Applications for site-directed molecular imaging agents coupled with drug delivery potential

Bibliography

• Haberkorn U. PET and SPECT. Handb Exp Pharmacol 2008;(185 Pt 2):13-35
   PubMedGoogle Scholar
• Hu G, Lijowski M, Zhang H, et al. Imaging of Vx-2 rabbit tumors with alpha(nu)beta3-integrin-targeted 111In nanoparticles. Int J Cancer 2007;120:1951-7
   PubMed Web of Science ®Google Scholar
• Lijowski M, Caruthers S, Hu G, et al. High sensitivity: high-resolution SPECT-CT/MR molecular imaging of angiogenesis in the Vx2 model. Invest Radiol 2009;44:15-22
   PubMed Web of Science ®Google Scholar
• Kleiter MM, Yu D, Mohammadian LA, et al. A tracer dose of technetium-99m-labeled liposomes can estimate the effect of hyperthermia on intratumoral doxil extravasation. Clin Cancer Res 2006;12:6800-7
   PubMed Web of Science ®Google Scholar
• Hsu AR, Cai W, Veeravagu A, et al. Multimodality molecular imaging of glioblastoma growth inhibition with vasculature-targeting fusion toxin VEGF121/rGel. J Nucl Med 2007;48:445-54
   PubMed Web of Science ®Google Scholar
• Wang H, Chen K, Cai W, et al. Integrin-targeted imaging and therapy with RGD4C-TNF fusion protein. Mol Cancer Ther 2008;7:1044-53
   PubMed Web of Science ®Google Scholar
• Cao Q, Cai W, Niu G, et al. Multimodality imaging of IL-18 – binding protein-Fc therapy of experimental lung metastasis. Clin Cancer Res 2008;14:6137-45
   PubMed Web of Science ®Google Scholar
• Cai W, Wu Y, Chen K, et al. In vitro and in vivo characterization of 64Cu-labeled Abegrin, a humanized monoclonal antibody against integrin alpha v beta 3. Cancer Res 2006;66:9673-81
   PubMed Web of Science ®Google Scholar
• Haubner R, Wester HJ, Burkhart F, et al. Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics. J Nucl Med 2001;42:326-36
   PubMed Web of Science ®Google Scholar
• Haubner R, Wester HJ, Reuning U, et al. Radiolabeled alpha(v)beta3 integrin antagonists: a new class of tracers for tumor targeting. J Nucl Med 1999;40:1061-71
   PubMed Web of Science ®Google Scholar
• Cai W, Chen K, Li ZB, et al. Dual-function probe for PET and near-infrared fluorescence imaging of tumor vasculature. J Nucl Med 2007;48:1862-70
   PubMed Web of Science ®Google Scholar
• Hsu AR, Hou LC, Veeravagu A, et al. In vivo near-infrared fluorescence imaging of integrin alphavbeta3 in an orthotopic glioblastoma model. Mol Imaging Biol 2006;8:315-23
   PubMed Web of Science ®Google Scholar
• Lee HY, Li Z, Chen K, et al. PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles. J Nucl Med 2008;49:1371-9
   PubMed Web of Science ®Google Scholar
• Harris TD, Cheesman E, Harris AR, et al. Radiolabeled divalent peptidomimetic vitronectin receptor antagonists as potential tumor radiotherapeutic and imaging agents. Bioconjug Chem 2007;18:1266-79
   PubMed Web of Science ®Google Scholar
• Meoli DF, Sadeghi MM, Krassilnikova S, et al. Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction. J Clin Invest 2004;113:1684-91
   PubMed Web of Science ®Google Scholar
• Onthank DC, Liu S, Silva PJ, et al. 90Y and 111In complexes of a DOTA-conjugated integrin alpha v beta 3 receptor antagonist: different but biologically equivalent. Bioconjug Chem 2004;15:235-41
   PubMed Web of Science ®Google Scholar
• Sadeghi MM, Krassilnikova S, Zhang J, et al. Detection of injury-induced vascular remodeling by targeting activated alphavbeta3 integrin in vivo. Circulation 2004;110:84-90
   PubMed Web of Science ®Google Scholar
• Cao Q, Li ZB, Chen K, et al. Evaluation of biodistribution and anti-tumor effect of a dimeric RGD peptide-paclitaxel conjugate in mice with breast cancer. Eur J Nucl Med Mol Imaging 2008;35:1489-98
   PubMed Web of Science ®Google Scholar
• Alam MR, Dixit V, Kang H, et al. Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis. Nucleic Acids Res 2008;36:2764-76
   PubMed Web of Science ®Google Scholar
• Giepmans BN, Adams SR, Ellisman MH, Tsien RY. The fluorescent toolbox for assessing protein location and function. Science 2006;312:217-24
