Safety of amide local anesthetics: new trends

Bibliography

• Horlocker TT. Complications of spinal and epidural anesthesia. Anesthesiol Clin North Am 2000;18:461-85
   PubMedGoogle Scholar
• Horlocker TT, McGregor DG, Matsushige DK, A retrospective review of 4767 consecutive spinal anesthetics: central nervous system complications. Perioperative Outcomes Group. Anesth Analg 1997;84:578-84
   PubMed Web of Science ®Google Scholar
• Lee LA, Posner KL, Domino KB, Injuries Associated with Regional Anesthesia in the 1980s and 1990s: a closed claims analysis. Anesthesiology 2004;101:143-52
   PubMed Web of Science ®Google Scholar
• Ben-David B. Complications of regional anesthesia: an overview. Anesthesiol Clin North America 2002;20:427-9, ix
   Google Scholar
• Auroy Y, Benhamou D, Bargues L, Major complications of regional anesthesia in France: the SOS regional anesthesia hotline service. Anesthesiology 2002;97:1274-80
   PubMed Web of Science ®Google Scholar
• Capdevila X, Pirat P, Bringuier S, Continuous peripheral nerve blocks in hospital wards after orthopedic surgery: a multicenter prospective analysis of the quality of postoperative analgesia and complications in 1,416 patients. Anesthesiology 2005;103:1035-45
   PubMed Web of Science ®Google Scholar
• Auroy Y, Narchi P, Messiah A, Serious complications related to regional anesthesia: results of a prospective survey in France. Anesthesiology 1997;87:479-86
   PubMed Web of Science ®Google Scholar
• Kopp SL, Horlocker TT, Warner ME, Cardiac arrest during neuraxial anesthesia: frequency and predisposing factors associated with survival. Anesth Analg 2005;100:855-65
   PubMed Web of Science ®Google Scholar
• Brown DL, Ransom DM, Hall JA, Regional anesthesia and local anesthetic-induced systemic toxicity: seizure frequency and accompanying cardiovascular changes. Anesth Analg 1995;81:321-8
   PubMed Web of Science ®Google Scholar
• Bax ND, Tucker GT, Lennard MS, Woods HF. The impairment of lignocaine clearance by propranolol-major contribution from enzyme inhibition. Br J Clin Pharmacol 1985;19:597-603
   PubMed Web of Science ®Google Scholar
• Kuhnert BR, Zuspan KJ, Kuhnert PM, Lack of influence of cimetidine on bupivacaine levels during parturition. Anesth Analg 1987;66:986-90
   PubMed Web of Science ®Google Scholar
• Siegmund JB, Wilson JH, Imhoff TE. Amiodarone interaction with lidocaine. J Cardiovasc Pharmacol 1993;21:513-5
   PubMed Web of Science ®Google Scholar
• Freysz M, Beal JL, Timour Q, Systemic toxicity of local anesthetics. Pharmacokinetic and pharmacodynamic factors. Ann Fr Anesth Reanim 1988;7:181-8
   PubMedGoogle Scholar
• Mather LE, Runciman WB, Carapetis RJ, Hepatic and renal clearances of lidocaine in conscious and anesthetized sheep. Anesth Analg 1986;65:943-9
   PubMed Web of Science ®Google Scholar
• Rosenberg PH, Veering BT, Urmey WF. Maximum recommended doses of local anesthetics: a multifactorial concept. Reg Anesth Pain Med 2004;29:564-75
   PubMed Web of Science ®Google Scholar
• O'Donnell BD, Iohom G. An estimation of the minimum effective anesthetic volume of 2% lidocaine in ultrasound-guided axillary brachial plexus block. Anesthesiology 2009;111:25-9
   PubMed Web of Science ®Google Scholar
• Fuzier R, Lapeyre-Mestre M, Samii K, Montastruc JL. Adverse drug reactions to local anaesthetics: a review of the French pharmacovigilance database. Drug Saf 2009;32:345-56
   PubMed Web of Science ®Google Scholar
• Nazir MS, Holdcroft A. Local anaesthetic drugs: adverse effects as reported through the ADROIT system in the UK. Pharmacoepidemiol Drug Saf 2009;18:1000-6
   PubMed Web of Science ®Google Scholar
