Search in:

Advanced search

Expert Opinion on Drug Delivery Volume 5, 2008 - Issue 2

Submit an article Journal homepage

163

Views

CrossRef citations to date

Altmetric

Technology Evaluation

TEMPE: Topical Eutectic-Like Mixture for Premature Ejaculation

Richard Henry Queen's University, Department of Anesthesiology, Kingston General Hospital, 76 Stuart Street, Kingston, Ontario, K7L 2V7, Canada

, MBCHB FRCPC,

Alvaro Morales Professor Queens University, Department of Urology, Kingston General Hospital, Kingston, Ontario, Canada

, MD FRCSC FACS &

Michael G Wyllie Chief Scientific Officer Plethora Solutions Plc., London, UK +44 0 1795 597330; +44 0 1795 597339; [email protected]

, PhD

Pages 251-261 | Published online: 05 Feb 2008

Cite this article
https://doi.org/10.1517/17425247.5.2.251

Full Article
Figures & data
References
Citations
Metrics
Reprints & Permissions

Bibliography

Laumann EO, Nicolosi A, Glasser DB, et al. Sexual problems among women and men aged 40 – 80 y: prevalence and correlates identified in the Global Study of Sexual Attitudes and Behaviors. Int J Impot Res 2005;17(1):39-57
PubMed Web of Science ®Google Scholar
Reading AE, Wiest WM. An analysis of self-reported sexual behavior in a sample of normal males. Arch Sex Behav 1984;13(1):69-83
PubMed Web of Science ®Google Scholar
Dunn KM, Croft PR, Hackett GI. Sexual problems: a study of the prevalence and need for health care in the general population. Fam Pract 1998;15(6):519-24
PubMed Web of Science ®Google Scholar
Frank E, Anderson C, Rubinstein D. Frequency of sexual dysfunction in “normal” couples. N Engl J Med 1978;299(3):111-5
PubMed Web of Science ®Google Scholar
Rowland D, Perelman M, Althof S, et al. Self-reported premature ejaculation and aspects of sexual functioning and satisfaction. J Sex Med 2004;1(2):225-32
PubMed Web of Science ®Google Scholar
Jannini EA, Lenzi A. Epidemiology of premature ejaculation. Curr Opin Urol 2005;15(6):399-403
PubMed Web of Science ®Google Scholar
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th edition. Text Revision. (ed.) American Psychiatric Association, Washington DC; 2000
Google Scholar
McMahon CGA, Incrocci C, Perelman L, et al. Disorders of orgasm and ejaculation in men. In: Lue TFB, Rosen R, Guiliano R, Khoury F, Montorsi S, F., editors. Sexual Medicine: Sexual Dysfunctions in Men and Women. Heath Publications, Paris; 2004. p. 411-68
Google Scholar
Symonds T, Roblin D, Hart K, Althof S. How does premature ejaculation impact a man s life? J Sex Marital Ther 2003;29(5):361-70
PubMed Web of Science ®Google Scholar
Patrick DL, Althof SE, Pryor JL, et al. Premature ejaculation: an observational study of men and their partners. J Sex Med 2005;2(3):358-67
PubMed Web of Science ®Google Scholar
Waldinger MD, Quinn P, Dilleen M, et al. A multinational population survey of intravaginal ejaculation latency time. J Sex Med 2005;2(4):492-7
PubMed Web of Science ®Google Scholar
De Amicis LA, Goldberg DC, Lopiccolo J, Friedman J, Davies L. Clinical follow-up of couples treated for sexual dysfunction. Arch Sex Behav 1985;14(4):467-89
PubMed Web of Science ®Google Scholar
Chue P. Gabapentin treatment for premature ejaculation. Can J Psychiatry 2004;49(9):644-5
PubMed Web of Science ®Google Scholar
Beretta G, Chelo E, Fanciullacci F, Zanollo A. Effect of an alpha-blocking agent (phenoxybenzamine) in the management of premature ejaculation. Acta Eur Fertil 1986;17(1):43-5
PubMedGoogle Scholar
Girgis SM, El-Haggar S, El-Hermouzy S. A double-blind trial of clomipramine in premature ejaculation. Andrologia 1982;14(4):364-8
PubMed Web of Science ®Google Scholar
