460
Views
86
CrossRef citations to date
0
Altmetric
Review

Polymeric nano- and microparticle technologies for oral gene delivery

&
Pages 197-213 | Published online: 09 May 2007

Bibliography

  • DRUGAN A, MILLER OJ, EVANS MI: Gene therapy. Fetal Ther. (1987) 2(4):232-241.
  • GOVERDHANA S, PUNTEL M, XIONG W et al.: Regulatable gene expression systems for gene therapy applications: progress and future challenges. Mol. Ther. (2005) 12(2):189-211.
  • ULMANEN I, KALLIO A: Gene therapy of somatic cells, the principle and techniques. Ann. Clin. Res. (1986) 18(5-6):316-321.
  • ROMANO G, PACILIO C, GIORDANO A: Gene transfer technology in therapy: current applications and future goals. Stem Cells (1999) 17(4):191-202.
  • LORETZ B, FOGER F, WERLE M, BERNKOP-SCHNURCH A: Oral gene delivery: strategies to improve stability of pDNA towards intestinal digestion. J. Drug Target (2006) 14(5):311-319.
  • ROTHMAN S, TSENG H, GOLDFINE I: Oral gene therapy: a novel method for the manufacture and delivery of protein drugs. Diabetes Technol. Ther. (2005) 7(3):549-557.
  • MARTIEN R, LORETZ B, SCHNURCH AB: Oral gene delivery: design of polymeric carrier systems shielding toward intestinal enzymatic attack. Biopolymers (2006) 83(4):327-336.
  • LYSIK MA, WU-PONG S: Innovations in oligonucleotide drug delivery. J. Pharm. Sci. (2003) 92(8):1559-1573.
  • CHENG X, MING X, CROYLE MA: PEGylated adenoviruses for gene delivery to the intestinal epithelium by the oral route. Pharm. Res. (2003) 20(9):1444-1451.
  • LECOLLINET S, GAVARD F, HAVENGA MJ et al.: Improved gene delivery to intestinal mucosa by adenoviral vectors bearing subgroup B and D fibers. J. Virol. (2006) 80(6):2747-2759.
  • ROMANO G, MICHELL P, PACILIO C, GIORDANO A: Latest developments in gene transfer technology: achievements, perspectives, and controversies over therapeutic applications. Stem Cells (2000) 18(1):19-39.
  • AMIJI MM (Ed.): Polymeric gene delivery: principles and applications. CRC Press, Boca Raton, FL (2005).
  • FOLDVARI M, BABIUK S, BADEA I: DNA delivery for vaccination and therapeutics through the skin. Curr. Drug Deliv. (2006) 3(1):17-28.
  • PATIL SD, RHODES DG, BURGESS DJ: DNA-based therapeutics and DNA delivery systems: a comprehensive review. AAPS J. (2005) 7(1):E61-E77.
  • LUO D, SALTZMAN WM: Synthetic DNA delivery systems. Nat. Biotechnol. (2000) 18(1):33-37.
  • PRIETO J, HERRAIZ M, SANGRO B et al.: The promise of gene therapy in gastrointestinal and liver diseases. Gut (2003) 52 (Suppl. 2):ii49-ii54.
  • DUBENSKY TW, Jr, LIU MA, ULMER JB: Delivery systems for gene-based vaccines. Mol. Med. (2000) 6(9):723-732.
  • PONCHEL G, IRACHE J: Specific and non-specific bioadhesive particulate systems for oral delivery to the gastrointestinal tract. Adv. Drug Deliv. Rev. (1998) 34(2-3):191-219.
  • DONNELLY JJ, WAHREN B, LIU MA: DNA vaccines: progress and challenges. J. Immunol. (2005) 175(2):633-639.
  • HORNER AA, VAN UDEN JH, ZUBELDIA JM, BROIDE D, RAZ E: DNA-based immunotherapeutics for the treatment of allergic disease. Immunol. Rev. (2001) 179:102-118.
  • JONES DH, CORRIS S, MCDONALD S, CLEGG JC, FARRAR GH: Poly(DL-lactide-co-glycolide)-encapsulated plasmid DNA elicits systemic and mucosal antibody responses to encoded protein after oral administration. Vaccine (1997) 15(8):814-817.
  • ROY K, MAO HQ, HUANG SK, LEONG KW: Oral gene delivery with chitosan--DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat. Med. (1999) 5(4):387-391.