• Belton KJ. Attitude survey of adverse drug-reaction reporting by health care professionals across the European Union. The European Pharmacovigilance Research Group. Eur J Clin Pharmacol 1997;52:423-7
   PubMed Web of Science ®Google Scholar
• Thiessard F, Roux E, Miremont-Salame G, Trends in spontaneous adverse drug reaction reports to the French pharmacovigilance system (1986-2001). Drug Saf 2005;28:731-40
   PubMed Web of Science ®Google Scholar
• Naguib M, Magboul MM, Samarkandi AH, Attia M. Adverse effects and drug interactions associated with local and regional anaesthesia. Drug Saf 1998;18:221-50
   PubMed Web of Science ®Google Scholar
• Ben-David B. Complications of peripheral blockade. Anesthesiol Clin North America 2002;20:695-707
   PubMedGoogle Scholar
• Scott DB. Evaluation of clinical tolerance of local anaesthetic agents. Br J Anaesth 1975;47(Suppl):328-31
   PubMedGoogle Scholar
• Apfelbaum JL, Shaw LM, Gross JB, Modification of lidocaine protein binding with CO2. Can Anaesth Soc J 1985;32:468-71
   PubMedGoogle Scholar
• Bisschop DY, Alardo JP, Razgallah B, Seizure induced by ropivacaine. Ann Pharmacother 2001;35:311-3
   PubMed Web of Science ®Google Scholar
• Crews J, Weller R, Moss J, James RL. Levobupivacaine for axillary brachial plexus block: a pharmacokinetic and clinical comparison in patients with normal renal function or renal disease. Anesth Analg 2002;95:219-23
   PubMed Web of Science ®Google Scholar
• Ladd LA, Mather LE. Central Effects Index-a semiquantitative method for the assessment of CNS toxicity of local anaesthetic agents in sheep. J Pharmacol Toxicol Methods 2000;44:467-76
   PubMed Web of Science ®Google Scholar
• Chang DH, Ladd LA, Wilson KA, Tolerability of large-dose intravenous levobupivacaine in sheep. Anesth Analg 2000;91:671-9
   PubMed Web of Science ®Google Scholar
• Ohmura S, Kawada M, Ohta T, Systemic toxicity and resuscitation in Bupivacaine-, Levobupivacaine-, or Ropivacaine-infused rats. Anesth Analg 2001;93:743-8
   PubMed Web of Science ®Google Scholar
• Sorenson EJ. Neurologic injuries associated with regional anesthesia. Reg Anesth Pain Med 2008;33:442-8
   PubMed Web of Science ®Google Scholar
• Neal JM, Bernards CM, Hadzic A, ASRA Practice advisory on neurologic complications in regional anesthesia and pain medicine. Reg Anesth Pain Med 2008;33:404-15
   PubMed Web of Science ®Google Scholar
• Welch MB, Brummett CM, Welch TD, Perioperative peripheral nerve injuries: a retrospective study of 380,680 cases during a 10-year period at a single institution. Anesthesiology 2009;111:490-7
   PubMed Web of Science ®Google Scholar
• Cheney FW, Domino KB, Caplan RA, Posner KL. Nerve injury associated with anesthesia: a closed claims analysis. Anesthesiology 1999;90:1062-9
   PubMed Web of Science ®Google Scholar
• Borgeat A, Dullenkopf A, Ekatodramis G, Nagy L. Evaluation of the lateral modified approach for continuous interscalene block after shoulder surgery. Anesthesiology 2003;99:436-42
   PubMed Web of Science ®Google Scholar
• Bergman BD, Hebl JR, Kent J, Horlocker TT. Neurologic complications of 405 consecutive continuous axillary catheters. Anesth Analg 2003;96:247-52
   PubMed Web of Science ®Google Scholar
• Hogan QH. Pathophysiology of peripheral nerve injury during regional anesthesia. Reg Anesth Pain Med 2008;33:435-41
   PubMed Web of Science ®Google Scholar
• Horlocker TT, Hebl JR, Gali B, Anesthetic, patient, and surgical risk factors for neurologic complications after prolonged total tourniquet time during total knee arthroplasty. Anesth Analg 2006;102:950-5
   PubMed Web of Science ®Google Scholar
• McLaren AC, Rorabeck CH. The pressure distribution under tourniquets. J Bone Joint Surg Am 1985;67:433-8
   PubMedGoogle Scholar
