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Delivery to mitochondria: a narrower approach for broader therapeutics

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Pages 909-935 | Published online: 05 Jun 2012

Bibliography

  • Murphy MP, Smith RAJ. Drug delivery in mitochondria: the key to mitochondrial medicine. Free Radic Biol Med 2000;28(10):1547-54
  • Langer R. Drug delivery and targeting. Nature 1998;392(6679):5-10
  • Alberts B, Bray D, Johnson A, Energy generation in mitochondria and chloroplasts. In: Essential cell biology. 2nd edition. Garlend Science; Newyork; 1998. p. 55-60
  • Iverson SL, Orrenius S. The cardiolipin-cytochrome c interaction and the mitochondrial regulation of apoptosis. Arch Biochem Biophys 2003;423:37-46
  • Nass S, Nass MMK. Ultramitochondrial fibers with DNA Characteristics. J Cell Biol 1963;19:593-629
  • Anderson S, Bankler AT, Barek BG. Sequence and organization of the human mitochondrial genome. Nature 1981;290:457-65
  • Grivell LA. Nucleo-mitochondrial interactions in mitochondrial gene expression. Crit Rev Biochem Mol Biol 1995;30:121-64
  • Sugioka K, Nakano M, Totsune-Nakano H, Mechanism of O2− generation in reduction and oxidation cycle of ubiquinones in a model of mitochondrial electron transport systems. Biochim Biophys Acta 1988;936:377-85
  • Bienert GP, Schjoerring JK, Jahn TP. Membrane transport of hydrogen peroxide. Biochim Biophys Acta 2006;1758:994-1003
  • Lee WK, Thevenod F. A role for mitochondrial aquaporins in cellular life-and-death decisions? Am J Physiol Cell Physiol 2006;291(2):C195-202
  • Droge W. Free radicals in the physiological control of cell function. Physiol Rev 2002;82:47-95
  • Daltont P, Shertzer H G, Puga A. Regulation of gene expression by reactive oxygen. Annu Rev Pharmacol Toxicol 1999;39:67-101
  • Talbot DA, Lambert AJ, Brand MD. Production of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3. FEBS LETT 2004;556:111-15
  • Petrosillo G. Reactive oxygen species generated from the mitochondrial electron transport chain induce cytochrome c dissociation from beef-heart submitochondrial particles via cardiolipin peroxidation. Possible role in the apoptosis. FEBS LETT 2001;509:435-8
  • Kagan VE, Borisenko GG, Tyurina YY, Oxidativelipidomics of apoptosis: redox catalytic interactions of cytochrome c with cardiolipin and phosphatidylserine. Free Radic Biol Med 2005;37:1963-85
  • Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 1979;59:527-605
  • Fridovich I. Superoxide dismutases. Adv Enzymol Relat Areas Mol Biol 1974;41:35-97
  • Ursini F, Maiorino M, Gregolin C. Phospholipid hydroperoxide glutathione peroxidase. Int J Tissue React 1986;8:99-103
  • Bohr VA. Repair of oxidative DNA damage in nuclear and mitochondrial DNA and some changes with aging in mammalian cells. Free Radic Biol Med 2002;32:804-12
  • Esterbauer H, Schaur RS, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 1991;11:81-128
  • Stadtman ER, OliveR CN. Metal-catalyzed oxidation of proteins. Physiological consequences. J BIOL CHEM 1991;266:2005-8
  • Halliwell B, Gutteridge JM. Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 1990;186:1-85
  • Cadenas E, Davies KJ. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 2000;29:222-30
  • Raha S, Robinson BH. Mitochondria, oxygen free radicals, disease and ageing. Trends Biochem Sci 2000;2(10):502-8
  • Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006;443:787-95
  • Trifunovic A. Mitochondrial DNA and ageing. Biochim Biophys Acta 2006;1757:611-17
  • Chinnery PF, Turnbull DM. Mitochondrial DNA mutations in the pathogenesis of human disease. Mol Med Today 2000;6:425-32
  • Bernardi P, Colonna R, Costantini P, The mitochondrial permeability transition. Biofactors 1998;8:273-81
