The promise of chitosan microspheres in drug delivery systems

Bibliography

• FU X, HUANG L, ZHAI M, LI W, LIU H: Analysis of natural carbohydrate biopolymer-high molecular chitosan and carboxymethyl chitosan by capillary zone electrophoresis. Carbohydrate Polymers (In Press).
   Google Scholar
• AGNIHOTRI SA, MALLIKARJUNA NN, AMINABHAVI TM: Recent advances on chitosan-based micro- and nanoparticles in drug delivery. J. Control. Rel. (2004) 100(1):5-28.
   PubMed Web of Science ®Google Scholar
• KUMAR MN, MUZZARELLI RA, MUZZARELLI C, SASHIWA H, DOMB AJ: Chitosan chemistry and pharmaceutical perspectives. Chem. Rev. (2004) 104(12):6017-6084.
   PubMed Web of Science ®Google Scholar
• SAHA TK, ICHIKAWA H, FUKUMORI Y: Gadolinium diethylenetriaminopentaacetic acid-loaded chitosan microspheres for gadolinium neutron-capture therapy. Carbohydrate Res. (2006) 341(17):2835-2841.
   PubMed Web of Science ®Google Scholar
• AGNIHOTRI SA, AMINABHAVI TM: Novel interpenetrating network chitosan-poly(ethylene oxide-g-acrylamide) hydrogel microspheres for the controlled release of capecitabine. Int. J. Pharm. (2006) 324(2):103-115.
   PubMed Web of Science ®Google Scholar
• LIU LS, LIU SQ, NG SY, FROIX M, OHNO T, HELLER J: Controlled release of interleukin-2 for tumour immunotherapy using alginate/chitosan porous microspheres. J. Control. Rel. (1997) 43(1):65-74.
   Web of Science ®Google Scholar
• GRANT J, BLICKER M, PIQUETTE-MILLER M, ALLEN C: Hybrid films from blends of chitosan and egg phosphatidylcholine for localized delivery of paclitaxel. J. Pharm. Sci. (2005) 94(7):1512-1527.
   PubMed Web of Science ®Google Scholar
• NSEREKO S, AMIJI M: Localized delivery of paclitaxel in solid tumors from biodegradable chitin microparticle formulations. Biomaterials (2002) 23(13):2723-2731.
   PubMed Web of Science ®Google Scholar
• MITRA S, GAUR U, GHOSH PC, MAITRA AN: Tumour targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanoparticles as carrier. J. Control. Rel. (2001) 74(1-3):317-323.
   PubMed Web of Science ®Google Scholar
• SINGH UV, UDUPA N: Methotrexate loaded chitosan and chitin microspheres-in vitro characterization and pharmacokinetics in mice bearing Ehrlich ascites carcinoma. J. Microencapsul. (1998) 15(5):581-594.
   PubMed Web of Science ®Google Scholar
• MINAS T, NEHRER S: Current concepts in the treatment of articular cartilage defects. Orthopedics (1997) 20: 525-538.
   PubMed Web of Science ®Google Scholar
• TEMENOFF JS, MIKOS AG: Review: tissue engineering for regeneration of articular cartilage. Biomaterials (2000) 21:431-440.
   Google Scholar
• LEE JE, KIM KE, KWON IC et al.: Effects of the controlled-released TGF-β1 from chitosan microspheres on chondrocytes cultured in a collagen/chitosan/glycosaminoglycan scaffold. Biomaterials (2004) 25(18):4163-4173.
   PubMed Web of Science ®Google Scholar
• LEE JE, KIM SE, KWON IC et al.: Effects of a chitosan scaffold containing TGF-β1 encapsulated chitosan microspheres on in vitro chondrocyte culture. Artif Organs (2004) 28(9):829-839.
   PubMed Web of Science ®Google Scholar
• JIANG T, ABDEL-FATTAH WI, LAURENCIN CT: In vitro evaluation of chitosan/poly(lactic acid-glycolic acid) sintered microsphere scaffolds for bone tissue engineering. Biomaterials (2006) 27(28):4894-4903.
