Advanced search
Publication Cover
Expert Opinion on Drug Delivery Volume 5, 2008 - Issue 4
Submit an article Journal homepage
849
Views
60
CrossRef citations to date
0
Altmetric
Review

Aiming for the heart: targeted delivery of drugs to diseased cardiac tissue

Robert C Scott Temple University, Department of Mechanical Engineering, 1947 North 12th St., Philadelphia, PA 19122, USA +1 215 204 4644; +1 215 204 4956; [email protected]
,
Deborah Crabbe Temple University, Department of Medicine, 1947 North 12th St., Philadelphia, PA 19122, USA
, MD,
Barbara Krynska Temple University, Department of Neurology, 1947 North 12th St., Philadelphia, PA 19122, USA
, PhD,
Ramin Ansari Temple University, Department of Neurology, 1947 North 12th St., Philadelphia, PA 19122, USA
, MD &
Mohammad F Kiani Temple University, Department of Mechanical Engineering, 1947 North 12th St., Philadelphia, PA 19122, USA +1 215 204 4644; +1 215 204 4956; [email protected]; Temple University, Department of Radiation Oncology, 1947 North 12th St., Philadelphia, PA 19122, USA
, PhD
Pages 459-470 | Published online: 21 Apr 2008

Bibliography

  • Rosamond W, Flegal K, Furie K, et al. Heart disease and stroke statistics – 2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2008;117(4):e25-146
  • Cohn JN, Ferrari R, Sharpe N. Cardiac remodelling – concepts and clinical implications: a consensus paper from an international forum on cardiac remodelling. Behalf of an International Forum on Cardiac Remodelling. J Am Coll Cardiol 2000;35(3):569-82
  • Bialik S, Geenen DL, Sasson IE, et al. Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53. J Clin Invest 1997;100(6):1363-72
  • Cleutjens JP, Blankesteijn WM, Daemen MJ, Smits JF. The infarcted myocardium: simply dead tissue, or a lively target for therapeutic interventions? Cardiovasc Res 1999;44(2):232-41
  • Toth A, Jeffers JR, Nickson P, et al. Targeted deletion of Puma attenuates cardiomyocyte death and improves cardiac function during ischemia-reperfusion. Am J Physiol Heart Circ Physiol 2006;291(1):H52-60
  • Satoh M, Shimoda Y, Akatsu T, et al. Elevated circulating levels of heat shock protein 70 are related to systemic inflammatory reaction through monocyte Toll signal in patients with heart failure after acute myocardial infarction. Eur J Heart Fail 2006;8(8):810-5
  • Gowda A, Yang CJ, Asimakis GK, et al. Cardioprotection by local heating: improved myocardial salvage after ischemia and reperfusion. Ann Thorac Surg 1998;65(5):1241-7
  • Sun Y, Kiani MF, Postlethwaite AE, Weber KT. Infarct scar as living tissue. Basic Res Cardiol 2002; 97(5):343-7
  • Urbanek K, Quaini F, Tasca G, et al. Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. Proc Natl Acad Sci USA 2003;100(18):10440-5
  • Urbanek K, Torella D, Sheikh F, et al. Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure. Proc Natl Acad Sci USA 2005;102(24):8692-7
  • Sun Y, Weber KT. Infarct scar: a dynamic tissue. Cardiovasc Res 2000;46(2):250-6
  • Wang B, Ansari R, Sun Y, et al. The scar neovasculature after myocardial infarction in rats. Am J Physiol Heart Circ Physiol 2005;289(1):H108-13
  • Cannon CP, Weintraub WS, Demopoulos LA, et al. Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban. N Engl J Med 2001;344(25):1879-87
  • Adorisio R, De LL, Rossi J, Gheorghiade M. Pharmacological treatment of chronic heart failure. Heart Fail Rev 2006;11(2):109-23
  • Beltrami AP, Urbanek K, Kajstura J, et al. Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med 2001;344(23):1750-7
  • Engel FB, Schebesta M, Duong MT, et al. p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes Dev 2005;19(10):1175-87
  • Nishiya D, Enomoto S, Omura T, et al. The long-acting Ca2+-channel blocker azelnidipine prevents left ventricular remodelling after myocardial infarction. J Pharmacol Sci 2007;103(4):391-7
  • Vertesaljai M, Piroth Z, Fontos G, et al. Drugs, gene transfer, signaling factors: a bench to bedside approach to myocardial stem cell therapy. Heart Fail Rev 2007
  • Tomita S, Li RK, Weisel RD, et al. Autologous transplantation of bone marrow cells improves damaged heart function. Circulation 1999;100(19 Suppl):II247-56
