylpyridinium toxicity to dopaminergic neurons in the rat. Proc. Natl. Acad. Sd. USA (1994) 91:5104–5108.
   PubMed Web of Science ®Google Scholar
• GALPERN WR, FRIM DM, TATTER SB,ALTAR CA, BEAL ME ISACSON O: Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration. Cell Transplant. (1996) 5:225–232.
   PubMed Web of Science ®Google Scholar
• KIRIK D, GEORGIEVSKA B, BJORKLUND A: Localized striatal delivery of GDNF as a treatment for Parkinson's disease. Nat. Neurosci. (2004) 7:105–110.
   PubMed Web of Science ®Google Scholar
• ROCERI M, HENDRIKS W RACAGNI G, ELLENBROEK BA, RIVA MA: Early maternal deprivation reduces the expression of BDNF and NMDA receptor subunits in rat hippocampus. Mol. Psychiatry(2002) 7:609–616.
   PubMed Web of Science ®Google Scholar
• SMITH MA, MAKINO S, KVETNANSKY R, POST PM: Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. Neurosci. (1995) 15:1768–1777.
   Web of Science ®Google Scholar
• LANG UE, HELLWEG R, GALLINAT J: BDNF serum concentrations in healthy volunteers are associated with depression-related personality traits. Neuropsychopharmacology (2004) 29:795–798.
   PubMed Web of Science ®Google Scholar
• DUMAN RS: Role of neurotrophic factorsin the aetiology and treatment of mood disorders. Neuromolecular Med. (2004) 5:11–25.
   PubMed Web of Science ®Google Scholar
• DUMAN RS: Synaptic plasticity and mood disorders. Mol. Psychiatry (2002) 7\(Suppl. 1):S29–S34.
   Google Scholar
• DIAS BG, BANERJEE SB, DUMAN RS, VAIDYA VA: Differential regulation of brain derived neurotrophic factor transcripts by antidepressant treatments in the adult rat brain. Neuropharmacology (2003) 45:553–563.
   PubMed Web of Science ®Google Scholar
• NIBUYA M, MORINOBU S, DUMAN RS: Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J. Neurosci. (1995) 15:7539–7547.
   PubMed Web of Science ®Google Scholar
• RUSSO-NEUSTADT AA, BEARD RC, HUANG YM, COTMAN CW: Physical activity and antidepressant treatment potentiate the expression of specific brain-derived neurotrophic factor transcripts in the rat hippocampus. Neuroscience (2000) 101:305–312.
   PubMed Web of Science ®Google Scholar
• IVY AS, RODRIGUEZ FG, GARCIA C,CHEN MJ, RUSSO-NEUSTADT AA: Noradrenergic and serotonergic blockade inhibits BDNF mRNA activation following exercise and antidepressant. Pharmacol. Biochem. Behav. (2003) 75:81–88.
   PubMed Web of Science ®Google Scholar
• COPPELL AL, PEI Q, ZETTERSTROM TS: Bi-phasic change in BDNF gene expression following antidepressant drug treatment. Neurophannacology (2003) 44:903–910.
   PubMed Web of Science ®Google Scholar
• ALTAR CA, WHITEHEAD RE, CHEN R, WORTWEIN G, MADSEN TM: Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain. Biol. Psychiatry (2003) 54:703–709.
   PubMed Web of Science ®Google Scholar
• XU H, STEVEN RJ, LI XM: Dose-related effects of chronic antidepressants on neuroprotective proteins BDNF, Bc1-2 and Cu/Zn-SOD in rat hippocampus. Neuropsychopharmacology (2003) 28:53–62.
   PubMed Web of Science ®Google Scholar
• GARZA AA, HA TG, GARCIA C, CHEN MJ, RUSSO-NEUSTADT AA: Exercise, antidepressant treatment, and BDNF mRNA expression in the ageing brain. Phannacol. Biochem. Behav. (2004) 77:209–220.
   PubMed Web of Science ®Google Scholar
• CHEN B, DOWLATSHAHI D, MACQUEEN GM, WANG JF, YOUNG LT: Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biol. Psychiatry (2001) 50:260–265.
   PubMed Web of Science ®Google Scholar
• CASTREN E: Neurotrophic effects of antidepressant drugs. Can: Opin. Phannacol. (2004) 4:58–64.
   PubMed Web of Science ®Google Scholar
• SAARELAINEN T, HEND OLIN P, LUCAS G et al.: Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioural effects. Neurosci. (2003) 23:349–357.
   Web of Science ®Google Scholar
• •Study demonstrating that antidepressants rapidly activate TrkB and that TrkB signalling is required for the behavioural effects of antidepressants.
   Google Scholar
• BOIVIE J: Central Pain. In: Textbook of Pain. Wall PD, Melzack R (Eds). Churchill Livingstone, London (1994):871–902.
   Google Scholar
• PEZET S, MALCANGIO M, MCMAHON SB: BDNF: a neuromodulator in nociceptive pathways? Brain Res. Brain Res. Rev (2002) 40:240–249.
