Improving inhaler technique, adherence to therapy and the precision of dosing: major challenges for pulmonary drug delivery

Bibliography

• Labiris NR, Dolovich MB. Pulmonary drug delivery. Part 1: physiological factors affecting therapeutic effectiveness of aerosolised medications. Br J Clin Pharmacol 2003;56:588-99
   PubMed Web of Science ®Google Scholar
• Ramsey BW, Pepe MS, Quan JM, et al. Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. N Engl J Med 1999;340:23-6
   PubMed Web of Science ®Google Scholar
• Kellermann DJ, Armer TA, Borland SW, Nelson TS. Dihydroergotamine inhalation aerosol for the treatment of migraine: insights from pharmaceutical and clinical development. In: Dalby RN, Byron PR, Peart J, et al. editors. Respiratory drug delivery Europe 2013. Davis Healthcare International; River Grove, Illinois; 2013. p. 35-45
   Google Scholar
• Patton J, Fishburn CS, Weers JG. The lungs as a portal of entry for systemic drug delivery. Proc Am Thorac Soc 2004;1:338-44
   PubMedGoogle Scholar
• Rau JL. The inhalation of drugs: advantages and problems. Respir Care 2005;50:367-82
   PubMedGoogle Scholar
• Dolovich MB, Dhand R. Aerosol drug delivery: developments in device design and clinical use. Lancet 2010;377:1032-45
   PubMed Web of Science ®Google Scholar
• Rubin BK. Pediatric aerosol therapy: new devices and new drugs. Respir Care 2011;56:1411-21
   PubMed Web of Science ®Google Scholar
• Rand CS. Patient adherence to COPD therapy. Eur Respir Rev 2005;14(Review 96):97-101
   Google Scholar
• Hindle M, Newton DAG, Chrystyn H. Investigations of an optimal inhaler technique with the use of urinary salbutamol excretion as a measure of relative bioavailability to the lung. Thorax 1993;48:607-10
   PubMed Web of Science ®Google Scholar
• Newman SP, Pavia D, Clarke SW. How should a pressurized beta-adrenergic bronchodilator be inhaled? Eur J Respir Dis 1981;62:3-20
   PubMedGoogle Scholar
• Arora D, Peart J, Byron PR. USA market 1990-2005: products and instructions for use. In: Dalby RN, Byron PR, Peart J, et al. editors. Respiratory drug delivery 2006. Davis Healthcare International; River Grove, Illinois; 2006. p. 955-9
   Google Scholar
• Molimard M, Raherison C, Lignot S, et al. Assessment of handling of inhaler devices in real life: an observational study in 3811 patients in primary care. J Aerosol Med 2003;16:249-54
   PubMedGoogle Scholar
• Crompton GK. Problems patients have using pressurized aerosol inhalers. Eur J Respir Dis 1982;63(Suppl 119):101-4
   Google Scholar
• Fink JB, Rubin BK. Problems with inhaler use: a call for improved clinician and patient education. Respir Care 2005;50:1360-75
   PubMedGoogle Scholar
• Vargas O, Martinez J, Ibanez J, et al. The use of metered-dose inhalers in hospital environments. J Aerosol Med Pulm Drug Deliv 2013;26:287-96
   PubMed Web of Science ®Google Scholar
• Bell J, Newman SP. The rejuvenated pressurised metered dose inhaler. Expert Opin Drug Deliv 2007;215-34
   PubMed Web of Science ®Google Scholar
• Telko MJ, Hickey AJ. Dry powder inhaler formulation. Respir Care 2005;50:1209-27
   PubMedGoogle Scholar
• Smith IJ, Parry-Billings M. The inhalers of the future? A review of dry powder devices on the market today. Pulm Pharmacol Ther 2003;16:79-95
   PubMed Web of Science ®Google Scholar
• Friebel C, Steckel H. Single-use disposable dry powder inhalers for pulmonary drug delivery. Expert Opin Drug Deliv 2011;7:1359-72
   Web of Science ®Google Scholar