  • Jackson KA, Majka SM, Wang H, et al. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest 2001;107(11):1395-402
  • Kudo M, Wang Y, Wani MA, et al. Implantation of bone marrow stem cells reduces the infarction and fibrosis in ischemic mouse heart. J Mol Cell Cardiol 2003;35(9):1113-9
  • Orlic D, Kajstura J, Chimenti S, et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci USA 2001;98(18):10344-9
  • Fukuda K. Use of adult marrow mesenchymal stem cells for regeneration of cardiomyocytes. Bone Marrow Transplant 2003;32(Suppl 1):S25-7
  • Schachinger V, Erbs S, Elsasser A, et al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med 2006;355(12):1210-21
  • Assmus B, Honold J, Schachinger V, et al. Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med 2006;355(12):1222-32
  • Condorelli G, Borello U, De Angelis L, et al. Cardiomyocytes induce endothelial cells to trans-differentiate into cardiac muscle: implications for myocardium regeneration. Proc Natl Acad Sci USA 2001;98(19):10733-8
  • Chien OK. Making a play at regrowing hearts. Science 2006;20(8):34-9
  • Wollert KC. Cell therapy for acute myocardial infarction. Curr Opin Pharmacol 2008
  • Annabi B, Lee YT, Turcotte S, et al. Hypoxia promotes murine bone-marrow-derived stromal cell migration and tube formation. Stem Cells 2003;21(3):337-47
  • Garmy-Susini B, Varner JA. Circulating endothelial progenitor cells. Br J Cancer 2005;93(8):855-8
  • Le Blanc K, Tammik C, Rosendahl K, et al. HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp Hematol 2003;31(10):890-6
  • Matsumoto R, Omura T, Yoshiyama M, et al. Vascular endothelial growth factor-expressing mesenchymal stem cell transplantation for the treatment of acute myocardial infarction. Arterioscler Thromb Vasc Biol 2005;25(6):1168-73
  • Tang YL, Tang Y, Zhang YC, et al. Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector. J Am Coll Cardiol 2005;46(7):1339-50
  • Suzuki K, Murtuza B, Smolenski RT, et al. Cell transplantation for the treatment of acute myocardial infarction using vascular endothelial growth factor-expressing skeletal myoblasts. Circulation 2001;104(12 Suppl 1):I207-12
  • Eriksson U, Alitalo K. VEGF receptor 1 stimulates stem-cell recruitment and new hope for angiogenesis therapies. Nat Med 2002;8(8):775-7
  • Coultas L, Chawengsaksophak K, Rossant J. Endothelial cells and VEGF in vascular development. Nature 2005;438(7070):937-45
  • Losordo DW, Vale PR, Symes JF, et al. Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia. Circulation 1998;98(25):2800-4
  • Machens HG, Salehi J, Weich H, et al. Angiogenic effects of injected VEGF165 and sVEGFR-1 (sFLT-1) in a rat flap model. J Surg Res 2003;111(1):136-42
  • Wang B, Scott RC, Pattillo CB, et al. Modelling oxygenation and selective delivery of drug carriers post-myocardial infarction. Adv Exp Med Biol 2008;614:333-43
  • Wang B, Scott RC, Pattillo CB, et al. Microvascular transport model predicts oxygenation changes in the infarcted heart after treatment. Am J Physiol Heart Circ Physiol 2007;293(6):H3732-9
  • Weber KT, Gerling IC, Kiani MF, et al. Aldosteronism in heart failure: a proinflammatory/fibrogenic cardiac phenotype. Search for biomarkers and potential drug targets. Curr Drug Targets 2003;4(6):505-16
  • Carmeliet P. Basic concepts of (Myocardial) angiogenesis: role of vascular endothelial growth factor and angiopoietin. Curr Interv Cardiol Rep 1999;1(4):322-35
  • Holash J, Wiegand SJ, Yancopoulos GD. New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene 1999;18(38):5356-62
  • Pettersson A, Nagy JA, Brown LF, et al. Heterogeneity of the angiogenic response induced in different normal adult tissues by vascular permeability factor/vascular endothelial growth factor. Lab Invest 2000;80(1):99-115
  • Orive G, Hernandez RM, Rodriguez GA, et al. Drug delivery in biotechnology: present and future. Curr Opin Biotechnol 2003;14(6):659-64
  • Dunehoo AL, Anderson M, Majumdar S, et al. Cell adhesion molecules for targeted drug delivery. J Pharm Sci 2006;95(9):1856-72
  • Pattillo CB, Sari-Sarraf F, Nallamothu R, et al. Targeting of the antivascular drug combretastatin to irradiated tumors results in tumor growth delay. Pharm Res 2005;22(7):1117-20