   PubMed Web of Science ®Google Scholar
• Contag CH. In vivo pathology: seeing with molecular specificity and cellular resolution in the living body. Annu Rev Pathol 2007;2:277-305
   PubMed Web of Science ®Google Scholar
• Weissleder R. Molecular imaging in cancer. Science 2006;312:1168-71
   PubMed Web of Science ®Google Scholar
• Lewis GD, Figari I, Fendly B, et al. Differential responses of human tumor cell lines to anti-p185HER2 monoclonal antibodies. Cancer Immunol Immunother 1993;37:255-63
   PubMed Web of Science ®Google Scholar
• Gee MS, Upadhyay R, Bergquist H, et al. Human breast cancer tumor models: molecular imaging of drug susceptibility and dosing during HER2/neu-targeted therapy. Radiology 2008;248:925-35
   PubMed Web of Science ®Google Scholar
• Bruchez MP. Turning all the lights on: quantum dots in cellular assays. Curr Opin Chem Biol 2005;9:533-7
   PubMed Web of Science ®Google Scholar
• Jaiswal JK, Goldman ER, Mattoussi H, Simon SM. Use of quantum dots for live cell imaging. Nat Methods 2004;1:73-8
   PubMed Web of Science ®Google Scholar
• Jaiswal JK, Simon SM. Potentials and pitfalls of fluorescent quantum dots for biological imaging. Trends Cell Biol 2004;14:497-504
   PubMed Web of Science ®Google Scholar
• Medintz IL, Uyeda HT, Goldman ER, Mattoussi H. Quantum dot bioconjugates for imaging, labelling and sensing. Nat Mater 2005;4:435-46
   PubMed Web of Science ®Google Scholar
• Michalet X, Pinaud FF, Bentolila LA, et al. Quantum dots for live cells, in vivo imaging, and diagnostics. Science 2005;307:538-44
   PubMed Web of Science ®Google Scholar
• So MK, Xu C, Loening AM, et al. Self-illuminating quantum dot conjugates for in vivo imaging. Nat Biotechnol 2006;24:339-43
   PubMed Web of Science ®Google Scholar
• Duncan R. The dawning era of polymer therapeutics. Nat Rev Drug Discov 2003;2:347-60
   PubMed Web of Science ®Google Scholar
• Chen AA, Derfus AM, Khetani SR, Bhatia SN. Quantum dots to monitor RNAi delivery and improve gene silencing. Nucleic Acids Res 2005;33:e190
   Google Scholar
• Gopalakrishnan G, Danelon C, Izewska P, et al. Multifunctional lipid/quantum dot hybrid nanocontainers for controlled targeting of live cells. Angew Chem Int Ed Engl 2006;45:5478-83
   PubMed Web of Science ®Google Scholar
• Tan WB, Jiang S, Zhang Y. Quantum-dot based nanoparticles for targeted silencing of HER2/neu gene via RNA interference. Biomaterials 2007;28:1565-71
   PubMed Web of Science ®Google Scholar
• Al-Jamal WT, Al-Jamal KT, Bomans PH, et al. Functionalized quantum dot–liposome hybrids as multimodal nanoparticles for cancer. Small 2008;4:1406-15
   PubMed Web of Science ®Google Scholar
• Gao X, Cui Y, Levenson RM, et al. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol 2004;22:969-76
   PubMed Web of Science ®Google Scholar
• Kennel SJ, Woodward JD, Rondinone AJ, et al. The fate of MAb-targeted Cd(125m)Te/ZnS nanoparticles in vivo. Nucl Med Biol 2008;35:501-14
   PubMed Web of Science ®Google Scholar
• Schipper ML, Cheng Z, Lee SW, et al. microPET-based biodistribution of quantum dots in living mice. J Nucl Med 2007;48:1511-8
   PubMed Web of Science ®Google Scholar
• Bagalkot V, Zhang L, Levy-Nissenbaum E, et al. Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on bi-fluorescence resonance energy transfer. Nano Lett 2007;7:3065-70
   PubMed Web of Science ®Google Scholar
• Weng KC, Noble CO, Papahadjopoulos-Sternberg B, et al. Targeted tumor cell internalization and imaging of multifunctional quantum dot-conjugated immunoliposomes in vitro and in vivo. Nano Lett 2008;8:2851-7
   PubMed Web of Science ®Google Scholar
• Kim DH, Rossi JJ. Strategies for silencing human disease using RNA interference. Nat Rev Genet 2007;8:173-84
   PubMed Web of Science ®Google Scholar
• Derfus AM, Chen AA, Min DH, et al. Targeted quantum dot conjugates for siRNA delivery. Bioconjug Chem 2007;18:1391-6
   PubMed Web of Science ®Google Scholar
• Yezhelyev MV, Qi L, O'Regan RM, et al. Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging. J Am Chem Soc 2008;130:9006-12
