Lipid emulsions in parenteral nutrition: current applications and future developments

Bibliography

• Waitzberg DL, Torrinhas RS, Jacintho TM. New parenteral lipid emulsions for clinical use. J Parenter Enteral Nutr 2006;30(4):351-67
   PubMed Web of Science ®Google Scholar
• Wanten GJ, Calder PC. Immune modulation by parenteral lipid emulsions. Am J Clin Nutr 2007;85(5):1171-84
   PubMed Web of Science ®Google Scholar
• Calder PC, Jensen GL, Koletzko BV, et al. Lipid emulsions in parenteral nutrition of intensive care patients: current thinking and future directions. Intensive Care Med 2010;36(5):735-49
   PubMed Web of Science ®Google Scholar
• Nordenström J, Jarstrand C, Wiernik A. Decreased chemotactic and random migration of leukocytes during Intralipid infusion. Am J Clin Nutr 1979;32(12):2416-22
   PubMed Web of Science ®Google Scholar
• Jarstrand C, Berghem L, Lahnborg G. Human granulocyte and reticuloendothelial system function during intra lipid infusion. J Parenter Enteral Nutr 1978;2(5):663-70
   PubMedGoogle Scholar
• Roche LD. Oxidative stress: the dark side of soybean-oil-based emulsions used in parenteral nutrition. Oxid Antioxid Med Sci 2012;1(1):11-14
   Google Scholar
• Wiernik A, Jarstrand C, Julander I. The effect of intralipid on mononuclear and polymorphonuclear phagocytes. Am J Clin Nutr 1983;37(2):256-61
   PubMed Web of Science ®Google Scholar
• Sedman P, Ramsden C, Brennan T, Guillou P. Pharmacological concentrations of lipid emulsions inhibit interleukin-2-dependent lymphocyte responses in vitro. J Parenter Enteral Nutr 1990;14(1):12-17
   PubMed Web of Science ®Google Scholar
• Sailer D, Muller M. Medium chain triglycerides in parenteral nutrition. J Parenter Enteral Nutr 1981;5(2):115-19
   PubMed Web of Science ®Google Scholar
• Sato N, Deckelbaum RJ, Neeser G, et al. Hydrolysis of mixed lipid emulsions containing medium-chain and long-chain triacylglycerol with lipoprotein lipase in plasma-like medium. J Parenter Enteral Nutr 1994;18(2):112-18
   PubMed Web of Science ®Google Scholar
• Johnson RC, Young SK, Cotter R, et al. Medium-chain-triglyceride lipid emulsion: metabolism and tissue distribution. Am J Clin Nutr 1990;52(3):502-8
   PubMed Web of Science ®Google Scholar
• Geliebter A, Torbay N, Bracco EF, et al. Overfeeding with medium-chain triglyceride diet results in diminished deposition of fat. Am J Clin Nutr 1983;37(1):1-4
   PubMed Web of Science ®Google Scholar
• Ulrich H, Pastores SM, Katz DP, Kvetan V. Parenteral use of medium-chain triglycerides: a reappraisal. Nutrition 1996;12(4):231-8
   PubMed Web of Science ®Google Scholar
• Ball M. Parenteral nutrition in the critically ill: use of a medium chain triglyceride emulsion. Intensive Care Med 1993;19(2):89-95
   PubMed Web of Science ®Google Scholar
• Bach A, Guiraud M, Gibault J, et al. Medium chain triglycerides in septic patients on total parenteral nutrition. Clin Nutr 1988;7(3):157-63
   Web of Science ®Google Scholar
• Jiang ZM, Zhang SY, Wang XR, et al. A comparison of medium-chain and long-chain triglycerides in surgical patients. Ann Surg 1993;217(2):175-84
   PubMed Web of Science ®Google Scholar
• Shizgal HM, Posner B. Insulin and the efficacy of total parenteral nutrition. Am J Clin Nutr 1989;50(6):1355-63
   PubMed Web of Science ®Google Scholar
• Halliwell B, Chirico S. Lipid peroxidation: its mechanism, measurement, and significance. Am J Clin Nutr 1993;57(5):715S-24S
   PubMed Web of Science ®Google Scholar
• Dargel R. Lipid peroxidation—a common pathogenetic mechanism? Exp Toxicol Pathol 1992;44(4):169-81
   PubMed Web of Science ®Google Scholar
• Esterbauer H. Cytotoxicity and genotoxicity of lipid-oxidation products. Am J Clin Nutr 1993;57(5):779S-85S
   PubMed Web of Science ®Google Scholar
• Eritsland J. Safety considerations of polyunsaturated fatty acids. Am J Clin Nutr 2000;71(1):197S-201S
   PubMed Web of Science ®Google Scholar
• Pontes-Arruda A. Biological benefits of an oleic acid–rich lipid emulsion for parenteral nutrition. Clin Nutr Suppl 2009;4(1):19-23
   Google Scholar
• Kalogeropoulos N, Panagiotakos DB, Pitsavos C, et al. Unsaturated fatty acids are inversely associated and n-6/n-3 ratios are positively related to inflammation and coagulation markers in plasma of apparently healthy adults. Clin Chim Acta 2010;411(7):584-91
