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Reviews

Side effects of common acne treatments

, MD, , MD, , MS & , MD PhD
Pages 39-51 | Published online: 20 Nov 2012

Bibliography

  • Mallon E, Newton JN, Klassen A, The quality of life in acne: a comparison with general medical conditions using generic questionnaires. Br J Dermatol 1999;140:672-6
  • Mulder MM, Sigurdsson V, van Zuuren EJ, Psychosocial impact of acne vulgaris. evaluation of the relation between a change in clinical acne severity and psychosocial state. Dermatology 2001;203:124-30
  • NIAMS: questions and Answers about Acne. Available from: http://www.niams.nih.gov/Health_Info/Acne/default.asp
  • Kurokawa I, Danby FW, Ju Q, New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol 2009;18:821-32
  • Farrar MD, Ingham E. Acne: inflammation. Clin Dermatol 2004;22:380-4
  • James WD, Berger TG, Elston DM. Andrews' diseases of the skin: clinical dermatology. Saunders Elvesier, 11th edition. China; 2011
  • Thiboutot D, Gollnick H, Bettoli V, New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group. J Am Acad Dermatol 2009;60:S1-50
  • Newman MD, Bowe WP, Heughebaert C, Shalita AR. Therapeutic considerations for severe nodular acne. Am J Clin Dermatol 2011;12:7-14
  • Bikowski JB. Clinical experience results with clindamycin 1% benzoyl peroxide 5% gel (Duac) as monotherapy and in combination. J Drugs Dermatol 2005;4:164-71
  • Bolognia J, Jorizzo J, Rapini R, Section 6. Dermatology. Mosby; London, Edinburgh, NY, Philadelphia, St Louis, Sydney, Toronto: 2003. p. 531-45
  • Gollnick H. Current concepts of the pathogenesis of acne: implications for drug treatment. Drugs 2003;63:1579-96
  • Shaw JC. Acne: effect of hormones on pathogenesis and management. Am J Clin Dermatol 2002;3:571-8
  • Bershad SV. The modern age of acne therapy: a review of current treatment options. Mt Sinai J Med 2001;68:279-86
  • Vieira AS, Beijamini V, Melchiors AC. The effect of isotretinoin on triglycerides and liver aminotransferases. An Bras Dermatol 2012;87:382-7
  • Alexiades-Armenakas M. Long-pulsed dye laser-mediated photodynamic therapy combined with topical therapy for mild to severe comedonal, inflammatory, or cystic acne. J Drugs Dermatol 2006;5:45-55
  • Worret WI, Fluhr JW. Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid. J Dtsch Dermatol Ges 2006;4:293-300
  • Lassus A. Local treatment of acne. A clinical study and evaluation of the effect of different concentrations of benzoyl peroxide gel. Curr Med Res Opin 1981;7:370-3
  • Mills OH Jr, Kligman AM, Pochi P, Comite H. Comparing 2.5%, 5%, and 10% benzoyl peroxide on inflammatory acne vulgaris. Int J Dermatol 1986;25:664-7
  • Sagransky M, Yentzer BA, Feldman SR. Benzoyl peroxide: a review of its current use in the treatment of acne vulgaris. Expert Opin Pharmacother 2009;10:2555-62
  • Morelli R, Lanzarini M, Vincenzi C, Reggiani M. Contact dermatitis due to benzoyl peroxide. Contact Dermat 1989;20:238-9
  • Minciullo PL, Patafi M, Giannetto L, Allergic contact angioedema to benzoyl peroxide. J Clin Pharm Ther 2006;31:385-7
  • Cunliffe WJ, Burke B. Benzoyl peroxide: lack of sensitization. Acta Derm Venereol 1982;62:458-9
  • Fulton JE Jr, Bradley S. The choice of vitamin A acid, erythromycin, or benzoyl peroxide for the topical treatment of acne. Cutis 1976;17:560-4
  • Roos TC, Jugert FK, Merk HF, Bickers DR. Retinoid metabolism in the skin. Pharmacol Rev 1998;50:315-33
  • Webster GF, Guenther L, Poulin YP, A multicenter, double-blind, randomized comparison study of the efficacy and tolerability of once-daily tazarotene 0.1% gel and adapalene 0.1% gel for the treatment of facial acne vulgaris. Cutis 2002;69:4-11
  • Clucas A, Verschoore M, Sorba V, Adapalene 0.1% gel is better tolerated than tretinoin 0.025% gel in acne patients. J Am Acad Dermatol 1997;36:S116-18