Kara H, Aydin S, Yucel M, et al. The efficacy of fluoxetine in the treatment of premature ejaculation: a double-blind placebo controlled study. J Urol 1996;156(5):1631-2
PubMed Web of Science ®Google Scholar
McMahon CG. Treatment of premature ejaculation with sertraline hydrochloride. Int J Impot Res 1998;10(3):181-4; discussion 185
PubMed Web of Science ®Google Scholar
McMahon CGT, Johnston K, H. Treatment of premature ejaculation with paroxetine hydrochloride. Int J Impot Res 1998;10(Suppl 3):S38
Google Scholar
Xin ZC, Chung WS, Choi YD, et al. Penile sensitivity in patients with primary premature ejaculation. J Urol 1996;156(3):979-81
PubMed Web of Science ®Google Scholar
Rowland DL, Haensel SM, Blom JH, Slob AK. Penile sensitivity in men with premature ejaculation and erectile dysfunction. J Sex Marital Ther 1993;19(3):189-97
PubMed Web of Science ®Google Scholar
Vanden Broucke H, Everaert K, Peersman W, et al. Ejaculation latency times and their relationship to penile sensitivity in men with normal sexual function. J Urol 2007;177(1):237-40
PubMed Web of Science ®Google Scholar
Vignoli GC. Premature ejaculation: new electrophysiologic approach. Urology 1978;11(1):81-2
PubMedGoogle Scholar
Xin ZC, Choi YD, Rha KH, Choi HK. Somatosensory evoked potentials in patients with primary premature ejaculation. J Urol 1997;158(2):451-5
PubMed Web of Science ®Google Scholar
Atikeler MK, Gecit I, Senol FA. Optimum usage of prilocaine-lidocaine cream in premature ejaculation. Andrologia 2002;34(6):356-9
PubMed Web of Science ®Google Scholar
Berkovitch M, Keresteci AG, Koren G. Efficacy of prilocaine-lidocaine cream in the treatment of premature ejaculation. J Urol 1995;154(4):1360-1
PubMed Web of Science ®Google Scholar
Busato W, Galindo CC. Topical anaesthetic use for treating premature ejaculation: a double-blind, randomized, placebo-controlled study. BJU Int 2004;93(7):1018-21
PubMed Web of Science ®Google Scholar
Choi HK, Jung GW, Moon KH, et al. Clinical study of SS-cream in patients with lifelong premature ejaculation. Urology 2000;55(2):257-61
PubMed Web of Science ®Google Scholar
Choi HK, Xin ZC, Choi YD, et al. Safety and efficacy study with various doses of SS-cream in patients with premature ejaculation in a double-blind, randomized, placebo controlled clinical study. Int J Impot Res 1999;11(5):261-4
PubMed Web of Science ®Google Scholar
Xin ZC, Choi YD, Lee SH, Choi HK. Efficacy of a topical agent SS-cream in the treatment of premature ejaculation: preliminary clinical studies. Yonsei Med J 1997;38(2):91-5
PubMedGoogle Scholar
Becker DE, Reed KL. Essentials of local anesthetic pharmacology. Anesth Prog 2006;53(3):98-108; quiz 109-10
PubMedGoogle Scholar
Juhlin L, Evers H. EMLA: a new topical anesthetic. Adv Dermatol 1990;5:75-91; discussion 92
PubMedGoogle Scholar
Frega A, Di Renzi F, Palazzetti PL, et al. Vulvar and penile HPV lesions: laser surgery and topic anaesthesia. Clin Exp Obstet Gynecol 1993;20(2):76-81
PubMedGoogle Scholar
Rylander E, Sjoberg I, Lillieborg S, Stockman O. Local anesthesia of the genital mucosa with a lidocaine/prilocaine cream (EMLA) for laser treatment of condylomata acuminata: a placebo-controlled study. Obstet Gynecol 1990;75(2):302-6
PubMed Web of Science ®Google Scholar
Dinsmore WW, Hackett G, Goldmeier D, et al. Topical eutectic mixture for premature ejaculation (TEMPE): a novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation. BJU Int 2007;99(2):369-75
PubMed Web of Science ®Google Scholar
McCoombe SG, Short RV. Potential HIV-1 target cells in the human penis. AIDS 2006;20(11):1491-5