   PubMed Web of Science ®Google Scholar
• Baer DJ, Judd JT, Clevidence BA, Tracy RP. Dietary fatty acids affect plasma markers of inflammation in healthy men fed controlled diets: a randomized crossover study. Am J Clin Nutr 2004;79(6):969-73
   PubMed Web of Science ®Google Scholar
• Granato D, Blum S, Rössle C, et al. Effects of parenteral lipid emulsions with different fatty acid composition on immune cell functions in vitro. J Parenter Enteral Nutr 2000;24(2):113-18
   PubMed Web of Science ®Google Scholar
• Yaqoob P, Knapper JA, Webb DH, et al. Effect of olive oil on immune function in middle-aged men. Am J Clin Nutr 1998;67(1):129-35
   PubMed Web of Science ®Google Scholar
• Cury-Boaventura MF, Gorjão R, De Lima TM, et al. Comparative toxicity of oleic and linoleic acid on human lymphocytes. Life Sci 2006;78(13):1448-56
   PubMed Web of Science ®Google Scholar
• Schmitz G, Ecker J. The opposing effects of n-3 and n-6 fatty acids. Prog Lipid Res 2008;47(2):147-55
   PubMed Web of Science ®Google Scholar
• Poudyal H, Panchal SK, Diwan V, Brown L. Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action. Prog Lipid Res 2011;50(4):372-87
   PubMed Web of Science ®Google Scholar
• Im DS. Omega-3 fatty acids in anti-inflammation (pro-resolution) and GPCRs. Prog Lipid Res 2012;51(3):232-7
   PubMed Web of Science ®Google Scholar
• Russo GL. Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention. Biochem Pharmacol 2009;77(6):937-46
   PubMed Web of Science ®Google Scholar
• Simopoulos AP. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother 2002;56(8):365-79
   PubMed Web of Science ®Google Scholar
• Xu Z, Li Y, Wang J, et al. Effect of omega-3 polyunsaturated fatty acids to reverse biopsy-proven parenteral nutrition-associated liver disease in adults. Clin Nutr 2012;31(2):217-23
   PubMed Web of Science ®Google Scholar
• Lilja HE, Finkel Y, Paulsson M, Lucas S. Prevention and reversal of intestinal failure–associated liver disease in premature infants with short bowel syndrome using intravenous fish oil in combination with omega-6/9 lipid emulsions. J Pediatr Surg 2011;46(7):1361-7
   PubMed Web of Science ®Google Scholar
• Diamond IR, Sterescu A, Pencharz PB, Wales PW. The rationale for the use of parenteral omega-3 lipids in children with short bowel syndrome and liver disease. Pediatr Surg Int 2008;24(7):773-8
   PubMed Web of Science ®Google Scholar
• Diamond IR, Sterescu A, Pencharz PB, et al. Changing the paradigm: omegaven for the treatment of liver failure in pediatric short bowel syndrome. J Pediatr Gastroenterol Nutr 2009;48(2):209-15
   PubMed Web of Science ®Google Scholar
• Fürst P, Kuhn K. Fish oil emulsions: what benefits can they bring? Clin Nutr 2000;19(1):7-14
   PubMed Web of Science ®Google Scholar
• Biolo G, Grimble G, Preiser JC, et al. Position paper of the ESICM Working Group on nutrition and metabolism. Intensive Care Med 2002;28(11):1512-20
   PubMed Web of Science ®Google Scholar
• Grimm H, Tibell A, Norrlind B, et al. Immunoregulation by parenteral lipids: impact of the n-3 to n-6 fatty acid ratio. J Parenter Enteral Nutr 1994;18(5):417-21
   PubMed Web of Science ®Google Scholar
• Grimm H, Schott J, Schwemmle K. Development of an immuno-neutral lipid emulsion for optimal postoperative management of intensive care patients. Langenbecks Arch Chir Suppl Kongressbd 1998;115:599-604
   PubMedGoogle Scholar
• Davis BC, Kris-Etherton PM. Achieving optimal essential fatty acid status in vegetarians: current knowledge and practical implications. Am J Clin Nutr 2003;78(3):640S-6S
   PubMed Web of Science ®Google Scholar
• Slim R, Hammock BD, Toborek M, et al. The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. Toxicol Appl Pharmacol 2001;171(3):184-93
   PubMed Web of Science ®Google Scholar
• Sammon AM. Dietary linoleic acid, immune inhibition and disease. Postgrad Med J 1999;75(881):129-32
   PubMed Web of Science ®Google Scholar
• James MJ, Gibson RA, Cleland LG. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr 2000;71(1):343S-8S
   PubMed Web of Science ®Google Scholar