  • OCHIYA T, NAGAHARA S, SANO A, ITOH H, TERADA M: Biomaterials for gene delivery: atelocollagen-mediated controlled release of molecular medicines. Curr. Gene Ther. (2001) 1(1):31-52.
  • DANG JM, LEONG KW: Natural polymers for gene delivery and tissue engineering. Adv. Drug Deliv. Rev. (2006) 58(4):487-499.
  • PUTNAM D: Polymers for gene delivery across length scales. Nat. Mater. (2006) 5(6):439-451.
  • KASHYAP N, MODI S, JAIN JP et al.: Polymers for advanced drug delivery. CRIPS (2004) 5(3):7-12.
  • KAI E, OCHIYA T: A method for oral DNA delivery with N-acetylated chitosan. Pharm. Res. (2004) 21(5):838-843.
  • HATTORI Y, MAITANI Y: Enhanced in vitro DNA transfection efficiency by novel folate-linked nanoparticles in human prostate cancer and oral cancer. J. Control. Release (2004) 97(1):173-183.
  • HOWARD KA, LI XW, SOMAVARAPU S et al.: Formulation of a microparticle carrier for oral polyplex-based DNA vaccines. Biochim. Biophys. Acta (2004) 1674(2):149-157.
  • KABANOV AV, FELGNER PL, SEYMOUR LW (eds.): Self-assembling complexes for gene delivery. Wiley & Sons (1998):197-218.
  • ARAL C, AKBUGA J: Preparation and in vitro transfection efficiency of chitosan microspheres containing plasmid DNA:poly(L-lysine) complexes. J. Pharm. Pharmceut. Sci. (2003) 6(3):321-326.
  • NIE Y, ZHANG ZR, DUAN YR: Combined use of polycationic peptide and biodegradable macromolecular polymer as a novel gene delivery system: a preliminary study. Drug Deliv. (2006) 13(6):441-446.
  • HEJAZI R, AMIJI M: Chitosan-based gastrointestinal delivery systems. J. Control. Release (2003) 89(2):151-165.
  • MUMPER RJ, WANG J, CLASPELL JM, ROLLAND AP: Novel polymeric carriers for gene delivery. Proc. Intern. Symp. Control. Rel. Bioact. Mater. (1995) 22:178-179.
  • THANOU M, FLOREA BI, GELDOF M, JUNGINGER HE, BORCHARD G: Quaternized chitosan oligomers as novel gene delivery vectors in epithelial cell lines. Biomaterials (2002) 23(1):153-159.
  • LEE KY, KWON IC, KIM YH, JO WH, JEONG SY: Preparation of chitosan self-aggregates as a gene delivery system. J. Control. Release (1998) 51(2-3):213-220.
  • BOZKIR A, SAKA OM: Chitosan nanoparticles for plasmid DNA delivery: effect of chitosan molecular structure on formulation and release characteristics. Drug Deliv. (2004) 11(2):107-112.
  • BORCHARD G: Chitosans for gene delivery. Adv. Drug Deliv. Rev. (2001) 52(2):145-150.
  • BLESSING T, KURSA M, HOLZHAUSER R, KIRCHEIS R, WAGNER E: Different strategies for formation of pegylated EGF-conjugated PEI/DNA complexes for targeted gene delivery. Bioconjug. Chem. (2001) 12(4):529-537.
  • CARLISLE RC, BETTINGER T, OGRIS M et al.: Adenovirus hexon protein enhances nuclear delivery and increases transgene expression of polyethylenimine/plasmid DNA vectors. Mol. Ther. (2001) 4(5):473-483.
  • KURSA M, WALKER GF, ROESSLER V et al.: Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer. Bioconjug. Chem. (2003) 14(1):222-231.
  • OGRIS M, BRUNNER S, SCHULLER S, KIRCHEIS R, WAGNER E: PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther. (1999) 6(4):595-605.
  • BOUSSIF O, LEZOUALC'H F, ZANTA MA et al.: A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl. Acad. Sci. USA (1995) 92(16):7297-7301.
  • GODBEY WT, WU KK, MIKOS AG: Poly(ethylenimine) and its role in gene delivery. J. Control. Release (1999) 60(2-3):149-160.
  • PARK MR, HAN KO, HAN IK et al.: Degradable polyethylenimine-alt-poly(ethylene glycol) copolymers as novel gene carriers. J. Control. Release (2005) 105(3):367-380.