• Newman S, Peart J. Dry powder inhalers. In: Newman S, Anderson P, Byron P, et al. Respiratory drug delivery: essential theory and practice. RDD Online/Virginia Commonwealth University; Richmond USA; 2009. p. 257-307
   Google Scholar
• Borgström L. On the use of dry powder inhalers in situations perceived as constrained. J Aerosol Med 2001;14:281-7
   PubMedGoogle Scholar
• Melani AS, Bracci LS, Rossi M. Reduced peak inspiratory effort through Diskus and Turbuhaler due to mishandling is common in clinical practice. Clin Drug Investig 2005;25:543-9
   PubMed Web of Science ®Google Scholar
• Burnell PKP, Petchey L, Prime D, Sumby BS. Patient inhalation profiles and dose emission characteristics from dry powder inhalers. In: Dalby RN, Byron PR, Farr SJ, editors. Respiratory drug delivery V. Interpharm Press; Buffalo Grove: 1996. p. 314-16
   Google Scholar
• Newman SP. Inhaler treatment options in COPD. Eur Respir Rev 2005;14(Review 96):102-8
   Google Scholar
• Tezky T, Holquist C. FDA Misadministration of capsules for inhalation. Drug Topics 2005
   Google Scholar
• Wieshammer S, Dreyhaupt J. Dry powder inhalers: which factors determine the frequency of handling errors? Respiration 2008;75:18-25
   PubMed Web of Science ®Google Scholar
• Melani AS, Bonavia M, Cilenti V, et al. Inhaler mishandling remains common in real life and is associated with reduced disease control. Respir Med 2011;105:930-8
   PubMed Web of Science ®Google Scholar
• Rootmensen GN, van Keimpema ARJ, Jansen HM, de Naan RJ. Predictors of incorrect inhalation technique in patients with asthma or COPD: a study using a validated videotaped scoring method. J Aerosol Med Pulm Drug Deliv 2010;23:323-8
   PubMed Web of Science ®Google Scholar
• Pedersen S, Dubus JC, Crompton GK. The ADMIT series – issues in inhalation therapy. 5) Inhaler selection in children with asthma. Prim Respir Care J 2010;19:209-16
   PubMedGoogle Scholar
• Geller DE. Comparing clinical features of the nebulizer, metered dose inhaler and dry powder inhaler. Respir Care 2005;50:1313-22
   PubMedGoogle Scholar
• Rubin BK. Bye-bye, blow-by. Respir Care 2007;52:891
   Google Scholar
• Giraud V, Roche N. Misuse of corticosteroid metered-dose inhaler is associated with decreased asthma stability. Eur Respir J 2002;19:246-51
   PubMed Web of Science ®Google Scholar
• Sullivan SD. The burden of uncontrolled asthma on the US health care system. Manag Care 2005;14(Suppl 8):4-7
   PubMedGoogle Scholar
• Lavorini F, Levy ML, Corrigan C, Crompton GK. The ADMIT series – issues in inhalation therapy. 6) Training tools for inhalation devices. Prim Respir Care J 2010;19:335-41
   PubMedGoogle Scholar
• Papi A, Haughney J, Virchow JC, et al. Inhaler devices for asthma: a call for action in a neglected field. Eur Respir J 2011;37:982-5
   PubMed Web of Science ®Google Scholar
• Price D, Bosnic-Anticevich S, Briggs A, et al. Inhaler competence in asthma: common errors, barriers to use, and recommended solutions. Respir Med 2013;107:37-46
   PubMed Web of Science ®Google Scholar
• Rand CS, Wise RA. Measuring adherence to asthma medication regimens. Am J Respir Crit Care Med 1994;149:S69-76
   PubMed Web of Science ®Google Scholar
• Rau JL. Determinants of patient adherence to an aerosol regimen. Respir Care 2005;50:1346-59
   PubMedGoogle Scholar
• Everard M. Regimen and device compliance: key factors determining therapeutic outcomes. J Aerosol Med 2006;19:67-73
   PubMedGoogle Scholar
• Cochrane MG, Bala MV, Downs KE, et al. Inhaled corticosteroids for asthma therapy: patient compliance, devices and inhalation technique. Chest 2000;117:542-50
