1,782
Views
271
CrossRef citations to date
0
Altmetric
Review

Targeted drug delivery via folate receptors

, & , PhD
Pages 309-319 | Published online: 05 Mar 2008

Bibliography

  • Lacey SW, Sanders JM, Rothberg KG, et al. Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosyl-phosphatidylinositol. J Clin Invest 1989;84:715-20
  • Ratnam M, Marquardt H, Duhring JL, Freisheim JH. Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA. Biochemistry 1989;28:8249-54
  • Elnakat H, Ratnam M. Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy. Adv Drug Deliv Rev 2004;56:1067-84
  • Shen F, Ross JF, Wang X, Ratnam M. Identification of a novel folate receptor, a truncated receptor, and receptor type b in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity. Biochemistry 1994;33:1209-15
  • Shen F, Wu M, Ross JF, et al. Folate receptor type gamma is primarily a secretory protein due to lack of an efficient signal for glycosylphosphatidylinositol modification: protein characterization and cell type specificity. Biochemistry 1995;34:5660-5
  • Wang H, Ross JF, Ratnam M. Structure and regulation of a polymorphic gene encoding folate receptor type gamma/gamma. Nucleic Acids Res 1998;26:2132-42
  • Kamen BA, Caston JD. Properties of a folate binding protein (FBP) isolated from porcine kidney. Biochem Pharmacol 1986;35:2323-9
  • da Costa M, Rothenberg SP. Purification and characterization of folate binding proteins from rat placenta. Biochim Biophys Acta 1996;1292:23-30
  • Spiegelstein O, Eudy JD, Finnell RH. Identification of two putative novel folate receptor genes in humans and mouse. Gene 2000;258(1-2):117-25
  • Ross JF, Wang H, Behm FG, et al. Folate receptor type b is a neutrophilic lineage marker and is differentially expressed in myeloid leukemia. Cancer 1999;85:348-57
  • Weitman SD, Lark RH, Coney LR, et al. Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues. Cancer Res 1992;52:3396-401
  • Birn H, Nielsen S, Christensen EI. Internalization and apical-to-basolateral transport of folate in rat kidney proximal tubule. Am J Physiol 1997;272:F70-8
  • Toffoli G, Cernigoi C, Russo A, et al. Overexpression of folate binding protein in ovarian cancers. Int J Cancer 1997;74:193-8
  • Kelley KM, Rowan BG, Ratnam M. Modulation of the folate receptor alpha gene by the estrogen receptor: mechanism and implications in tumor targeting. Cancer Res 2003;63:2820-8
  • Tran T, Shatnawi A, Zheng X, et al. Enhancement of folate receptor alpha expression in tumor cells through the glucocorticoid receptor: a promising means to improved tumor detection and targeting. Cancer Res 2005;65:4431-41
  • Nakashima-Matsushita N, Homma T, Yu S, et al. Selective expression of folate receptor b and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis. Arthritis Rheum 1999;42:1609-16
  • Nakamura M, Nagayoshi R, Ijiri K, et al. Nitration and chlorination of folic acid by peroxynitrite and hypochlorous acid, and the selective binding of 10-nitro-folate to folate receptor β. Biochem Biophys Res Commun 2002;297:1238-44
  • Sadasivan E, da Costa M, Rothenberg SP, Brink L. Purification, properties, and immunological characterization of folate-binding proteins from human leukemia cells. Biochim Biophys Acta 1987;925:36-47
  • Sadasivan E, Rothenberg SP, da Costa M, Brink L. Characterization of multiple forms of folate-binding protein from human leukemia cells. Biochim Biophys Acta 1986;882:311-21
  • Paulos CM, Turk MJ, Breur GJ, Low PS. Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis. Adv Drug Deliv Rev 2004;56:1205-17
  • Pan XQ, Zheng X, Shi G, et al. Strategy for the treatment of acute myelogenous leukemia based on folate receptor β-targeted liposomal doxorubicin combined with receptor induction using all-trans retinoic acid. Blood 2002;100:594-602