• Mihalko WM, Rohrbacher B, McGrath B. Transient peroneal nerve palsies from injuries placed in traction splints. Am J Emerg Med 1999;17:160-2
   PubMed Web of Science ®Google Scholar
• Lee CT, Espley AJ. Perioperative ulnar neuropathy in orthopaedics: association with tilting the patient. Clin Orthop Relat Res 2002;396:106-11
   PubMedGoogle Scholar
• Fanelli G, Casati A, Garancini P, Torri G. Nerve stimulator and multiple injection technique for upper and lower limb blockade: failure rate, patient acceptance, and neurologic complications. Study Group on Regional Anesthesia. Anesth Analg 1999;88:847-52
   PubMed Web of Science ®Google Scholar
• Chan VW, Brull R, McCartney CJ, An ultrasonographic and histological study of intraneural injection and electrical stimulation in pigs. Anesth Analg 2007;104:1281-4
   PubMed Web of Science ®Google Scholar
• Perlas A, Niazi A, McCartney C, The sensitivity of motor response to nerve stimulation and paresthesia for nerve localization as evaluated by ultrasound. Reg Anesth Pain Med 2006;31:445-50
   PubMed Web of Science ®Google Scholar
• Liguori GA. Complications of regional anesthesia: nerve injury and peripheral neural blockade. J Neurosurg Anesthesiol 2004;16:84-6
   PubMed Web of Science ®Google Scholar
• Benumof JL. Permanent loss of cervical spinal cord function associated with interscalene block performed under general anesthesia. Anesthesiology 2000;93:1541-4
   PubMed Web of Science ®Google Scholar
• Kaufman BR, Nystrom E, Nath S, Debilitating chronic pain syndromes after presumed intraneural injections. Pain 2000;85:283-6
   PubMed Web of Science ®Google Scholar
• Kitagawa N, Oda M, Totoki T. Possible mechanism of irreversible nerve injury caused by local anesthetics: detergent properties of local anesthetics and membrane disruption. Anesthesiology 2004;100:962-7
   PubMed Web of Science ®Google Scholar
• Kasaba T, Onizuka S, Takasaki M. Procaine and mepivacaine have less toxicity in vitro than other clinically used local anesthetics. Anesth Analg 2003;97:85-90
   PubMed Web of Science ®Google Scholar
• Bouaziz H. Neurotoxicité des anesthésiques locaux: mécanismes physiopathologiques et implications cliniques. Praticien en anesthésie-réanimation 2005;9:1S14-9
   Google Scholar
• Perez-Castro R, Patel S, Garavito-Aguilar ZV, Cytotoxicity of local anesthetics in human neuronal cells. Anesth Analg 2009;108:997-1007
   PubMed Web of Science ®Google Scholar
• Tripathi M, Nath SS, Gupta RK. Paraplegia after intracord injection during attempted epidural steroid injection in an awake-patient. Anesth Analg 2005;101:1209-11
   PubMed Web of Science ®Google Scholar
• Tsui BC, Armstrong K. Can direct spinal cord injury occur without paresthesia? A report of delayed spinal cord injury after epidural placement in an awake patient. Anesth Analg 2005;101:1212-4
   PubMed Web of Science ®Google Scholar
• Faccenda KA, Finucane BT. Complications of regional anaesthesia Incidence and prevention. Drug Saf 2001;24:413-42
   PubMed Web of Science ®Google Scholar
• Pollock JE. Transient neurologic symptoms: etiology, risk factors, and management. Reg Anesth Pain Med 2002;27:581-6
   PubMed Web of Science ®Google Scholar
• Ben-David B, Rawa R. Complications of neuraxial blockade. Anesthesiol Clin North America 2002;20:669-93
   PubMedGoogle Scholar
• Zaric D, Pace NL. Transient neurologic symptoms (TNS) following spinal anaesthesia with lidocaine versus other local anaesthetics. Cochrane Database Syst Rev 2009;2:CD003006
   PubMed Web of Science ®Google Scholar
• Liu SS, McDonald SB. Current issues in spinal anesthesia. Anesthesiology 2001;94:888-906
   PubMed Web of Science ®Google Scholar
• Freedman JM, Li DK, Drasner K, Transient neurologic symptoms after spinal anesthesia: an epidemiologic study of 1,863 patients. Anesthesiology 1998;89:633-41