   PubMed Web of Science ®Google Scholar
• HAN G, CHEN HL, SUN XY, GAO JQ, LIANG WQ: Preparation and release behavior of chitosan scaffolds encapsulating proteins loaded in PLGA microspheres. Yao Xue Xue Bao (2006) 41(6):493-497.
   PubMedGoogle Scholar
• LEE JY, SEOL YJ, KIM KH et al.: Transforming growth factor (TGF)-β1 releasing tricalcium phosphate/chitosan microgranules as bone substitutes. Pharm. Res. (2004) 21(10):1790-1796.
   PubMed Web of Science ®Google Scholar
• LAUWO JAK, AGRAWAL DK, EMENIKE IV: Some pharmaceutical studies on sustained release coprecipitates of ampicillin-trihydrate with acrylic resin (Eudragit®-RS). Drug Dev. Ind. Pharm. (1990) 16:1375-1389.
   Web of Science ®Google Scholar
• BODMEIER R, CHEN H, TYLE P, JAROSZ P: Pseudophedrine HCL microspheres formulated into an oral suspension dosage form. J. Control. Rel. (1991) 15:65-77.
   Web of Science ®Google Scholar
• ROKHADE AP, PATIL SA, AMINABHAVI TM: Synthesis and characterization of semi-interpenetrating polymer network microspheres of acrylamide grafted dextran and chitosan for controlled release of acyclovir. Carbohydrate Polymers (In Press).
   Google Scholar
• GENTA I, CONTI B, PERUGINI P, PAVANETTO F, SPADARO A, PUGLISI G: Bioadhesive microspheres for ophthalmic administration of acyclovir. J. Pharm. Pharmacol. (1997) 49(8):737-742.
   PubMed Web of Science ®Google Scholar
• ANAL AK, STEVENS WF, REMUÑÁN-LÓPEZ C: Ionotropic cross-linked chitosan microspheres for controlled release of ampicillin. Int. J. Pharm. (2006) 312(1-2):166-173.
   PubMed Web of Science ®Google Scholar
• GIUNCHEDI P, GENTA I, CONTI B, MUZZARELLI RAA, CONTE U: Preparation and characterization of ampicillin loaded methylpyrrolidinone chitosan and chitosan microspheres. Biomaterials (1998) 19(1-3):157-161.
   PubMed Web of Science ®Google Scholar
• GIUNCHEDI P, JULIANO C, GAVINI E, COSSU M, SORRENTI M: Formulation and in vivo evaluation of chlorhexidine buccal tablets prepared using drug-loaded chitosan microspheres. Eur. J. Pharm. Biopharm. (2002) 53(2):233-239.
   PubMed Web of Science ®Google Scholar
• ORHAN Z, CEVHER E, MULAZIMOGLU L et al.: The preparation of ciprofloxacin hydrochloride-loaded chitosan and pectin microspheres: their evaluation in an animal osteomyelitis model. J. Bone Joint Surg. Br. (2006) 88(2):270-275.
   PubMedGoogle Scholar
• YIN C, HOU C, JIANG L, GU Q: Research on carboxymethyl chitosan acting as the adjuvant for implantable degradable microspheres. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi (2004) 21(3):350-354.
   PubMedGoogle Scholar
• CERCHIARA T, LUPPI B, BIGUCCI F, PETRACHI M, ORIENTI I, ZECCHI V: Controlled release of vancomycin from freeze-dried chitosan salts coated with different fatty acids by spray-drying. J. Microencapsul. (2003) 20(4):473-478.
   PubMed Web of Science ®Google Scholar
• MAJITHIYA RJ, MURTHY RS: Chitosan-based mucoadhesive microspheres of clarithromycin as a delivery system for antibiotic to stomach. Curr. Drug Deliv. (2005) 2(3):235-242.
   PubMedGoogle Scholar
• GOVENDER S, PILLAY V, CHETTY DJ, ESSACK SY, DANGOR CM, GOVENDER T: Optimisation and characterisation of bioadhesive controlled release tetracycline microspheres. Int. J. Pharm. (2005) 306(1-2):24-40.
