360
Views
197
CrossRef citations to date
0
Altmetric
Review

Glial fibrillary acidic protein and related glial proteins as biomarkers of neurotoxicity

&
Pages 433-442 | Published online: 10 May 2005

Bibliography

  • SUTCLIFFE JG: mRNA in the mammalian central nervous system. Ann. Rev Neurosci. (1988) 11:157–1998.
  • O'CALLAGHAN JP, JENSEN KF: Enhanced expression of glial fibrillary acidic protein and the cupric silver degeneration reaction can be used as sensitive and early indicators of neurotoxicity. Neurotoxicology (1992) 13(1):113–122.
  • O'CALLAGHAN JP: Quantitative features of reactive gliosis following toxicant-induced damage of the CNS. Ann. NY Acad. Sci. (1993) 679:195–210.
  • O'CALLAGHAN JP, JENSEN KF, MILLER DB: Quantitative aspects of drug and toxicant-induced astrogliosis. Neurochem. Int. (1995) 26(2):115–124.
  • •This review expands on the points made in sections 4.1-4.3.
  • LITTLE AR, O'CALLAGHAN JP: Astrogliosis in the adult and developing CNS: is there a role for proinflammatory cytokines? Neurotoxicology (2001) 22(5):607–618.
  • LITTLE AR, BENKOVIC SA, MILLER DB, O'CALLAGHAN JP: Chemically induced neuronal damage and gliosis: enhanced expression of the proinflammatory chemokine, monocyte chemoattractant protein (MCP)-1, without a corresponding increase in proinflammatory cytokines(1). Neuroscience (2002) 115(1):307–320.
  • SRIRAM K, MATHESON JM, BENKOVIC SA et al.: Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's disease. FASEB J. (2002) 16(11):1474–1476
  • SRIRAM K, BENKOVIC SA, HEBERT MA, MILLER DB, O'CALLAGHAN JP: Induction of gp130-related cytokines and activation of JAK2/STAT3 pathway in astrocytes precedes up-regulation of glial fibrillary acidic protein in the 1-methy1-4-phenyl-1,2,3,6-tetrahydropyridine model of neurodegeneration: key signaling pathway for astrogliosis in vivo? J. Biol. Chem. (2004) 279(19):19936–19947.
  • SRIRAM K, O'CALLAGHAN JP: Signaling mechanisms underlying toxicant-induced gliosis. In: The Role of Clio in Neurotoxicig, (2nd Ed). Aschner M, Costa LG (Eds), CRC Press, Boca Raton, Florida (2005) pp141–171.
  • •A review of the current state of knowledge of the signaling mechanisms responsible for induction of gliosis.
  • GROSS CJ, KRAMER JA: The role of investigative molecular toxicology in early stage drug development. Expert Opin. Drug Sal: (2003) 2(2):147–159.
  • IRWIN S: Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. Psychopharmacologia (1968) 13(3):222–257.
  • GERBER GJ, O'SHAUGHNESSY D: Comparison of the behavioral effects of neurotoxic and systemically toxic agents; how discriminatory are behavioral tests of neurotoxicity? Neurobehav. Toxicol 7eratol (1986) 8(6):703–710.
  • SHEETS LP, HAMILTON BE SANGHA GK, THYSSEN JH: Subchronic neurotoxicity screening studies with six organophosphate insecticides: an assessment of behavior and morphology relative to cholinesterase inhibition. Fundam. Appl. Toxicol (1997) 35(1):101–119.
  • MIDDAUGH LD, DOW-EDWARDS D, LI AA et al.: Neurobehavioral assessment: a survey of use and value in safety assessment studies. Toxic& Sci. (2003) 76(2):250–261.
  • SWITZER RC 3rd: Application of silver degeneration stains for neurotoxicity testing. Toxicol Pathol. (2000) 28(1):70–83.
  • •Comprehensive review of the application of silver degeneration stains for neurotoxicity screening.