  • Wang H, Zheng X, Behm FG, Ratnam M. Differentiation-independent retinoid induction of folate receptor type β, a potential tumor target in myeloid leukemia. Blood 2000;96:3529-36
  • Rijnboutt S, Jansen G, Posthuma G, et al. Endocytosis of GPI-linked membrane folate receptor-alpha. J Cell Biol 1996;132:35-47
  • Miotti S, Canevari S, Menard S, et al. Characterization of human ovarian carcinoma-associated antigens defined by novel monoclonal antibodies with tumor-restricted specificity. Int J Cancer 1987;39:297-303
  • Kalofonos HP, Karamouzis MV, Epenetos AA. Radioimmunoscintigraphy in patients with ovarian cancer. Acta Oncol 2001;40:549-57
  • Elgqvist J, Andersson H, Bäck T, et al. Therapeutic efficacy and tumor dose estimations in radioimmunotherapy of intraperitoneally growing OVCAR-3 cells in nude mice with 211At-labeled monoclonal antibody MX35. J Nucl Med 2005;46:1907-15
  • Kranz DM, Patrick TA, Brigle KE, et al. Conjugates of folate and anti-T-cell-receptor antibodies specifically target folate-receptor-positive tumor cells for lysis. Proc Natl Acad Sci USA 1995;92:9057-61
  • Melani C, Figini M, Nicosia D, et al. Targeting of interleukin 2 to human ovarian carcinoma by fusion with a single-chain Fv of antifolate receptor antibody. Cancer Res 1998;58:4146-54
  • Ebel W, Routhier EL, Foley B, et al. Preclinical evaluation of MORAb-003, a humanized monoclonal antibody antagonizing folate receptor-alpha. Cancer Immun 2007;7:6
  • Zhao XB, Lee RJ. Tumor-selective targeted delivery of genes and antisense oligodeoxyribonucleotides via the folate receptor. Adv Drug Deliv Rev 2004;56:1193-204
  • Reddy JA, Allagadda VM, Leamon CP. Targeting therapeutic and imaging agents to folate receptor positive tumors. Curr Pharm Biotechnol 2005;6:131-50
  • Leamon CP, Reddy JA. Folate-targeted chemotherapy. Adv Drug Deliv Rev 2004;56:1127-41
  • Lu Y, Low PS. Folate-mediated delivery of macromolecular anticancer therapeutic agents. Adv Drug Deliv Rev 2002;54:675-93
  • Lu Y, Sega E, Leamon CP, et al. Folate receptor-targeted immunotherapy of cancer: mechanism and therapeutic potential. Adv Drug Deliv Rev 2004;56:1161-76
  • Ke CY, Mathias CJ, Green MA. Folate-receptor-targeted radionuclide imaging agents. Adv Drug Deliv Rev 2004;56:1143-60
  • Mathias CJ, Lewis MR, Reichert DE, et al. Preparation of 66Ga- and 68Ga-labeled Ga(III)-deferoxamine-folate as potential folate-receptor-targeted PET radiopharmaceuticals. Nucl Med Biol 2003;30:725-31
  • Mathias CJ, Wang S, Lee RJ, et al. Tumor-selective radiopharmaceutical targeting via receptor-mediated endocytosis of gallium-67-deferoxamine-folate. J Nucl Med 1996;37:1003-8
  • Mathias CJ, Wang S, Waters DJ, et al. Indium-111-DTPA-folate as a potential folate-receptor-targeted radiopharmaceutical. J Nucl Med 1998;39:1579-85
  • Guo W, Hinkle GH, Lee RJ. 99mTc-HYNIC-folate: a novel receptor-based targeted radiopharmaceutical for tumor imaging. J Nucl Med 1999;40:1563-9
  • Trump DP, Mathias CJ, Yang Z, et al. Synthesis and evaluation of 99mTc(CO)(3)-DTPA-folate as a folate-receptor-targeted radiopharmaceutical. Nucl Med Biol 2002;29:569-73
  • Reddy JA, Xu LC, Parker N, et al. Preclinical evaluation of 99mTc-EC20 for imaging folate receptor-positive tumors. J Nucl Med 2004;45:857-66
  • Ke CY, Mathias CJ, Yang ZF, et al. Synthesis and evaluation of folate-bis(thiosemicarbazone) and folate-CYCLAM conjugates for possible use as folate-receptor-targeted copper radiopharmaceuticals. J Labelled Compd Radiopharm 1999;42:S821-3
  • Paulos CM, Varghese B, Widmer WR, et al. Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis. Arthritis Res Ther 2006;8:R77
  • Konda SD, Wang S, Brechbiel M, et al. Biodistribution of a 153Gd-folate dendrimer, generation = 4, in mice with folate-receptor positive and negative ovarian tumor xenografts. Invest Radiol 2002;37:199-204