   PubMed Web of Science ®Google Scholar
• COPPI G, IANNUCCELLI V, SALA N, BONDI M: Alginate microparticles for Polymyxin B Peyer’s patches uptake: microparticles for antibiotic oral administration. J. Microencapsul. (2004) 21(8):829-839.
   PubMed Web of Science ®Google Scholar
• PENG X, ZHANG L: Surface fabrication of hollow microspheres from N-methylated chitosan cross-linked with glutaraldehyde. Langmuir (2005) 21(3):1091-1095.
   PubMed Web of Science ®Google Scholar
• PANDEY R, KHULLER GK: Chemotherapeutic potential of alginate-chitosan microspheres as anti-tubercular drug carriers. J. Antimicrob. Chemother. (2004) 53(4):635-640.
   PubMed Web of Science ®Google Scholar
• TAKISHIMA J, ONISHI H, MACHIDA Y: Prolonged intestinal absorption of cephradine with chitosan-coated ethylcellulose microparticles in rats. Biol. Pharm. Bull. (2002) 25(11):1498-1502.
   PubMed Web of Science ®Google Scholar
• CEVHER E, ORHAN Z, MÜLAZIMOĞLU L et al.: Characterization of biodegradable chitosan microspheres containing vancomycin and treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with prepared microspheres. Int. J. Pharm. (2006) 317(2):127-135.
   PubMed Web of Science ®Google Scholar
• BLANCO MD, GÓMEZ C, OLMO R, MUÑIZ E, TEIJÓN JM: Chitosan microspheres in PLG films as devices for cytarabine release. Int. J. Pharm. (2000) 202(1-2):29-39
   PubMed Web of Science ®Google Scholar
• MACHIDA Y, NAGAI T, ABE M, SANNAN T: Use of chitosan and hydroxypropylchitosan in drug formulations to effect sustained release. Drug Des. Deliv. (1986) 1(2):119-130.
   PubMedGoogle Scholar
• ELCIN YM, DIXIT V, GITNICK G: Controlled release of endothelial cell growth factor from chitosan-albumin microspheres for localized angiogenesis: in vitro and in vivo studies. Artif. Cells Blood Substit. Immobil. Biotechnol. (1996) 24(3):257-271.
   PubMed Web of Science ®Google Scholar
• HE P, DAVIS SS, ILLUM L: In vitro evaluation of the mucoadhesive properties of chitosan microspheres. Int. J. Pharm. (1998) 166(1):75-88.
   Web of Science ®Google Scholar
• ÇELIK Ö, AKBUGĞA J: Preparation of superoxide dismutase loaded chitosan microspheres: characterization and release studies. Eur. J. Pharm. Biopharm.(1998) 66(1):42-47.
   Google Scholar
• SCHALLY AV: LH-RH analogues: I. Their impact on reproductive medicine. Gynecol. Endocrinol. (1999) 13(6):401-409.
   PubMed Web of Science ®Google Scholar
• XUE ZX, YANG GP, ZHANG ZP et al.: Application of chitosan microspheres as carriers of LH-RH analogue TX46. React. Funct. Polym. (2006) 66(9):893-901.
   Web of Science ®Google Scholar
• WANG LY, GU YH, ZHOU QZ, MA GH, WAN YH, SU ZG: Preparation and characterization of uniform-sized chitosan microspheres containing insulin by membrane emulsification and a two-step solidification process. Colloids Surf. B Biointerfaces (2006) 50(2):126-135.
   PubMed Web of Science ®Google Scholar
• KOFUJI K, MURATA Y, KAWASHIMA S: Sustained insulin release with biodegradation of chitosan gel beads prepared by copper ions. Int. J. Pharm. (2005) 303(1-2):95-103.
   PubMed Web of Science ®Google Scholar
• CHO BC, KIM JY, LEE JH et al.: The bone regenerative effect of chitosan microsphere-encapsulated growth hormone on bony consolidation in mandibular distraction osteogenesis in a dog model. J. Craniofac. Surg. (2004) 15(2):299-311.