  • Ashkenazi A, Dixit VM. Apoptosis control by death and decoy receptors. Curr Opin Cell Biol 1999;11:255-60
  • Green DR, Reed JC. Mitochondria and apoptosis. Science 1998;281:1309-12
  • Martinou JC, Desagher S, Antonsson B. Cytochrome c release from mitochondria: all or nothing. Nat Cell Biol 2000;2:E41-3
  • Earnshaw WC, Martins LM, Kaufmann S.H. Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem 1999;68:383-424
  • Gross A. Caspase cleaved BID targets mitochondria and is required for cytochrome c release while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem 1999;274:1156-63
  • Kaplan J. Friedreich's ataxia is a mitochondrial disorder. Proc Natl Acad Sci USA 1999;96(20):10948-9
  • NishikawA T, Edelstein D, Du XL, Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 2000;404(6779):787-90
  • Schapira AH, Mann VM, Cooper JM, Mitochondrial function in Parkinson's disease. the royal kings and queens parkinson's disease research group. Ann Neurol 1992;32(Suppl):S116-24
  • Tabrizi SJ, Workman J, Hart PE, Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse. Ann Neurol 2000;47(1):80-6
  • Koehler CM, Leuenberger D, Merchant S, Human deafness dystonia syndrome is a mitochondrial disease. Proc Natl Acad Sci USA 1999;96(5):2141-6
  • Kroemer G, Dallaporta B, Resche-rignon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol 1998;60:619-42
  • Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev 1998;78(2):547-81
  • Stanley WC, Lopaschuk GD, Hall JL, Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions: potential for pharmacological interventions. Cardiovasc Res 1997;33:243-57
  • Qian T, Herman B, Lemasters JJ. The mitochondrial permeability transition mediates both necrotic and apoptotic death of hepatocytes exposed to Br-A23187. Toxicol Appl Pharmacol 1999;154:117-25
  • Ruuge EK, Ledenev AN, Lakomkin VL, Free radical metabolites in myocardium during ischemia and reperfusion. Am J Physiol 1991;261:81-6
  • Vercesi AE. Ca2+ transport and oxidative damage of mitochondria. Braz J Med Biol Res 1993;26(5):441-57
  • Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem J 1999;341:233-49
  • Choi DW. Ischemia-induced neuronal apoptosis. Curr Opin Neurobiol 1996;6(5):667-72
  • Maulik N, Yoshida T, Das DK. Oxidative stress developed during the reperfusion of ischemic myocardium induces apoptosis. Free Radic Biol Med 1998;24:869-75
  • Morino K, Petersen K, Dufour S, Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J Clin Invest 2005;115:3587-93
  • Anello M, Lupi R, Spampinato D, Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients. Diabetologia 2005;48:282-9
  • Eto K, Tsubamoto Y, Terauchi Y, Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science 1999;283(5404):981-5
  • Allen JA, Coombs MM. Covalent binding of polycyclic aromatic compounds to mitochondrial and nuclear DNA. Nature 1980;287:244-5
  • Wallace DC. Mitochondrial DNA variation in human evolution, degenerative disease, and aging. Am J Hum Genet 1995;57(2):201-23
  • Wallace DC. Mitochondrial diseases in man and mouse. Science 1999;283(5407):1482-8
  • Wallace DC. Diseases of the mitochondrial DNA. Annu Rev Biochem 1992;61:1175-212
  • Wallace DC. Mitochondrial DNA sequence variation in human evolution. Proc Natl Acad Sci USA 1994;91(19):8739-46
  • Pitkanen S, Robinson BH. Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase. J Clin Invest 1996;98(2):345-51
  • Newman NJ. Leber's hereditary optic neuropathy. New genetic considerations. Arch Neurol 1993;50:540-8
  • Goto Y, Nonaka I, Horai S. A mutation in the tRNA(Leu) (UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies. Nature 1990;348:651-3
  • Shoffner JM, Lott MT, Lezza AM, Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNA(Lys) mutation. Cell 1990;61:931-7