   PubMed Web of Science ®Google Scholar
• Qi L, Gao X. Quantum dot–amphipol nanocomplex for intracellular delivery and real-time imaging of siRNA. ACS Nano 2008;2:1403-10
   PubMed Web of Science ®Google Scholar
• Comsa DC, Farrell TJ, Patterson MS. Quantification of bioluminescence images of point source objects using diffusion theory models. Phys Med Biol 2006;51:3733-46
   PubMed Web of Science ®Google Scholar
• Takeda M, Tada H, Higuchi H, et al. In vivo single molecular imaging and sentinel node navigation by nanotechnology for molecular targeting drug delivery systems and tailor-made medicine. Breast Cancer 2008;15:145-52
   PubMed Web of Science ®Google Scholar
• Shashkov EV, Everts M, Galanzha EI, Zharov VP. Quantum dots as multimodal photoacoustic and photothermal contrast agents. Nano Lett 2008;8:3953-8
   PubMed Web of Science ®Google Scholar
• Chatterjee DK, Fong LS, Zhang Y. Nanoparticles in photodynamic therapy: an emerging paradigm. Adv Drug Deliv Rev 2008;60:1627-37
   PubMed Web of Science ®Google Scholar
• Donnelly RF, McCarron PA, Morrow DI, et al. Photosensitiser delivery for photodynamic therapy. Part 1: topical carrier platforms. Expert Opin Drug Deliv 2008;5:757-66
   PubMed Web of Science ®Google Scholar
• Donnelly RF, McCarron PA, Woolfson D. Drug delivery systems for photodynamic therapy. Recent Pat Drug Deliv Formul 2009;3:1-7
   PubMedGoogle Scholar
• Stefflova K, Chen J, Zheng G. Killer beacons for combined cancer imaging and therapy. Curr Med Chem 2007;14:2110-25
   PubMed Web of Science ®Google Scholar
• Hemming AW, Davis NL, Dubois B, et al. Photodynamic therapy of squamous cell carcinoma. An evaluation of a new photosensitizing agent, benzoporphyrin derivative and new photoimmunoconjugate. Surg Oncol 1993;2:187-96
   PubMed Web of Science ®Google Scholar
• Schell C, Hombrecher HK. Synthesis and investigation of glycosylated mono- and diarylporphyrins for photodynamic therapy. Bioorg Med Chem 1999;7:1857-65
   PubMed Web of Science ®Google Scholar
• Schmidt-Erfurth U, Diddens H, Birngruber R, Hasan T. Photodynamic targeting of human retinoblastoma cells using covalent low-density lipoprotein conjugates. Br J Cancer 1997;75:54-61
   PubMed Web of Science ®Google Scholar
• Vrouenraets MB, Visser GW, Stewart FA, et al. Development of meta-tetrahydroxyphenylchlorin-monoclonal antibody conjugates for photoimmunotherapy. Cancer Res 1999;59:1505-13
   PubMed Web of Science ®Google Scholar
• Vrouenraets MB, Visser GW, Stigter M, et al. Targeting of aluminum (III) phthalocyanine tetrasulfonate by use of internalizing monoclonal antibodies: improved efficacy in photodynamic therapy. Cancer Res 2001;61:1970-5
   PubMed Web of Science ®Google Scholar
• Stefflova K, Li H, Chen J, Zheng G. Peptide-based pharmacomodulation of a cancer-targeted optical imaging and photodynamic therapy agent. Bioconjug Chem 2007;18:379-88
   PubMed Web of Science ®Google Scholar
• Chen Y, Gryshuk A, Achilefu S, et al. A novel approach to a bifunctional photosensitizer for tumor imaging and phototherapy. Bioconjug Chem 2005;16:1264-74
   PubMed Web of Science ®Google Scholar
• Zheng G, Chen J, Stefflova K, et al. Photodynamic molecular beacon as an activatable photosensitizer based on protease-controlled singlet oxygen quenching and activation. Proc Natl Acad Sci USA 2007;104:8989-94
   PubMed Web of Science ®Google Scholar
• Lai CW, Wang YH, Lai CH, et al. Iridium-complex-functionalized Fe3O4/SiO2 core/shell nanoparticles: a facile three-in-one system in magnetic resonance imaging, luminescence imaging, and photodynamic therapy. Small 2008;4:218-24
   PubMed Web of Science ®Google Scholar
• Chourpa I, Lei FH, Dubois P, et al. Intracellular applications of analytical SERS spectroscopy and multispectral imaging. Chem Soc Rev 2008;37:993-1000
   PubMed Web of Science ®Google Scholar
• Keren S, Zavaleta C, Cheng Z, et al. Noninvasive molecular imaging of small living subjects using Raman spectroscopy. Proc Natl Acad Sci USA 2008;105:5844-9