   PubMed Web of Science ®Google Scholar
• ILLUM L, JABBAL-GILL I, HINCHCLIFFE M, FISHER AN, DAVIS SS: Chitosan as a novel nasal delivery system for vaccines. Adv. Drug Deliv. Rev. (2001) 51(10):81-96.
   PubMed Web of Science ®Google Scholar
• KANG ML, KANG SG, JIANG HL et al.: In vivo induction of mucosal immune responses by intranasal administration of chitosan microspheres containing Bordetella bronchiseptica DNT. Eur. J. Pharm. Biopharm. (2006) 63(2):215-220.
   PubMed Web of Science ®Google Scholar
• JIANG HL, PARK IK, SHIN NR et al.: In vitro study of the immune stimulating activity of an athrophic rhinitis vaccine associated to chitosan microspheres. Eur. J. Pharm. Biopharm. (2004) 58(3):471-476.
   PubMed Web of Science ®Google Scholar
• JAGANATHAN KS, RAO YUB, SINGH P et al.: Development of a single dose tetanus toxoid formulation based on polymeric microspheres: a comparative study of poly(d,l-lactic-co-glycolic acid) versus chitosan microspheres. Int. J. Pharm. (2005) 294(1-2):23-32.
   PubMed Web of Science ®Google Scholar
• MI FL, SHYU SS, CHEN CT, SCHOUNG JY: Porous chitosan microsphere for controlling the antigen release of Newcastle disease vaccine: preparation of antigen-adsorbed microsphere and in vitro release. Biomaterials (1999) 20(17):1603-1612.
   PubMed Web of Science ®Google Scholar
• ZHAO H, WU B, WU H et al.: Protective immunity in rats by intranasal immunization with Streptococcus mutans glucan-binding protein D encapsulated into chitosan-coated poly(lactic-co-glycolic acid) microspheres. Biotechnol. Lett. (2006) 28(16):1299-304.
   PubMed Web of Science ®Google Scholar
• LAMEIRO MH, MALPIQUE R, SILVA AC, ALVES PM, MELO E: Encapsulation of adenoviral vectors into chitosan-bile salt microparticles for mucosal vaccination. J. Biotechnol. (2006) 126(2):152-162.
   PubMed Web of Science ®Google Scholar
• VAN DER LUBBEN IM, VAN OPDORP FA, HENGEVELD MR et al.: Transport of chitosan microparticles for mucosal vaccine delivery in a human intestinal M-cell model. J. Drug Target. (2002) 10(6):449-456.
   PubMed Web of Science ®Google Scholar
• VAN DER LUBBEN IM, KONINGS FA, BORCHARD G, VERHOEF JC, JUNGINGER HE: In vivo uptake of chitosan microparticles by murine Peyer’s patches: visualization studies using confocal laser scanning microscopy and immunohistochemistry. J. Drug Target. (2001) 9(1):39-47.
   PubMed Web of Science ®Google Scholar
• HAGHIGHI HR, GONG J, GYLES CL et al.: Probiotics stimulate production of natural antibodies in chickens. Clin. Vaccine Immunol. (2006) 13(9):975-980.
   PubMed Web of Science ®Google Scholar
• GAGNON M, KHEADR EE, DABOUR N, RICHARD D, FLISS I: Effect of Bifidobacterium thermacidophilum probiotic feeding on enterohemorrhagic Escherichia coli O157: H7 infection in BALB/c mice. Int. J. Food Microbiol. (2006) 111(1):26-33.
   PubMed Web of Science ®Google Scholar
• CABANA MD, SHANE AL, CHAO C, OLIVA-HEMKER M: Probiotics in primary care pediatrics. Clin. Pediatr. (2006) 45(5):405-410.
   PubMed Web of Science ®Google Scholar
• BAI AP, OUYANG Q: Probiotics and inflammatory bowel diseases. Postgrad. Med. J. (2006) 82(968):376-382.
   PubMed Web of Science ®Google Scholar
• SALMINEN S, ISOLAURI E: Intestinal colonization, microbiota, and probiotics. J. Pediatr. (2006) 149(5 Suppl.):S115-S120.