   PubMed Web of Science ®Google Scholar
• de Jong RH, Ronfeld RA, DeRosa RA. Cardiovascular effects of convulsant and supraconvulsant doses of amide local anesthetics. Anesth Analg 1982;61:3-9
   PubMed Web of Science ®Google Scholar
• Hotvedt R, Refsum H, Helgesen KG. Cardiac electrophysiologic and hemodynamic effects related to plasma levels of bupivacaine in the dog. Anesth Analg 1985;64:388-94
   PubMed Web of Science ®Google Scholar
• Timour Q, Freysz M, Lang J, Electrophysiological study in the dog of the risk of cardiac toxicity of bupivacaine. Arch Int Pharmacodyn Ther 1987;287:65-77
   PubMedGoogle Scholar
• Kotelko DM, Shnider SM, Dailey PA, Bupivacaine-induced cardiac arrhythmias in sheep. Anesthesiology 1984;60:10-8
   PubMed Web of Science ®Google Scholar
• Reiz S, Nath S. Cardiotoxicity of local anaesthetic agents. Br J Anaesth 1986;58:736-46
   PubMed Web of Science ®Google Scholar
• de La Coussaye JE, Brugada J, Allessie MA. Electrophysiologic and arrhythmogenic effects of bupivacaine. A study with high-resolution ventricular epicardial mapping in rabbit hearts. Anesthesiology 1992;77:132-41
   PubMed Web of Science ®Google Scholar
• Lynch C, III. Depression of myocardial contractility in vitro by bupivacaine, etidocaine, and lidocaine. Anesth Analg 1986;65:551-9
   PubMed Web of Science ®Google Scholar
• Liu P, Feldman HS, Covino BM, Acute cardiovascular toxicity of intravenous amide local anesthetics in anesthetized ventilated dogs. Anesth Analg 1982;61:317-22
   PubMed Web of Science ®Google Scholar
• Chamberlain BK, Volpe P, Fleischer S. Inhibition of calcium-induced calcium release from purified cardiac sarcoplasmic reticulum vesicles. J Biol Chem 1984;259:7547-53
   PubMed Web of Science ®Google Scholar
• Mio Y, Fukuda N, Kusakari Y, Bupivacaine attenuates contractility by decreasing sensitivity of myofilaments to Ca2+ in rat ventricular muscle. Anesthesiology 2002;97:1168-77
   PubMed Web of Science ®Google Scholar
• de La Coussaye JE, Eledjam JJ, Brugada J, Do beta adrenergic receptor blockaders increase bupivacaine cardiotoxicity? Ann Fr Anesth Reanim 1990;9:132-6
   PubMed Web of Science ®Google Scholar
• Edouard AR, Berdeaux A, Ahmad R, Samii K. Cardiovascular interactions of local anesthetics and calcium entry blockers in conscious dogs. Reg Anesth 1991;16:95-100
   PubMedGoogle Scholar
• Finegan BA, Whiting RW, Tam YK, Clanachan AS. Enhancement of bupivacaine toxicity by diltiazem in anaesthetized dogs. Br J Anaesth 1992;69:492-7
   PubMed Web of Science ®Google Scholar
• Howie MB, Mortimer W, Candler EM, Does nifedipine enhance the cardiovascular depressive effects of bupivacaine? Reg Anesth 1989;14:19-25
   PubMedGoogle Scholar
• Timour Q, Freysz M, Couzon P, Possible role of drug interactions in bupivacaine-induced problems related to intraventricular conduction disorders. Reg Anesth 1990;15:180-5
   PubMedGoogle Scholar
• Freysz M, Timour Q, Mazze RI, Potentiation by mild hypothermia of ventricular conduction disturbances and reentrant arrhythmias induced by bupivacaine in dogs. Anesthesiology 1989;70:799-804
   PubMed Web of Science ®Google Scholar
• Komai H, Rusy BF. Effects of bupivacaine and lidocaine on AV conduction in the isolated rat heart: modification by hyperkalemia. Anesthesiology 1981;55:281-5
   PubMed Web of Science ®Google Scholar
• Rosen MA, Thigpen JW, Shnider SM, Bupivacaine-induced cardiotoxicity in hypoxic and acidotic sheep. Anesth Analg 1985;64:1089-96
   PubMed Web of Science ®Google Scholar
• Sage DJ, Feldman HS, Arthur GR, Influence of lidocaine and bupivacaine on isolated guinea pig atria in the presence of acidosis and hypoxia. Anesth Analg 1984;63:1-7
   PubMed Web of Science ®Google Scholar
