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Expert Opinion on Drug Safety Volume 4, 2005 - Issue 3
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Review

Pharmacotherapy of erectile dysfunction: focus on cardiovascular safety

Thorsten ReffelmannUniversity of Southern California The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine, Keck School of Medicine, 1225 Wilshire Boulevard, Los Angeles, CA 90017-2395USATel: +1 213 977 4050; Fax: +1 213 977 4107;E-mail: [email protected]
&
Robert A KlonerUniversity of Southern California The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine, Keck School of Medicine, 1225 Wilshire Boulevard, Los Angeles, CA 90017-2395USATel: +1 213 977 4050; Fax: +1 213 977 4107;E-mail: [email protected]
Pages 531-540 | Published online: 10 May 2005

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  • ••Comprehensive discussion of riskand value of sildenafil in patients with cardiovascular disease, including recommendations for its use.
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  • •Efficacy of sildenafil for erectile dysfunction.
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  • ••Detailed guidelines for estimating thecardiovascular risk of sexual activity in cardiac patients.
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  • •Interesting study on the potential of PDE5 inhibitors in primary pulmonary hypertension.
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  • ••Systematic investigation ontissue distribution, pharmacology and functional implications of PDE5 isoforms.
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  • •Excellent review on pharmacology of the three PDE5 inhibitors.
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  • ••Study in patients on effects of sildenafilon the coronary circulation.
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  • •Well-performed study on exercise tolerance.
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  • •Evaluation of side effects in patients with heart failure.
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  • •Evaluation of side effects in patients with heart failure.
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  • •Estimate of the risk of myocardial infarction during sexual intercourse.
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  • •Interesting summary of studies investigating cardiovascular events in patients taking tadalafil.
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