• Buenestado A, Cortijo J, Sanz MJ, et al. Olive oil–based lipid Emulsion's neutral effects on neutrophil functions and leukocyte–endothelial cell interactions. J Parenter Enteral Nutr 2006;30(4):286-96
   PubMed Web of Science ®Google Scholar
• Fraser I, Neoptolemos J, Woods P, et al. The effect of intralipid on human lymphocyte and monocyte function. Clin Nutr 1983;2(1):37-40
   PubMedGoogle Scholar
• Grimm H, Tibell A, Norrlind B, et al. Nutrition and allorejection impact of lipids. Transpl Immunol 1995;3(1):62-7
   PubMedGoogle Scholar
• Cavicchi M, Beau P, Crenn P, et al. Prevalence of liver disease and contributing factors in patients receiving home parenteral nutrition for permanent intestinal failure. Ann Intern Med 2000;132(7):525-32
   PubMed Web of Science ®Google Scholar
• Stanley JC. Should we be concerned about the dietary ω-6:ω-3 polyunsaturated fatty acid ratio? Lipid Technol 2007;19(5):112-13
   Google Scholar
• Grau-Carmona T, Morán-García V, García-de-Lorenzo A, et al. Effect of an enteral diet enriched with eicosapentaenoic acid, gamma-linolenic acid and anti-oxidants on the outcome of mechanically ventilated, critically ill, septic patients. Clin Nutr 2011;30(5):578-84
   PubMed Web of Science ®Google Scholar
• Fan YY, Chapkin RS. Importance of dietary gamma-linolenic acid in human health and nutrition. J Nutr 1998;128(9):1411-14
   PubMed Web of Science ®Google Scholar
• DeLuca P, Rothman D, Zurier RB. Marine and botanical lipids as immunomodulatory and therapeutic agents in the treatment of rheumatoid arthritis. Rheum Dis Clin North Am 1995;21(3):759-77
   PubMed Web of Science ®Google Scholar
• Fan YY, Ramos KS, Chapkin RS. Dietary gamma-linolenic acid enhances mouse macrophage-derived prostaglandin E1 which inhibits vascular smooth muscle cell proliferation. J Nutr 1997;127(9):1765-71
   PubMed Web of Science ®Google Scholar
• Pacht ER, DeMichele SJ, Nelson JL, et al. Enteral nutrition with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants reduces alveolar inflammatory mediators and protein influx in patients with acute respiratory distress syndrome. Crit Care Med 2003;31(2):491-500
   PubMed Web of Science ®Google Scholar
• Pontes-Arruda A, Aragão AMA, Albuquerque JD. Effects of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in mechanically ventilated patients with severe sepsis and septic shock. Crit Care Med 2006;34(9):2325-33
   PubMed Web of Science ®Google Scholar
• Singer P, Theilla M, Fisher H, et al. Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury. Crit Care Med 2006;34(4):1033-8
   PubMed Web of Science ®Google Scholar
• Bernabe-Garcia M, Lopez-Alarcon M, Blanco-Favela F, et al. Beneficial effects of the n-3 long-chain polyunsaturated fatty acids in surgical patients: updating the evidence. Prostaglandins Leukot Essent Fatty Acids 2011;85(5):261-6
   PubMed Web of Science ®Google Scholar
• Burdge G. Metabolism of alpha-linolenic acid in humans. Prostaglandins Leukot Essent Fatty Acids 2006;75(3):161-8
   PubMed Web of Science ®Google Scholar
• Burdge GC, Calder PC. Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. Reprod Nutr Dev 2005;45(5):581-98
   PubMedGoogle Scholar
• Brenna JT, Salem N Jr, Sinclair AJ, Cunnane SC. alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. Prostaglandins Leukot Essent Fatty Acids 2009;80(2-3):85
   PubMed Web of Science ®Google Scholar
• Barceló-Coblijn G, Collison LW, Jolly CA, Murphy EJ. Dietary alpha-linolenic acid increases brain but not heart and liver docosahexaenoic acid levels. Lipids 2005;40(8):787-98
   PubMed Web of Science ®Google Scholar
• Barceló-Coblijn G, Murphy EJ. Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefits for human health and a role in maintaining tissue n-3 fatty acid levels. Prog Lipid Res 2009;48(6):355-74
   PubMed Web of Science ®Google Scholar
• Burdge G, Wootton S. Conversion of alpha-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women. Prostaglandins Leukot Essent Fatty Acids 2003;69(4):283-90
   PubMed Web of Science ®Google Scholar
• Vijaimohan K, Jainu M, Sabitha K, et al. Beneficial effects of alpha linolenic acid rich flaxseed oil on growth performance and hepatic cholesterol metabolism in high fat diet fed rats. Life Sci 2006;79(5):448-54