• Timour Q, Freysz M, Mazze R, Enhancement by hyponatremia and hyperkalemia of ventricular conduction and rhythm disorders caused by bupivacaine. Anesthesiology 1990;72:1051-6
   PubMed Web of Science ®Google Scholar
• Heavner JE. Cardiac dysrhythmias induced by infusion of local anesthetics into the lateral cerebral ventricle of cats. Anesth Analg 1986;65:133-8
   PubMed Web of Science ®Google Scholar
• Thomas RD, Behbehani MM, Coyle DE, Denson DD. Cardiovascular toxicity of local anesthetics: an alternative hypothesis. Anesth Analg 1986;65:444-50
   PubMed Web of Science ®Google Scholar
• Dony P, Dewinde V, Vanderick B, The comparative toxicity of ropivacaine and bupivacaine at equipotent doses in rats. Anesth Analg 2000;91:1489-92
   PubMed Web of Science ®Google Scholar
• Mather LE, Chang DH. Cardiotoxicity with modern local anaesthetics: is there a safer choice? Drugs 2001;61:333-42
   PubMed Web of Science ®Google Scholar
• Morrison SG, Dominguez JJ, Frascarolo P, Reiz S. A comparison of the electrocardiographic cardiotoxic effects of racemic bupivacaine, levobupivacaine, and ropivacaine in anesthetized swine. Anesth Analg 2000;90:1308-14
   PubMed Web of Science ®Google Scholar
• Pitkanen M, Feldman HS, Arthur GR, Covino BG. Chronotropic and inotropic effects of ropivacaine, bupivacaine, and lidocaine in the spontaneously beating and electrically paced isolated, perfused rabbit heart. Reg Anesth 1992;17:183-92
   PubMedGoogle Scholar
• Denson DD, Behbehani MM, Gregg RV. Enantiomer-specific effects of an intravenously administered arrhythmogenic dose of bupivacaine on neurons of the nucleus tractus solitarius and the cardiovascular system in the anesthetized rat. Reg Anesth 1992;17:311-6
   PubMedGoogle Scholar
• Gristwood RW. Cardiac and CNS toxicity of levobupivacaine: strengths of evidence for advantage over bupivacaine. Drug Saf 2002;25:153-63
   PubMed Web of Science ®Google Scholar
• Huang YF, Pryor ME, Mather LE, Veering BT. Cardiovascular and central nervous system effects of intravenous levobupivacaine and bupivacaine in sheep. Anesth Analg 1998;86:797-804
   PubMed Web of Science ®Google Scholar
• Mazoit JX, Boico O, Samii K. Myocardial uptake of bupivacaine: II. Pharmacokinetics and pharmacodynamics of bupivacaine enantiomers in the isolated perfused rabbit heart. Anesth Analg 1993;77:477-82
   PubMed Web of Science ®Google Scholar
• Groban L, Deal DD, Vernon JC, Ventricular arrhythmias with or without programmed electrical stimulation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine, and ropivacaine. Anesth Analg 2000;91:1103-11
   PubMed Web of Science ®Google Scholar
• Zink W, Graf BM. The toxicity of local anesthetics: the place of ropivacaine and levobupivacaine. Curr Opin Anaesthesiol 2008;21:645-50
   PubMed Web of Science ®Google Scholar
• Guinet P, Estebe JP, Ratajczak-Enselme M, Electrocardiographic and hemodynamic effects of intravenous infusion of bupivacaine, ropivacaine, levobupivacaine, and lidocaine in anesthetized ewes. Reg Anesth Pain Med 2009;34:17-23
   PubMed Web of Science ®Google Scholar
• Leone R, Conforti A, Venegoni M, Drug-induced anaphylaxis: case/non-case study based on an italian pharmacovigilance database. Drug Saf 2005;28:547-56
   PubMed Web of Science ®Google Scholar
• Fuzier R, Lapeyre-Mestre M, Mertes PM, Immediate- and delayed-type allergic reactions to amide local anesthetics: clinical features and skin testing. Pharmacoepidemiol Drug Saf 2009;18:595-601
   PubMed Web of Science ®Google Scholar
• Ali B, Zafari AM. Narrative review: cardiopulmonary resuscitation and emergency cardiovascular care: review of the current guidelines. Ann Intern Med 2007;147:171-9
   PubMed Web of Science ®Google Scholar