   PubMed Web of Science ®Google Scholar
• Report by the Task Force for Compliance. Non-compliance with medications: an economic tragedy with important implications for health care reform. National Pharmaceutical Council, Washington, DC, USA; 1994
   Google Scholar
• Cross S. Asthma inhalation delivery systems: the patient's viewpoint. J Aerosol Med 2001;14(Suppl 1):S3-7
   Google Scholar
• Dolce JJ, Crisp C, Manzella B, et al. Medication adherence patterns in chronic obstructive pulmonary disease. Chest 1991;99:837-41
   PubMed Web of Science ®Google Scholar
• Pritchard JN, Nikander K. Impact of intervention and feedback on adherence to treatment. In: Dalby RN, Byron PR, Peart J, et al. editors. Respiratory drug delivery 2012. Davis Healthcare International; River Grove, Illinois: 2012. p. 271-82
   Google Scholar
• Rubin BK. What does it mean when a patient says “my medication is not working”? Chest 2004;126:972-81
   PubMed Web of Science ®Google Scholar
• Tashkin DP, Rand C, Nides M, et al. A nebulizer chronolog to monitor compliance with inhaler use. Am J Med 1991;91:33S-6S
   PubMed Web of Science ®Google Scholar
• Everard ML. Clinical consequences of inhaler non-adherence in asthma and COPD. In: Dalby RN, Byron PR, Peart J, et al. editors. Respiratory drug delivery 2012. Davis Healthcare International; River Grove, Illinois; 2012. p. 251-60
   Google Scholar
• Milgrom H, Bender B, Ackerson L, et al. Non-compliance and treatment failure in children with asthma. J Allergy Clin Immunol 1996;98:1051-7
   PubMed Web of Science ®Google Scholar
• Barner JC, Makhinova TV. Economic implications of inhaler non-adherence in asthma and COPD in the US. In: Dalby RN, Byron PR, Peart J, et al. editors. Respiratory drug delivery 2012. Davis Healthcare International; River Grove, Illinois: 2012. p. 261-70
   Google Scholar
• Denyer J. Adherence monitoring in drug delivery. Expert Opin Drug Deliv 2010;7:1127-31
   PubMed Web of Science ®Google Scholar
• Dolovich MB, Ahrens RC, Hess DR, et al. Device selection and outcomes of aerosol therapy: evidence-based guidelines. Chest 2005;127:335-71
   PubMed Web of Science ®Google Scholar
• Price D, Haughney J, Sims E, et al. Effectiveness of inhaler types for real-world asthma management: retrospective observational study using the GPRD. J Asthma Allergy 2011;4:37-47
   PubMedGoogle Scholar
• Lavorini F, Fontana GA. Inhaler technique and patient's preference for dry powder inhalers. Expert Opin Drug Deliv 2013; early on-line publication
   Web of Science ®Google Scholar
• Newman SP, Weisz AWB, Talaee N, et al. Improvement of drug delivery with a breath actuated pressurised aerosol for patients with poor inhaler technique. Thorax 1991;46:712-16
   PubMed Web of Science ®Google Scholar
• Price D, Thomas M, Mitchell G, et al. Improvement of asthma control with a breath-actuated pressurized metered dose inhaler: a prescribing claim study of 5556 patients using a traditional pressurized metered dose inhaler or a breath-actuated device. Respir Med 2003;97:12-19
   PubMed Web of Science ®Google Scholar
• Byron PR. Platform selection for inhaled drugs: biological and regulatory merit of different approaches. In: Dalby RN, Byron PR, Peart J, et al. editors. Respiratory drug delivery Europe 2005. Davis Healthcare International; River Grove, Illinois; 2005. p. 1-17
   Google Scholar