   PubMed Web of Science ®Google Scholar
• Morise A, Sérougne C, Gripois D, et al. Effects of dietary alpha linolenic acid on cholesterol metabolism in male and female hamsters of the LPN strain. J Nutr Biochem 2004;15(1):51-61
   PubMed Web of Science ®Google Scholar
• Morise A, Mourot J, Riottot M, et al. Dose effect of alpha-linolenic acid on lipid metabolism in the hamster. Reprod Nutr Dev 2005;45(4):405-18
   PubMedGoogle Scholar
• Cunnane SC, Hamadeh MJ, Liede AC, et al. Nutritional attributes of traditional flaxseed in healthy young adults. Am J Clin Nutr 1995;61(1):62-8
   PubMed Web of Science ®Google Scholar
• Mandaşescu S, Mocanu V, Dăscaliţa A, et al. Flaxseed supplementation in hyperlipidemic patients. Rev Med Chir Soc Med Nat Iasi 2005;109(3):502-6
   PubMedGoogle Scholar
• Caughey GE, Mantzioris E, Gibson RA, et al. The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am J Clin Nutr 1996;63(1):116-22
   PubMed Web of Science ®Google Scholar
• Thies F, Miles E, Nebe-von-Caron G, et al. Influence of dietary supplementation with long-chain n−3 or n−6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults. Lipids 2001;36(11):1183-93
   PubMed Web of Science ®Google Scholar
• Zhao G, Etherton TD, Martin KR, et al. Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women. J Nutr 2004;134(11):2991-7
   PubMed Web of Science ®Google Scholar
• Riediger ND, Othman RA, Suh M, Moghadasian MH. A systemic review of the roles of n-3 fatty acids in health and disease. J Am Diet Assoc 2009;109(4):668-79
   PubMed Web of Science ®Google Scholar
• Tai CC, Ding ST. N-3 polyunsaturated fatty acids regulate lipid metabolism through several inflammation mediators: mechanisms and implications for obesity prevention. J Nutr Biochem 2010;21(5):357-63
   PubMed Web of Science ®Google Scholar
• Innis S, Novak E, Keller B. Long chain omega-3 fatty acids: micronutrients in disguise. Prostaglandins Leukot Essent Fatty Acids 2013;88(1):91-5
   PubMed Web of Science ®Google Scholar
• Lombardo YB, Chicco AG. Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review. J Nutr Biochem 2006;17(1):1-13
   PubMed Web of Science ®Google Scholar
• Calder PC. Long-chain n-3 fatty acids and cardiovascular disease: further evidence and insights. Nutr Res 2004;24(10):761-72
   Web of Science ®Google Scholar
• Torrejon C, Jung U, Deckelbaum R. n-3 Fatty acids and cardiovascular disease: actions and molecular mechanisms. Prostaglandins Leukot Essent Fatty Acids 2007;77(5):319-26
   PubMed Web of Science ®Google Scholar
• Calder P, Grimble R. Polyunsaturated fatty acids, inflammation and immunity. Eur J Clin Nutr 2002;56:S14-19
   PubMed Web of Science ®Google Scholar
• Leaf A, Kang JX. Omega-3 fatty acids and cardiovascular disease. In: Simopoulos AP, Pavlou KN, editor. Nutrition and fitness: diet, genes, physical activity and health. Volume 89 World Rev Nutr Diet. Karger; Basel: 2001. p. 161-72
   Google Scholar
• Adkins Y, Kelley DS. Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids. J Nutr Biochem 2010;21(9):781-92
   PubMed Web of Science ®Google Scholar
• James M, Proudman S, Cleland L. Fish oil and rheumatoid arthritis: past, present and future. Proc Nutr Soc 2010;69(03):316-23
   PubMedGoogle Scholar
• Calder PC. Immunomodulation by omega-3 fatty acids. Prostaglandins Leukot Essent Fatty Acids 2007;77(5):327-35
   PubMed Web of Science ®Google Scholar
• Seidner DL, Mascioli EA, Istfan NW, et al. Effects of long-chain triglyceride emulsions on reticuloendothelial system function in humans. J Parenter Enteral Nutr 1989;13(6):614-19
   PubMed Web of Science ®Google Scholar
• Gura KM, Lee S, Valim C, et al. Safety and efficacy of a fish-oil–based fat emulsion in the treatment of parenteral nutrition–associated liver disease. Pediatrics 2008;121(3):e678-e86
   PubMed Web of Science ®Google Scholar
• Kruimel JW, Naber TH, van der Vliet JA, et al. Parenteral structured triglyceride emulsion improves nitrogen balance and is cleared faster from the blood in moderately catabolic patients. J Parenter Enteral Nutr 2001;25(5):237-44
   PubMed Web of Science ®Google Scholar
