115
Views
21
CrossRef citations to date
0
Altmetric
Review

Intranasal delivery of vaccines against HIV

&
Pages 247-259 | Published online: 28 Feb 2006

Bibliography

  • PEPPOLONI S, RUGGIERO P, CONTORNI M et al.: Mutants of the Escherichia coli heat-labile enterotoxin as safe and strong adjuvants for intranasal delivery of vaccines. Expert Rev. Vaccines (2003) 2(2):285-293.
  • MESTECKY J, MOLDOVEANU Z, RUSSELL MW: Immunologic uniqueness of the genital tract: challenge for vaccine development. Am. J. Reprod. Immunol. (2005) 53(5):208-214.
  • MCGHEE JR, LAMM ME, STROBER W: Mucosal immune responses. In: Mucosal Immunology. PL Ogra, J Mestecky, ME Lamm, W Strober, J Bienenstock, JR McGhee (Eds), Academic Press, San Diego, CA, USA (1999):485-506.
  • GALLICHAN WS, ROSENTHAL KL: Specific secretory immune responses in the female genital tract following intranasal immunization with a recombinant adenovirus expressing glycoprotein B of herpes simplex virus. Vaccine (1995) 13(16):1589-1595.
  • STAATS HF, MONTGOMERY SP, PALKER TJ: Intranasal immunization is superior to vaginal, gastric, or rectal immunization for the induction of systemic and mucosal anti-HIV antibody responses. AIDS Res. Hum. Retroviruses (1997) 13(11):945-952.
  • WU HY, ABDU S, STINSON D, RUSSELL MW: Generation of female genital tract antibody responses by local or central (common) mucosal immunization. Infect. Immun. (2000) 68(10):5539-5545.
  • JOHANSSON EL, RASK C, FREDRIKSSON M et al.: Antibodies and antibody-secreting cells in the female genital tract after vaginal or intranasal immunization with cholera toxin B subunit or conjugates. Infect. Immun. (1998) 66(2):514-520.
  • DI TOMMASO A, SALETTI G, PIZZA M et al.: Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvant. Infect. Immun. (1996) 64(3):974-979.
  • BERGQUIST C, JOHANSSON EL, LAGERGARD T, HOLMGREN J, RUDIN A: Intranasal vaccination of humans with recombinant cholera toxin B subunit induces systemic and local antibody responses in the upper respiratory tract and the vagina. Infect. Immun. (1997) 65(7):2676-2684.
  • KUPER CF, KOORNSTRA PJ, HAMELEERS DM et al.: The role of nasopharyngeal lymphoid tissue. Immunol. Today (1992) 13(6):219-224.
  • MOORE KL, DALLEY AF: Clinically Oriented Anatomy. Lippincott Williams & Wilkins, Baltimore, MD, USA (1999):935-935.
  • FUJIMURA Y: Evidence of M cells as portals of entry for antigens in the nasopharyngeal lymphoid tissue of humans. Virchows Arch. (2000) 436(6):560-566.
  • POPE M: Mucosal dendritic cells and immunodeficiency viruses. J. Infect. Dis. (1999) 179(Suppl. 3):S427-S430.
  • BRANDTZAEG P: Humoral immune response patterns of human mucosae: induction and relation to bacterial respiratory tract infections. J. Infect. Dis. (1992) 165(Suppl. 1):S167-S176.
  • BRANDTZAEG P, BAEKKEVOLD ES, FARSTAD IN et al.: Regional specialization in the mucosal immune system: what happens in the microcompartments? Immunol. Today (1999) 20(3):141-151.
  • BOYAKA PN, WRIGHT PF, MARINARO M et al.: Human nasopharyngeal-associated lymphoreticular tissues : functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils. Am. J. Pathol. (2000) 157(6):2023-2035.
  • GRAEME-COOK F, BHAN AK, HARRIS NL: Immunohistochemical characterization of intraepithelial and subepithelial mononuclear cells of the upper airways. Am. J. Pathol. (1993) 143(5):1416-1422.
  • YEAMAN GR, WHITE HD, HOWELL A, PRABHALA R, WIRA CR: The mucosal immune system in the human female reproductive tract: potential insights into the heterosexual transmission of HIV. AIDS Res. Hum. Retroviruses (1998) 14(Suppl. 1):S57-S62.