  • Jones SP, Trocha SD, Strange MB, et al. Leukocyte and endothelial cell adhesion molecules in a chronic murine model of myocardial reperfusion injury. Am J Physiol Heart Circ Physiol 2000;279(5):H2196-201
  • Lestini BJ, Sagnella SM, Xu Z, et al. Surface modification of liposomes for selective cell targeting in cardiovascular drug delivery. J Control Rel 2002;78(1-3):235-47
  • Torchilin VP. Recent approaches to intracellular delivery of drugs and DNA and organelle targeting. Ann Rev Biomed Eng 2006
  • Lindner JR, Kaul S. Delivery of drugs with ultrasound. Echocardiography 2001;18(4):329-37
  • Newman CM, Bettinger T. Gene therapy progress and prospects: ultrasound for gene transfer. Gene Ther 2007;14(6):465-75
  • Vancraeynest D, Havaux X, Pouleur AC, et al. Myocardial delivery of colloid nanoparticles using ultrasound-targeted microbubble destruction. Eur Heart J 2006;27(2):237-45
  • Torchilin VP. Targeted polymeric micelles for delivery of poorly soluble drugs. Cell Mol Life Sci 2004;61(19-20):2549-59
  • Lukyanov AN, Hartner WC, Torchilin VP. Increased accumulation of PEG-PE micelles in the area of experimental myocardial infarction in rabbits. J Control Rel 2004;94(1):187-93
  • Suzuki K, Murtuza B, Smolenski RT, et al. Overexpression of interleukin-1 receptor antagonist provides cardioprotection against ischemia-reperfusion injury associated with reduction in apoptosis. Circulation 2001;104(12 Suppl 1):I308-I3
  • Torchilin VP, Khaw BA, Smirnov VN, Haber E. Preservation of antimyosin antibody activity after covalent coupling to liposomes. Biochem Biophys Res Commun 1979;89(4):1114-9
  • Liang W, Levchenko T, Khaw BA, Torchilin V. ATP-containing immunoliposomes specific for cardiac myosin. Curr Drug Deliv 2004;1(1):1-7
  • Torchilin VP, Klibanov AL, Huang L, et al. Targeted accumulation of polyethylene glycol-coated immunoliposomes in infarcted rabbit myocardium. FASEB J 1992;6(9):2716-9
  • Klibanov AL, Khaw BA, Nossiff N, et al. Targeting of macromolecular carriers and liposomes by antibodies to myosin heavy chain. Am J Physiol 1991;261(4 Suppl):60-5
  • Khaw BA, DaSilva J, Hartner WC. Cytoskeletal-antigen specific immunoliposome-targeted in vivo preservation of myocardial viability. J Control Rel 2007;120(1-2):35-40
  • Sun B, Fan H, Honda T, et al. Activation of NF kappa B and expression of ICAM-1 in ischemic-reperfused canine myocardium. J Mol Cell Cardiol 2001;33(1):109-19
  • Villanueva FS, Lu E, Bowry S, et al. Myocardial ischemic memory imaging with molecular echocardiography. Circulation 2007;115(3):345-52
  • Scott RC, Wang B, Nallamothu R, et al. Targeted delivery of antibody conjugated liposomal drug carriers to rat myocardial infarction. Biotechnol Bioeng 2007;96(4):795-802
  • Arai M, Masui Y, Goldschmidt-Clermont P, et al. P-selectin inhibition prevents early neutrophil activation but provides only modest protection against myocardial injury in dogs with ischemia and forty-eight hours reperfusion. J Am Coll Cardiol 1999;34(1):280-8
  • Hayward R, Campbell B, Shin YK, et al. Recombinant soluble P-selectin glycoprotein ligand-1 protects against myocardial ischemic reperfusion injury in cats. Cardiovasc Res 1999;41(1):65-76
  • Fukushima S, Coppen SR, Varela-Carver A, et al. A novel strategy for myocardial protection by combined antibody therapy inhibiting both P-selectin and intercellular adhesion molecule-1 via retrograde intracoronary route. Circulation 2006;114(1 Suppl):I251-6
  • Sakuma T, Sari I, Goodman CN, et al. Simultaneous integrin alphavbeta3 and glycoprotein IIb/IIIa inhibition causes reduction in infarct size in a model of acute coronary thrombosis and primary angioplasty. Cardiovasc Res 2005;66(3):552-61
  • Murohara T, Margiotta J, Phillips LM, et al. Cardioprotection by liposome-conjugated sialyl Lewisx-oligosaccharide in myocardial ischaemia and reperfusion injury. Cardiovasc Res 1995;30(6):965-74
  • Chen S, Shohet RV, Bekeredjian R, et al. Optimization of ultrasound parameters for cardiac gene delivery of adenoviral or plasmid deoxyribonucleic acid by ultrasound-targeted microbubble destruction. J Am Coll Cardiol 2003;42(2):301-8
  • Chatterjee D, Jain P, Sarkar K. Ultrasound-mediated destruction of contrast microbubbles used for medical imaging and drug delivery. Physics Fluids 2005;17(10)