   Web of Science ®Google Scholar
• LJUNGH A, WADSTROM T: Lactic acid bacteria as probiotics. Curr. Issues Intest. Microbiol. (2006) 7(2):73-89.
   PubMedGoogle Scholar
• LEE JS, CHA DS, PARK HJ: Survival of freeze-dried Lactobacillus bulgaricus KFRI 673 in chitosan-coated calcium alginate microparticles. J. Agric. Food Chem. (2004) 52(24):7300-7305.
   Google Scholar
• KOSARAJU SL, D’ATH L, LAWRENCE A: Preparation and characterisation of chitosan microspheres for antioxidant delivery. Carbohydrate Polymers (2006) 64(2):163-167.
   Web of Science ®Google Scholar
• HARIKARNPAKDEE S, LIPIPUN V, SUTANTHAVIBUL N, RITTHIDEJ GC: Spray-dried mucoadhesive microspheres: preparation and transport through nasal cell monolayer. AAPS PharmSciTech. (2006) 7(1):E12.
   PubMed Web of Science ®Google Scholar
• CERCHIARA T, LUPPI B, CHIDICHIMO G, BIGUCCI F, ZECCHI V: Chitosan and poly(methyl vinyl ether-co-maleic anhydride) microparticles as nasal sustained delivery systems. Eur. J. Pharm. Biopharm. (2005) 61(3):195-200.
   PubMed Web of Science ®Google Scholar
• MARTINAC A, FILIPOVIC-GRCIC J, PERISSUTTI B, VOINOVICH D, PAVELIC Z: Spray-dried chitosan/ethylcellulose microspheres for nasal drug delivery: swelling study and evaluation of in vitro drug release properties. J. Microencapsul. (2005) 22(5):549-561.
   PubMed Web of Science ®Google Scholar
• KRAULAND AH, GUGGIİ D, BERNKOP-SCHNURCH A: Thiolated chitosan microparticles: a vehicle for nasal peptide drug delivery. Int. J. Pharm. (2006) 307(2):270-277.
   PubMed Web of Science ®Google Scholar
• GAVINI E, HEGGE AB, RASSU G et al.: Nasal administration of carbamazepine using chitosan microspheres: in vitro/in vivo studies. Int. J. Pharm. (2006) 307(1):9-15.
   PubMed Web of Science ®Google Scholar
• GAVINI E, RASSU G, SANNA V, COSSU M, GIUNCHEDI P: Mucoadhesive microspheres for nasal administration of an antiemetic drug, metoclopramide: in vitro/ex vivo studies. J. Pharm. Pharmacol. (2005) 57(3):287-294.
   PubMed Web of Science ®Google Scholar
• VARSHOSAZ J, SADRAI H, ALINAGARI R: Nasal delivery of insulin using chitosan microspheres. J. Microencapsul. (2004) 21(7):761-774.
   PubMed Web of Science ®Google Scholar
• JAIN SK, CHOURASIA MK, JAIN AK, JAIN RK, SHRIVASTAVA AK: Development and characterization of mucoadhesive microspheres bearing salbutamol for nasal delivery. Drug Deliv. (2004) 11(2):113-122.
   PubMed Web of Science ®Google Scholar
• LIM ST, FORBES B, MARTIN GP, BROWN MB: In vivo and in vitro characterization of novel microparticulates based on hyaluronan and chitosan hydroglutamate. AAPS PharmSciTech. (2001) 2(4):E20.
   PubMedGoogle Scholar
• ILLUM L, WATTS P, FİISHER AN et al.: Intranasal delivery of morphine. J. Pharmacol. Exp. Ther. (2002) 301(1):391-400.
   PubMed Web of Science ®Google Scholar
• TURKOGLU OF, EROGLU H, OKUTAN O et al.: The efficiency of dexamethasone sodium phosphate–encapsulated chitosan microspheres after cold injury. Surg. Neurol. (2005) 64(Suppl. 2):S11-S16.