  • JOHANSSON EL, RUDIN A, WASSEN L, HOLMGREN J: Distribution of lymphocytes and adhesion molecules in human cervix and vagina. Immunol. (1999) 96(2):272-277.
  • HU J, GARDNER MB, MILLER CJ: Simian immunodeficiency virus rapidly penetrates the cervicovaginal mucosa after intravaginal inoculation and infects intraepithelial dendritic cells. J. Virol. (2000) 74(13):6087-6095.
  • LOHMAN BL, MILLER CJ, MCCHESNEY MB: Antiviral cytotoxic T lymphocytes in vaginal mucosa of simian immunodeficiency virus-infected rhesus macaques. J.Immunol. (1995) 155(12):5855-5860.
  • MCCHESNEY MB, COLLINS JR, MILLER CJ: Mucosal phenotype of antiviral cytotoxic T lymphocytes in the vaginal mucosa of SIV-infected rhesus macaques. AIDS Res. Hum. Retroviruses (1998) 14(Suppl. 1):S63-S66.
  • CHALLACOMBE SJ, RAHMAN D, O’HAGAN DT: Salivary, gut, vaginal and nasal antibody responses after oral immunization with biodegradable microparticles. Vaccine (1997) 15(2):169-175.
  • UGOZZOLI M, O’HAGAN DT, OTT GS: Intranasal immunization of mice with herpes simplex virus type 2 recombinant gD2: the effect of adjuvants on mucosal and serum antibody responses. Immunol. (1998) 93(4):563-571.
  • PARR MB, PARR EL: Immunohistochemical localization of immunoglobulins A, G and M in the mouse female genital tract. J. Reprod. Fertil. (1985) 74(2):361-370.
  • THAPARR MA, PARR EL, BOZZOLA JJ, PARR MB: Secretory immune responses in the mouse vagina after parenteral or intravaginal immunization with an immunostimulating complex (ISCOM). Vaccine (1991) 9(2):129-133.
  • O’HAGAN DT, RAFFERTY D, MCKEATING JA, ILLUM L: Vaginal immunization of rats with a synthetic peptide from human immunodeficiency virus envelope glycoprotein. J. Gen. Virol. (1992) 73(Pt 8):2141-2145.
  • O’HAGAN DT, RAFFERTY D, WHARTON S, ILLUM L: Intravaginal immunization in sheep using a bioadhesive microsphere antigen delivery system. Vaccine (1993) 11(6):660-664.
  • VAJDY M, GARDNER J, NEIDLEMAN J et al.: Human immunodeficiency virus type 1 Gag-specific vaginal immunity and protection after local immunizations with sindbis virus-based replicon particles. J. Infect. Dis. (2001) 184(12):1613-1616.
  • GUPTA S, JANANI R, BIN Q et al.: Characterization of HIV-gag-specific IFNγ-expressing cells following protective mucosal immunization with alphavirus replicon particles. J. Virol. (2005) 79(11):7135-7145.
  • WIRA CR, RICHARDSON J, PRABHALA R: Endocrine regulation of mucosal immunity: effect of sex hormones and cytokines on the afferent and efferent arms of the immune system in the female reproductive tract. In: Handbook of Mucosal Immunology. PL Ogra, J Mestecky, ME Lamm, JR McGhee, W Strober, J Bienenstock. (Eds), Academic Press, San Diego, CA, USA (1994):705-718.
  • STAATS HF, NICHOLS WG, PALKER TJ et al.: Mucosal immunity to HIV-1: systemic and vaginal antibody responses after intranasal immunization with the HIV-1 C4/V3 peptide T1SP10 MN(A). J. Immunol. (1996) 157(1):462-472.
  • HOLMGREN J, ADAMSSON J, ANJUERE F et al.: Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA. Immunol. Lett. (2005) 97(2):181-188.
  • NEIDLEMAN JA, VAJDY M, UGOZZOLI M, OTT G, O’HAGAN D: Genetically detoxified mutants of heat-labile enterotoxin from Escherichia coli are effective adjuvants for induction of cytotoxic T cell responses against HIV-1 gag-p55. Immunology (2000) 101(1):154-160.
  • MORRIS CB, CHENG E, THANAWASTIEN A, CARDENAS-FREYTAG L, CLEMENTS JD: Effectiveness of intranasal immunization with HIV-gp160 and an HIV-1 env CTL epitope peptide (E7) in combination with the mucosal adjuvant LT(R192G). Vaccine (2000) 18(18):1944-1951.