  • Shohet RV, Chen S, Zhou YT, et al. Echocardiographic destruction of albumin microbubbles directs gene delivery to the myocardium. Circulation 2000;101(22):2554-6
  • Zhigang W, Zhiyu L, Haitao R, et al. Ultrasound-mediated microbubble destruction enhances VEGF gene delivery to the infarcted myocardium in rats. Clin Imaging 2004;28(6):395-8
  • Korpanty G, Chen S, Shohet RV, et al. Targeting of VEGF-mediated angiogenesis to rat myocardium using ultrasonic destruction of microbubbles. Gene Ther 2005;12(17):1305-12
  • Woo YJ, Panlilio CM, Cheng RK, et al. Myocardial regeneration therapy for ischemic cardiomyopathy with cyclin A2. J Thorac Cardiovasc Surg 2007;133(4):927-33
  • Okubo S, Wildner O, Shah MR, et al. Gene transfer of heat-shock protein 70 reduces infarct size in vivo after ischemia/reperfusion in the rabbit heart. Circulation 2001;103(6):877-81
  • Jayasankar V, Bish LT, Pirolli TJ, et al. Local myocardial overexpression of growth hormone attenuates postinfarction remodelling and preserves cardiac function. Ann Thorac Surg 2004;77(6):2122-9
  • Pleger ST, Most P, Boucher M, et al. Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue. Circulation 2007;115(19):2506-15
  • Laguens R, Cabeza MP, Vera JG, et al. Entrance in mitosis of adult cardiomyocytes in ischemic pig hearts after plasmid-mediated rhVEGF165 gene transfer. Gene Ther 2002;9(24):1676-81
  • Sun L, Cui M, Wang Z, et al. Mesenchymal stem cells modified with angiopoietin-1 improve remodelling in a rat model of acute myocardial infarction. Biochem Biophys Res Commun 2007;357(3):779-84
  • Scheinowitz M, Kotlyar A, Zimand S, et al. Basic fibroblast growth factor induces myocardial hypertrophy following acute infarction in rats. Exp Physiol 1998;83(5):585-93
  • Sakakibara Y, Tambara K, Sakaguchi G, et al. Toward surgical angiogenesis using slow-released basic fibroblast growth factor. Eur J Cardiothorac Surg 2003;24(1):105-11
  • Hsieh PC, MacGillivray C, Gannon J, et al. Local controlled intramyocardial delivery of platelet-derived growth factor improves postinfarction ventricular function without pulmonary toxicity. Circulation 2006;114(7):637-44
  • Davis ME, Hsieh PC, Takahashi T, et al. Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. Proc Natl Acad Sci USA 2006;103(21):8155-60
  • Klibanov AL. Ultrasound molecular imaging with targeted microbubble contrast agents. J Nucl Cardiol 2007;14(6):876-84
  • Alkan-Onyuksel H, Demos SM, Lanza GM, et al. Development of inherently echogenic liposomes as an ultrasonic contrast agent. J Pharm Sci 1996;85(5):486-90
  • Bull JL. The application of microbubbles for targeted drug delivery. Expert Opin Drug Deliv 2007;4(5):475-93
  • Villanueva FS, Jankowski RJ, Klibanov S, et al. Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells. Circulation 1998;98:1-5
  • Villanueva FS, Wagner WR, Vannan MA, Narula J. Targeted ultrasound imaging using microbubbles. Cardiol Clin 2004;22(2):283-98, vii
  • Quaia E. Microbubble ultrasound contrast agents: an update. Eur Radiol 2007;17(8):1995-2008
  • Weller GE, Lu E, Csikari MM, et al. Ultrasound imaging of acute cardiac transplant rejection with microbubbles targeted to intercellular adhesion molecule-1. Circulation 2003;108(2):218-24
  • Kondo I, Ohmori K, Oshita A, et al. Leukocyte-targeted myocardial contrast echocardiography can assess the degree of acute allograft rejection in a rat cardiac transplantation model. Circulation 2004;109(8):1056-61
  • Christiansen JP, Leong-Poi H, Klibanov AL, et al. Noninvasive imaging of myocardial reperfusion injury using leukocyte-targeted contrast echocardiography. Circulation 2002;105(15):1764-7
  • Lindner JR, Coggins MP, Kaul S, et al. Microbubble persistence in the microcirculation during ischemia/reperfusion and inflammation is caused by integrin- and complement-mediated adherence to activated leukocytes. Circulation 2000;101(6):668-75
  • Demos SM, kan-Onyuksel H, Kane BJ, et al. In vivo targeting of acoustically reflective liposomes for intravascular and transvascular ultrasonic enhancement. J Am Coll Cardiol 1999;33(3):867-75
  • Hamilton AJ, Huang SL, