Metered-dose inhalers: actuators old and new

Bibliography

• BROCKLEBANK D, RAM F, WRIGHT J et al.: Comparison of the effectiveness of inhaler devices in asthma and chronic obstructive airways disease: a systematic review of the literature. Health Technol. Assess. (2001) 5(26):1-149.
   PubMedGoogle Scholar
• THIEL CG: From Susie’s question to CFC free: an inventor’s perspective on 40 years of MDI development and regulation. Proceedings of Respiratory Drug Delivery V. Phoenix, AZ, USA (1996):115-124.
   Google Scholar
• FREEDMAN T: Medihaler therapy for bronchial asthma: a new type of aerosol therapy. Postgrad. Med. (1956) 12:667-673.
   Google Scholar
• RAU JL: The inhalation of drugs: advantages and problems. Respir. Care (2005) 50(3):367-382.
   PubMedGoogle Scholar
• NEWMAN SP, NEWHOUSE MT: Effect of add-on devices for aerosol drug delivery: deposition studies and clinical aspects. J. Aerosol Med. (1996) 9(1):55-70.
   PubMedGoogle Scholar
• NEWMAN SP: Principles of metered-dose inhaler design. Respir. Care (2005) 50(9):1177-1190.
   PubMedGoogle Scholar
• RICHARDS J, HIRST P, PITCAIRN G et al.: Deposition and pharmacokinetics of flunisolide delivered from pressurized inhalers containing non-CFC and CFC propellants. J. Aerosol Med. (2001) 14(2):197-208.
   PubMedGoogle Scholar
• VERSTEEG HK, HARGRAVE G: Fundamentals and resilience of the original MDI actuator design. Proceedings of Respiratory Drug Delivery X. Boca Raton, FL, USA (2006) 1:91-100.
   Google Scholar
• EVERARD ML: Aerosol therapy past, present, and future: a clinician’s perspective. Respir. Care (2000) 45(6):769-776.
   PubMedGoogle Scholar
• RAU JL: Practical problems with aerosol therapy in COPD. Respir. Care (2006) 51(2):158-172.
   PubMed Web of Science ®Google Scholar
• VAN BEERENDONK I, MESTERS I, MUDDE AN, TAN TD: Assessment of the inhalation technique in outpatients with asthma or chronic obstructive pulmonary disease using a metered-dose inhaler or dry powder device. J. Asthma (1998) 35(3):273-279.
   PubMed Web of Science ®Google Scholar
• HENDELES L, HATTON RC, COONS TJ, CARLSON L: Automatic replacement of albuterol nebulizer therapy by metered-dose inhaler and valved holding chamber. Am. J. Health Syst. Pharm. (2005) 62:1053-1061.
   PubMed Web of Science ®Google Scholar
• GROSSMAN J: The evolution of inhaler technology. J. Asthma (1994) 31(1):55-64.
   PubMed Web of Science ®Google Scholar
• GUNAWARDENA KA, SOHAL T, JONES JI, UPCHURCH FC, CROMPTON GK: The Spacehaler for delivery of salbutamol: a comparison with the standard metered-dose inhaler plus Volumatic spacer device. Respir. Med. (1997) 91(5):311-316.
   PubMed Web of Science ®Google Scholar
• CROMPTON GK: Problems patients have using pressurized aerosol inhalers. Eur. J. Respir. Dis. Suppl. (1982) 119:101-104.
   PubMedGoogle Scholar
• SONG WS, MULLON J, REGAN NA, ROTH BJ: Instruction of hospitalized patients by respiratory therapists on metered-dose inhaler use leads to decrease in patient errors. Respir. Care (2005) 50(8):1040-1045.
   PubMedGoogle Scholar
• BLOOMFIELD P, CROMPTON GK, WINSEY NJ: A tube spacer to improve inhalation of drugs from pressurised aerosols. Br. Med. J. (1979) 2(6203):1479.
   PubMedGoogle Scholar
• LEWIS DA, MEAKIN BJ, BRAMBILLA G: New actuators versus old: reasons and results for actuator modifications for HFA solution MDIs. Proceedings of Respiratory Drug Delivery X. Boca Raton, FL, USA (2006) 1:101-110.
   Google Scholar
• LOUCA E, LEUNG K, COATES AL, MITCHELL JP, NAGEL MW: Comparison of three valved holding chambers for the delivery of fluticasone propionate-HFA to an infant face model. J. Aerosol Med. (2006) 19(2):160-167.
   Google Scholar
• DUBUS JC, DOLOVICH M: Emitted doses of salbutamol pressurized metered-dose inhaler from five different plastic spacer devices. Fundam. Clin. Pharmacol. (2000) 14(3):219-224.
   Google Scholar
• LEE H, EVANS HE: Evaluation of inhalation aids of metered dose inhalers in asthmatic children. Chest (1987) 91(3):366-369.
   Google Scholar
• KISSOON N, TEELUCKSINGH S, BLAKE KV, KESSER B, MURPHY SP, GELLER D: Plastic bottles as spacers for a pressurized metered-dose inhaler: in vitro characteristics. West Indian Med. J. (2001) 50(3):189-193.
   PubMed Web of Science ®Google Scholar
• OBGANDZE TN, NEMSADZE KP, CHKHAIDZE IG, PERADZE DI: Effectiveness of treatment of bronchoobstruction in children with acute respiratory infections using home-made spacer. Georgian Med. News (2005) 118:46-49.
   PubMedGoogle Scholar
• SINGHAL T, GARG H, ARORA HS, LODHA R, PANDEY RM, KABRA SK: Efficacy of a home-made spacer with acute exacerbation of bronchial asthma: a randomized controlled trial. Indian J. Pediatr. (2001) 68(1):37-40.
   PubMedGoogle Scholar
• SAMARANAYAKE SW, PERERA BJ: Paper spacers coupled to metered dose inhalers in family practice. Ceylon Med. J. (1998) 43(3):147-150.
   Google Scholar
• ZAR H, STREUN S, LEVIN M, WEINBERG E, SWINGLER G: Randomised controlled trial of the efficacy of a metered dose inhaler with bottle spacer for bronchodilator therapy in acute lower airways obstruction. Arch. Dis. Child. (2006) (In Press).
   PubMedGoogle Scholar
• NEWMAN SP, STEED KP, HOOPER G, JONES JI, UPCHURCH FC: Improved targeting of beclomethasone diproprionate (250 micrograms metered dose inhaler) to the lungs of asthmatics with the Spacehaler. Respir. Med. (1999) 93(6):424-431.
   PubMed Web of Science ®Google Scholar
• ELVECROG J: Metered dose inhalers in a CFC-free future. Pharm. Tech. Eur. (1997) 9:52-55.
   Google Scholar
• DOLOVICH MB, AHRENS RC, HESS DR et al.: Device selection and outcomes of aerosol therapy. Chest (2005) 127(1):335-371.
   PubMed Web of Science ®Google Scholar
• NEWMAN SP, WEISZ AW, TALAEE N, CLARKE SW: Improvement of drug delivery with a breath actuated pressurised aerosol for patients with poor inhaler technique. Thorax (1991) 46(10):712-716.
   Google Scholar
• PEDERSON S, FROST L, ARNFRED T: Errors in inhalation technique and efficiency in inhaler use in asthmatic children. Allergy (1986) 46:118-124.
   Google Scholar
• CROMPTON GK: Problems patients have using pressurized aerosol inhalers. Eur. J. Respir. Dis. (1982) 63(Suppl. 119):101-104.
   Google Scholar
• COADY TJ, DAVIES HJ, BARNES P: Evaluation of a breath actuated pressurized aerosol. Clin. Allergy (1976) 6(1):1-6.
   PubMedGoogle Scholar
• KELLOWAY JS, KOCHEVAR JW, SVEUM RJ, HAHN MA: Evaluation of the Autohaler actuator: the effect of written patient instructions on correct use. J. Asthma (1993) 30(5):373-379.
   PubMed Web of Science ®Google Scholar
• BACON RJ, MCDERMENT I, BELL J: A new breath operated actuator. Proceedings of Respiratory Drug Delivery VIII. Tucson, AZ, USA (2002) 2:403-406.
   Google Scholar
• PRICE D, THOMAS M, MITCHELL G, NIZIOL C, FEATHERSTONE R: Improvement of asthma control with a breath-actuated pressurised metred dose inhaler (BAI): a prescribing claims study of 5556 patients using a traditional pressurised metred dose inhaler (MDI) or a breath-actuated device. Respir. Med. (2003) 97(1):12-19.
   Google Scholar
• CHAPMAN KR, LOVE L, BRUBAKER H: A comparison of breath-actuated and conventional metered-dose inhaler inhalation techniques in elderly subjects. Chest (1993) 104(5):1332-1336.
   PubMed Web of Science ®Google Scholar
• CLARK AR: Metered atomization for respiratory drug delivery. PhD Thesis. Loughborough University of Technology (1991).