   PubMedGoogle Scholar
• •Review summarising and discussing the possibility that BDNF is a neuromodulator in the spinal dorsal horn.
   Google Scholar
• APFEL SC, WRIGHT DE, WIIDEMAN AM, DORMIA C, SNIDER WD, KESSLER JA: Nerve growth factor regulates the expression of brain-derived neurotrophic factor mRNA in the peripheral nervous system. Mol. Cell Neurosci. (1996) 7:134–142.
   PubMed Web of Science ®Google Scholar
• ZHOU XF, CHIE ET, DENG YS et al.: Injured primary sensory neurons switch phenotype for brain-derived neurotrophic factor in the rat. Neuroscience (1999) 92:841–853.
   PubMed Web of Science ®Google Scholar
• FUKUOKA T, KONDO E, DAI Y, HASHIMOTO N, NOGUCHI K: Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal nerve ligation model. J. Neurosci. (2001) 21:4891–4900.
   PubMed Web of Science ®Google Scholar
• CHO HJ, KIM JK, PARK HC et al: Changes in brain-derived neurotrophic factor immunoreactivity in rat dorsal root ganglia, spinal cord, and gracile nuclei following cut or crush injuries. Exp. Neurol. (1998) 154:224–230.
   PubMed Web of Science ®Google Scholar
• CHO HJ, KIM JK, ZHOU XF, RUSH RA: Increased brain-derived neurotrophic factor immunoreactivity in rat dorsal root ganglia and spinal cord following peripheral inflammation. Brain Res. (1997) 764:269–272.
   PubMed Web of Science ®Google Scholar
• LEVER IJ, BRADBURY EJ, CUNNINGHAM JR et al.: Brain-derived neurotrophic factor is released in the dorsal horn by distinctive patterns of afferent fibre stimulation. Neurosci. (2001) 21:4469–4477.
   Web of Science ®Google Scholar
• WALKER SM, MITCHELL VA, WHITE DM, RUSH RA, DUGGAN AW: Release of immunoreactive brain-derived neurotrophic factor in the spinal cord of the rat following sciatic nerve transection. Brain Res. (2001) 899:240–247.
   PubMed Web of Science ®Google Scholar
• PEZET S, CUNNINGHAM J, PATEL J et al.: BDNF modulates sensory neuron synaptic activity by a facilitation of GABA transmission in the dorsal horn. Ma Cell Neurosci. (2002) 21:51–62.
   PubMed Web of Science ®Google Scholar
• LEVER I, CUNNINGHAM J, GRIST J,YIP PK, MALCANGIO M: Release of BDNF and GABA in the dorsal horn of neuropathic rats. Ear.' Neurosci. (2003) 18:1169–1174.
   PubMed Web of Science ®Google Scholar
• MICHAEL GJ, AVERILL S, NITKUNAN A et al.: Nerve growth factor treatment increases brain-derived neurotrophic factor selectively in TrkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cord. NeuroscL (1997) 17:8476–8490.
   PubMed Web of Science ®Google Scholar
• MANNION RJ, COSTIGAN M, DECOSTERD I et al.: Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity. Proc. Natl Acad. Sci. USA (1999) 96:9385–9390.
   PubMed Web of Science ®Google Scholar
• ERNFORS P, ROSARIO CM, MERLIO JP, GRANT G, ALDSKOGIUS H, PERSSON H: Expression of mRNAs for neurotrophin receptors in the dorsal root ganglion and spinal cord during development and following peripheral or central axotomy. Brant Rat MM. Brant Res. (1993) 17:217–226.
   PubMed Web of Science ®Google Scholar
• MICHAEL GJ, AVERILL S, SHORTLAND PJ, YAN Q, PRIESTLEY JV: Axotomy results in major changes in BDNF expression by dorsal root ganglion cells: BDNF expression in large trkB and trkC cells, in pericellular baskets, and in projections to deep dorsal horn and dorsal column nuclei. Eur: Neurosci. (1999) 11:3539–3551.
   PubMed Web of Science ®Google Scholar
• YAN Q, RADEKE MJ, MATHESON CR, TALVENHEIMO J, WELCHER AA, FEINSTEIN SC: Immunocytochemical localization of TrkB in the central nervous system of the adult rat. Comp. Neurol (1997) 378:135–157.
   PubMed Web of Science ®Google Scholar
• ZHOU XF, PARADA LF, SOPPET D, RUSH RA: Distribution of trkB tyrosine kinase immunoreactivity in the rat central nervous system. Brant Res. (1993) 622:63–70.
   PubMed Web of Science ®Google Scholar
• GARRAWAY SM, PETRUSKA JC, MENDELL LM: BDNF sensitizes the response of lamina II neurons to high threshold primary afferent inputs. Eur.j Neurosci. (2003) 18:2467–2476.