   PubMed Web of Science ®Google Scholar
• JAMEELA SR, KUMARY TV, LAL AV, JAYAKRISHNAN A: Progesterone-loaded chitosan microspheres: a long acting biodegradable controlled delivery system. J. Control. Rel. (1998) 52(1-2):17-24.
   PubMed Web of Science ®Google Scholar
• JIANG DS, LONG SY, HUANG J, XIAO HY, ZHOU JY: Immobilization of Pycnoporus sanguineus laccase on magnetic chitosan microspheres. Biochem. Eng. J. (2005) 25(1):15-23.
   Web of Science ®Google Scholar
• SHENTU J, WU J, SONG W, JIA Z: Chitosan microspheres as immobilized dye affinity support for catalase adsorption. Int. J. Biolog. Macromol. (2005) 37(1-2):42-46.
   PubMed Web of Science ®Google Scholar
• MARTINS AO, LUIZ DA SILVA E, CARASEK E, LARANJEIRA MCM, DE FÁVERE VT: Sulphoxine immobilized onto chitosan microspheres by spray drying: application for metal ions preconcentration by flow injection analysis. Talanta (2004) 63(2):397-403.
   PubMed Web of Science ®Google Scholar
• MARRACHE F, VULLIERME MP, ROY C et al.: Arterial phase enhancement and body mass index are predictors of response to chemoembolisation for liver metastases of endocrine tumours. Br. J. Cancer. (2007) 96(1):49-55.
   PubMed Web of Science ®Google Scholar
• WANG YM, SHI TS, PU YL, ZHU JG, ZHAO YL: Studies on hepatic arterial embolization with cisplatin-chitosan-microspheres in dogs. Yao Xue Xue Bao. (1995) 30(12):891-895.
   PubMedGoogle Scholar
• MISIRLI Y, OZTURK E, KURSAKLIOGLU H, DENKBAS EB: Preparation and characterization of Mitomycin-C loaded chitosan-coated alginate microspheres for chemoembolization. J. Microencapsul. (2005) 22(2):167-178.
   PubMed Web of Science ®Google Scholar
• EROGLU M, KURSAKLIOGLU H, MISIRLI Y et al.: Chitosan-coated alginate microspheres for embolization and/or chemoembolization: in vivo studies. J. Microencapsul. (2006) 23(4):367-376.
   PubMed Web of Science ®Google Scholar
• HALLING PJ, ASENJO JA, DUNNILL P: Nonporous magnetic supports for proteases, cell-lytic enzymes, and ribonuclease: limits of reactant size. Biotechnol. Bioeng. (1979) 21(12):2359-2363.
   PubMed Web of Science ®Google Scholar
• DUNNIL P, LILLY LETTER MD: Purification of enzymes using magnetic bio-affinity materials. Biotechnol. Bioeng. (1974) 16(7):987-990.
   PubMed Web of Science ®Google Scholar
• YOSHIMOTO T, MIHAMA T, TAKAHASHI K, SAITO Y, INADA Y: Chemical modification of enzymes with activated magnetic modifier. Biochem. Biophys. Res. Commun. (1987) 145(2):908-914.
   PubMed Web of Science ®Google Scholar
• ANSELL RJ, MOSBACH K: Magnetic molecularly imprinted polymer beads for drug radioligand binding assay. Analyst (1998) 123(7):1611-1616.
   PubMed Web of Science ®Google Scholar
• BRAMBLE JL, GRAVES DJ, BRODELIUS P: Plant cell culture using a novel bioreactor: the magnetically stabilized fluidized bed. Biotechnol. Prog. (1990) 6(6):452-457.
   PubMed Web of Science ®Google Scholar
• TANYOLAÇ D, ÖZDURAL AR: Preparation of low-cost magnetic nitrocellulose microbeads. React. Funct. Polym. (2000) 45(3):235-242.
   Web of Science ®Google Scholar
• TANYOLAÇ D, ÖZDURAL AR: A new low cost magnetic material: magnetic polyvinylbutyral microbeads. React. Funct. Polym. (2000) 43(3):279-286.