   PubMed Web of Science ®Google Scholar
• Bianco A, Kostarelos K, Prato M. Applications of carbon nanotubes in drug delivery. Curr Opin Chem Biol 2005;9:674-9
   PubMed Web of Science ®Google Scholar
• Feazell RP, Nakayama-Ratchford N, Dai H, Lippard SJ. Soluble single-walled carbon nanotubes as longboat delivery systems for platinum(IV) anticancer drug design. J Am Chem Soc 2007;129:8438-9
   PubMed Web of Science ®Google Scholar
• Liu Z, Chen K, Davis C, et al. Drug delivery with carbon nanotubes for in vivo cancer treatment. Cancer Res 2008;68:6652-60
   PubMed Web of Science ®Google Scholar
• Bhirde AA, Patel V, Gavard J, et al. Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. ACS Nano 2009;3:307-16
   PubMed Web of Science ®Google Scholar
• Pantarotto D, Briand JP, Prato M, Bianco A. Translocation of bioactive peptides across cell membranes by carbon nanotubes. Chem Commun (Camb) 2004;16-7
   PubMed Web of Science ®Google Scholar
• Kam NW, Dai H. Carbon nanotubes as intracellular protein transporters: generality and biological functionality. J Am Chem Soc 2005;127:6021-6
   PubMed Web of Science ®Google Scholar
• Liu Y, Wu DC, Zhang WD, et al. Polyethylenimine-grafted multiwalled carbon nanotubes for secure noncovalent immobilization and efficient delivery of DNA. Angew Chem Int Ed Engl 2005;44:4782-5
   PubMed Web of Science ®Google Scholar
• Kam NW, Liu Z, Dai H. Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing. J Am Chem Soc 2005;127:12492-3
   PubMed Web of Science ®Google Scholar
• Liu Z, Cai W, He L, et al. In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. Nat Nanotechnol 2007;2:47-52
   PubMed Web of Science ®Google Scholar
• Kam NW, O'Connell M, Wisdom JA, Dai H. Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. Proc Natl Acad Sci USA 2005;102:11600-5
   PubMed Web of Science ®Google Scholar
• Cherukuri P, Bachilo SM, Litovsky SH, Weisman RB. Near-infrared fluorescence microscopy of single-walled carbon nanotubes in phagocytic cells. J Am Chem Soc 2004;126:15638-9
   PubMed Web of Science ®Google Scholar
• Cherukuri P, Gannon CJ, Leeuw TK, et al. Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence. Proc Natl Acad Sci USA 2006;103:18882-6
   PubMed Web of Science ®Google Scholar
• Welsher K, Liu Z, Daranciang D, Dai H. Selective probing and imaging of cells with single walled carbon nanotubes as near-infrared fluorescent molecules. Nano Lett 2008;8:586-90
   PubMed Web of Science ®Google Scholar
• Warheit DB, Laurence BR, Reed KL, et al. Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol Sci 2004;77:117-25
   PubMed Web of Science ®Google Scholar
• Lam CW, James JT, McCluskey R, Hunter RL. Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol Sci 2004;77:126-34
   PubMed Web of Science ®Google Scholar
• Maynard AD, Baron PA, Foley M, et al. Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material. J Toxicol Environ Health A 2004;67:87-107
   PubMed Web of Science ®Google Scholar
• Yokoyama A, Sato Y, Nodasaka Y, et al. Biological behavior of hat-stacked carbon nanofibers in the subcutaneous tissue in rats. Nano Lett 2005;5:157-61
   PubMed Web of Science ®Google Scholar
• Singh R, Pantarotto D, Lacerda L, et al. Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc Natl Acad Sci USA 2006;103:3357-62
   PubMed Web of Science ®Google Scholar
• Mayer CR, Geis NA, Katus HA, Bekeredjian R. Ultrasound targeted microbubble destruction for drug and gene delivery. Expert Opin Drug Deliv 2008;5:1121-38
   PubMed Web of Science ®Google Scholar
• Lanza GM, Abendschein DR, Hall CS, et al. Molecular imaging of stretch-induced tissue factor expression in carotid arteries with intravascular ultrasound. Invest Radiol 2000;35:227-34
   PubMed Web of Science ®Google Scholar
• Lanza GM, Trousil RL, Wallace KD, et al. In vitro characterization of a novel, tissue-targeted ultrasonic contrast system with acoustic microscopy. J Acoust Soc Am 1998;104:3665-72