  • Cunliffe WJ, Caputo R, Dreno B, Clinical efficacy and safety comparison of adapalene gel and tretinoin gel in the treatment of acne vulgaris: europe and U.S. multicenter trials. J Am Acad Dermatol 1997;36:S126-34
  • Caron D, Sorba V, Kerrouche N, Clucas A. Split-face comparison of adapalene 0.1% gel and tretinoin 0.025% gel in acne patients. J Am Acad Dermatol 1997;36:S110-12
  • Cunliffe WJ, Poncet M, Loesche C, Verschoore M. A comparison of the efficacy and tolerability of adapalene 0.1% gel versus tretinoin 0.025% gel in patients with acne vulgaris: a meta-analysis of five randomized trials. Br J Dermatol 1998;139(Suppl 52):48-56
  • Dunlap FE, Baker MD, Plott RT, Verschoore M. Adapalene 0.1% gel has low skin irritation potential even when applied immediately after washing. Br J Dermatol 1998;139(Suppl 52):23-5
  • Leyden JJ, Hickman JG, Jarratt MT, The efficacy and safety of a combination benzoyl peroxide/clindamycin topical gel compared with benzoyl peroxide alone and a benzoyl peroxide/erythromycin combination product. J Cutan Med Surg 2001;5:37-42
  • Tu P, Li GQ, Zhu XJ, A comparison of adapalene gel 0.1% vs. tretinoin gel 0.025% in the treatment of acne vulgaris in China. J Eur Acad Dermatol Venereol 2001;15(Suppl 3):31-6
  • Thielitz A, Gollnick H. Topical retinoids in acne vulgaris: update on efficacy and safety. Am J Clin Dermatol 2008;9:369-81
  • Brand B, Gilbert R, Baker MD, Cumulative irritancy comparison of adapalene gel 0.1% versus other retinoid products when applied in combination with topical antimicrobial agents. J Am Acad Dermatol 2003;49:S227-32
  • Phillips TJ. An update on the safety and efficacy of topical retinoids. Cutis 2005;75:14-22. 24
  • Pariser D, Colon LE, Johnson LA, Gottschalk RW. Adapalene 0.1% gel compared to tazarotene 0.1% cream in the treatment of acne vulgaris. J Drugs Dermatol 2008;7:s18-23
  • Marks R. Pharmacokinetics and safety review of tazarotene. J Am Acad Dermatol 1998;39:S134-8
  • Topical retinoids during pregnancy (continued). Prescrire Int 2005;14:100-1
  • Gollnick HP, Draelos Z, Glenn MJ, Adapalene-benzoyl peroxide, a unique fixed-dose combination topical gel for the treatment of acne vulgaris: a transatlantic, randomized, double-blind, controlled study in 1670 patients. Br J Dermatol 2009;161:1180-9
  • Leyden JJ, Nighland M, Rossi AB, Ramaswamy R. Irritation potential of tretinoin gel microsphere pump versus adapalene plus benzoyl peroxide gel. J Drugs Dermatol 2010;9:998-1003
  • Loesche C, Pernin C, Poncet M. Adapalene 0.1% and benzoyl peroxide 2.5% as a fixed-dose combination gel is as well tolerated as the individual components alone in terms of cumulative irritancy. Eur J Dermatol 2008;18:524-6
  • Langner A, Chu A, Goulden V, Ambroziak M. A randomized, single-blind comparison of topical clindamycin + benzoyl peroxide and adapalene in the treatment of mild to moderate facial acne vulgaris. Br J Dermatol 2008;158:122-9
  • Ross JI, Eady EA, Cove JH, Resistance to erythromycin and clindamycin in cutaneous propionibacteria is associated with mutations in 23S rRNA. Dermatology 1998;196:69-70
  • Ross JI, Snelling AM, Carnegie E, Antibiotic-resistant acne: lessons from Europe. Br J Dermatol 2003;148:467-78
  • Gollnick HP, Krautheim A. Topical treatment in acne: current status and future aspects. Dermatology 2003;206:29-36
  • Lesher JL Jr, Chalker DK, Smith JG Jr, An evaluation of a 2% erythromycin ointment in the topical therapy of acne vulgaris. J Am Acad Dermatol 1985;12:526-31
  • Fisher AA. Adverse reactions to topical clindamycin, erythromycin and tetracycline. Cutis 1983;32:415, 419, 424, 428
  • Becker LE, Bergstresser PR, Whiting DA, Topical clindamycin therapy for acne vulgaris. A cooperative clinical study. Arch Dermatol 1981;117:482-5