  • Rotig A, Lonlay PD, Chretien D, Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia. Nat Genet 1997;17(2):215-17
  • Lutsenko S, Cooper MJ. Localization of the Wilson's disease protein product to mitochondria. Proc Natl Acad Sci USA 1998;95(11):6004-9
  • Halestrap A, Kerr P, Javadov S, Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart. Biochim Biophys Acta 1998;1366(1-2):79-94
  • Hsu LJ, Sagara Y, Arroyo A, Alpha-synuclein promotes mitochondrial defi cit and oxidative stress. Am J Pathol 2000;157:401-10
  • Canet-aviles RM, Wilson MA, Miller DW, The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc Natl Acad Sci USA 2004;101:9103-8
  • Yan SD, Fu J, Soto C, An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease. Nature 1997;389:689-95
  • Liberman EA, Topaly VP, Tsofina LM, Mechanism of Coupling of Oxidative Phosphorylation and the Membrane Potential of Mitochondria. Nature 1969;222:1076-8
  • Ross MF, Kelso GF, Blaikie FH, Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology. Biochemistry 2005;70:222-30
  • Murphy MP. Targeting lipophilic cations to mitochondria. Biochim Biophys Acta 2008;1777:1028-31
  • Kelso GF, Porteous CM, Coulter CV, Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J Biol Chem 2001;276:4588-96
  • Smith RA, Porteous CM, Coulter CV, Selective targeting of an antioxidant to mitochondria. Eur J Biochem 1999;263:709-16
  • Brown SE, Ross MF, Sanjuan-pla A, Targeting lipoic acid to mitochondria: synthesis and characterization of a triphenylphosphonium-conjugated alpha-lipoyl derivative. Free Radic Biol Med 2007;42:1766-80
  • Murphy MP, Echtay KS, Blaikie FH, Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tertbutylnitrone. J Biol Chem 2003;278:48534-45
  • Filipovska A, Kelso GF, Brown SE, Synthesis and characterization of a triphenylphosphonium-conjugated peroxidase mimetic:insights into the interaction of ebselen with mitochondria. J Biol Chem 2005;280:24113-26
  • Dolezal P, Likic V, Tachezy J, Evolution of the Molecular Machines for Protein Import into Mitochondria. Science 2006;313:314-18
  • Eilers M, Hwang S, Schatz G. Unfolding and refolding of a purified precursor protein during import into isolated mitochondria. EMBO J 1988;7:1139-45
  • Neupert W, Herrmann JM. Translocation of Proteins into Mitochondria. Annu Rev Biochem 2007;76:723-49
  • Yamada Y, Harashima H. Mitochondrial drug delivery systems for macromolecule and their therapeutic application to mitochondrial diseases. Adv Drug Deliv Rev 2008;60:1439-62
  • Tanaka M, Borgeld HJ, Zhang J, Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria. J Biomed Sci 2002;9(6 Pt 1):534-41
  • Torchilin VP, Rammohan R, Weissig V, TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors. Proc Natl Acad Sci USA 2001;98:8786-91
  • Shokolenko IN, Alexeyev MF, Ledoux SP, TAT-mediated protein transduction and targeted delivery of fusion proteins into mitochondria of breast cancer cells. DNA Repair (Amst) 2005;4:511-18
  • Horton KL, Stewart KM, Fonseca SB, Mitochondria-penetrating peptides. Chem Biol 2008;15(4):375-82
  • Wender PA, Mitchell DJ, Pattabiraman K, Molecular transporters: the design, synthesis, and evaluation of molecules that enable or enhance cellular uptake. Proc Natl Acad Sci USA 2000;97:13003-8
  • Chiu YL, Ali A, Chu CY, Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells. Chem Biol 2004;11(8):1165-75
  • Magnus R, Yogesh M, Markus S, Cellular Uptake Studies with beta-Peptides. Chembiochem 2002;3:257-9
  • Bonduelle CV, Gillies ER. Dendritic guanidines as efficient analogues of cell penetrating peptides. Pharmaceuticals 2010;14(2):368-76
  • Gammon ST, Villalobos VM, Prior JL, Quantitative analysis of permeation peptide complexed labeled with Technetium-99 m: chiral and sequence specific effects on net cell uptake. Bioconjug Chem 2003;14(2):368-376.