  • Choi H, Choi SR, Zhou R, et al. Iron oxide nanoparticles as magnetic resonance contrast agent for tumor imaging via folate receptor-targeted delivery. Acad Radiol 2004;11:996-1004
  • Aronov O, Horowitz AT, Gabizon A, Gibson D. Folate-targeted PEG as a potential carrier for carboplatin analogs. Synthesis and in vitro studies. Bioconjug Chem 2003;14:563-74
  • Liu J, Kolar C, Lawson TA, Gmeiner WH. Targeted drug delivery to chemoresistant cells: folic acid derivatization of FdUMP[10] enhances cytotoxicity toward 5-FU-resistant human colorectal tumor cells. J Org Chem 2001;66:5655-63
  • Majoros IJ, Myc A, Thomas T, et al. PAMAM dendrimer-based multifunctional conjugate for cancer therapy: synthesis, characterization, and functionality. Biomacromolecules 2006;7:572-9
  • Ladino CA, Chari RV, Bourret LA, et al. Folate-maytansinoids: target-selective drugs of low molecular weight. Int J Cancer 1997;73:859-64
  • Reddy JA, Dorton R, Westrick E, et al. Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate. Cancer Res 2007;67:4434-42
  • Suzuki T, Hisakawa S, Itoh Y, et al. Design, synthesis, and biological activity of folalte receptor-targeted prodrug of thiolate histone deacetylase inhibitors. Bioorg Med Chem Lett 2007;17:4208-12
  • Lu Y, Low PS. Folate targeting of haptens to cancer cell surfaces mediates immunotherapy of syngeneic murine tumors. Cancer Immunol Immunother 2002;51:153-62
  • Varghese B, Haase N, Low PS. Depletion of folate-receptor-positive macrophages leads to alleviation of symptoms and prolonged survival in two murine models of systemic lupus erythematosus. Mol Pharm 2007;4:679-85
  • Lu Y, Sega E, Low PS. Folate receptor-targeted immunotherapy: induction of humoral and cellular immunity against hapten-decorated cancer cells. Int J Cancer 2005;116:710-9
  • Li S, Deshmukh HM, Huang L. Folate-mediated targeting of antisense oligodeoxynucleotides to ovarian cancer cells. Pharm Res 1998;15:1540-5
  • Springer CJ, Niculescu-Duvaz II. Antibody-directed enzyme prodrug therapy (ADEPT). Adv Drug Deliv Rev 1997;26:151-72
  • Sudimack J, Lee RJ. Targeted drug delivery via the folate receptor. Adv Drug Deliv Rev 2000;41:147-62
  • Leamon CP, Low PS. Delivery of macromolecules into living cells: a method that exploits folate receptor endocytosis. Proc Natl Acad Sci USA 1991;88:5572-6
  • Leamon CP, Low PS. Membrane folate-binding proteins are responsible for folate-protein conjugate endocytosis into cultured cells. Biochem J 1993;291(Pt 3):855-60
  • Turek JJ, Leamon CP, Low PS. Endocytosis of folate-protein conjugates: ultrastructural localization in KB cells. J Cell Sci 1993;106(Pt 1):423-30
  • Das Sarma J, Duttagupta C, Ali E, et al. Direct microtitre plate enzyme immunoassay of folic acid without heat denaturation of serum. J Immunol Methods 1995;184:7-14
  • Lu JY, Lowe DA, Kennedy MD, et al. Folate-targeted enzyme prodrug cancer therapy utilizing penicillin-V amidase and a doxorubicin prodrug. J Drug Target 1999;7:43-53
  • Lee S, Murthy N. Targeted delivery of catalase and superoxide dismutase to macrophages using folate. Biochem Biophys Res Commun 2007;360:275-9
  • Roy EJ, Gawlick U, Orr BA, et al. Folate-mediated targeting of T cells to tumors. Adv Drug Deliv Rev 2004;56:1219-31
  • Roy EJ, Cho BK, Rund LA, et al. Targeting T-cells against brain tumors with a bispecific ligand-antibody conjugate. Int J Cancer 1998;76:761-6
  • Rund LA, Cho BK, Manning TC, et al. Bispecific agents target endogenous murine T cells against human tumor xenografts. Int J Cancer 1999;83:141-9
  • Gabizon A, Horowitz AT, Goren D, et al. Targeting folate receptor with folate linked to extremities of poly(ethylene glycol)-grafted liposomes: in vitro studies. Bioconjug Chem 1999;10:289-98