  • KATAYOSE S, KATAOKA K: Water-soluble polyion complex associates of DNA and poly(ethylene glycol)-poly(L-lysine) block copolymer. Bioconjug. Chem. (1997) 8(5):702-707.
  • WOLFERT MA, SCHACHT EH, TONCHEVA V et al.: Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers. Hum. Gene Ther. (1996) 7(17):2123-2133.
  • FUNHOFF AM, VAN NOSTRUM CF, LOK MC et al.: Cationic polymethacrylates with covalently linked membrane destabilizing peptides as gene delivery vectors. J. Control. Release (2005) 101(1-3):233-246.
  • ARTURSSON P, ARRO E, EDMAN P, ERICSSON JL, SJOHOLM I: Biodegradable microspheres. V: stimulation of macrophages with microparticles made of various polysaccharides. J. Pharm. Sci. (1987) 76(2):127-133.
  • TABATA Y, IKADA Y: Macrophage phagocytosis of biodegradable microspheres composed of L-lactic acid/glycolic acid homo- and copolymers. J. Biomed. Mater. Res. (1988) 22(10):837-858.
  • HSU YY, HAO T, HEDLEY ML: Comparison of process parameters for microencapsulation of plasmid DNA in poly(D,L-lactic-co-glycolic) acid microspheres. J. Drug Target (1999) 7(4):313-323.
  • NEWMAN KD, ELAMANCHILI P, KWON GS, SAMUEL J: Uptake of poly(D,L-lactic-co-glycolic acid) microspheres by antigen-presenting cells in vivo. J. Biomed. Mater. Res. (2002) 60(3):480-486.
  • MOK H, PARK TG: PEG-assisted DNA solubilization in organic solvents for preparing cytosol specifically degradable PEG/DNA nanogels. Bioconjug. Chem. (2006) 17(6):1369-1372.
  • KAUL G, AMIJI M: Biodistribution and targeting potential of poly(ethylene glycol)-modified gelatin nanoparticles in subcutaneous murine tumor model. J. Drug Target (2004) 12(9-10):585-591.
  • KAUL G, AMIJI M: Cellular interactions and in vitro DNA transfection studies with poly(ethylene glycol)-modified gelatin nanoparticles. J. Pharm. Sci. (2005) 94(1):184-198.
  • KAUL G, AMIJI M: Tumor-targeted gene delivery using poly(ethylene glycol)-modified gelatin nanoparticles: in vitro and in vivo studies. Pharm. Res. (2005) 22(6):951-961.
  • KOMMAREDDY S, AMIJI M: Preparation and evaluation of thiol-modified gelatin nanoparticles for intracellular DNA delivery in response to glutathione. Bioconjug. Chem. (2005) 16(6):1423-1432.
  • TRUONG VL, WALSH SM, SCHWEIBERT E et al.: Gene transfer by DNA-gelatin nanospheres. Arc. Biochem. Biophys. (1999) 361:47-56.
  • TRUONG-LE VL, AUGUST JT, LEONG KW: Controlled gene delivery by DNA-gelatin nanospheres. Hum. Gene Ther. (1998) 9(12):1709-1717.
  • ZILLIES J, COESTER C: Evaluating gelatin based nanoparticles as a carrier system for double stranded oligonucleotides. J. Pharm. Pharm. Sci. (2005) 7(4):17-21.
  • TAKEUCHI H, YAMAMOTO H, KAWASHIMA Y.: Mucoadhesive nanoparticulate systems for peptide drug delivery. Adv. Drug Deliv. Rev. (2001) 47:39-54.
  • COUVREUR P: Polyalkylcyanoacrylates as colloidal drug carriers. Crit. Rev. Ther. Drug Carrier Syst. (1988) 5(1):1-20.
  • DELIE F: Evaluation of nano- and microparticle uptake by the gastrointestinal tract. Adv. Drug Deliv. Rev. (1998) 34(2-3):221-233.
  • NARAYANI R: Oral delivery of insulin - making needles needless. Trends Biomater. Artif. Organs (2001) 15(1):12-16.
  • SAKUMA S, SUZUKI N, SUDO R et al.: Optimized chemical structure of nanoparticles as carriers for oral delivery of salmon calcitonin. Int. J. Pharm. (2002) 239(1-2):185-195.