• Aya AG, de la Coussaye JE, Robert E, Comparison of the effects of racemic bupivacaine, levobupivacaine, and ropivacaine on ventricular conduction, refractoriness, and wavelength: an epicardial mapping study. Anesthesiology 2002;96:641-50
   PubMed Web of Science ®Google Scholar
• Clarkson CW, Hondeghem LM. Mechanism for bupivacaine depression of cardiac conduction: fast block of sodium channels during the action potential with slow recovery from block during diastole. Anesthesiology 1985;62:396-405
   PubMed Web of Science ®Google Scholar
• de La Coussaye JE, Eledjam JJ, Bruelle P, Mechanisms of the putative cardioprotective effect of hexamethonium in anesthetized dogs given a large dose of bupivacaine. Anesthesiology 1994;80:595-605
   PubMed Web of Science ®Google Scholar
• Groban L, Deal DD, Vernon JC, Cardiac resuscitation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine, and ropivacaine in anesthetized dogs. Anesth Analg 2001;92:37-43
   PubMed Web of Science ®Google Scholar
• Hiller DB, Gregorio GD, Ripper R, Epinephrine impairs lipid resuscitation from bupivacaine overdose: a threshold effect. Anesthesiology 2009;111:498-505
   PubMed Web of Science ®Google Scholar
• Weinberg GL, Di Gregorio G, Ripper R, Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose. Anesthesiology 2008;108:907-13
   PubMed Web of Science ®Google Scholar
• Weinberg GL, Ripper R, Murphy P, Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart. Reg Anesth Pain Med 2006;31:296-303
   PubMed Web of Science ®Google Scholar
• Foxall G, McCahon R, Lamb J, Levobupivacaine-induced seizures and cardiovascular collapse treated with Intralipid. Anaesthesia 2007;62:516-8
   PubMed Web of Science ®Google Scholar
• Litz RJ, Popp M, Stehr SN, Koch T. Successful resuscitation of a patient with ropivacaine-induced asystole after axillary plexus block using lipid infusion. Anaesthesia 2006;61:800-1
   PubMed Web of Science ®Google Scholar
• Weinberg G. Lipid infusion resuscitation for local anesthetic toxicity: proof of clinical efficacy. Anesthesiology 2006;105:7-8
   PubMed Web of Science ®Google Scholar
• Hicks SD, Salcido DD, Logue ES, Lipid emulsion combined with epinephrine and vasopressin does not improve survival in a swine model of bupivacaine-induced cardiac arrest. Anesthesiology 2009;111:138-46
   PubMed Web of Science ®Google Scholar
• Mayr VD, Mitterschiffthaler L, Neurauter A, A comparison of the combination of epinephrine and vasopressin with lipid emulsion in a porcine model of asphyxial cardiac arrest after intravenous injection of bupivacaine. Anesth Analg 2008;106:1566-71
   PubMed Web of Science ®Google Scholar
• Zausig YA, Zink W, Keil M, Lipid emulsion improves recovery from bupivacaine-induced cardiac arrest, but not from ropivacaine- or mepivacaine-induced cardiac arrest. Anesth Analg 2009;109:1323-6
   PubMed Web of Science ®Google Scholar
• Mazoit JX, Le Guen R, Beloeil H, Benhamou D. Binding of long-lasting local anesthetics to lipid emulsions. Anesthesiology 2009;110:380-6
   PubMed Web of Science ®Google Scholar
• Corman SL, Skledar SJ. Use of lipid emulsion to reverse local anesthetic-induced toxicity. Ann Pharmacother 2007;41:1873-7
   PubMed Web of Science ®Google Scholar
• Favier JC, Da Conceicao M, Fassassi M, Successful resuscitation of serious bupivacaine intoxication in a patient with pre-existing heart failure. Can J Anaesth 2003;50:62-6
   PubMed Web of Science ®Google Scholar
• Klein SM, Pierce T, Rubin Y, Successful resuscitation after ropivacaine-induced ventricular fibrillation. Anesth Analg 2003;97:901-3
   PubMed Web of Science ®Google Scholar
• Hogan Q, Dotson R, Erickson S, Local anesthetic myotoxicity: a case and review. Anesthesiology 1994;80:942-7