   PubMed Web of Science ®Google Scholar
• Lanza GM, Wallace KD, Scott MJ, et al. A novel site-targeted ultrasonic contrast agent with broad biomedical application. Circulation 1996;94:3334-40
   PubMed Web of Science ®Google Scholar
• Ladam-Marcus V, Mac G, Job L, et al. Contrast-enhanced ultrasound and liver imaging: review of the literature. J Radiol 2009;90:93-108
   PubMed Web of Science ®Google Scholar
• Qin S, Caskey CF, Ferrara KW. Ultrasound contrast microbubbles in imaging and therapy: physical principles and engineering. Phys Med Biol 2009;54:R27-57
   PubMed Web of Science ®Google Scholar
• Porter TR, Cwajg J. Myocardial contrast echocardiography: a new gold standard for perfusion imaging? Echocardiography 2001;18:79-87
   PubMed Web of Science ®Google Scholar
• Nakano H, Ishida Y, Hatakeyama T, et al. Contrast-enhanced intraoperative ultrasonography equipped with late Kupffer-phase image obtained by sonazoid in patients with colorectal liver metastases. World J Gastroenterol 2008;14:3207-11
   PubMed Web of Science ®Google Scholar
• Oldenburg A, Albrecht T. Baseline and contrast-enhanced ultrasound of the liver in tumor patients. Ultraschall Med 2008;29:488-98
   PubMed Web of Science ®Google Scholar
• Watanabe R, Matsumura M, Munemasa T, et al. Mechanism of hepatic parenchyma-specific contrast of microbubble-based contrast agent for ultrasonography: microscopic studies in rat liver. Invest Radiol 2007;42:643-51
   PubMed Web of Science ®Google Scholar
• Lee DJ, Lyshchik A, Huamani J, et al. Relationship between retention of a vascular endothelial growth factor receptor 2 (VEGFR2)-targeted ultrasonographic contrast agent and the level of VEGFR2 expression in an in vivo breast cancer model. J Ultrasound Med 2008;27:855-66
   PubMed Web of Science ®Google Scholar
• Palmowski M, Huppert J, Hauff P, et al. Vessel fractions in tumor xenografts depicted by flow- or contrast-sensitive three-dimensional high-frequency Doppler ultrasound respond differently to antiangiogenic treatment. Cancer Res 2008;68:7042-9
   PubMed Web of Science ®Google Scholar
• Rossi F, Leone VF, Vignoli M, et al. Use of contrast-enhanced ultrasound for characterization of focal splenic lesions. Vet Radiol Ultrasound 2008;49:154-64
   PubMed Web of Science ®Google Scholar
• Wang B, Wang L, Zhou XB, et al. Thrombolysis effect of a novel targeted microbubble with low-frequency ultrasound in vivo. Thromb Haemost 2008;100:356-61
   PubMed Web of Science ®Google Scholar
• Takalkar AM, Klibanov AL, Rychak JJ, et al. Binding and detachment dynamics of microbubbles targeted to P-selectin under controlled shear flow. J Control Release 2004;96:473-82
   PubMed Web of Science ®Google Scholar
• Ottoboni S, Short RE, Kerby MB, et al. Characterization of the in vitro adherence behavior of ultrasound responsive double-shelled microspheres targeted to cellular adhesion molecules. Contrast Media Mol Imaging 2006;1:279-90
   PubMed Web of Science ®Google Scholar
• Ellegala DB, Leong-Poi H, Carpenter JE, et al. Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to alpha(v)beta3. Circulation 2003;108:336-41
   PubMed Web of Science ®Google Scholar
• Willmann JK, Cheng Z, Davis C, et al. Targeted microbubbles for imaging tumor angiogenesis: assessment of whole-body biodistribution with dynamic micro-PET in mice. Radiology 2008;249:212-9
   PubMed Web of Science ®Google Scholar
• Willmann JK, Lutz AM, Paulmurugan R, et al. Dual-targeted contrast agent for US assessment of tumor angiogenesis in vivo. Radiology 2008;248:936-44
   PubMed Web of Science ®Google Scholar
• Lindner JR. Microbubbles in medical imaging: current applications and future directions. Nat Rev Drug Discov 2004;3:527-32
   PubMed Web of Science ®Google Scholar
• Keller MW, Segal SS, Kaul S, Duling B. The behavior of sonicated albumin microbubbles within the microcirculation: a basis for their use during myocardial contrast echocardiography. Circ Res 1989;65:458-67
   PubMed Web of Science ®Google Scholar