  • FLORENCE AT: The oral absorption of micro- and nanoparticulates: neither exceptional nor unusual. Pharm. Res. (1997) 14(3):259-266.
  • QUINTANAR-GUERRERO DA, ALLEMANN E; FESSI H; DOELKER E: Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers. Drug Development and Industrial Pharmacy (1998) 24(12):1113-1128.
  • SHENOY D, LITTLE S, LANGER R, AMIJI M: Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs. 1. In vitro evaluations. Mol. Pharm. (2005) 2(5):357-366.
  • SOLARO R: Nanostructured polymeric systems in targeted release of proteic drugs and in tissue engineering. China-EU Forum on Nanosized Technology. Beijng (2002).
  • GENERAL S, THUNEMANN AF: pH-sensitive nanoparticles of poly(amino acid) dodecanoate complexes. Int. J. Pharm. (2001) 230(1-2):11-24.
  • MANSOURI S, LAVIGNE P, CORSI K et al.: Chitosan-DNA nanoparticles as non-viral vectors in gene therapy: strategies to improve transfection efficacy. Eur. J. Pharm. Biopharm. (2004) 57(1):1-8.
  • JANES KA, CALVO P, ALONSO MJ: Polysaccharide colloidal particles as delivery systems for macromolecules. Adv. Drug Deliv. Rev. (2001) 47(1):83-97.
  • THUNEMANN AF, GENERAL S: Nanoparticles of a polyelectrolyte-fatty acid complex: carriers for Q10 and triiodothyronine. J. Control. Release (2001) 75(3):237-247.
  • AKIYOSHI K, KOBAYASHI S, SHICHIBE S et al.: Self-assembled hydrogel nanoparticle of cholesterol-bearing pullulan as a carrier of protein drugs: complexation and stabilization of insulin. J. Control. Release (1998) 54(3):313-320.
  • DU J, ZHANG S, SUN R et al.: Novel polyelectrolyte carboxymethyl konjac glucomannan-chitosan nanoparticles for drug delivery. II. Release of albumin in vitro. J. Biomed. Mater. Res. B Appl Biomater (2005) 72(2):299-304.
  • GENERAL S, RUDLOFF J, THUNEMANN AF: Hollow nanoparticles via stepwise complexation and selective decomplexation of poly(ethylene imine). Chem Commun (Camb) (2002) 5:534-535.
  • SANG YOO H, GWAN PARK T: Biodegradable nanoparticles containing protein-fatty acid complexes for oral delivery of salmon calcitonin. J. Pharm. Sci. (2004) 93(2):488-495.
  • SUN YP, MEZIANI MJ, PATHAK P, QU L: Polymeric nanoparticles from rapid expansion of supercritical fluid solution. Chemistry (2005) 11(5):1366-1373.
  • YOUNG TJ, JOHNSON KP, PACE GW, MISHRA AK: Phospholipid-stabilized nanoparticles of cyclosporine A by rapid expansion from supercritical to aqueous solution. AAPS PharmSciTech. (2004) 5(1):E11.
  • KERNELL AM, RINGERTZ NR: Cytochemical characterization of deoxyribonucleoprotein by UV-microspectrophotometry on heat denatured cell nuclei. Exp Cell Res (1972) 72(1):240-251.
  • LUNAU M, LEMKE A, WALTHER K, MARTENS-HABBENA W, SIMON M: An improved method for counting bacteria from sediments and turbid environments by epifluorescence microscopy. Environ Microbiol (2005) 7(7):961-968.
  • VALLE O, LIEN T, KNUTSEN G: Fluorometric determination of DNA and RNA in Chlamydomonas using ethidium bromide. J. Biochem. Biophys. Methods (1981) 4(5-6):271-277.
  • TEARE JM, ISLAM R, FLANAGAN R et al.: Measurement of nucleic acid concentrations using the DyNA Quant and the GeneQuant. Biotechniques (1997) 22(6):1170-1174.
  • HU FQ, YUAN H, ZHANG HH, FANG M: Preparation of solid lipid nanoparticles with clobetasol propionate by a novel solvent diffusion method in aqueous system and physicochemical characterization. Int. J. Pharm. (2002) 239(1-2):121-128.
  • VAN DER LUBBEN IM, KERSTEN G, FRETZ MM et al.: Chitosan microparticles for mucosal vaccination against diphtheria: oral and nasal efficacy studies in mice. Vaccine (2003) 21(13-14):1400-1408.