  • MANOCHA M, PAL PC, CHITRALEKHA KT et al.: Enhanced mucosal and systemic immune response with intranasal immunization of mice with HIV peptides entrapped in PLG microparticles in combination with Ulex Europaeus-I lectin as M cell target. Vaccine (2005) 23(48-49):5599-5617.
  • HORNER AA, DATTA SK, TAKABAYASHI K et al.: Immunostimulatory DNA-based vaccines elicit multifaceted immune responses against HIV at systemic and mucosal sites. J. Immunol. (2001) 167(3):1584-1591.
  • BRADNEY CP, SEMPOWSKI GD, LIAO HX, HAYNES BF, STAATS HF: Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin G (IgG) and IgA antibodies in serum and mucosal secretions after nasal immunization. J. Virol. (2002) 76(2):517-524.
  • ALBU DI, JONES-TROWER A, WORON AM et al.: Intranasal vaccination using interleukin-12 and cholera toxin subunit B as adjuvants to enhance mucosal and systemic immunity to human immunodeficiency virus type 1 glycoproteins. J. Virol. (2003) 77(10):5589-5597.
  • BORSUTZKY S, FIORELLI V, EBENSEN T et al.: Efficient mucosal delivery of the HIV-1 Tat protein using the synthetic lipopeptide MALP-2 as adjuvant. Eur. J. Immunol. (2003) 33(6):1548-1556.
  • SAKAUE G, HIROI T, NAKAGAWA Y et al.: HIV mucosal vaccine: nasal immunization with gp160-encapsulated hemagglutinating virus of Japan-liposome induces antigen-specific CTLs and neutralizing antibody responses. J. Immunol. (2003) 170(1):495-502.
  • MANTIS NJ, KOZLOWSKI PA, MIELCARZ DW, WEISSENHORN W, NEUTRA MR: Immunization of mice with recombinant gp41 in a systemic prime/mucosal boost protocol induces HIV-1-specific serum IgG and secretory IgA antibodies. Vaccine (2001) 19(28-29):3990-4001.
  • MATOBA N, MAGERUS A, GEYER BC et al.: A mucosally targeted subunit vaccine candidate eliciting HIV-1 transcytosis-blocking Abs. Proc. Natl. Acad. Sci. USA (2004) 101(37):13584-13589.
  • KLAVINSKIS LS, GAO L, BARNFIELD C, LEHNER T, PARKER S: Mucosal immunization with DNA-liposome complexes. Vaccine (1997) 15(8):818-820.
  • SASAKI S, HAMAJIMA K, FUKUSHIMA J et al.: Comparison of intranasal and intramuscular immunization against human immunodeficiency virus type 1 with a DNA-monophosphoryl lipid A adjuvant vaccine. Infect. Immun. (1998) 66(2):823-826.
  • HAMAJIMA K, SASAKI S, FUKUSHIMA J et al.: Intranasal administration of HIV-DNA vaccine formulated with a polymer, carboxymethylcellulose, augments mucosal antibody production and cell-mediated immune response. Clin. Immunol. Immunopathol. (1998) 88(2):205-210.
  • XIN KQ, LU Y, HAMAJIMA K et al.: Immunization of RANTES expression plasmid with a DNA vaccine enhances HIV-1-specific immunity. Clin. Immunol. (1999) 92(1):90-96.
  • SINGH M, BRIONES M, OTT G, O’HAGAN D: Cationic microparticles: a potent delivery system for DNA vaccines. Proc. Natl. Acad. Sci. USA (2000) 97(2):811-816.
  • SINGH M, VAJDY M, GARDNER J, BRIONES M, O’HAGAN D: Mucosal immunization with HIV-1 gag DNA on cationic microparticles prolongs gene expression and enhances local and systemic immunity. Vaccine (2001) 20(3-4):594-602.
  • WANG X, HONE DM, HADDAD A, SHATA MT, PASCUAL DW: M cell DNA vaccination for CTL immunity to HIV. J. Immunol. (2003) 171(9):4717-4725.
  • HAMAJIMA K, KOJIMA Y, MATSUI K et al.: Chitin Micro-Particles (CMP): a useful adjuvant for inducing viral specific immunity when delivered intranasally with an HIV-DNA vaccine. Viral Immunol. (2003) 16(4):541-547.