   Web of Science ®Google Scholar
• WANG YM, WANG YX, FENG LX: Preparation and magnetic properties of [P(St-co-AA)]Ni microspheres. J. Appl. Polym. Sci. (1997) 64(9):1843-1848.
   Web of Science ®Google Scholar
• TAKAHASHI K, KODERA Y, MIİHAMIİ T, SAITO Y, INADA Y: Magnetic lipase active in organic solvents. Biochem. Biophys. Res. Commun. (1987) 142(2):291-296.
   PubMed Web of Science ®Google Scholar
• DENKBA EB, KILIÇAY E, BIRLIKSEVEN C, ÖZTÜRK E: Magnetic chitosan microspheres: preparation and characterization. React. Funct. Polym. (2002) 50(3):225-232.
   Web of Science ®Google Scholar
• WU Y, GUO J, YANG W, WANG C, FU S: Preparation and characterization of chitosan–poly(acrylic acid) polymer magnetic microspheres. Polym. (2006) 47(15):5287-5294
   Web of Science ®Google Scholar
• MOORE A, BASILION JP, CHIOCCA EA, WEISSLEDER R: Measuring transferrin receptor gene expression by NMR imaging. Biochim. Biophys. Acta. (1998) 1402(3):239-249.
   PubMed Web of Science ®Google Scholar
• KIM DK, ZHANG Y, KEHR J, KLASON T, BJELKE B, MUHAMMED M: Characterization and MRI study of surfactant-coated superparamagnetic nanoparticles administered into the rat brain. J. Magnetism and Magnetic Materials (2001) 225(1-2):256-261.
   Web of Science ®Google Scholar
• MORALES MP, BOMATI-MIGUEL O, PÉREZ DE ALEJO R, RUIZ-CABELLO J, VEINTEMILLAS-VERDAGUER S, O’GRADY K: Contrast agents for MRI based on iron oxide nanoparticles prepared by laser pyrolysis. J. Magnetism and Magnetic Materials (2003) 266(1-2):102-109
   Web of Science ®Google Scholar
• KIM EH, AHN Y, LEE HS: Biomedical applications of superparamagnetic iron oxide nanoparticles encapsulated within chitosan. J. Alloys and Compounds. (In Press).
   Google Scholar
• LEE HS, KIM EH, SHAO H, KWAK BK: Synthesis of SPIO-chitosan microspheres for MRI-detectable embolotherapy. J. Magnetism and Magnetic Materials (2005) 293(1):102-105
   Web of Science ®Google Scholar
• GULIYEVA U, ONER F, OZSOY S, HAZIROGLU R: Chitosan microparticles containing plasmid DNA as potential oral gene delivery system. Eur. J. Pharm. Biopharm. (2006) 62(1):17-25.
   PubMed Web of Science ®Google Scholar
• AKBUĞGA J, ÖZBASŞ-TURAN S, ERDOĞGAN N: Plasmid-DNA loaded chitosan microspheres for in vitro IL-2 expression. Eur. J. Pharm. Biopharm. (2004) 58(3):501-507.
   PubMed Web of Science ®Google Scholar
• YUN YH, JIANG H, CHAN R, CHEN W: Sustained release of PEG-g-chitosan complexed DNA from poly(lactide-co-glycolide). J. Biomater. Sci. Polym. Ed. (2005) 16(11):1359-1378.
   PubMed Web of Science ®Google Scholar
• LAMEIRO MH, MALPIQUE R, SILVA AC, ALVES PM, MELO E: Encapsulation of adenoviral vectors into chitosan-bile salt microparticles for mucosal vaccination. J. Biotechnol. (2006) 126(2):152-162.
   PubMed Web of Science ®Google Scholar
• ARAL C, AKBUGA J: Preparation and in vitro transfection efficiency of chitosan microspheres containing plasmid DNA:poly(L-lysine) complexes. J. Pharm. Pharm. Sci. (2003) 6(3):321-326.
   PubMed Web of Science ®Google Scholar
• OZBAS-TURAN S, ARAL C, KABASAKAL L, KEYER-UYSAL M, AKBUGA J: Co-encapsulation of two plasmids in chitosan microspheres as a non-viral gene delivery vehicle. J. Pharm. Pharm. Sci. (2003) 6(1):27-32.