  • Siegle RJ, Fekety R, Sarbone PD, Effects of topical clindamycin on intestinal microflora in patients with acne. J Am Acad Dermatol 1986;15:180-5
  • Green L, Cirigliano M, Gwazdauskas JA, Gonzalez P. The Tolerability Profile of Clindamycin 1%/Benzoyl Peroxide 5% Gel vs. Adapalene 0.1%/Benzoyl Peroxide 2.5% Gel for Facial Acne: results of Two Randomized, Single-Blind, Split-Face Studies. J Clin Aesthet Dermatol 2012;5:16-24
  • Kircik LH. Harnessing the anti-inflammatory effects of topical dapsone for management of acne. J Drugs Dermatol 2010;9:667-71
  • Piette WW, Taylor S, Pariser D, Hematologic safety of dapsone gel, 5%, for topical treatment of acne vulgaris. Arch Dermatol 2008;144:1564-70
  • Webster GF. Is topical dapsone safe in glucose-6-phosphate dehydrogenase-deficient and sulfonamide-allergic patients? J Drugs Dermatol 2010;9:532-6
  • Graupe K, Cunliffe WJ, Gollnick HP, Zaumseil RP. Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports. Cutis 1996;57:20-35
  • Akhavan A, Bershad S. Topical acne drugs: review of clinical properties, systemic exposure, and safety. Am J Clin Dermatol 2003;4:473-92
  • Thiboutot D, Thieroff-Ekerdt R, Graupe K. Efficacy and safety of azelaic acid (15%) gel as a new treatment for papulopustular rosacea: results from two vehicle-controlled, randomized phase III studies. J Am Acad Dermatol 2003;48:836-45
  • Haider A, Shaw JC. Treatment of acne vulgaris. JAMA 2004;292:726-35
  • Khocht A, Calem B, Deasy M. Use of anti-inflammatory medications in managing atypical gingivitis associated with hypermobile Ehlers-Danlos syndrome: a case report. J Periodontol 2004;75:1547-52
  • Zaidi Z. Acne vulgaris--an update on pathophysiology and treatment. J Pak Med Assoc 2009;59:635-7
  • Simonart T, Dramaix M, De Maertelaer V. Efficacy of tetracyclines in the treatment of acne vulgaris: a review. Br J Dermatol 2008;158:208-16
  • Smith K, Leyden JJ. Safety of doxycycline and minocycline: a systematic review. Clin Ther 2005;27:1329-42
  • Tan HH. Antibacterial therapy for acne: a guide to selection and use of systemic agents. Am J Clin Dermatol 2003;4:307-14
  • Sloan B, Scheinfeld N. The use and safety of doxycycline hyclate and other second-generation tetracyclines. Expert Opin Drug Saf 2008;7:571-7
  • Lebrun-Vignes B, Kreft-Jais C, Castot A, Chosidow O. Comparative analysis of adverse drug reactions to tetracyclines: results of a French national survey and review of the literature. Br J Dermatol 2012;166:1333-41
  • Leyden JJ, Del Rosso JQ. Oral antibiotic therapy for acne vulgaris: pharmacokinetic and pharmacodynamic perspectives. J Clin Aesthet Dermatol 2011;4:40-7
  • Gammon WR, Meyer C, Lantis S, Comparative efficacy of oral erythromycin versus oral tetracycline in the treatment of acne vulgaris. A double-blind study. J Am Acad Dermatol 1986;14:183-6
  • Okudaira T, Kotegawa T, Imai H, Effect of the treatment period with erythromycin on cytochrome P450 3A activity in humans. J Clin Pharmacol 2007;47:871-6
  • Cooper WO, Ray WA, Griffin MR. Prenatal prescription of macrolide antibiotics and infantile hypertrophic pyloric stenosis. Obstet Gynecol 2002;100:101-6
  • Lucky AW. Quantitative documentation of a premenstrual flare of facial acne in adult women. Arch Dermatol 2004;140:423-4
  • George R, Clarke S, Thiboutot D. Hormonal therapy for acne. Semin Cutan Med Surg 2008;27:188-96
  • Archer DF, Lasa IL. Tailoring combination oral contraceptives to the individual woman. J Womens Health (Larchmt) 2011;20:879-91
  • Haroun M. Hormonal therapy of acne. J Cutan Med Surg 2004;8(Suppl 4):6-10
  • Shaw JC. Low-dose adjunctive spironolactone in the treatment of acne in women: a retrospective analysis of 85 consecutively treated patients. J Am Acad Dermatol 2000;43:498-502