  • LOCHER CP, WITT SA, ASHLOCK BM, LEVY JA: Evaluation of genetic immunization adjuvants to improve the effectiveness of a human immunodeficiency virus type 2 (HIV-2) envelope DNA vaccine. DNA Cell Biol. (2004) 23(2):107-110.
  • CANNON G, WEISSMAN D: RNA based vaccines. DNA Cell Biol. (2002) 21(12):953-961.
  • MARTINON F, KRISHNAN S, LENZEN G et al.: Induction of virus-specific cytotoxic T lymphocytes in vivo by liposome-entrapped mRNA. Eur. J. Immunol. (1993) 23(7):1719-1722.
  • POLO JM, GARDNER JP, JI Y et al.: Alphavirus DNA and particle replicons for vaccines and gene therapy. Dev. Biol. (Basel) (2000) 104:181-185.
  • LI HO, ZHU YF, ASAKAWA M et al.: A cytoplasmic RNA vector derived from nontransmissible Sendai virus with efficient gene transfer and expression. J. Virol. (2000) 74(14):6564-6569.
  • SCHOEN C, KOLB-MAURER A, GEGINAT G et al.: Bacterial delivery of functional messenger RNA to mammalian cells. Cell Microbiol. (2005) 7(5):709-724.
  • MICHIELS A, TUYAERTS S, BONEHILL A et al.: Electroporation of immature and mature dendritic cells: implications for dendritic cell-based vaccines. Gene Ther. (2005) 12(9):772-782.
  • YOSHII K, HAYASAKA D, GOTO A et al.: Packaging the replicon RNA of the Far-Eastern subtype of tick-borne encephalitis virus into single-round infectious particles: development of a heterologous gene delivery system. Vaccine (2005) 23(30):3946-3956.
  • SHINYA K, FUJII Y, ITO H et al.: Characterization of a neuraminidase-deficient influenza a virus as a potential gene delivery vector and a live vaccine. J. Virol. (2004) 78(6):3083-3088.
  • AHLQUIST P, SCHWARTZ M, CHEN J et al.: Viral and host determinants of RNA virus vector replication and expression. Vaccine (2005) 23(15):1784-1787.
  • RAYNER JO, DRYGA SA, KAMRUD KI: Alphavirus vectors and vaccination. Rev. Med. Virol. (2002) 12(5):279-296.
  • SCHLESINGER S: Alphavirus vectors: development and potential therapeutic applications. Expert Opin. Biol. Ther. (2001) 1(2):177-191.
  • SCHLESINGER S, DUBENSKY TW: Alphavirus vectors for gene expression and vaccines. Curr. Opin. Biotechnol. (1999) 10(5):434-439.
  • LEITNER WW, HWANG LN, DEVEER MJ et al.: Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways. Nat. Med. (2003) 9(1):33-39.
  • CALEY IJ, BETTS MR, IRLBECK DM et al.: Humoral, mucosal, and cellular immunity in response to a human immunodeficiency virus type 1 immunogen expressed by a Venezuelan equine encephalitis virus vaccine vector. J. Virol. (1997) 71(4):3031-3038.
  • BERGLUND P, QUESADA-ROLANDER M, PUTKONEN P et al.: Outcome of immunization of cynomolgus monkeys with recombinant Semliki Forest virus encoding human immunodeficiency virus type 1 envelope protein and challenge with a high dose of SHIV-4 virus. AIDS Res. Hum. Retroviruses (1997) 13(17):1487-1495.
  • BRAND D, LEMIALE F, TURBICA I et al.: Comparative analysis of humoral immune responses to HIV type 1 envelope glycoproteins in mice immunized with a DNA vaccine, recombinant Semliki Forest virus RNA, or recombinant Semliki Forest virus particles. AIDS Res. Hum. Retroviruses (1998) 14(15):1369-1377.
  • PAN CH, VALSAMAKIS A, COLELLA T et al.: Inaugural article: modulation of disease, T cell responses, and measles virus clearance in monkeys vaccinated with H-encoding alphavirus replicon particles. Proc. Natl. Acad. Sci. USA (2005) 102(33):11581-11588.
  • BELYAKOV IM, MOSS B, STROBER W, BERZOFSKY JA: Mucosal vaccination overcomes the barrier to recombinant vaccinia immunization caused by preexisting poxvirus immunity. Proc. Natl. Acad. Sci. USA (1999) 96(8):4512-4517.