PubMed Web of Science ®Google Scholar
Szabo R, Short RV. How does male circumcision protect against HIV infection? BMJ 2000;320(7249):1592-4
PubMed Web of Science ®Google Scholar
Henry R, Morales A. Topical lidocaine-prilocaine spray for the treatment of premature ejaculation: a proof of concept study. Int J Impot Res 2003;15(4):277-81
PubMed Web of Science ®Google Scholar
Aydin ON, Eyigor M, Aydin N. Antimicrobial activity of ropivacaine and other local anaesthetics. Eur J Anaesthesiol 2001;18(10):687-94
Web of Science ®Google Scholar
Berg JO, Mossner BK, Skov MN, et al. Antibacterial properties of EMLA and lidocaine in wound tissue biopsies for culturing. Wound Repair Regen 2006;14(5):581-5
PubMed Web of Science ®Google Scholar
Kerenyi M, Batai R, Juhasz V, Batai I. Lidocaine/prilocaine cream (EMLA) has an antibacterial effectin vitro. J Hosp Infect 2004;56(1):75-6
PubMed Web of Science ®Google Scholar
AstraZeneca. EMLA Product Information; 2006
Google Scholar
Morales A, Barada J, Wyllie MG. A review of the current status of topical treatments for premature ejaculation. BJU Int 2007;100(3):493-501
PubMed Web of Science ®Google Scholar
Gittleman MCM, Lu J, M. Synergistic effect of meatal application of dyclonine/alprostadil cream for the treatment of early ejaculation (EE) in a double-blind and crossover study. Proceedings of the 8th Congress of the European Society for Sexual Medicine. Copenhagen, Denmark. J Sex Med 2005;3(s3):176
Google Scholar
Athanasios Z, Polyanthi P, George K. The efficacy of duloxetine in the treatment of premature ejaculation. Int Urol Nephrol 2007;39(1):115-8
PubMed Web of Science ®Google Scholar
Waldinger MD, Olivier B. Utility of selective serotonin reuptake inhibitors in premature ejaculation. Curr Opin Investig Drugs 2004;5(7):743-7
PubMedGoogle Scholar
Waldinger MD, Zwinderman AH, Olivier B. On-demand treatment of premature ejaculation with clomipramine and paroxetine: a randomized, double-blind fixed-dose study with stopwatch assessment. Eur Urol 2004;46(4):510-5; discussion 516
PubMed Web of Science ®Google Scholar
Andersson KE, Mulhall JP, Wyllie MG. Pharmacokinetic and pharmacodynamic features of dapoxetine, a novel drug for ‘on-demand’ treatment of premature ejaculation. BJU Int 2006;97(2):311-5
PubMed Web of Science ®Google Scholar
Press release (October 2005 ). Available from: www.jnj.com/news/jnj_news/20051026_164127.htm
Google Scholar
Smith TW. Adult sexual behavior in 1989: number of partners, frequency of intercourse and risk of AIDS. Fam Plann Perspect 1991;23(3):102-7
PubMedGoogle Scholar
Wyllie MG. Clinical trials for aspiring dummies (and urologists). BJU Int 2007;99(4):939-40
PubMed Web of Science ®Google Scholar

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Share icon
Back to Top

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.

People also read
Recommended articles
Cited by

To cite this article:

Reference style: APA Chicago Harvard

Citation copied to clipboard

Reference styles above use APA (6th edition), Chicago (16th edition) & Harvard (10th edition)

Download citation

Download a citation file in RIS format that can be imported by citation management software including EndNote, ProCite, RefWorks and Reference Manager.

Choose format: RIS BibTex RefWorks Direct Export

Choose options: Citation Citation & abstract Citation & references

TEMPE: Topical Eutectic-Like Mixture for Premature Ejaculation

Bibliography

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

TEMPE: Topical Eutectic-Like Mixture for Premature Ejaculation

Bibliography

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date