• Lindner JR, Ismail S, Spotnitz WD, et al. Albumin microbubble persistence during myocardial contrast echocardiography is associated with microvascular endothelial glycocalyx damage. Circulation 1998;98:2187-94
   PubMed Web of Science ®Google Scholar
• Miller DL, Quddus J. Diagnostic ultrasound activation of contrast agent gas bodies induces capillary rupture in mice. Proc Natl Acad Sci USA 2000;97:10179-84
   PubMed Web of Science ®Google Scholar
• Price RJ, Skyba DM, Kaul S, Skalak TC. Delivery of colloidal particles and red blood cells to tissue through microvessel ruptures created by targeted microbubble destruction with ultrasound. Circulation 1998;98:1264-7
   PubMed Web of Science ®Google Scholar
• Mukherjee D, Wong J, Griffin B, et al. Ten-fold augmentation of endothelial uptake of vascular endothelial growth factor with ultrasound after systemic administration. J Am Coll Cardiol 2000;35:1678-86
   PubMed Web of Science ®Google Scholar
• Iwasaki M, Adachi Y, Nishiue T, et al. Hepatocyte growth factor delivered by ultrasound-mediated destruction of microbubbles induces proliferation of cardiomyocytes and amelioration of left ventricular contractile function in Doxorubicin-induced cardiomyopathy. Stem Cells 2005;23:1589-97
   PubMed Web of Science ®Google Scholar
• Chen S, Ding JH, Bekeredjian R, et al. Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology. Proc Natl Acad Sci USA 2006;103:8469-74
   PubMed Web of Science ®Google Scholar
• Hauff P, Seemann S, Reszka R, et al. Evaluation of gas-filled microparticles and sonoporation as gene delivery system: feasibility study in rodent tumor models. Radiology 2005;236:572-8
   PubMed Web of Science ®Google Scholar
• Hall CS, Marsh JN, Scott MJ, et al. Time evolution of enhanced ultrasonic reflection using a fibrin-targeted nanoparticulate contrast agent. J Acoust Soc Am 2000;108:3049-57
   PubMed Web of Science ®Google Scholar
• Klegerman ME, Zou Y, McPherson DD. Fibrin targeting of echogenic liposomes with inactivated tissue plasminogen activator. J Liposome Res 2008;18:95-112
   PubMed Web of Science ®Google Scholar
• Negishi Y, Endo Y, Fukuyama T, et al. Delivery of siRNA into the cytoplasm by liposomal bubbles and ultrasound. J Control Release 2008;132:124-30
   PubMed Web of Science ®Google Scholar
• Huang SL, McPherson DD, Macdonald RC. A method to co-encapsulate gas and drugs in liposomes for ultrasound-controlled drug delivery. Ultrasound Med Biol 2008;34:1272-80
   PubMed Web of Science ®Google Scholar
• Kee PH, Abruzzo TA, Smith DA, et al. Synthesis, acoustic stability, and pharmacologic activities of papaverine-loaded echogenic liposomes for ultrasound controlled drug delivery. J Liposome Res 2008;18:263-77
   PubMed Web of Science ®Google Scholar
• Xi X, Yang F, Chen D, et al. A targeting drug-delivery model via interactions among cells and liposomes under ultrasonic excitation. Phys Med Biol 2008;53:3251-65
   PubMed Web of Science ®Google Scholar
• Kik K, Lwow F, Szmigiero L. Polymeric drug carriers activated by ultrasounds energy. Polim Med 2007;37:59-65
   PubMedGoogle Scholar
• Steinberg Y, Schroeder A, Talmon Y, et al. Triggered release of aqueous content from liposome-derived sol-gel nanocapsules. Langmuir 2007;23:12024-31
   PubMed Web of Science ®Google Scholar
• Husseini GA, Diaz de la Rosa MA, Gabuji T, et al. Release of doxorubicin from unstabilized and stabilized micelles under the action of ultrasound. J Nanosci Nanotechnol 2007;7:1028-33
   PubMed Web of Science ®Google Scholar
• Zeng Y, Pitt WG. A polymeric micelle system with a hydrolysable segment for drug delivery. J Biomater Sci Polym Ed 2006;17:591-604
   PubMed Web of Science ®Google Scholar
• Lanting B, Barfett J. Encapsulated calcium carbonate suspensions: a drug delivery vehicle sensitive to ultrasound disruption. Mcgill J Med 2006;9:108-10
   PubMedGoogle Scholar
• Mulder WJ, Strijkers GJ, van Tilborg GA, et al. Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging. NMR Biomed 2006;19:142-64
   PubMed Web of Science ®Google Scholar