• Kellerman DJ, Forst A, Combs DL, et al. Assessment of the consistency of absorption of dihydroergotamine following oral inhalation: pooled results from four clinical studies. J Aerosol Med Pulm Drug Deliv 2013;26:297-306
   PubMed Web of Science ®Google Scholar
• Lavorini F, Fontana GA. Targeting drugs to the airways: the role of spacer devices. Expert Opin Drug Deliv 2009;6:91-102
   PubMed Web of Science ®Google Scholar
• Newman SP. Additional technologies for pressurized metered dose inhalers. In: Newman S, Anderson P, Byron P, et al. Respiratory drug delivery: essential theory and practice. RDD Online/Virginia Commonwealth University; Richmond USA: 2009. p. 217-56
   Google Scholar
• Dunbar C, Scheuch G, Sommerer K, et al. In vitro and in vivo dose delivery characteristics of large porous particles for inhalation. Int J Pharm 2002;245:179-89
   PubMed Web of Science ®Google Scholar
• Geller DE, Weers J, Hauerding S. Development of an inhaled dry-powder formulation of tobramycin using PulmoSphere technology. J Aerosol Med Pulm Drug Deliv 2011;24:175-82
   PubMed Web of Science ®Google Scholar
• Young PM, Crapper J, Philips G, et al. Overcoming dose limitations using the Orbital multi-breath dry powder inhaler. J Aerosol Med Pulm Drug Deliv 2013;26; early on-line publication
   Google Scholar
• Dalby RN, Spallek M, Voshaar T. A review of the development of Respimat soft mist inhaler. Int J Pharm 2004;283:1-9
   PubMed Web of Science ®Google Scholar
• Myers DJ, Spyker DA, Cassella JV. Staccato® system performance: consistency of dosing in clinical use. In: Dalby RN, Byron PR, Peart J, et al. editors. Respiratory drug delivery Europe 2013. Davis Healthcare International; River Grove, Illinois: 2013. p. 223-6
   Google Scholar
• Azouz W, Campbell J, Stephenson J, et al. Improved metered dose inhaler technique when a coordination cap is used. J Aerosol Med Pulm Drug Deliv 2013;26; early on-line publication
   Google Scholar
• Al-Showair RAM, Pearson SB, Chrystyn H. The potential of the 2Tone trainer to help patients use their metered dose inhalers. Chest 2007;131:1776-82
   PubMed Web of Science ®Google Scholar
• Al-Showair RAM, Tarsin WY, Assi KH, et al. Can all patients with COPD use the correct inhalation flow with all inhalers and does training help? Respir Med 2007;101:2395-401
   PubMed Web of Science ®Google Scholar
• Yohannes AM, Connolly MJ, Hanania NA. Ten years of tiotropium: clinical impact and patient perspectives. Int J Chron Obstruct Pulmon Dis 2013;8:117-25
   PubMed Web of Science ®Google Scholar
• Restrepo RD, Alvarez MT, Wittnebel LD, et al. Medication adherence issues in patients treated for COPD. Int J Chron Obstruct Pulmon Dis 2008;3:371-84
   PubMedGoogle Scholar
• Salama RO, Young PM, Rogueda P, et al. Advances in drug delivery: is triple therapy the future for treatment of chronic obstructive pulmonary disease? Expert Opin Pharmacother 2011;12:1913-32
   PubMed Web of Science ®Google Scholar
• van der Palen J, Klein JJ, van Heerwarden CLA, et al. Multiple inhalers confuse asthma patients. Eur Respir J 1999;14:1034-7
   PubMed Web of Science ®Google Scholar
• Thomas M, Price D, Chrystyn H, et al. Inhaled corticosteroids for asthma: impact of practice level device switching on asthma control. BMC Pulm Med 2009;9:1
   PubMedGoogle Scholar
• Lavorini F, Ninane V, Haughney J, et al. Switching from branded to generic inhaled medications: potential impact on asthma and COPD. Expert Opin Drug Deliv 2013;10:1597-602
   PubMed Web of Science ®Google Scholar
• Fink JB. Inhalers in asthma management: is demonstration the key to compliance? Respir Care 2005;50:598-600