  • Fonseca SB, Pereira MP, Mourtada R, Re-routing chlorambucil to the mitochondria enhances potency and combats drug resistance in cancer cells. Chem Biol 2011;18(4):445-53
  • Kelly LM, Pereira JP, Yi T, EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues. J Immunol 2011;187(6):3026-32
  • Kagawa Y, Inoki Y, Endo H. Gene therapy by mitochondrial transfer. Adv Drug Deliv Rev 2001;49:107-19
  • Dimauro S. Mitochondrial myopathies. Curr Opin Rheumatol 2006;18(6):636-41
  • Martin LJ, Parkinson's disease alphasynuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J Neurosci 2006;26:41-50
  • Sarzi E, Bourdon A, Chre´tien D, Mitochondrial DNA depletion is a prevalent cause of multiple respiratory chain deficiency in childhood. J Pediatr 2007;150:531-4
  • Holt IJ, Harding A, Morgan JA. Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature 1988;331:717-19
  • Chinnery PF. Mitochondrial disorders overview- mitochondrial encephalomyopathies, mitochondrial myopathies, oxidative phosphorylation disorders, respiratory chain disorders (initial posting: June 8, 2000; Last Update: September 16, 2010). In: Pagon RA, editor. Gene reviews. University of Washington; Seattle: 2010
  • Mackenzie JA, Payne RM. Mitochondrial protein import and human health and disease. Biochim Biophys Acta 2007;1772(5):509-23
  • Holt IJ, Harding AE, Petty RK, A new mitochondrial disease associated with mo\⊂itochondrial DNA heteroplasmi. Am J Hum Genet 1990;46:428-33
  • Taylor RW, Chinnery PF, Turnbull DM, Lightowlers RN. Selective inhibition of mutent human mitochondrial DNA replication in vitro by peptide nucleic acid. Nat Genet 1997;15:212-15
  • Yamada Y, Akita H, Kogure K, Mitochondrial drug delivery and mitochondrial disease therapy-an approach to liposome-based delivery targeted to mitochondria. Mitochondrion 2007;7(1-2):63-71
  • D'souza GG, Rammohan R, Cheng SM, DQAsome-mediated delivery of plasmid DNA toward mitochondria in living cells. J Control Release 2003;92(1-2):189-97
  • Flierl A, Jackson C, Cottrell B, Targeted delivery of DNA to the mitochondria compartment via import sequence conjugated peptide nucleic acid. Mol Ther 2003;7:550-7
  • Seibel P, Trappe J, Villani G. Transfection of mitochondria: strategy towards a gene therapy of mitochondrial DNA diseases. Nucleic Acids Res 1995;23(1):10-17
  • Chinnery PF, Taylor RW, Diekert K, Peptid nucleic acid and delivery to human mitochondria. Gene Ther 1999;6(12):1919-28
  • Del Gaizo V, Payne RM. A novel TAT-mitochondrial signal sequence fusion protein is processed, stays in mitochondria, and crosses the placenta. Mol Ther 2003;7:720-30
  • Mukhopadhyay A, Weiner H. Delivery of Drugs and macromolecules to Mitochondria. Adv Drug Deliv Rev 2007;59(8):729-38
  • Weissig V, Boddapati SV, Cheng SM, Liposomes and Liposome-like Vesicles for Drug and DNA Delivery to Mitochondria. J Liposome Res 2006;16:249-64
  • Kogure K, Moriguchi R, Sasaki K, Development of a non-viral multifunctional envelope-type nano device by a novel lipid film hydration method. J Control Release 2004;98:317-23
  • Moriguchi R, Kogure K, Akita H, A multifunctional envelope-type nano device for novel gene delivery of siRNA plasmids. Int J Pharm 2005;301:277-85
  • Murphy MP, Smith RA. Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu Rev Pharmacol Toxicol 2007;47:629-56
  • James AM, Cocheme HM, Murphy MP. Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing. Mech Ageing Dev 2005;126:982-6
  • Graham D, Huynh NN, Hamilton CA, Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy. Hypertension 2009;54:322-8
  • Samuni A, Winkelsberg D, Pinson A, Nitroxide stable radicals protect beating cardiomyocytes against oxidative damage. J Clin Invest 1991;87(5):1526-30