  • HOFMANN-LEHMANN R, VLASAK J, WILLIAMS AL et al.: Live attenuated, nef-deleted SIV is pathogenic in most adult macaques after prolonged observation. AIDS (2003) 17(2):157-166.
  • RUPRECHT RM: Live attenuated AIDS viruses as vaccines: promise or peril? Immunol. Rev. (1999) 170:135-149.
  • BABA TW, LISKA V, KHIMANI AH et al.: Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques. Nat. Med. (1999) 5(2):194-203.
  • BABA TW, JEONG YS, PENNICK D et al.: Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques. Science (1995) 267(5205):1820-1825.
  • WYAND MS, MANSON K, MONTEFIORI DC et al.: Protection by live, attenuated simian immunodeficiency virus against heterologous challenge. J. Virol. (1999) 73(10):8356-8363.
  • JOHNSON RP, LIFSON JD, CZAJAK SC et al.: Highly attenuated vaccine strains of simian immunodeficiency virus protect against vaginal challenge: inverse relationship of degree of protection with level of attenuation. J. Virol. (1999) 73(6):4952-4961.
  • GHERARDI MM, NAJERA JL, PEREZ-JIMENEZ E et al.: Prime-boost immunization schedules based on influenza virus and vaccinia virus vectors potentiate cellular immune responses against human immunodeficiency virus Env protein systemically and in the genitorectal draining lymph nodes. J. Virol. (2003) 77(12):7048-7057.
  • GHERARDI MM, PEREZ-JIMENEZ E, NAJERA JL, ESTEBAN M: Induction of HIV immunity in the genital tract after intranasal delivery of a MVA vector: enhanced immunogenicity after DNA prime-modified vaccinia virus Ankara boost immunization schedule. J. Immunol. (2004) 172(10):6209-6220.
  • STEVCEVA L, ALVAREZ X, LACKNER AA et al.: Both mucosal and systemic routes of immunization with the live, attenuated NYVAC/simian immunodeficiency virus SIV(gpe) recombinant vaccine result in gag-specific CD8(+) T-cell responses in mucosal tissues of macaques. J. Virol. (2002) 76(22):11659-11676.
  • BERTLEY FM, KOZLOWSKI PA, WANG SW et al.: Control of simian/human immunodeficiency virus viremia and disease progression after IL-2-augmented DNA-modified vaccinia virus Ankara nasal vaccination in nonhuman primates. J. Immunol. (2004) 172(6):3745-3757.
  • AMARA RR, VILLINGER F, ALTMAN JD et al.: Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science (2001) 292(5514):69-74.
  • VOGEL TU, REYNOLDS MR, FULLER DH et al.: Multispecific vaccine-induced mucosal cytotoxic T lymphocytes reduce acute-phase viral replication but fail in long-term control of simian immunodeficiency virus SIVmac239. J. Virol. (2003) 77(24):13348-13360.
  • SANTRA S, BAROUCH DH, KORIOTH-SCHMITZ B et al.: Recombinant poxvirus boosting of DNA-primed rhesus monkeys augments peak but not memory T lymphocyte responses. Proc. Natl. Acad. Sci. USA (2004) 101(30):11088-11093.
  • WANG SW, BERTLEY FM, KOZLOWSKI PA et al.: An SHIV DNA/MVA rectal vaccination in macaques provides systemic and mucosal virus-specific responses and protection against AIDS. AIDS Res. Hum. Retroviruses (2004) 20(8):846-859.
  • BAROUCH DH, MCKAY PF, SUMIDA SM et al.: Plasmid chemokines and colony-stimulating factors enhance the immunogenicity of DNA priming-viral vector boosting human immunodeficiency virus type 1 vaccines. J. Virol. (2003) 77(16):8729-8735.
  • PEACOCK JW, NORDONE SK, JACKSON SS et al.: Gender differences in human immunodeficiency virus type 1-specific CD8 responses in the reproductive tract and colon following nasal peptide priming and modified vaccinia virus Ankara boosting. J. Virol. (2004) 78(23):13163-13172.
  • EDGHILL-SMITH Y, BRAY M, WHITEHOUSE CA et al.: Smallpox vaccine does not protect macaques with AIDS from a lethal monkeypox virus challenge. J. Infect. Dis. (2005) 191(3):372-381.