   PubMedGoogle Scholar
• Lavorini F, Magnan A, Dubus CJ, et al. Effect of incorrect use of dry powder inhalers on management of patients with asthma and COPD. Respir Med 2008;102:593-604
   PubMed Web of Science ®Google Scholar
• Basheti IA, Reddel HK, Armour CL, Bosnic-Anticevich SZ. Counseling about Turbuhaler technique: needs assessment and effective strategies for community pharmacists. Respir Care 2005;50:617-23
   PubMedGoogle Scholar
• Basheti IA, Reddel HK, Armour CL, Bosnic-Anticevich SZ. Improved asthma outcomes with a simple inhaler technique intervention by community pharmacists. J Allergy Clin Immunol 2007;119:1537-8
   PubMed Web of Science ®Google Scholar
• Laube BL, Janssens HM, de Jongh FH, et al. ERS/ISAM task force consensus statement. Eur Respir J 2011;37:1308-417
   PubMed Web of Science ®Google Scholar
• Cain WT, Cable G, Oppenheimer JJ. The ability of the community pharmacist to learn the proper actuation techniques of inhaler devices. J Allergy Clin Immunol 2001;108:918-20
   PubMed Web of Science ®Google Scholar
• Self TH, Arnold RB, Czosnowski LM, et al. Inadequate skill of healthcare professionals in using asthma inhalation devices. J Asthma 2007;44:593-8
   PubMed Web of Science ®Google Scholar
• Toumas M, Basheti IA, Bosnic-Anticevich SZ. Comparison of small group training with self-directed internet-based training in inhaler techniques. Am J Pharm Educ 2009;73:85
   PubMed Web of Science ®Google Scholar
• Erickson SR, Chang A, Johnson CE, Gruppen LD. Lecture versus web tutorial for pharmacy students' learning of MDI technique. Ann Pharmacother 2003;37:500-5
   PubMed Web of Science ®Google Scholar
• Nides MA, Tashkin DP, Simmons MS, et al. Improving inhaler adherence in a clinical trial through use of the nebulizer chronolog. Chest 1993;104:501-7
   PubMed Web of Science ®Google Scholar
• Blaiss MS. Inhaler technique and adherence to therapy. Curr Med Res Opin 2007;23(Suppl 3):13-20
   PubMedGoogle Scholar
• Dalby R, Byron P. In vitro assessment of inhaled products. In: Newman S, Anderson P, Byron P, et al. editors. Respiratory drug delivery: essential theory and practice. RDD Online/Virginia Commonwealth University; Richmond USA: 2009. p. 59-96
   Google Scholar
• Borgström L, Asking L, Beckman O, et al. Dose variation, within and between individuals, with different inhalation systems. In: Dalby RN, Byron PR, Farr SJ, editors. Respiratory drug delivery V. Interpharm Press, Buffalo Grove; 1996; p. 19-24
   Google Scholar
• Borgstrom L, Olsson B, Thorsson L. Degree of throat deposition can explain the variability in lung deposition of inhaled drugs. J Aerosol Med 2006;19:473-83
   PubMedGoogle Scholar
• Leach CL, Davidson PJ, Boudreau RJ. Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone. Eur Respir J 1998;12:1346-53
   PubMed Web of Science ®Google Scholar
• Thorsson L, Kenyon CJ, Newman SP, Borgström L. Lung deposition of budesonide in asthmatics: a comparison of different formulations. Int J Pharm 1998;168:119-27
   Web of Science ®Google Scholar
• Pitcairn GR, Reader S, Pavia D, Reader S. Deposition of corticosteroid aerosol in the human lung by Respimat soft mist inhaler compared to deposition by metered dose inhaler or by Turbuhaler dry powder inhaler. J Aerosol Med 2005;18:264-72
   PubMedGoogle Scholar
• Farr SJ, Warren SJ, Lloyd P, et al. Comparison of in vitro and in vivo efficiencies of a novel unit-dose aerosol generator and a pressurized metered dose inhaler. Int J Pharm 2000;198:63-70