  • GUNDERSEN HJ: Stereology: the fast lane between neuroanatomy and brain function - or still only a tightrope? Acta Neurol. Scand. Suppl. (1992) 137:8–13.
  • SCHMITZ C, HOF PR: Design-based stereology in neuroscience. Neuroscience (2005) 130(4):813–831.
  • DE OLMOS JS, BELTRAMINO CA, DE OLMOS DE LORENZO S: Use of an amino-cupric-silver technique for the detection of early and semiacute neuronal degeneration caused by neurotoxicants, hypoxia, and physical trauma. Neurotoxicol Teratol. (1994) 16(6):545–561.
  • SCHMUED LC, HOPKINS KJ: Fluoro-Jade B: A high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res. (2000) 874(2):123–130.
  • SCHMUED LC, HOPKINS KJ: Fluoro-Jade: novel fluorochromes for detecting toxicant-induced neuronal degeneration. Toxicol. Patna (2000) 28(1):91–99.
  • •A review describing the application of Fluoro-Jade staining for detecting neurodegeneration; includes fairly extensive validation studies.
  • LORD PG, PAPOIAN T: Genomics and drug toxicity. Science (2004) 306(5696):575.
  • RIDET JL, MALHOTRA SK, PRIVAT A, GAGE FH: Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurasci. (1997) 20(12):570–577.
  • NORENBERG MD: The reactive astrocyte. In: The Role of Glia in Neurotoxicity (2nd Ed). Aschner M, Costa LG (Eds), CRC Press, Boca Raton, Florida (2005) 73–92.
  • ••Concise review of the features associatedwith reactive ghosts; dispels many of the `myths' associated with this cellular reaction to injury.
  • NORTON WT, AQUINO DA, HOZUMI I, CHIU FC, BROSNAN CF: Quantitative aspects of reactive gliosis: a review. Neurochein. Res. (1992) 17(9):877–885.
  • O'CALLAGHAN JP: Quantification of glial fibrillary acidic protein: comparison of slot-immunobinding assays with a novel sandwich ELISA. Neurotoxicol Teratol. (1991) 13(3):275–281.
  • O'CALLAGHAN JP: Measurement of glial fibrillary acidic protein. In: Current Protocols in Toxicology. Maines MD, Costa LG, Hodgson E, Reed DJ, Sipes IG (Eds). John Wiley & Sons, New York (2002) Sections 12.8.1–12.8.12.
  • ••Provides detailed good laboratorypractice-compliant protocol for quantitative measurement of GFAP by sandwich ELISA.
  • KASHON ML, ROSS GW, O'CALLAGHAN JP et al: Associations of cortical astrogliosis with cognitive performance and dementia status. Alzheliners Dis. (2004) 6(6):595–604.
  • KREUTZBERG GW: Microglia: a sensor for pathological events in the CNS. Trends Neuracci. (1996) 19(8):312–318.
  • STREIT WJ: The role of microglia in neurotoxicity. In: The Role of Glia in Neurotoxicio, (2nd Ed). Aschner M, Costa LG (Eds), CRC Press, Boca Raton, Florida (2005) 29–40.
  • MILLER DB, REINHARD JF Jr, DANIELS AJ, O'CALLAGHAN JP: Diethyldithiocarbamate potentiates the neurotoxicity of in vivo 1-methy1-4-phenyl-1,2,3,6-tetrahydropyridine and of in vitro 1-methyl-4-phenylpyridinium. Neurochein. (1991) 57:541–549.
  • COMMITTEE ON ANIMAL AND TRANSLATIONAL NEUROSCIENCE: Translational neuroscience accomplishments, Society for Neuroscience, 2003.

Websites

  • http://www.epa.goviopptsfrs/ OPPTS_Harmonized/ 870_Health_Effects_Test_Guidelines/ Series/870-6200.pdf USEPA: Health effects test guidelines: OPPTS 870.6200 Neurotoxicity Screening Battery. USEPA publication 712-C-98-238 (1998).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.