   PubMed Web of Science ®Google Scholar
• Zink W, Graf BM. Local anesthetic myotoxicity. Reg Anesth Pain Med 2004;29:333-40
   PubMed Web of Science ®Google Scholar
• Zink W, Bohl JR, Hacke N, The long term myotoxic effects of bupivacaine and ropivacaine after continuous peripheral nerve blocks. Anesth Analg 2005;101:548-54
   PubMed Web of Science ®Google Scholar
• Zink W, Seif C, Bohl JR, The acute myotoxic effects of bupivacaine and ropivacaine after continuous peripheral nerve blockades. Anesth Analg 2003;97:1173-9
   PubMed Web of Science ®Google Scholar
• Zink W, Missler G, Sinner B, Differential Effects of Bupivacaine and Ropivacaine Enantiomers on Intracellular Ca2+ Regulation in Murine Skeletal Muscle Fibers. Anesthesiology 2005;102:793-8
   PubMed Web of Science ®Google Scholar
• Esswein MB, von Noorden GK. Paresis of a vertical rectus muscle after cataract extraction. Am J Ophthalmol 1993;116:424-30
   PubMed Web of Science ®Google Scholar
• Golnik KC, West CE, Kaye E, Incidence of ocular misalignment and diplopia after uneventful cataract surgery. J Cataract Refract Surg 2000;26:1205-9
   PubMed Web of Science ®Google Scholar
• Gomez-Arnau JI, Yanguela J, Gonzalez A, Anaesthesia-related diplopia after cataract surgery. Br J Anaesth 2003;90:189-93
   PubMed Web of Science ®Google Scholar
• Koide R, Honda M, Kora Y, Ozawa T. Diplopia after cataract surgery. J Cataract Refract Surg 2000;26:1198-204
   PubMed Web of Science ®Google Scholar
• Ong-Tone L, Pearce WG. Inferior rectus muscle restriction after retrobulbar anesthesia for cataract extraction. Can J Ophthalmol 1989;24:162-5
   PubMed Web of Science ®Google Scholar
• Rainin EA, Carlson BM. Postoperative diplopia and ptosis. A clinical hypothesis based on the myotoxicity of local anesthetics. Arch Ophthalmol 1985;103:1337-9
   PubMed Web of Science ®Google Scholar
• Salama H, Farr AK, Guyton DL. Anesthetic myotoxicity as a cause of restrictive strabismus after scleral buckling surgery. Retina 2000;20:478-82
   PubMed Web of Science ®Google Scholar
• Han SK, Kim JH, Hwang JM. Persistent diplopia after retrobulbar anesthesia. J Cataract Refract Surg 2004;30:1248-53
   PubMed Web of Science ®Google Scholar
• Carlson BM, Emerick S, Komorowski TE, Extraocular muscle regeneration in primates. Local anesthetic-induced lesions. Ophthalmology 1992;99:582-9
   PubMed Web of Science ®Google Scholar
• Komorowski TE, Shepard B, Okland S, Carlson BM. An electron microscopic study of local anesthetic-induced skeletal muscle fiber degeneration and regeneration in the monkey. J Orthop Res 1990;8:495-503
   PubMed Web of Science ®Google Scholar
• McLoon LK, Nguyen LT, Wirtschafter J. Time course of the regenerative response in bupivacaine injured orbicularis oculi muscle. Cell Tissue Res 1998;294:439-47
   PubMed Web of Science ®Google Scholar
• Nouette-Gaulain K, Bellance N, Prevost B, Erythropoietin protects against local anesthetic myotoxicity during continuous regional analgesia. Anesthesiology 2009;110:648-59
   PubMed Web of Science ®Google Scholar
• Carlson BM, Rainin EA. Rat extraocular muscle regeneration. Repair of local anesthetic-induced damage. Arch Ophthalmol 1985;103:1373-7
   PubMed Web of Science ®Google Scholar
• Foster AH, Carlson BM. Myotoxicity of local anesthetics and regeneration of the damaged muscle fibers. Anesth Analg 1980;59:727-36
   PubMed Web of Science ®Google Scholar
• Kytta J, Heinonen E, Rosenberg PH, Effects of repeated bupivacaine administration on sciatic nerve and surrounding muscle tissue in rats. Acta Anaesthesiol Scand 1986;30:625-9
   PubMed Web of Science ®Google Scholar
• Duguez S, Feasson L, Denis C, Freyssenet D. Mitochondrial biogenesis during skeletal muscle regeneration. Am J Physiol Endocrinol Metab 2002;282:E802-9