• Lehner F, Demmelmair H, Röschinger W, et al. Metabolic effects of intravenous LCT or MCT/LCT lipid emulsions in preterm infants. J Lipid Res 2006;47(2):404-11
   PubMed Web of Science ®Google Scholar
• Goulet O, de Potter S, Antébi H, et al. Long-term efficacy and safety of a new olive oil–based intravenous fat emulsion in pediatric patients: a double-blind randomized study. Am J Clin Nutr 1999;70(3):338-45
   PubMed Web of Science ®Google Scholar
• Upadhyay N, Kumar R, Mandotra S, et al. Safety and healing efficacy of Sea buckthorn (Hippophae rhamnoides L.) seed oil on burn wounds in rats. Food Chem Toxicol 2009;47(6):1146-53
   PubMed Web of Science ®Google Scholar
• Yang B, Kallio H. Composition and physiological effects of sea buckthorn (Hippophaë) lipids. Trends Food Sci Tech 2002;13(5):160-7
   Web of Science ®Google Scholar
• Xing J, Yang B, Dong Y, et al. Effects of sea buckthorn (Hippophaë rhamnoides L.) seed and pulp oils on experimental models of gastric ulcer in rats. Fitoterapia 2002;73(7):644-50
   PubMed Web of Science ®Google Scholar
• Asif M. Health effects of omega-3, 6, 9 fatty acids: perilla frutescens is a good example of plant oils. Orient Pharm Exp Med 2011;11(1):51-9
   PubMedGoogle Scholar
• Kurowska E, Dresser G, Deutsch L, et al. Bioavailability of omega-3 essential fatty acids from perilla seed oil. Prostaglandins Leukot Essent Fatty Acids 2003;68(3):207-12
   PubMed Web of Science ®Google Scholar
• Chang HH, Chen CS, Lin JY. Dietary perilla oil lowers serum lipids and ovalbumin-specific IgG1, but increases total IgE levels in ovalbumin-challenged mice. Food Chem Toxicol 2009;47(4):848-54
   PubMed Web of Science ®Google Scholar
• Ihara-Watanabe M, Umekawa H, Takahashi T, Furuichi Y. Comparative effects of safflower oil and perilla oil on serum and hepatic lipid levels, fatty acid compositions of serum and hepatic phospholipids, and hepatic mRNA expressions of 3-hydroxy-3-methylglutaryl CoA reductase, LDL receptor, and cholesterol 7alpha-hydroxylase in young and adult rats. Food Res Int 2000;33(10):893-900
   Web of Science ®Google Scholar
• Cho YY, Kwon EY, Kim HJ, et al. Low trans structured fat from flaxseed oil improves plasma and hepatic lipid metabolism in apo E−/− mice. Food Chem Toxicol 2009;47(7):1550-5
   PubMed Web of Science ®Google Scholar
• Espada C, Berra M, Martinez M, et al. Effect of Chia oil (Salvia hispanica) rich in ω-3 fatty acids on the eicosanoid release, apoptosis and T-lymphocyte tumor infiltration in a murine mammary gland adenocarcinoma. Prostaglandins Leukot Essent Fatty Acids 2007;77(1):21-8
   PubMed Web of Science ®Google Scholar
• Garnacho-Montero J, Ortiz-Leyba C, Jiménez-Jiménez F, et al. Clinical and metabolic effects of two lipid emulsions on the parenteral nutrition of septic patients. Nutrition 2002;18(2):134-8
   PubMed Web of Science ®Google Scholar
• Chen FM, Wang JY, Huang TJ, et al. Efficacy of medium-chain triglycerides compared with long-chain triglycerides in total parenteral nutrition in patients with digestive tract cancer undergoing surgery. Kaohsiung J Med Sci 2005;21(11):487-94
   PubMedGoogle Scholar
• Grau T, Ruiz de Adana JC, Zubillaga S, et al. Randomized study of two different fat emulsions in total parenteral nutrition of malnourished surgical patients: effect of infectious morbidity and mortality. Nutr Hosp 2003;18(3):159
   PubMedGoogle Scholar
• Radermacher P, Santak B, Strobach H, et al. Fat emulsions containing medium chain triglycerides in patients with sepsis syndrome: effects on pulmonary hemodynamics and gas exchange. Intensive Care Med 1992;18(4):231-4
   PubMed Web of Science ®Google Scholar
• Smirniotis V, Kostopanagiotou G, Vassiliou J, et al. Long chain versus medium chain lipids in patients with ARDS: effects on pulmonary haemodynamics and gas exchange. Intensive Care Med 1998;24(10):1029-33
   PubMed Web of Science ®Google Scholar
• Smyrniotis V, Kostopanagiotou G, Arkadopoulos N, et al. Long-chain versus medium-chain lipids in acute pancreatitis complicated by acute respiratory distress syndrome: effects on pulmonary hemodynamics and gas exchange. Clin Nutr 2001;20(2):139-43
   PubMed Web of Science ®Google Scholar