  • CHAN KS, VERARDI PH, LEGRAND FA, YILMA TD: Nef from pathogenic simian immunodeficiency virus is a negative factor for vaccinia virus. Proc. Natl. Acad. Sci. USA (2005) 102(24):8734-8739.
  • HARRER E, BAUERLE M, FERSTL B et al.: Therapeutic vaccination of HIV-1-infected patients on HAART with a recombinant HIV-1 nef-expressing MVA: safety, immunogenicity and influence on viral load during treatment interruption. Antivir. Ther. (2005) 10(2):285-300.
  • FRANCHINI G, GURUNATHAN S, BAGLYOS L, PLOTKIN S, TARTAGLIA J: Poxvirus-based vaccine candidates for HIV: two decades of experience with special emphasis on canarypox vectors. Expert Rev. Vaccines (2004) 3(4 Suppl.):S75-S88.
  • IM EJ, HANKE T: MVA as a vector for vaccines against HIV-1. Expert Rev. Vaccines (2004) 3(4 Suppl.):S89-S97.
  • AMARA RR, ROBINSON HL: A new generation of HIV vaccines. Trends Mol. Med. (2002) 8(10):489-495.
  • ROSE NF, MARX PA, LUCKAY A et al.: An effective AIDS vaccine based on live attenuated vesicular stomatitis virus recombinants. Cell (2001) 106(5):539-549.
  • EGAN MA, CHONG SY, ROSE NF et al.: Immunogenicity of attenuated vesicular stomatitis virus vectors expressing HIV type 1 env and SIV gag proteins: comparison of intranasal and intramuscular vaccination routes. AIDS Res. Hum. Retroviruses (2004) 20(9):989-1004.
  • HAGLUND K, LEINER I, KERKSIEK K et al.: High-level primary CD8(+) T-cell response to human immunodeficiency virus type 1 gag and env generated by vaccination with recombinant vesicular stomatitis viruses. J. Virol. (2002) 76(6):2730-2738.
  • SCHMITT B: Vesicular stomatitis. Vet. Clin. North Am. Food Anim. Pract. (2002) 18(3):453-459, vii-viii.
  • LETCHWORTH GJ, RODRIGUEZ LL, DEL CBARRERA J: Vesicular stomatitis. Vet. J. (1999) 157(3):239-260.
  • KOVACS GM, HARRACH B, ZAKHARTCHOUK AN, DAVISON AJ: Complete genome sequence of simian adenovirus 1: an Old World monkey adenovirus with two fiber genes. J. Gen. Virol. (2005) 86(Pt 6):1681-1686.
  • CHOI EH, KIM HS, EUN BW et al.: Adenovirus type 7 peptide diversity during outbreak, Korea, 1995-2000. Emerg. Infect. Dis. (2005) 11(5):649-654.
  • GRAY GC, SETTERQUIST SF, JIRSA SJ, DESJARDIN LE, ERDMAN DD: Emergent strain of human adenovirus endemic in Iowa. Emerg. Infect. Dis. (2005) 11(1):127-128.
  • CHEN HL, CHIOU SS, HSIAO HP et al.: Respiratory adenoviral infections in children: a study of hospitalized cases in southern Taiwan in 2001-2002. J. Trop. Pediatr. (2004) 50(5):279-284.
  • LICHTENSTEIN DL, WOLD WS: Experimental infections of humans with wild-type adenoviruses and with replication-competent adenovirus vectors: replication, safety, and transmission. Cancer Gene Ther. (2004) 11(12):819-829.
  • ROELVINK PW, LIZONOVA A, LEE JG et al.: The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F. J. Virol. (1998) 72(10):7909-7915.
  • LEMIALE F, KONG WP, AKYUREK LM et al.: Enhanced mucosal immunoglobulin A response of intranasal adenoviral vector human immunodeficiency virus vaccine and localization in the central nervous system. J. Virol. (2003) 77(18):10078-10087.
  • THOMAS CE, EHRHARDT A, KAY MA: Progress and problems with the use of viral vectors for gene therapy. Nat. Rev. Genet. (2003) 4(5):346-358.
  • NATUK RJ, CHANDA PK, LUBECK MD et al.: Adenovirus-human immunodeficiency virus (HIV) envelope recombinant vaccines elicit high-titered HIV-neutralizing antibodies in the dog model. Proc. Natl. Acad. Sci. USA (1992) 89(16):7777-7781.