   PubMed Web of Science ®Google Scholar
• Amaniti E, Drampa F, Kouzi-Koliakos K, Ropivacaine myotoxicity after single intramuscular injection in rats. Eur J Anaesthesiol 2006;23:130-5
   PubMed Web of Science ®Google Scholar
• Irwin W, Fontaine E, Agnolucci L, Bupivacaine myotoxicity is mediated by mitochondria. J Biol Chem 2002;277:12221-7
   PubMed Web of Science ®Google Scholar
• Zink W, Graf BM, Sinner B, Differential effects of bupivacaine on intracellular Ca2 + regulation: potential mechanisms of its myotoxicity. Anesthesiology 2002;97:710-6
   PubMed Web of Science ®Google Scholar
• Wakata N, Sugimoto H, Iguchi H, Bupivacaine hydrochloride induces muscle fiber necrosis and hydroxyl radical formation-dimethyl sulphoxide reduces hydroxyl radical formation. Neurochem Res. 2001;26:841-4
   PubMed Web of Science ®Google Scholar
• Sztark F, Malgat M, Dabadie P, Mazat JP. Comparison of the effects of bupivacaine and ropivacaine on heart cell mitochondrial bioenergetics. Anesthesiology 1998;88:1340-9
   PubMed Web of Science ®Google Scholar
• Nouette-Gaulain K, Sirvent P, Canal-Raffin M, Effects of intermittent femoral nerve injections of bupivacaine, levobupivacaine, and ropivacaine on mitochondrial energy metabolism and intracellular calcium homeostasis in rat psoas muscle. Anesthesiology 2007;106:1026-34
   PubMed Web of Science ®Google Scholar
• Nouette-Gaulain K, Dadure C, Morau D, Age-dependent bupivacaine-induced muscle toxicity during continuous peripheral nerve block in rats. Anesthesiology 2009;111:1120-7
   PubMed Web of Science ®Google Scholar
• Petty DH, Jazrawi LM, Estrada LS, Andrews JR. Glenohumeral chondrolysis after shoulder arthroscopy: case reports and review of the literature. Am J Sports Med 2004;32:509-15
   PubMed Web of Science ®Google Scholar
• Hansen BP, Beck CL, Beck EP, Townsley RW. Postarthroscopic glenohumeral chondrolysis. Am J Sports Med 2007;35:1628-34
   PubMed Web of Science ®Google Scholar
• Busfield BT, Romero DM. Pain pump use after shoulder arthroscopy as a cause of glenohumeral chondrolysis. Arthroscopy 2009;25:647-52
   PubMed Web of Science ®Google Scholar
• Solomon DJ, Navaie M, Stedje-Larsen ET, Glenohumeral chondrolysis after arthroscopy: a systematic review of potential contributors and causal pathways. Arthroscopy 2009;25:1329-42
   PubMed Web of Science ®Google Scholar
• Gomoll AH, Yanke AB, Kang RW, Long-term effects of bupivacaine on cartilage in a rabbit shoulder model. Am J Sports Med 2009;37:72-7
   PubMed Web of Science ®Google Scholar
• Gomoll AH, Kang RW, Williams JM, Chondrolysis after continuous intra-articular bupivacaine infusion: an experimental model investigating chondrotoxicity in the rabbit shoulder. Arthroscopy 2006;22:813-9
   Google Scholar
• Chu CR, Izzo NJ, Papas NE, Fu FH. In vitro exposure to 0.5% bupivacaine is cytotoxic to bovine articular chondrocytes. Arthroscopy 2006;22:693-9
   PubMed Web of Science ®Google Scholar
• Chu CR, Izzo NJ, Coyle CH, The in vitro effects of bupivacaine on articular chondrocytes. J Bone Joint Surg Br 2008;90:814-20
   Google Scholar
• Piper SL, Kim HT. Comparison of ropivacaine and bupivacaine toxicity in human articular chondrocytes. J Bone Joint Surg Am 2008;90:986-91
   PubMed Web of Science ®Google Scholar
• Singelyn FJ, Lhotel L, Fabre B. Pain relief after arthroscopic shoulder surgery: a comparison of intraarticular analgesia, suprascapular nerve block, and interscalene brachial plexus block. Anesth Analg 2004;99:589-92
   PubMed Web of Science ®Google Scholar
• Johansson SGO, O'B Hourihane J, Bousquet J, A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy 2001;56:813-24
   PubMed Web of Science ®Google Scholar