• Chambrier C, Lauverjat M, Bouletreau P. Structured triglyceride emulsions in parenteral nutrition. Nutr Clin Pract 2006;21(4):342-50
   PubMedGoogle Scholar
• Sandström R, Hyltander A, Korner U, Lundholm K. Structured triglycerides were well tolerated and induced increased whole body fat oxidation compared with long-chain triglycerides in postoperative patients. J Parenter Enteral Nutr 1995;19(5):381-6
   PubMed Web of Science ®Google Scholar
• Göbel Y, Koletzko B, Böhles HJ, et al. Parenteral fat emulsions based on olive and soybean oils: a randomized clinical trial in preterm infants. J Pediatr Gastroenterol Nutr 2003;37(2):161-7
   PubMed Web of Science ®Google Scholar
• Hartman C, Ben-Artzi E, Berkowitz D, et al. Olive oil-based intravenous lipid emulsion in pediatric patients undergoing bone marrow transplantation: a short-term prospective controlled trial. Clin Nutr 2009;28(6):631-5
   PubMed Web of Science ®Google Scholar
• Reimund JM, Rahmi G, Escalin G, et al. Efficacy and safety of an olive oil-based intravenous fat emulsion in adult patients on home parenteral nutrition. Aliment Pharmacol Ther 2005;21(4):445-54
   PubMed Web of Science ®Google Scholar
• Garnacho-Montero J, Ortiz-Leyba C, Garnacho-Montero M, et al. Effects of three intravenous lipid emulsions on the survival and mononuclear phagocyte function of septic rats. Nutrition 2002;18(9):751-4
   PubMed Web of Science ®Google Scholar
• Umpierrez GE, Spiegelman R, Zhao V, et al. A double-blind, randomized clinical trial comparing soybean oil–based versus olive oil–based lipid emulsions in adult medical–surgical intensive care unit patients requiring parenteral nutrition. Crit Care Med 2012;40(6):1792-8
   PubMed Web of Science ®Google Scholar
• Onar P, Yildiz BD, Yildiz EA, et al. Olive oil–based fat emulsion versus soy oil–based fat emulsion in abdominal oncologic surgery. Nutr Clin Pract 2011;26(1):61-5
   PubMed Web of Science ®Google Scholar
• Mateu-de Antonio J, Grau S, Luque S, et al. Comparative effects of olive oil-based and soyabean oil-based emulsions on infection rate and leucocyte count in critically ill patients receiving parenteral nutrition. Br J Nutr 2008;99(4):846-54
   PubMed Web of Science ®Google Scholar
• Tappy L, Berger MM, Schwarz JM, et al. Metabolic effects of parenteral nutrition enriched with n-3 polyunsaturated fatty acids in critically ill patients. Clin Nutr 2006;25(4):588-95
   PubMed Web of Science ®Google Scholar
• Khor BS, Liaw SJ, Shih HC, Wang LS. Randomized, double blind, placebo-controlled trial of fish-oil-based lipid emulsion infusion for treatment of critically ill patients with severe sepsis. Asian J Surg 2011;34(1):1-10
   PubMed Web of Science ®Google Scholar
• Liang B, Wang S, Ye YJ, et al. Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients. World J Gastroenterol 2008;14(15):2434-9
   PubMed Web of Science ®Google Scholar
• Jiang Z, Wilmore D, Wang X, et al. Randomized clinical trial of intravenous soybean oil alone versus soybean oil plus fish oil emulsion after gastrointestinal cancer surgery. Br J Surg 2010;97(6):804-9
   PubMed Web of Science ®Google Scholar
• Heller AR, Rössler S, Litz RJ, et al. Omega-3 fatty acids improve the diagnosis-related clinical outcome. Crit Care Med 2006;34(4):972-9
   PubMed Web of Science ®Google Scholar
• Chen B, Zhou Y, Yang P, et al. Safety and efficacy of fish oil–enriched parenteral nutrition regimen on postoperative patients undergoing major abdominal surgery a meta-analysis of randomized controlled trials. J Parenter Enteral Nutr 2010;34(4):387-94
   PubMed Web of Science ®Google Scholar
• Wei C, Hua J, Bin C, Klassen K. Impact of lipid emulsion containing fish oil on outcomes of surgical patients: systematic review of randomized controlled trials from Europe and Asia. Nutrition 2010;26(5):474-81
   PubMed Web of Science ®Google Scholar
• de Miranda Torrinhas RS, Santana R, Garcia T, et al. Parenteral fish oil as a pharmacological agent to modulate postoperative immune response: a randomized, double-blind, and controlled clinical trial in patients with gastrointestinal cancer. Clin Nutr 2013;32(4):503-10
   PubMed Web of Science ®Google Scholar