• Torchilin VP. PEG-based micelles as carriers of contrast agents for different imaging modalities. Adv Drug Deliv Rev 2002;54:235-52
   PubMed Web of Science ®Google Scholar
• Dear JW, Kobayashi H, Brechbiel MW, Star RA. Imaging acute renal failure with polyamine dendrimer-based MRI contrast agents. Nephron Clin Pract 2006;103:c45-9
   PubMed Web of Science ®Google Scholar
• Kobayashi H, Brechbiel MW. Dendrimer-based nanosized MRI contrast agents. Curr Pharm Biotechnol 2004;5:539-49
   PubMed Web of Science ®Google Scholar
• Maeda H, Seymour LW, Miyamoto Y. Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo. Bioconjug Chem 1992;3:351-62
   PubMed Web of Science ®Google Scholar
• Anderson SA, Rader RK, Westlin WF, et al. Magnetic resonance contrast enhancement of neovasculature with alpha(v)beta(3)-targeted nanoparticles. Magn Reson Med 2000;44:433-9
   PubMed Web of Science ®Google Scholar
• Sipkins DA, Cheresh DA, Kazemi MR, et al. Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging. Nat Med 1998;4:623-6
   PubMed Web of Science ®Google Scholar
• Winter PM, Morawski AM, Caruthers SD, et al. Molecular imaging of angiogenesis in early-stage atherosclerosis with alpha(v)beta3-integrin-targeted nanoparticles. Circulation 2003;108:2270-4
   PubMed Web of Science ®Google Scholar
• Winter PM, Caruthers SD, Kassner A, et al. Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel alpha(nu)beta3-targeted nanoparticle and 1.5 tesla magnetic resonance imaging. Cancer Res 2003;63:5838-43
   PubMed Web of Science ®Google Scholar
• Schmieder AH, Winter PM, Caruthers SD, et al. Molecular MR imaging of melanoma angiogenesis with alphanubeta3-targeted paramagnetic nanoparticles. Magn Reson Med 2005;53:621-7
   PubMed Web of Science ®Google Scholar
• Toussaint JF, LaMuraglia GM, Southern JF, et al. Magnetic resonance images lipid, fibrous, calcified, hemorrhagic, and thrombotic components of human atherosclerosis in vivo. Circulation 1996;94:932-8
   PubMed Web of Science ®Google Scholar
• Skinner MP, Yuan C, Mitsumori L, et al. Serial magnetic resonance imaging of experimental atherosclerosis detects lesion fine structure, progression and complications in vivo. Nat Med 1995;1:69-73
   PubMed Web of Science ®Google Scholar
• Flacke S, Fischer S, Scott MJ, et al. Novel MRI contrast agent for molecular imaging of fibrin: implications for detecting vulnerable plaques. Circulation 2001;104:1280-5
   PubMed Web of Science ®Google Scholar
• Nasongkla N, Bey E, Ren J, et al. Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive DDSs. Nano Lett 2006;6:2427-30
   PubMed Web of Science ®Google Scholar
• Hanessian S, Grzyb JA, Cengelli F, Juillerat-Jeanneret L. Synthesis of chemically functionalized superparamagnetic nanoparticles as delivery vectors for chemotherapeutic drugs. Bioorg Med Chem 2008;16:2921-31
   PubMed Web of Science ®Google Scholar
• Lanza GM, Yu X, Winter PM, et al. Targeted antiproliferative drug delivery to vascular smooth muscle cells with a magnetic resonance imaging nanoparticle contrast agent: implications for rational therapy of restenosis. Circulation 2002;106:2842-7
   PubMed Web of Science ®Google Scholar
• Yu MK, Jeong YY, Park J, et al. Drug-loaded superparamagnetic iron oxide nanoparticles for combined cancer imaging and therapy in vivo. Angew Chem Int Ed Engl 2008;47:5362-5
   PubMed Web of Science ®Google Scholar
• Xu H, Baidoo K, Gunn AJ, et al. Design, synthesis, and characterization of a dual modality positron emission tomography and fluorescence imaging agent for monoclonal antibody tumor-targeted imaging. J Med Chem 2007;50:4759-65
   PubMed Web of Science ®Google Scholar
• Chen K, Li ZB, Wang H, et al. Dual-modality optical and positron emission tomography imaging of vascular endothelial growth factor receptor on tumor vasculature using quantum dots. Eur J Nucl Med Mol Imaging 2008;35:2235-44
   PubMed Web of Science ®Google Scholar
• Kircher MF, Mahmood U, King RS, et al. A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation. Cancer Res 2003;63:8122-5