   Google Scholar
• DUNBAR CA, WATKINS AP, MILLER JF: An experimental investigation of the spray issued from a pMDI using laser diagnostic techniques. J. Aerosol Med. (1997) 10(4):351-368.
   Google Scholar
• GANDERTON D, LEWIS D, DAVIES R, MEAKIN B, BRAMBILLA G, CHURCH T: Modulite: a means of designing the aerosols generated by pressurized metered dose inhalers. Respir. Med. (2002) 96(Suppl. D):S3-S8.
   PubMed Web of Science ®Google Scholar
• CLARK AR: MDIs: physics of aerosol formation. J. Aerosol Med. (1996) 9(Suppl. 1):S19-S26.
   Google Scholar
• DAVIES RJ, LEWIS DA, GANDERTON D, MEAKIN BJ, BRAMBILLA G, MURPHY SD, NICHOLLS TR: Velocity profiling of a new HFA budesonide pMDI. Proceedings of Respiratory Drug Delivery VIII. Tucson, AZ, USA (2002) 2:759-762.
   Google Scholar
• STEIN SW, GABRIO BJ: Understanding throat deposition during cascade impactor testing. Proceedings of Respiratory Drug Delivery VII. Tarpon Springs, FL, USA (2000) 2:287-290.
   Google Scholar
• STEIN SW, MYRDAL PB: A theoretical and experimental analysis of formulation and device parameters affecting solution MDI size distributions. J. Pharm. Sci. (2004) 93(8):2158-2175.
   Google Scholar
• MEAKIN BJ, GANDERTON D, PANZA I, VENTURA P: Drug delivery from pressurised metered dose inhalers (pMDIs) containing BDP using the Chiesi Jet actuator. Proceedings of Respiratory Drug Delivery V. Phoenix, AZ, USA (1996):370-373.
   Google Scholar
• LEWIS DA, MEAKIN BJ, BRAMBILLA G: Theory and practice with solution systems. Proceedings of Respiratory Drug Delivery IX. Palm Desert, CA, USA (2004) 1:109-115.
   Google Scholar
• VERSTEEG HK, HARGRAVE G, HARRINGTON L, SHRUBB I, HODSON D: The use of computational fluid dynamics (CFD) to predict pMDI air flows and aerosol plume formation. Proceedings of Respiratory Drug Delivery VII. Tarpon Springs, FL, USA (2000) 2:257-264.
   Google Scholar
• FINLAY WH: The Mechanics of Inhaled Pharmaceutical Aerosols. Academic Press, San Diego, CA, USA (2001).
   Google Scholar
• BRAMBILLA G, DAVIES RJ, LEWIS DA, GEORGE SC, GANDERTON D, MEAKIN BJ: Formulation of oestrogens as HFA solution pMDIs. J. Aerosol Med. (2003) 16(2):211.
   Google Scholar
• TANENBAUM MF, BRAMANTE T, SHU F, ANGEL A, PARK J: Minimization of actuator (mouthpiece) clogging for solution inhalation aerosol products. Proceedings of Respiratory Drug Delivery VI. Hilton Head, SC, USA (1998) 2:429-434.
   Google Scholar
• SMYTH H, BRACE G, BARBOUR T, GALLION J, GROVE J, HICKEY AJ: Spray pattern analysis for metered dose inhalers: effect of actuator design. Pharm. Res. (2006) 23(7):1591-1596.
   PubMed Web of Science ®Google Scholar
• MEAKIN BJ, LEWIS DA, GANDERTON D et al.: Effects of actuator orifice diameter on beclomethasone dipropionate delivery from a pMDI HFA solution formulation. Proceedings of Respiratory Drug Delivery VI. Hilton Head, SC, USA (1998) 2:363-366.
   Google Scholar
• MEAKIN BJ, LEWIS DA, CHURCH TK, GANDERTON D, RICHARDS J, BRAMBILLA G: A comparative formoterol HFA pMDI delivery performance from an integral device. Proceedings of Respiratory Drug Delivery IX. Palm Desert, CA, USA (2004) 2:845-848.
   Google Scholar
• MEAKIN BJ, LEWIS DA, CHURCH TK, GANDERTON D, BRAMBILLA G: Budesonide 200 HFA Modulite delivery from the Chiesi Jet. Drug Deliv. Lungs (2003) 14:126-128.