   PubMed Web of Science ®Google Scholar
• Mathioudakis AG, Mathioudakis GA. Tiotropium inhaler devices: seeking convenience when mortality is at stake? J Aerosol Med Pulm Drug Deliv 2013;26:120
   PubMed Web of Science ®Google Scholar
• Farr SJ, Rowe AM, Rubsamen R, Taylor G. Aerosol deposition in the human lung following administration from a microprocessor controlled pressurised metered dose inhaler. Thorax 1995;60:639-44
   Google Scholar
• Farr SJ, Schuster JA, Lloyd P, et al. AERx-development of a novel liquid aerosol delivery system: concept to clinic. In: Dalby RN, Byron PR, Farr SJ, editors. Respiratory drug delivery V. Interpharm Press; Buffalo Grove; 1996. p. 175-85
   Google Scholar
• Noymer P, Schuster J, Holst P, et al. AERx-Essence: efficiency and breath control without electronics. In: Dalby RN, Byron PR, Peart J, et al. editors. Respiratory drug delivery IX. Davis Healthcare International; River Grove, Illinois; 2004. p. 255-62
   Google Scholar
• Fleming FS. Flexible, smart and low cost: the MicroDose DPI, a true platform inhaler. 2007. Available from: www.OnDrugDelivery.com
   Google Scholar
• Dhand R. Intelligent nebulizers in the age of the internet: the I-neb adaptive aerosol delivery system. J Aerosol Med Pulm Drug Deliv 2010;23(Suppl 1):iii-v
   PubMed Web of Science ®Google Scholar
• Denyer J, Nikander K, Smith NJ. Adaptive aerosol delivery (AAD) technology. Expert Opin Drug Deliv 2004;1:165-76
   PubMedGoogle Scholar
• Denyer J, Dyche T. The adaptive aerosol delivery (AAD) technology: past, present and future. J Aerosol Med Pulm Drug Deliv 2010;23(Suppl 1):S1-10
   PubMed Web of Science ®Google Scholar
• Denyer J, Pavia D, Zierenberg B. New liquid drug aerosol devices for inhalation therapy. Eur Respir Rev 2000;10(Review 72):187-91
   Google Scholar
• Daniels T, Goodacre L, Sutton C, et al. Accurate assessment of adherence: self reporting and clinician report vs electronic monitoring of nebulizers. Chest 2011;140:425-32
   PubMed Web of Science ®Google Scholar
• McNamara PS, McCormack P, McDonald AJ, et al. Open adherence monitoring using routine data download from an adaptive aerosol delivery nebuliser in children with cystic fibrosis. J Cystic Fibros 2009;8:258-63
   PubMed Web of Science ®Google Scholar
• Bennett WD. Controlled inhalation of aerosolised therapeutics. Expert Opin Drug Deliv 2005;2:763-7
   PubMedGoogle Scholar
• Bennett WD, Brown JS, Zeman KL, et al. Targeting delivery of aerosols to different lung regions. J Aerosol Med 2002;15:179-88
   PubMedGoogle Scholar
• Brand P, Friemel I, Meyer T, et al. Total deposition of therapeutic particles during spontaneous and controlled inhalations. J Pharm Sci 2000;89:724-31
   PubMed Web of Science ®Google Scholar
• Brand P, Schulte M, Wencker M, et al. Lung deposition of inhaled alpha1-proteinase inhibitor in cystic fibrosis and alpha1-antitrypsin deficiency. Eur Respir J 2009;34:354-60
   PubMed Web of Science ®Google Scholar
• Brand P, Beckmann H, Maas Enriquez M, et al. Peripheral deposition of alpha-1 protease inhibitor using commercial inhalation devices. Eur Respir J 2003;22:262-7
   Google Scholar
• George J, Kong DCM, Thoman R, Stewart K. Factors associated with medication non-adherence in patients with COPD. Chest 2005;128:3198-204
   PubMed Web of Science ®Google Scholar
• Lee-Wong M, Mayo PH. Results of a programme to improve house staff use of metered dose inhalers and spacers. Postgrad Med J 2003;79:221-5
   PubMed Web of Science ®Google Scholar