   PubMed Web of Science ®Google Scholar
• Veiseh O, Sun C, Gunn J, et al. Optical and MRI multifunctional nanoprobe for targeting gliomas. Nano Lett 2005;5:1003-8
   PubMed Web of Science ®Google Scholar
• Saad M, Garbuzenko OB, Ber E, et al. Receptor targeted polymers, dendrimers, liposomes: which nanocarrier is the most efficient for tumor-specific treatment and imaging? J Control Release 2008;130:107-14
   PubMed Web of Science ®Google Scholar
• Lee JH, Jun YW, Yeon SI, et al. Dual-mode nanoparticle probes for high-performance magnetic resonance and fluorescence imaging of neuroblastoma. Angew Chem Int Ed Engl 2006;45:8160-2
   PubMed Web of Science ®Google Scholar
• Bakalova R, Zhelev Z, Aoki I, et al. Multimodal silica-shelled quantum dots: direct intracellular delivery, photosensitization, toxic, and microcirculation effects. Bioconjug Chem 2008;19:1135-42
   PubMed Web of Science ®Google Scholar
• Bakalova R, Zhelev Z, Aoki I, et al. Silica-shelled single quantum dot micelles as imaging probes with dual or multimodality. Anal Chem 2006;78:5925-32
   PubMed Web of Science ®Google Scholar
• Magana D, Perera SC, Harter AG, et al. Switching-on superparamagnetism in Mn/CdSe quantum dots. J Am Chem Soc 2006;128:2931-9
   PubMed Web of Science ®Google Scholar
• van Tilborg GA, Mulder WJ, Chin PT, et al. Annexin A5-conjugated quantum dots with a paramagnetic lipidic coating for the multimodal detection of apoptotic cells. Bioconjug Chem 2006;17:865-8
   PubMed Web of Science ®Google Scholar
• Baleizao C, Nagl S, Schaferling M, et al. Dual fluorescence sensor for trace oxygen and temperature with unmatched range and sensitivity. Anal Chem 2008;80:6449-57
   PubMed Web of Science ®Google Scholar
• Chen JW, Pham W, Weissleder R, Bogdanov A Jr. Human myeloperoxidase: a potential target for molecular MR imaging in atherosclerosis. Magn Reson Med 2004;52:1021-8
   PubMed Web of Science ®Google Scholar
• Hafez IM, Ansell S, Cullis PR. Tunable pH-sensitive liposomes composed of mixtures of cationic and anionic lipids. Biophys J 2000;79:1438-46
   PubMed Web of Science ®Google Scholar
• Hafez IM, Cullis PR. Tunable pH-sensitive liposomes. Methods Enzymol 2004;387:113-34
   PubMed Web of Science ®Google Scholar
• Karagianis G, Reiss JA, Marchesini R, et al. Biophysical and biological evaluation of porphyrin–bisacridine conjugates. Anticancer Drug Des 1996;11:205-20
   PubMedGoogle Scholar
• Pikkemaat JA, Wegh RT, Lamerichs R, et al. Dendritic PARACEST contrast agents for magnetic resonance imaging. Contrast Media Mol Imaging 2007;2:229-39
   PubMed Web of Science ®Google Scholar
• Traitel T, Goldbart R, Kost J. Smart polymers for responsive drug delivery systems. J Biomater Sci Polym Ed 2008;19:755-67
   PubMed Web of Science ®Google Scholar
• Viglianti BL, Abraham SA, Michelich CR, et al. In vivo monitoring of tissue pharmacokinetics of liposome/drug using MRI: illustration of targeted delivery. Magn Reson Med 2004;51:1153-62
   PubMed Web of Science ®Google Scholar
• Mulder WJ, Koole R, Brandwijk RJ, et al. Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe. Nano Lett 2006;6:1-6
   PubMed Web of Science ®Google Scholar
• Oostendorp M, Douma K, Hackeng TM, et al. Quantitative molecular magnetic resonance imaging of tumor angiogenesis using cNGR-labeled paramagnetic quantum dots. Cancer Res 2008;68:7676-83
   PubMed Web of Science ®Google Scholar
• Yang J, Lim EK, Lee HJ, et al. Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection. Biomaterials 2008;29:2548-55
   PubMed Web of Science ®Google Scholar
• Choi JS, Park JC, Nah H, et al. A hybrid nanoparticle probe for dual-modality positron emission tomography and magnetic resonance imaging. Angew Chem Int Ed Engl 2008;47:6259-62
   PubMed Web of Science ®Google Scholar
• Mulder WJ, Griffioen AW, Strijkers GJ, et al. Magnetic and fluorescent nanoparticles for multimodality imaging. Nanomed 2007;2:307-24
   PubMed Web of Science ®Google Scholar