  • Yemisci A, Gorgulu A, Piskin S. Effects and side-effects of spironolactone therapy in women with acne. J Eur Acad Dermatol Venereol 2005;19:163-6
  • Franks S, Layton A, Glasier A. Cyproterone acetate/ethinyl estradiol for acne and hirsutism: time to revise prescribing policy. Hum Reprod 2008;23:231-2
  • Savidou I, Deutsch M, Soultati AS, Hepatotoxicity induced by cyproterone acetate: a report of three cases. World J Gastroenterol 2006;12:7551-5
  • Hinkel A, Berges RR, Pannek J, Cyproterone acetate in the treatment of advanced prostatic cancer: retrospective analysis of liver toxicity in the long-term follow-up of 89 patients. Eur Urol 1996;30:464-70
  • Gooren L. Hormone treatment of the adult transsexual patient. Horm Res 2005;64(Suppl 2):31-6
  • Merritt B, Burkhart CN, Morrell DS. Use of isotretinoin for acne vulgaris. Pediatr Ann 2009;38:311-20
  • Nelson AM, Gilliland KL, Cong Z, Thiboutot DM. 13-cis Retinoic acid induces apoptosis and cell cycle arrest in human SEB-1 sebocytes. J Invest Dermatol 2006;126:2178-89
  • Fraunfelder FW, Fraunfelder FT. Evidence for a probable causal relationship between tretinoin, acitretin, and etretinate and intracranial hypertension. J Neuroophthalmol 2004;24:214-16
  • McLane J. Analysis of common side effects of isotretinoin. J Am Acad Dermatol 2001;45:S188-94
  • Sampaio S, Bagatin E. A 65-year experience treating acne, including 26 years with oral isotretinoin. An Bras Dermatol 2008;83:361-7
  • Bozkurt B, Irkec MT, Atakan N, Lacrimal function and ocular complications in patients treated with systemic isotretinoin. Eur J Ophthalmol 2002;12:173-6
  • Brito MF, Sant'Anna IP, Galindo JC, Evaluation of clinical adverse effects and laboratory alterations in patients with acne vulgaris treated with oral isotretinoin. An Bras Dermatol 2010;85:331-7
  • Landau M, Mesterman R, Ophir J, Clinical significance of markedly elevated serum creatine kinase levels in patients with acne on isotretinoin. Acta Derm Venereol 2001;81:350-2
  • Bershad S, Rubinstein A, Paterniti JR, Changes in plasma lipids and lipoproteins during isotretinoin therapy for acne. N Engl J Med 1985;313:981-5
  • Vieira AS, Beijamini V, Melchiors AC. The effect of isotretinoin on triglycerides and liver aminotransferases. An Bras Dermatol 2012;87:382-7
  • Haedersdal M, Togsverd-Bo K, Wulf HC. Evidence-based review of lasers, light sources and photodynamic therapy in the treatment of acne vulgaris. J Eur Acad Dermatol Venereol 2008;22:267-78
  • Taub AF. Photodynamic therapy for the treatment of acne: a pilot study. J Drugs Dermatol 2004;3:S10-14
  • Wiegell SR, Wulf HC. Photodynamic therapy of acne vulgaris using methyl aminolaevulinate: a blinded, randomized, controlled trial. Br J Dermatol 2006;154:969-76
  • Itoh Y, Ninomiya Y, Tajima S, Ishibashi A. Photodynamic therapy of acne vulgaris with topical delta-aminolaevulinic acid and incoherent light in Japanese patients. Br J Dermatol 2001;144:575-9
  • Taylor MN, Gonzalez ML. The practicalities of photodynamic therapy in acne vulgaris. Br J Dermatol 2009;160:1140-8
  • Kasche A, Luderschmidt S, Ring J, Hein R. Photodynamic therapy induces less pain in patients treated with methyl aminolevulinate compared to aminolevulinic acid. J Drugs Dermatol 2006;5:353-6
  • Sakamoto FH, Lopes JD, Anderson RR. Photodynamic therapy for acne vulgaris: a critical review from basics to clinical practice: part I. Acne vulgaris: when and why consider photodynamic therapy? J Am Acad Dermatol 2010;63:183-93
  • Sakamoto FH, Torezan L, Anderson RR. Photodynamic therapy for acne vulgaris: a critical review from basics to clinical practice: part II. Understanding parameters for acne treatment with photodynamic therapy. J Am Acad Dermatol 2010;63:195-211
  • UpToDate. Waltham, MA, 2012.

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