  • NATUK RJ, LUBECK MD, CHANDA PK et al.: Immunogenicity of recombinant human adenovirus-human immunodeficiency virus vaccines in chimpanzees. AIDS Res. Hum. Retroviruses (1993) 9(5):395-404.
  • LUBECK MD, NATUK RJ, CHENGALVALA M et al.: Immunogenicity of recombinant adenovirus-human immunodeficiency virus vaccines in chimpanzees following intranasal administration. AIDS Res. Hum. Retroviruses (1994) 10(11):1443-1449.
  • BAROUCH DH, NABEL GJ: Adenovirus vector-based vaccines for human immunodeficiency virus type 1. Hum. Gene Ther. (2005) 16(2):149-156.
  • SHIVER JW, EMINI EA: Recent advances in the development of HIV-1 vaccines using replication-incompetent adenovirus vectors. Ann. Rev. Med. (2004) 55:355-372.
  • SANTRA S, SEAMAN MS, XU L et al.: Replication-defective adenovirus serotype 5 vectors elicit durable cellular and humoral immune responses in nonhuman primates. J. Virol. (2005) 79(10):6516-6522.
  • MASCOLA JR, SAMBOR A, BEAUDRY K et al.: Neutralizing antibodies elicited by immunization of monkeys with DNA plasmids and recombinant adenoviral vectors expressing human immunodeficiency virus type 1 proteins. J. Virol. (2005) 79(2):771-779.
  • GOMEZ-ROMAN VR, PATTERSON LJ, VENZON D et al.: Vaccine-elicited antibodies mediate antibody-dependent cellular cytotoxicity correlated with significantly reduced acute viremia in rhesus macaques challenged with SIVmac251. J. Immunol. (2005) 174(4):2185-2189.
  • CASIMIRO DR, BETT AJ, FU TM et al.: Heterologous human immunodeficiency virus type 1 priming-boosting immunization strategies involving replication-defective adenovirus and poxvirus vaccine vectors. J. Virol. (2004) 78(20):11434-11438.
  • GOMEZ-ROMAN VR, ROBERT-GUROFF M: Adenoviruses as vectors for HIV vaccines. AIDS Rev. (2003) 5(3):178-185.
  • FERKO B, STASAKOVA J, SEREINIG S et al.: Hyperattenuated recombinant influenza A virus nonstructural-protein-encoding vectors induce human immunodeficiency virus type 1 Nef-specific systemic and mucosal immune responses in mice. J. Virol. (2001) 75(19):8899-8908.
  • FERKO B, KATINGER D, GRASSAUER A et al.: Chimeric influenza virus replicating predominantly in the murine upper respiratory tract induces local immune responses against human immunodeficiency virus type 1 in the genital tract. J. Infect. Dis. (1998) 178(5):1359-1368.
  • MUSTER T, FERKO B, KLIMA A et al.: Mucosal model of immunization against human immunodeficiency virus type 1 with a chimeric influenza virus. J. Virol. (1995) 69(11):6678-6686.
  • KANG SM, GUO L, YAO Q, SKOUNTZOU I, COMPANS RW: Intranasal immunization with inactivated influenza virus enhances immune responses to coadministered simian-human immunodeficiency virus-like particle antigens. J. Virol. (2004) 78(18):9624-9632.
  • CROTTY S, ANDINO R: Poliovirus vaccine strains as mucosal vaccine vectors and their potential use to develop an AIDS vaccine. Adv. Drug Deliv. Rev. (2004) 56(6):835-852.
  • TAN GS, MCKENNA PM, KOSER ML et al.: Strong cellular and humoral anti-HIV Env immune responses induced by a heterologous rhabdoviral prime-boost approach. Virology (2005) 331(1):82-93.
  • DURRANI Z, MCINERNEY TL, MCLAIN L et al.: Intranasal immunization with a plant virus expressing a peptide from HIV-1 gp41 stimulates better mucosal and systemic HIV-1-specific IgA and IgG than oral immunization. J. Immunol. Methods (1998) 220(1-2):93-103.
  • AKAGI T, KAWAMURA M, UENO M et al.: Mucosal immunization with inactivated HIV-1-capturing nanospheres induces a significant HIV-1-specific vaginal antibody response in mice. J. Med. Virol. (2003) 69(2):163-172.
  • MIYAKE A, AKAGI T, ENOSE Y et al.: Induction of HIV-specific antibody response and protection against vaginal SHIV transmission by intranasal immunization with inactivated SHIV-capturing nanospheres in macaques. J. Med. Virol. (2004) 73(3):368-377.