  • Gabizon A, Horowitz AT, Goren D, et al. In vivo fate of folate-targeted polyethylene-glycol liposomes in tumor-bearing mice. Clin Cancer Res 2003;9:6551-9
  • Lee RJ, Low PS. Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis. J Biol Chem 1994;269:3198-204
  • Zhao XB, Muthusamy N, Byrd JC, et al. Cholesterol as a bilayer anchor for PEGylation and targeting ligand in folate-receptor-targeted liposomes. J Pharm Sci 2007;96:2424-35
  • Pan XQ, Wang H, Lee RJ. Antitumor activity of folate receptor-targeted liposomal doxorubicin in a KB oral carcinoma murine xenograft model. Pharm Res 2003;20:417-22
  • Lee RJ, Low PS. Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro. Biochim Biophys Acta 1995;1233:134-44
  • Lu Y, Wu J, Gonit M, et al. Role of formulation composition in folate receptor-targeted liposomal doxorubicin delivery to acute myelogenous leukemia cells. Mol Pharm 2007;4:707-12
  • Pan XQ, Lee RJ. In vivo antitumor activity of folate receptor-targeted liposomal daunorubicin in a murine leukemia model. Anticancer Res 2005;25:343-6
  • Ni S, Stephenson SM, Lee RJ. Folate receptor targeted delivery of liposomal daunorubicin into tumor cells. Anticancer Res 2002;22:2131-5
  • Sudimack JJ, Guo W, Tjarks W, et al. A novel pH-sensitive liposome formulation containing oleyl alcohol. Biochim Biophys Acta 2002;1564:31-7
  • Wu J, Liu Q, Lee RJ. A folate receptor-targeted liposomal formulation for paclitaxel. Int J Pharm 2006;316:148-53
  • Sudimack JJ, Adams D, Rotaru J, et al. Folate receptor-mediated liposomal delivery of a lipophilic boron agent to tumor cells in vitro for neutron capture therapy. Pharm Res 2002;19:1502-8
  • Stephenson SM, Yang W, Stevens PJ, et al. Folate receptor-targeted liposomes as possible delivery vehicles for boron neutron capture therapy. Anticancer Res 2003;23:3341-5
  • Stevens PJ, Sekido M, Lee RJ. Synthesis and evaluation of a hematoporphyrin derivative in a folate receptor-targeted solid-lipid nanoparticle formulation. Anticancer Res 2004;24:161-5
  • Chiu SJ, Marcucci G, Lee RJ. Efficient delivery of an antisense oligodeoxyribonucleotide formulated in folate receptor-targeted liposomes. Anticancer Res 2006;26:1049-56
  • Goren D, Horowitz AT, Tzemach D, et al. Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump. Clin Cancer Res 2000;6:1949-57
  • Turk MJ, Waters DJ, Low PS. Folate-conjugated liposomes preferentially target macrophages associated with ovarian carcinoma. Cancer Lett 2004;213:165-72
  • Stevens PJ, Sekido M, Lee RJ. A folate receptor-targeted lipid nanoparticle formulation for a lipophilic paclitaxel prodrug. Pharm Res 2004;21:2153-7
  • Park EK, Lee SB, Lee YM. Preparation and characterization of methoxy poly(ethylene glycol)/poly(epsilon-caprolactone) amphiphilic block copolymeric nanospheres for tumor-specific folate-mediated targeting of anticancer drugs. Biomaterials 2005;26:1053-61
  • Kim SH, Jeong JH, Mok H, et al. Folate receptor targeted delivery of polyelectrolyte complex micelles prepared from ODN-PEG-folate conjugate and cationic lipids. Biotechnol Prog 2007;23:232-7
  • Seow WY, Xue JM, Yang YY. Targeted and intracellular delivery of paclitaxel using multi-functional polymeric micelles. Biomaterials 2007;28:1730-40
  • Yoo HS, Park TG. Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA-PEG block copolymer. J Control Rel 2001;70:63-70
  • Douglas JT, Rogers BE, Rosenfeld ME, et al. Targeted gene delivery by tropism-modified adenoviral vectors. Nat Biotechnol 1996;14:1574-8
  • Kim YK, Choi JY, Yoo MK, et al. Receptor-mediated gene delivery by folate-PEG-baculovirus in vitro. J Biotechnol 2007;131:353-61