• Xiong J, Zhu S, Zhou Y, et al. Regulation of omega-3 fish oil emulsion on the SIRS during the initial stage of severe acute pancreatitis. J Huazhong Univ Sci Technolog Med Sci 2009;29(1):35-8
   PubMed Web of Science ®Google Scholar
• Wang X, Li W, Li N, Li J. ω-3 fatty acids–supplemented parenteral nutrition decreases hyperinflammatory response and attenuates systemic disease sequelae in severe acute pancreatitis: a randomized and controlled study. J Parenter Enteral Nutr 2008;32(3):236-41
   PubMed Web of Science ®Google Scholar
• Wichmann MW, Thul P, Czarnetzki HD, et al. Evaluation of clinical safety and beneficial effects of a fish oil containing lipid emulsion (Lipoplus, MLF541): data from a prospective, randomized, multicenter trial. Crit Care Med 2007;35(3):700-6
   PubMed Web of Science ®Google Scholar
• Barbosa VM, Miles EA, Calhau C, et al. Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial. Crit Care 2010;14(1):R5
   PubMedGoogle Scholar
• Grimm H, Mertes N, Goeters C, et al. Improved fatty acid and leukotriene pattern with a novel lipid emulsion in surgical patients. Eur J Nutr 2006;45(1):55-60
   PubMed Web of Science ®Google Scholar
• Grimm H. A balanced lipid emulsion—a new concept in parenteral nutrition. Clin Nutr Suppl 2005;1(3):25-30
   Google Scholar
• Senkal M, Geier B, Hannemann M, et al. Supplementation of ω-3 fatty acids in parenteral nutrition beneficially alters phospholipid fatty acid pattern. J Parenter Enteral Nutr 2007;31(1):12-17
   PubMed Web of Science ®Google Scholar
• Mayer K, Fegbeutel C, Hattar K, et al. ω-3 vs. ω-6 lipid emulsions exert differential influence on neutrophils in septic shock patients: impact on plasma fatty acids and lipid mediator generation. Intensive Care Med 2003;29(9):1472-81
   PubMed Web of Science ®Google Scholar
• Pluess TT, Hayoz D, Berger MM, et al. Intravenous fish oil blunts the physiological response to endotoxin in healthy subjects. Intensive Care Med 2007;33(5):789-97
   PubMed Web of Science ®Google Scholar
• Mayer K, Gokorsch S, Fegbeutel C, et al. Parenteral nutrition with fish oil modulates cytokine response in patients with sepsis. Am J Respir Crit Care Med 2003;167(10):1321-8
   PubMed Web of Science ®Google Scholar
• Han YY, Lai SL, Ko WJ, et al. Effects of fish oil on inflammatory modulation in surgical intensive care unit patients. Nutr Clin Pract 2012;27(1):91-8
   PubMed Web of Science ®Google Scholar
• Wang J, Yu JC, Kang WM, Ma ZQ. Superiority of a fish oil–enriched emulsion to medium-chain triacylglycerols/long-chain triacylglycerols in gastrointestinal surgery patients: a randomized clinical trial. Nutrition 2012;28(6):623-9
   PubMed Web of Science ®Google Scholar
• Mirtallo JM, Dasta JF, Kleinschmidt KC, Varon J. State of the art review: intravenous fat emulsions: current applications, safety profile, and clinical implications. Ann Pharmacother 2010;44(4):688-700
   PubMed Web of Science ®Google Scholar
• Koletzko B. Intravenous lipid emulsions for infants: when and which? Am J Clin Nutr 2012;96(2):225-6
   PubMed Web of Science ®Google Scholar
• Demirel G, Oguz SS, Celik IH, et al. The metabolic effects of two different lipid emulsions used in parenterally fed premature infants—A randomized comparative study. Early Hum Dev 2012;88(7):499-501
   PubMed Web of Science ®Google Scholar
• Gawecka A, Michalkiewicz J, Kornacka MK, et al. Immunologic properties differ in preterm infants fed olive oil vs soy-based lipid emulsions during parenteral nutrition. J Parenter Enteral Nutr 2008;32(4):448-53
   PubMed Web of Science ®Google Scholar
• Carlson SJ, Fallon EM, Kalish BT, et al. The role of the ω-3 fatty acid DHA in the human life cycle. J Parenter Enteral Nutr 2013;37(1):15-22
   PubMed Web of Science ®Google Scholar
• D'Ascenzo R, D'Egidio S, Angelini L, et al. Parenteral nutrition of preterm infants with a lipid emulsion containing 10% fish oil: effect on plasma lipids and long-chain polyunsaturated fatty acids. J Pediatr 2011;159(1):33-8; e1
   PubMed Web of Science ®Google Scholar
• Tomsits E, Pataki M, Tölgyesi A, et al. Safety and efficacy of a lipid emulsion containing a mixture of soybean oil, medium-chain triglycerides, olive oil, and fish oil: a randomised, double-blind clinical trial in premature infants requiring parenteral nutrition. J Pediatr Gastroenterol Nutr 2010;51(4):514-21