   PubMed Web of Science ®Google Scholar
• HEJAZI R, AMIJI M: Stomach-specific anti-H. pylori therapy: Part III: effect of chitosan microspheres crosslinking on the gastric residence and local tetracycline concentrations in fasted gerbils. Int. J. Pharm. (2004) 272(1-2):99-108.
   PubMed Web of Science ®Google Scholar
• EL-GIBALY I: Development and in vitro evaluation of novel floating chitosan microcapsules for oral use: comparison with non-floating chitosan microspheres. Int. J. Pharm. (2002) 249(1-2):7-21.
   PubMed Web of Science ®Google Scholar
• HEJAZI R, AMIJI M: Stomach-specific anti-H. pylori therapy. I: preparation and characterization of tetracyline-loaded chitosan microspheres. Int. J. Pharm. (2002) 235(1-2):87-94.
   PubMed Web of Science ®Google Scholar
• PORTERO A, REMUNAN-LOPEZ C, CRIADO MT, ALONSO MJ: Reacetylated chitosan microspheres for controlled delivery of anti-microbial agents to the gastric mucosa. J. Microencapsul. (2002) 19(6):797-809.
   PubMed Web of Science ®Google Scholar
• WILLIAMS III RO, BARRON MK, ALONSO MJ, REMUÑÁN-LÓPEZ C: Investigation of a pMDI system containing chitosan microspheres and P134a. Int. J. Pharm. (1998) 174(1-2):209-222.
   Web of Science ®Google Scholar
• HUANG YC, YEH MK, CHENG SN, CHIANG CH: The characteristics of betamethasone-loaded chitosan microparticles by spray-drying method. J. Microencapsul. (2003) 20(4):459-472.
   PubMed Web of Science ®Google Scholar
• HUANG YC, CHIANG CH, YEH MK: Optimizing formulation factors in preparing chitosan microparticles by spray-drying method. J. Microencapsul. (2003) 20(2):247-260.
   PubMed Web of Science ®Google Scholar
• HUANG Y, YEH M, CHİIANG C: Formulation factors in preparing BTM-chitosan microspheres by spray drying method. Int. J. Pharm. (2002) 242(1-2):239-242.
   PubMed Web of Science ®Google Scholar
• GRENHA A, SEIJO B, REMUNAN-LOPEZ C: Microencapsulated chitosan nanoparticles for lung protein delivery. Eur. J. Pharm. Sci. (2005) 25(4-5):427-437.
   PubMed Web of Science ®Google Scholar
• YAMAMOTO H, KUNO Y, SUGİIMOTO S, TAKEUCHI H, KAWASHIMA Y: Surface-modified PLGA nanosphere with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctions. J. Control. Rel. (2005) 102(2):373-381.
   PubMed Web of Science ®Google Scholar
• BIVAS-BENITA M, VAN MEIJGAARDEN KE, FRANKEN KL et al.: Pulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A*0201-restricted T-cell epitopes of Mycobacterium tuberculosis.Vaccine (2004) 22(13-14):1609-1615.
   PubMed Web of Science ®Google Scholar
• VARSHOSAZ J, JAFFARIAN DEHKORDI A, GOLAFSHAN S: Colon-specific delivery of mesalazine chitosan microspheres. J. Microencapsul. (2006) 23(3):329-339.
   PubMed Web of Science ®Google Scholar
• WITTAYA-AREEKUL S, KRUENATE J, PRAHSARN C: Preparation and in vitro evaluation of mucoadhesive properties of alginate/chitosan microparticles containing prednisolone. Int. J. Pharm. (2006) 312(1-2):113-118.
   PubMed Web of Science ®Google Scholar
• RAIİ G, JAIİN SK, AGRAWAL S, BHADRA S, PANCHOLI SS, AGRAWAL GP: Chitosan hydrochloride based microspheres of albendazole for colonic drug delivery. Pharmazie (2005) 60(2):131-134.
   PubMed Web of Science ®Google Scholar