  • Gottschalk S, Cristiano RJ, Smith LC, Woo SL. Folate receptor mediated DNA delivery into tumor cells: potosomal disruption results in enhanced gene expression. Gene Ther 1994;1:185-91
  • Mislick KA, Baldeschwieler JD, Kayyem JF, Meade TJ. Transfection of folate-polylysine DNA complexes: evidence for lysosomal delivery. Bioconjug Chem 1995;6:512-5
  • Ward CM, Pechar M, Oupicky D, et al. Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate-mediated targeting in vitro and prolonged plasma circulation in vivo. J Gene Med 2002;4:536-47
  • Guo W, Lee RL. Receptor-targeted gene delivery via folate-conjugated polyethylenimine. AAPS Pharm Sci 1999;1:E19
  • Benns JM, Mahato RI, Kim SW. Optimization of factors influencing the transfection efficiency of folate-PEG-folate-graft-polyethylenimine. J Control Rel 2002;79:255-69
  • Chan P, Kurisawa M, Chung JE, et al. Synthesis and characterization of chitosan-g-poly(ethylene glycol)-folate as a non-viral carrier for tumor-targeted gene delivery. Biomaterials 2007;28:540-9
  • van Steenis JH, van Maarseveen EM, Verbaan FJ, et al. Preparation and characterization of folate-targeted PEG-coated pDMAEMA-based polyplexes. J Control Rel 2003;87:167-76
  • Xu L, Pirollo KF, Chang EH. Tumor-targeted p53-gene therapy enhances the efficacy of conventional chemo/radiotherapy. J Control Rel 2001;74:115-28
  • Hofland HE, Masson C, Iginla S, et al. Folate-targeted gene transfer in vivo. Mol Ther 2002;5:739-44
  • Dauty E, Remy JS, Zuber G, Behr JP. Intracellular delivery of nanometric DNA particles via the folate receptor. Bioconjug Chem 2002;13:831-9
  • Lee RJ, Huang L. Lipidic vector systems for gene transfer. Crit Rev Ther Drug Carrier Syst 1997;14:173-206
  • Reddy JA, Abburi C, Hofland H, et al. Folate-targeted, cationic liposome-mediated gene transfer into disseminated peritoneal tumors. Gene Ther 2002;9:1542-50
  • Lee RJ, Huang L. Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer. J Biol Chem 1996;271:8481-7
  • Gosselin MA, Guo W, Lee RJ. Incorporation of reversibly cross-linked polyplexes into LPDII vectors for gene delivery. Bioconjug Chem 2002;13:1044-53
  • Shi G, Guo W, Stephenson SM, et al. Efficient intracellular drug and gene delivery using folate receptor-targeted pH-sensitive liposomes composed of cationic/anionic lipid combinations. J Control Rel 2002;80:309-19
  • Reddy JA, Low PS. Enhanced folate receptor mediated gene therapy using a novel pH-sensitive lipid formulation. J Control Rel 2000;64:27-37
  • Reddy JA, Dean D, Kennedy MD, et al. Optimization of folate-conjugated liposomal vectors for folate receptor-mediated gene therapy. J Pharm Sci 1999;88:1112-8
  • Wang S, Lee RJ, Cauchon G, et al. Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol. Proc Natl Acad Sci USA 1995;92:3318-22
  • Leamon CP, Cooper SR, Hardee GE. Folate-liposome-mediated antisense oligodeoxynucleotide targeting to cancer cells: evaluation in vitro and in vivo. Bioconjug Chem 2003;14:738-47
  • Rait AS, Pirollo KF, Ulick D, et al. HER-2-targeted antisense oligonucleotide results in sensitization of head and neck cancer cells to chemotherapeutic agents. Ann NY Acad Sci 2003;1002:78-89
  • Rait AS, Pirollo KF, Xiang L, et al. Tumor-targeting, systemically delivered antisense HER-2 chemosensitizes human breast cancer xenografts irrespective of HER-2 levels. Mol Med 2002;8:475-86
  • Zhou W, Yuan X, Wilson A, et al. Efficient intracellular delivery of oligonucleotides formulated in folate receptor-targeted lipid vesicles. Bioconjug Chem 2002;13:1220-5
  • Kim SH, Mok H, Jeong JH, et al. Comparative evaluation of target-specific GFP gene silencing efficiencies for antisense ODN, synthetic siRNA, and siRNA plasmid complexed with PEI-PEG-FOL conjugate. Bioconjug Chem 2006;17:241-4

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.