  • Wipf P, Xiao J, Jiang J, Mitochondrial targeting of selective electron scavengers: synthesis and biological analysis of hemigramicidin-TEMPO conjugates. J Am Chem Soc 2005;127:12460-1
  • Szatrowski TP. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res 1991;51:794-8
  • Kawanishi S, Hiraku Y, Pinlaor S, Oxidative and nitrative DNA damage in animals and Oxidative and nitrative DNA damage in animals and inflammation-related carcinogenesis. Biol Chem 2006;387:365-72
  • Irani K, Xia Y, Zweier JL, Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science 1997;275:1649-52
  • Brandon MB, Baldi P, Wallace DC. Mitochondrial mutations in cancer. Oncogene 2006;25:4647-62
  • Behrend LH, Henderson G, Zwacka RM. Reactive oxygen species in oncogenic transformation. Biochem Soc Trans 2003;31:1441-4
  • Kissil JL, Walmsley MJ, Hanlon L, Requirement for Rac1 in a K-ras induced lung cancer in the mouse. Cancer Res 2007;67:8089-94
  • Kopnin PB, Agapova LS, Kopnin BP, Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability. Cancer Res 2007;67:4671-8
  • Indo HP, Davidson M, Yen HC, Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage. Mitochondrion 2007;7:106-18
  • Hu Y, Rosen DG, Zhou Y, Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress. J Biol Chem 2005;280:39485-92
  • Clerkin JS, Naughton R, Quiney C, Mechanisms of ROS modulated cell survival during carcinogenesis. Cancer Lett 2008;226:30-6
  • Nishikawa M. Reactive oxygen species in tumor metastasis. Cancer Lett 2008;266:53-9
  • Wu WS. The signaling mechanism of ROS in tumor progression. Cancer Metastasis Rev 2006;25:695-705
  • Ushio-Fukai M. Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. Cancer Lett 2008;266:37-52
  • Pervaiz S. Tumor intracellular redox status and drug resistance serendipity or a causal relationship? Curr Pharm Des 2004;10:1969-77
  • Sullivan R, Graham CH. Chemo-sensitization of cancer by nitric oxide. Curr Pharm Des 2008;14:1113-23
  • Kong Q, Beel JA, Lillehei KO. A threshold concept for cancer therapy. Med Hypotheses 2000;55:29-35
  • Hour TC, Huang CY, Lin CC, Characterization of molecular events in a series of bladder urothelial carcinoma cell lines with progressive resistance to arsenic trioxide. Anticancer Drugs 2004;15:779-85
  • Boddapati SV, Tongcharoensiriku P, Hanson RN, Mitochondriotropic liposomes. J Liposome Res 2005;15(1–2):49-58
  • Dimas K, Demetzos C, Vaos V, Labdane type diterpenes down-regulate the expression of c-myc protein, but not of bcl-2, in human leukemia T-cells undergoing apoptosis. Leuk Res 2001;25(6):449-54
  • Patel NR, Hatziantoniou S, Georgopoulos A, Mitochondria-targeted liposomes improve the apoptotic and cytotoxic action of sclareol. J Liposome Res 2010;20(3):244-9
  • Kakudo T, Chaki S, Futaki S, Transferrin-modified liposomes equipped with a pH sensitive fusogenic peptide: an artificial viral-like delivery system. Biochemistry 2004;43:5618-28
  • Khalil IA, Kogure K, Futaki S, High density of octaarginine stimulates macropinocytosis leading to efficient intracellular trafficking for gene expression. J Biol Chem 2006;281:3544-51
  • Yamada Y, Shinohara Y, Kakudo T, Mitochondrial delivery of mastoparan with transferrin liposomes equipped with a pH-sensitive fusogenic peptide for selective cancer therapy. Int J Pharm 2005;303(1-2):1-7
  • Forssen E, Willis M. Ligand-targeted liposomes. Adv Drug Deliv Rev 1998;29:249-71
  • Kamiya H, Akita H, Harashima H. Pharmacokinetic and pharmacodynamic considerations in gene therapy. Drug Discov Today 2003;8:990-6
  • Boddapati SV, D'souza GGM, Erdogan S, Organelle-Targeted Nanocarriers: specific Delivery of Liposomal Ceramide to Mitochondria Enhances Its Cytotoxicity in Vitro and in Vivo. Nano Lett 2008;8(8):2559-63