  • DUMAIS N, PATRICK A, MOSS RB, DAVIS HL, ROSENTHAL KL: Mucosal immunization with inactivated human immunodeficiency virus plus CpG oligodeoxynucleotides induces genital immune responses and protection against intravaginal challenge. J. Infect. Dis. (2002) 186(8):1098-1105.
  • JIANG JQ, PATRICK A, MOSS RB, ROSENTHAL KL: CD8+ T-cell-mediated cross-clade protection in the genital tract following intranasal immunization with inactivated human immunodeficiency virus antigen plus CpG oligodeoxynucleotides. J. Virol. (2005) 79(1):393-400.
  • KAWAHARA M, MATSUO K, NAKASONE T et al.: Combined intrarectal/intradermal inoculation of recombinant Mycobacterium bovis bacillus Calmette-Guerin (BCG) induces enhanced immune responses against the inserted HIV-1 V3 antigen. Vaccine (2002) 21(3-4):158-166.
  • GOLDING B, ELLER N, LEVY L et al.: Mucosal immunity in mice immunized with HIV-1 peptide conjugated to Brucella abortus. Vaccine (2002) 20(9-10):1445-1450.
  • DEML L, SPETH C, DIERICH MP, WOLF H, WAGNER R: Recombinant HIV-1 Pr55gag virus-like particles: potent stimulators of innate and acquired immune responses. Mol. Immunol. (2005) 42(2):259-277.
  • YAO Q, BU Z, VZOROV A, YANG C, COMPANS RW: Virus-like particle and DNA-based candidate AIDS vaccines. Vaccine (2003) 21(7-8):638-643.
  • YAO Q: Enhancement of mucosal immune responses by chimeric influenza HA/SHIV virus-like particles. Res. Initiat. Treat. Action (2003) 8(2):20-21.
  • GRONOWSKI AM, HILBERT DM, SHEEHAN KC, GAROTTA G, SCHREIBER RD: Baculovirus stimulates antiviral effects in mammalian cells. J. Virol. (1999) 73(12):9944-9951.
  • XU F, HONG M, ULMER JB: Immunogenicity of an HIV-1 gag DNA vaccine carried by attenuated Shigella. Vaccine (2003) 21(7-8):644-648.
  • SHATA MT, HONE DM: Vaccination with a Shigella DNA vaccine vector induces antigen-specific CD8(+) T cells and antiviral protective immunity. J. Virol. (2001) 75(20):9665-9670.
  • DEVICO AL, FOUTS TR, SHATA MT et al.: Development of an oral prime-boost strategy to elicit broadly neutralizing antibodies against HIV-1. Vaccine (2002) 20(15):1968-1974.
  • VECINO WH, MORIN PM, AGHA R, JACOBS WR Jr, FENNELLY GJ: Mucosal DNA vaccination with highly attenuated Shigella is superior to attenuated Salmonella and comparable to intramuscular DNA vaccination for T cells against HIV. Immunol. Lett. (2002) 82(3):197-204.
  • MUTSCH M, ZHOU W, RHODES P et al.: Use of the inactivated intranasal influenza vaccine and the risk of Bell’s palsy in Switzerland. N. Engl. J. Med. (2004) 350(9):896-903.
  • COUCH RB: Nasal vaccination, Escherichia coli enterotoxin, and Bell’s palsy. N. Engl. J. Med. (2004) 350(9):860-861.
  • PIERCY J: Bell’s palsy. Br. Med. J. (2005) 330(7504):1374.
  • VAN GINKEL FW, JACKSON RJ, YUKI Y, MCGHEE JR: Cutting edge: the mucosal adjuvant cholera toxin redirects vaccine proteins into olfactory tissues. J. Immunol. (2000) 165(9):4778-4782.
  • ERIKSSON AM, SCHON KM, LYCKE NY: The cholera toxin-derived CTA1-DD vaccine adjuvant administered intranasally does not cause inflammation or accumulate in the nervous tissues. J. Immunol. (2004) 173(5):3310-3319.
  • VAN GINKEL FW, JACKSON RJ, YOSHINO N et al.: Enterotoxin-based mucosal adjuvants alter antigen trafficking and induce inflammatory responses in the nasal tract. Infect. Immun. (2005) 73(10):6892-6902.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.