   PubMed Web of Science ®Google Scholar
• KERR BJ, BRADBURY EJ, BENNETT DL et al: Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord. J. Neurosci. (1999) 19:5138–5148.
   PubMed Web of Science ®Google Scholar
• MIKI K, FUKUOKA T, TOKUNAGA A, KONDO E, DAI Y, NOGUCHI K: Differential effect of brain-derived neurotrophic factor on high-threshold mechanosensitivity in a rat neuropathic pain model. Neurosci. Lett. (2000) 278:85–88.
   PubMed Web of Science ®Google Scholar
• EATON MJ, BLITS B, RUITENBERG MJ, VERHAAGEN J, OUDEGA M: Amelioration of chronic neuropathic pain after partial nerve injury by adeno-associated viral (AAV) vector-mediated overexpression of BDNF in the rat spinal cord. Gene Titer: (2002) 9:1387–1395.
   Google Scholar
• BINDER DK, CROLL SD, GALL CM, SCHARFMAN HE: BDNF and epilepsy: too much of a good thing? Trends Neurosci. (2001) 24:47–53.
   Google Scholar
• BINDER DK, ROUTBORT MJ, RYAN TE, YANCOPOULOS GD, MCNAMARA JO: Selective inhibition of kindling development by intraventricular administration of TrkB receptor body. Neurosci. (1999) 19:1424–1436.
   Web of Science ®Google Scholar
• KOKAIA M, ERNFORS P, KOKAIA Z, ELMER E, JAENISCH R, LINDVALL O: Suppressed epileptogenesis in BDNF mutant mice. Exp. Neurol (1995) 133:215–224.
   PubMed Web of Science ®Google Scholar
• BINDER DK, ROUTBORT MJ, MCNAMARA JO: Immunohistochemical evidence of seizure-induced activation of trk receptors in the mossy fibre pathway of adult rat hippocampus. Neurosci. (1999) 19:4616–4626.
   Web of Science ®Google Scholar
• LAHTEINEN S, PITKANEN A, KOPONEN E, SAARELAINEN T, CASTREN E: Exacerbated status epilepticus and acute cell loss but no changes in epileptogenesis, in mice with increased brain-derived neurotrophic factor signalling. Neuroscience (2003) 122:1081–1092.
   PubMed Web of Science ®Google Scholar
• LAHTEINEN S, PITKANEN A, SAARELAINEN T, NISSINEN J, KOPONEN E, CASTREN E: Decreased BDNF signalling in transgenic mice reduces epileptogenesis. Eur. Neurosci. (2002) 15:721–734.
   PubMed Web of Science ®Google Scholar
• XU B, MICHALSKI B, RACINE RJ, FAHNESTOCK M: The effects of brain-derived neurotrophic factor (BDNF) administration on kindling induction, Trk expression and seizure-related morphological changes. Neuroscience (2004) 126:521–531.
   PubMed Web of Science ®Google Scholar
• OSEHOBO P, ADAMS B, SAZGAR M, XU Y, RACINE RJ, FAHNESTOCK M: Brain-derived neurotrophic factor infusion delays amygdala and perforant path kindling without affecting paired-pulse measures of neuronal inhibition in adult rats. Neuroscience (1999) 92:1367–1375.
   PubMed Web of Science ®Google Scholar
• LARMET Y, REIBEL S, CARNAHAN J, NAWA H, MARESCAUX C, DEPAULIS A: Protective effects of brain-derived neurotrophic factor on the development of hippocampal kindling in the rat. Neuroreport (1995) 6:1937–1941.
   PubMed Web of Science ®Google Scholar
• FRANK L, VENTIMIGLIA R, ANDERSON K, LINDSAY RM, RUDGE JS: BDNF downregulates neurotrophin responsiveness, TrkB protein and TrkB mRNA levels in cultured rat hippocampal neurons. Eur: Neurosci. (1996) 8:1220–1230.
   PubMed Web of Science ®Google Scholar
• KNUSEL B, GAO H, OKAZAKI T et al: Ligand-induced downregulation of Trk messenger RNA, protein and tyrosine phosphorylation in rat cortical neurons. Neuroscience (1997) 78:851–862.
   PubMed Web of Science ®Google Scholar
• CROLL SD, WIEGAND SJ, ANDERSON KD, LINDSAY RM, NAWA H: Regulation of neuropeptides in adult rat forebrain by the neurotrophins BDNF and NGF. Eur.j Neurosci. (1994) 6:1343–1353.
   PubMed Web of Science ®Google Scholar
• REIBEL S, VIVIEN-ROELS B, LE BT et al.: Overexpression of neuropeptide Y induced by brain-derived neurotrophic factor in the rat hippocampus is long lasting. Eur.j Neurosci. (2000) 12:595–605.
   PubMed Web of Science ®Google Scholar
• ALTAR CA: Neurotrophins and depression. Trends Pharmacol ScL (1999) 20:59–61.
   PubMed Web of Science ®Google Scholar