  • Siskind LJ. Mitochondrial Ceramide and the Induction of Apoptosis. J Bioenerg Biomembr 2005;37:143-53
  • Malhi SS, Budhirajaa A, Arora S Intracellular delivery of redox cycler-doxorubicin tothe mitochondria of cancer cell by folate receptor targeted mitocancerotropic liposomes. Int J Pharm 2012;432(1-2):63-74
  • Weissig V. From serendipity to mitochondria-targeted nano carriers. Pharm Res 2011;28:2657-68
  • Rosa MD, Gambacorta A, Gliozzi A. Structure, biosynthesis, and physicochemical properties of archaebacterial lipds. Microbiol Rev 1986;50:70-80
  • Weissig VL. Selective DNA release from DQAsome/DNA complexes at mitochondria-like membranes. Drug Deliv 2000;7:1-5
  • Weissig V, Torchilin VP. Mitochondriotropic cationic vesicles: a strategy towards mitochondrial gene therapy. Curr Pharm Biotechnol 2000;1:325-46
  • Weissig V, D'souza GG, Torchilin VP. DQAsome/DNA complexes release DNA upon contact with isolated mouse liver mitochondria. J Control Release 2001;75:401-8
  • Wattiaux R, Jadot M, Warnier-Pirotte MT, Cationic lipids destabilize lysosomal membrane in vitro. FEBS Lett 1997;417:199-202
  • Zuhorn IS, Hoekstra D. On the mechanism of cationic amphiphile-mediated transfection.To fuse or not to fuse: is that the question? J Membr Biol 2002;189:167-79
  • Lasch J, Meye A, Taubert H, Dequalinium vesicles form stable complexes with plasmid DNA which are protected from DNase attack. Biol Chem 1999;380:647-52
  • Cheng SM, Pabba S, Torchilin VP, Towards mitochondria-specific delivery of apoptosis-inducing agents: DQAsomal incorporated paclitaxel. J Drug Deliv Sci Technol 2005;15(1):81-6
  • D'souza GG, Cheng SM, Boddapati SV, Nanocarrier-assisted sub-cellular targeting to the site of mitochondria improves the pro-apoptotic activity of paclitaxel. J Drug Target 2008;16(7):578-85
  • Salnikov V, LukyanenkO YO, FredericK CA, Probing the Outer Mitochondrial Membrane in Cardiac Mitochondria with Nanoparticles. Biophys J 2007;92(3):1058-71
  • Ju-Nam Y, Bricklebank N, Allen DW, Phosphonioalkylthiosulfate zwitterions—new masked thiol ligands for the formation of cationic functionalised gold nanoparticles. Org Biomol chem 2006;4(23):4345-51
  • Zhao B, Yin JJ, Bilski PJ, Enhanced photodynamic efficacy towards melanoma cells by encapsulation of Pc4 in silica nanoparticles. Toxicol Appl Pharmacol 2009;241(2):163-72
  • Cuchelkar V, Kopeckova P, Kopecek J. Novel HPMA copolymer-bound constructs for combined tumor and mitochondrial targeting. Mol Pharm 2008;5(5):776-86
  • Futaki S, Suzuki T, Ohashi W, Argininerich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery. J Biol Chem 2001;276:5836-40
  • Nakase I, Niwa M, Takeuchi T, Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement. Mol Ther 2004;10:1011-22
  • Yamada Y, Furukawa R, Yasuzaki Y, Dual Function MITO-Porter, a Nano Carrier Integrating Both Efficient Cytoplasmic Delivery and Mitochondrial Macromolecule Delivery. Mol Ther 2011;19(8):1449-56
  • Asoh S, Ohsawa I, Mori T, Protection against ischemic brain injury by protein therapeutics. Proc Natl Acad Sci USA 2002;99:17107-12
  • Medda R, Jakobs S, Hell SW, 4Pi microscopy of quantum Dot-labelled cellular structures. J Struct Biol 2006;156:517-23
  • Hoshino A, Fujioka K, Oku T, Quantum dots targeted to the assigned organelle in living cells. Microbiol Immunol 2004;48(12):985-94
  • Paunesku T, Rajh T, Wiederrecht G. Biology of TiO2-oligonucleotide nanocomposites. Nat Mater 2003;2:343-6
  • Weissig V, Boddapati SV, Jabr L, Mitochondria-specific nanotechnology. Nanomedicine 2007;2(3):275-85
  • Gaucher G, Dufresne MH, Sant VP, Block copolymer micelles: preparation, characterization and application in drug delivery. J Control Release 2005;109:169−188.