   PubMed Web of Science ®Google Scholar
• Goulet O, Antébi H, Wolf C, et al. A new intravenous fat emulsion containing soybean oil, medium-chain triglycerides, olive oil, and fish oil: a single-center, double-blind randomized study on efficacy and safety in pediatric patients receiving home parenteral nutrition. J Parenter Enteral Nutr 2010;34(5):485-95
   PubMed Web of Science ®Google Scholar
• Gura KM, Duggan CP, Collier SB, et al. Reversal of parenteral nutrition–associated liver disease in two infants with short bowel syndrome using parenteral fish oil: implications for future management. Pediatrics 2006;118(1):e197-201
   PubMed Web of Science ®Google Scholar
• Puder M, Valim C, Meisel JA, et al. Parenteral fish oil improves outcomes in patients with parenteral nutrition associated liver injury. Ann Surg 2009;250(3):395-402
   PubMed Web of Science ®Google Scholar
• Lee SI, Valim C, Johnston P, et al. Impact of fish oil-based lipid emulsion on serum triglyceride, bilirubin, and albumin levels in children with parenteral nutrition-associated liver disease. Pediatr Res 2009;66(6):698-703
   PubMed Web of Science ®Google Scholar
• Sigalet D, Boctor D, Robertson M, et al. Improved outcomes in paediatric intestinal failure with aggressive prevention of liver disease. Eur J Pediatr Surg 2009;19(06):348-53
   PubMedGoogle Scholar
• Pironi L, Colecchia A, Guidetti M, et al. Fish oil-based emulsion for the treatment of parenteral nutrition associated liver disease in an adult patient. E Spen Eur E J Clin Nutr Metab 2010;5(5):e243-e46
   Google Scholar
• Fuchs J, Fallon EM, Gura KM, Puder M. Use of an omega-3 fatty acid–based emulsion in the treatment of parenteral nutrition–induced cholestasis in patients with microvillous inclusion disease. J Pediatr Surg 2011;46(12):2376-82
   PubMed Web of Science ®Google Scholar
• Heller AR, Rössel T, Gottschlich B, et al. Omega-3 fatty acids improve liver and pancreas function in postoperative cancer patients. Int J Cancer 2004;111(4):611-16
   PubMed Web of Science ®Google Scholar
• Shin JI, Namgung R, Park MS, Lee C. Could lipid infusion be a risk for parenteral nutrition-associated cholestasis in low birth weight neonates? Eur J Pediatr 2008;167(2):197-202
   PubMed Web of Science ®Google Scholar
• Zambrano E, El-Hennawy M, Ehrenkranz RA, et al. Total parenteral nutrition induced liver pathology: an autopsy series of 24 newborn cases. Pediatr Dev Pathol 2004;7(5):425-32
   PubMed Web of Science ®Google Scholar
• Colomb V, Jobert-Giraud A, Lacaille F, et al. Role of lipid emulsions in cholestasis associated with long-term parenteral nutrition in children. J Parenter Enteral Nutr 2000;24(6):345-50
   PubMed Web of Science ®Google Scholar
• Reimund JM, Arondel Y, Joly F, et al. Potential usefulness of olive oil-based lipid emulsions in selected situations of home parenteral nutrition-associated liver disease. Clin Nutr 2004;23(6):1418-25
   PubMed Web of Science ®Google Scholar
• Thomas-Gibson S, Jawhari A, Atlan P, et al. Safe and efficacious prolonged use of an olive oil-based lipid emulsion (ClinOleic ©) in chronic intestinal failure. Clin Nutr 2004;23(4):697-703
   PubMed Web of Science ®Google Scholar
• Pálová S, Charvat J, Kvapil M. Comparison of soybean oil-and olive oil-based lipid emulsions on hepatobiliary function and serum triacylglycerols level during realimentation. J Int Med Res 2008;36(3):587-93
   PubMed Web of Science ®Google Scholar
• Staun M, Pironi L, Bozzetti F, et al. ESPEN guidelines on parenteral nutrition: home parenteral nutrition (HPN) in adult patients. Clin Nutr 2009;28(4):467-79
   PubMed Web of Science ®Google Scholar
• Klek S, Chambrier C, Singer P, et al. Four-week parenteral nutrition using a third generation lipid emulsion (SMOFlipid)–A double-blind, randomised, multicentre study in adults. Clin Nutr 2013;32(2):224-31
   PubMed Web of Science ®Google Scholar
• Vanek VW, Seidner DL, Allen P, et al. A.S.P.E.N. position paper: clinical role for alternative intravenous fat emulsions. Nutr Clin Pract 2012;27(2):150-92
   PubMed Web of Science ®Google Scholar