  • VAN DER LUBBEN IM, VERHOEF JC, VAN AELST AC, BORCHARD G, JUNGINGER HE: Chitosan microparticles for oral vaccination: preparation, characterization and preliminary in vivo uptake studies in murine Peyer's patches. Biomaterials (2001) 22(7):687-694.
  • LI JK, WANG N, WU XS: A novel biodegradable system based on gelatin nanoparticles and poly(lactic-co-glycolic acid) microspheres for protein and peptide drug delivery. J. Pharm. Sci. (1997) 86(8):891-895.
  • MAKRAUER FL, BURAKOFF R: Biologic and novel therapy of the inflammatory bowel diseases. Curr Med Chem -Anti-Inflammatory and Anti-Allergy Agents (2005) 4:319-331.
  • ARDIZZONE S, BIANCHI PORRO G: Inflammatory bowel disease: new insights into pathogenesis and treatment. J. Intern. Med. (2002) 252(6):475-496.
  • PODOLSKY DK: Inflammatory bowel disease. N. Engl. J. Med. (2002) 347(6):417-429.
  • KORZENIK JR, PODOLSKY DK: Evolving knowledge and therapy of inflammatory bowel disease. Nat. Rev. Drug Discov. (2006) 5(3):197-209.
  • CHEN J, YANG WL, LI G et al.: Transfection of mEpo gene to intestinal epithelium in vivo mediated by oral delivery of chitosan-DNA nanoparticles. World J. Gastroenterol. (2004) 10(1):112-116.
  • HAAS J, RAVI KUMAR MN, BORCHARD G, BAKOWSKY U, LEHR CM: Preparation and characterization of chitosan and trimethyl-chitosan-modified poly-(epsilon-caprolactone) nanoparticles as DNA carriers. AAPS PharmSciTech. (2005) 6(1):E22-E30.
  • PRABHA S, ZHOU WZ, PANYAM J, LABHASETWAR V: Size-dependency of nanoparticle-mediated gene transfection: studies with fractionated nanoparticles. Int. J. Pharm. (2002) 244(1-2):105-115.
  • TINSLEY-BOWN AM, FRETWELL R, DOWSETT AB, DAVIS SL, FARRAR GH: Formulation of poly(D,L-lactic-co-glycolic acid) microparticles for rapid plasmid DNA delivery. J. Control. Release (2000) 66(2-3):229-241.
  • O'HAGAN D T, SINGH M, ULMER JB: Microparticle-based technologies for vaccines. Methods (2006) 40(1):10-19.
  • COHEN J: Naked DNA points way to vaccines. Science (1993) 259(5102):1691-1692.
  • FU TM, FRIEDMAN A, ULMER JB, LIU MA, DONNELLY JJ: Protective cellular immunity: cytotoxic T-lymphocyte responses against dominant and recessive epitopes of influenza virus nucleoprotein induced by DNA immunization. J. Virol. (1997) 71(4):2715-2721.
  • ULMER JB, DECK RR, DEWITT CM et al.: Protective immunity by intramuscular injection of low doses of influenza virus DNA vaccines. Vaccine (1994) 12(16):1541-1544.
  • CHEN SC, JONES DH, FYNAN EF et al.: Protective immunity induced by oral immunization with a rotavirus DNA vaccine encapsulated in microparticles. J. Virol. (1998) 72:5757-5761.
  • HERRMANN JE, CHEN SC, JONES DH et al.: Immune responses and protection obtained by oral immunization with rotavirus VP4 and VP7 DNA vaccines encapsulated in microparticles. Virology (1999) 259(1):148-153.
  • KANEKO H, BEDNAREK I, WIERZBICKI A et al.: Oral DNA vaccination promotes mucosal and systemic immune responses to HIV envelope glycoprotein. Virology (2000) 267(1):8-16.
  • MITTAL SK, AGGARWAL N, SAILAJA G et al.: Immunization with DNA, adenovirus or both in biodegradable alginate microspheres: effect of route of inoculation on immune response. Vaccine (2000) 19(2-3):253-263.
  • HE XW, WANG F, JIANG L et al.: Induction of mucosal and systemic immune response by single-dose oral immunization with biodegradable microparticles containing DNA encoding HBsAg. J. Gen. Virol. (2005) 86(Pt 3):601-610.

Patents

Websites

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.