  • Sharma A, Soliman GM, Al-Hajaj N, Design and evaluation of multifunctional nano-carriers for selective delivery of coenzyme q10 to mitochondria. Biomacromolecules 2012;13:239-52
  • Melo PS, De-Azevedo MM, Frungillo L, Nanocytotoxicity: violacein and violacein-loaded poly (D, L-lactide-co-glycolide) nanoparticles acting on human leukemic cells. J Biomed Nanotechnol 2009;5(2):192-201
  • SAmuelson LE, Dukes MJ, Hunt CR, TSPO targeted dendrimer imaging agent: synthesis, characterization, and cellular internalization. Bioconjug Chem 2009;20(11):2082-9
  • Lee JH, Cha KE, Kim MS, Nano-sized polyamidoamine (PAMAM) dendrimer-induced apoptosis mediated by mitochondrial dysfunction. Toxicol Lett 2009;190(2):202-7
  • Labieniec M, Gabryelak T. Preliminary biological evaluation of poli(amidoamine) (PAMAM) dendrimer G3.5 on selected parameters of rat liver mitochondria. Mitochondrion 2008;8(4):305-12
  • Pupure J, Fernandes MAS, Santos MS, Mitochondria as the target for mildronate's protective effects in azidothymidine (AZT)-induced toxicity of isolated rat liver mitochondria. Cell Biochem Funct 2008;26(5):620-31
  • Antonenko Y, Avetisyan AV, Bakeeva LE, Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of an aging program. 1. Cationic plastoquinone derivatives: synthesis and in vitro studies. Biochemistry (Mosc) 2008;73:1273-87
  • Patricia C, Adriana CA, Pehar M, Mitochondrial Dysfunction in SOD1G93A-Bearing Astrocytes Promotes Motor Neuron Degeneration: prevention by Mitochondrial-Targeted Antioxidants, The Journal of Neuroscience. 2008;28(16):4115-22
  • Jauslin ML, Meier T, Smith RA, Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. FASEB J 2003;17:1972-4
  • Li YC, Fung KP, Kwok TT, Mitochondria-targeting drug oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells. Chemotherapy 2004;50(2):55-62
  • Imaizumi S, Woolworth V, Fishman RA, Liposome-entrapped superoxide dismutase reduces cerebral infarction in cerebral ischemia in rats. Stroke 1990;21:1312-17
  • Mkandawire M, Pohl A, Gubarevich T, Selective targeting of green fluorescent nanodiamond conjugates to mitochondria in HeLa cells. J Biophotonics 2009;2(10):596-606
  • Liguori L, Lenormand JL. Production of recombinant proteoliposomes for therapeutic uses. Methods Enzymol 2009;465:209-23
  • D'souza GG, Boddapati SV, Weissig V. Mitochondrial leader sequence-plasmid DNA conjugates delivered into mammalian cells by DQAsomes co-localize with mitochondria. Mitochondrion 2005;5(5):352-8
  • Trachootham D, Alexandre J, Huang P. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 2009;8(7):579-91

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