   Google Scholar
• MITCHELL JP, NAGEL MW: Spacer and holding chamber testing in-vitro: a critical analysis with examples. Proceedings of Respiratory Drug Delivery VII. Tarpon Springs, FL, USA (2000) 1:265-274.
   Google Scholar
• KWOK P, CHAN HK: Electrostatic charges of metered dose inhaler aerosols sampled from plastic spacers. Proceedings of Respiratory Drug Delivery X. Boca Raton, FL, USA (2006) 1:121-132.
   Google Scholar
• KEIL JC, KOTIAN R, PEART J: Using and interpreting aerosol electrostatic data from the electrical low pressure impactor. Proceedings of Respiratory Drug Delivery X. Boca Raton, FL, USA (2006) 1:267-278.
   Google Scholar
• KOTIAN R, PEART J: Influence of formulation components on inherent electrostatic properties of HFA propelled solution pMDIs. Proceedings of Respiratory Drug Delivery X. Boca Raton, FL, USA (2006) 3:947-950.
   Google Scholar
• PEART J: Influence of static charge on dynamic performance of inhaled drug products. Proceedings of Academy of Pharmaceutical Sciences Inhalation. (2007) Bath, UK.
   Google Scholar
• BRAMBILLA G, GANDERTON D, LEWIS DA, MEAKIN BJ, GARZIA R: The modulation of clouds generated by pMDIs. J. Aerosol Med. (1999) 12:119.
   PubMedGoogle Scholar
• MEAKIN BJ, LEWIS DA, GANDERTON D, BRAMBILLA G: Countering challenges posed by mimicry of CFC performance using HFA systems. Proceedings of Respiratory Drug Delivery VII. Tarpon Springs, FL, USA (2000) 1:99-107.
   Google Scholar
• BERRY J, KLINE LC, SHERWOOD JK et al.: Influence of the size of micronized active pharmaceutical ingredient on the aerodynamic particle size and stability of a metered dose inhaler. Drug Dev. Ind. Pharm. (2004) 30(7):705-714.
   Google Scholar
• BERRY J, HEIMBECHER S, HART JL, SEQUEIRA J: Influence of the metering chamber volume and actuator design on the aerodynamic particle size of a metered dose inhaler. Drug Dev. Ind. Pharm. (2003) 29(8):865-876.
   Google Scholar
• SMYTH HD: The influence of formulation variables on the performance of alternative propellant-driven metered dose inhalers. Adv. Drug Deliv. Rev. (2003) 55(7):807-828.
   Google Scholar
• WILLIAMS RO, LIU J, KOLENG JJ: Influence of metering chamber volume and water level on the emitted dose of a suspension-based pMDI containing propellant 134a. Pharm. Res. (1997) 14(4):438-443.
   Google Scholar
• BERRY J, KLINE L, NAINI V, CHAUDHRY S, HART J, SEQUEIRA J: Influence of the valve lubricant on the aerodynamic particle size of a metered dose inhaler. Drug Dev. Ind. Pharm. (2004) 30(3):267-275.
   Google Scholar
• BERRY J, KLINE LC, HART JL, SEQUEIRA J: Influence of the storage orientation on the aerodynamic particle size of a suspension metered dose inhaler containing propellant HFA-227. Drug Dev. Ind. Pharm. (2003) 29(6):631-639.
   Google Scholar
• GUPTA A, STEIN SW, MYRDAL PB: Balancing ethanol cosolvent concentration with product performance in 134a-based pressurized metered dose inhalers. J. Aerosol Med. (2003) 16(2):167-174.
   PubMedGoogle Scholar
• STEIN SW, MYRDAL PB, GABRIO BJ, OBEREIT D, BECK TJ: Evaluation of a new aerodynamic particle sizer spectrometer for size distribution measurements of solution metered dose inhalers. J. Aerosol Med. (2003) 16(2):107-119.
   PubMedGoogle Scholar
• DOMNICK J, DURST F: Measurement of bubble size, velocity and concentration in flashing flow behind a sudden constriction. Int. J. Multiphase Flow (1995) 21(6):1047-1062.
   Web of Science ®Google Scholar
• BRAMBILLA G, GANDERTON D, GARZIA R, LEWIS D, MEAKIN B, VENTURA P: Modulation of aerosol clouds produced by pressurised inhalation aerosols. Int. J. Pharm. (1999) 186(1):53-61.
   PubMedGoogle Scholar
• HOCHRAINER D, HOLZ H, KREHER C, SCAFFIDI L, SPALLEK M, WACHTEL H: Comparison of the aerosol velocity and spray duration of Respimat® Soft Mist® inhaler and pressurized metered dose inhalers. J. Aerosol Med. (2005) 18(3):273-282.
   PubMedGoogle Scholar
• NEWMAN SP, STEED KP, HOOPER G, JONES JI, UPCHURCH FC: Improved targeting of beclomethasone diproprionate (250 micrograms metered dose inhaler) to the lungs of asthmatics with the Spacehaler. Respir. Med. (1999) 93(6):424-431.
   Google Scholar
• GABRIO BJ, STEIN SW, VELASQUEZ DJ: A new method to evaluate plume characteristics of hydrofluoroalkane and chlorofluorocarbon metered dose inhalers. Int. J. Pharm.(1999) 186(1):3-12.
   Google Scholar
• ROSS DL, GABRIO BJ: Advances in metered dose inhaler technology with the development of a chlorofluorocarbon-free drug delivery system. Int. J. Pharm. (1999) 12(3):151-160.
   Google Scholar
• BRAMBILLA G, CHURCH T, KEEBLE C, LEWIS D, MEAKIN B: The determination of the plume temperature for budesonide HFA metered dose inhalers. Proceedings of Drug Delivery to the Lungs 17. Edinburgh, Scotland, UK (2006):94-97.
   Google Scholar
• BRAMBILLA G, CHURCH TK, LEWIS DA, MEAKIN BJ: Control of plume temperature emitted from metered dose inhalers. (In Press).
   Google Scholar
• WILBY M, PURKINS G: The 3M™ integrated dose by dose counter for pMDIs. Proceedings of Drug Delivery to the Lungs 17. Edinburgh, Scotland, UK (2006):288-291.
   Google Scholar
• BRADSHAW DR: Developing dose counters: an appraisal based on regulator, pharma, and user needs. Proceedings of Respiratory Drug Delivery X. Boca Raton, FL, USA (2006) 1:121-132.
   Google Scholar
• CAIN WT, OPPENHEIMER JJ: The misconception of using floating patterns as an accurate means of measuring the contents of metered-dose inhaler devices. Ann. Allergy Asthma Immunol. (2001) 87(5):417-419.
   PubMed Web of Science ®Google Scholar
• HOLT S, HOLT A, WEATHERALL M, MASOLI M, BEASLEY R: Metered dose inhalers: a need for dose counters. Respirology (2005) 10(1):105-106.
   Google Scholar
• JULIUS SM, SHERMAN JM, HENDELES L: Accuracy of three electronic monitors for metered-dose inhalers. Chest (2002) 121(3):871-876.
   Google Scholar
• O’CONNOR SL, BENDER BG, GAVIN-DEVITT LA: Measuring adherence with the Doser CT in children with asthma. J. Asthma (2004) 41(6):663-670.
   Google Scholar
• APTER AJ, TOR M, FELDMAN HI: Testing the reliability of old and new features of a new electronic monitor for metered dose inhalers. Ann. Allergy Asthma Immunol. (2001) 86(4):421-424.
   PubMed Web of Science ®Google Scholar
• FARR SJ, ROWE AM, RUBSAMEN R, TAYLOR G: Aerosol deposition in the human lung following administration from a microprocessor controlled pressurised metered dose inhaler. Thorax (1995) 50(6):639-644.
   Google Scholar
• BRAMBILLA G, BERRILL S, DAVIES RJ et al.: Formulation of leuprolide as a HFA solution pMDI. J. Aerosol Med. (2003) 16(2):209.
   Google Scholar
• BRAMBILLA G, DAVIES RJ, LEWIS DA, GEORGE SC, GANDERTON D, MEAKIN BJ: Formulation of an analogue of apomorphine as an HFA solution pMDIs. J. Aerosol Med. (2003) 16(2):209.
   Google Scholar
• SMYTH HD: Propellant-driven metered-dose inhalers for pulmonary drug delivery. Expert Opin. Drug Deliv. (2005) 2(1):53-74.
   PubMedGoogle Scholar
• RAM FS: Clinical efficacy of inhaler devices containing β(2)-agonist bronchodilators in the treatment of asthma: cochrane systematic review and meta-analysis of more than 100 randomized, controlled trials. Am. J. Respir. Med. (2003) 2(4):349-365.
   Google Scholar
• NOYMER P, SCHUSTER, J, HOLST, P et al.: AERx®-Essence™: efficiency and breath control without electronics. Proceedings of Respiratory Drug Delivery IX. Palm Desert, CA, USA (2004) 1:255-262.
   Google Scholar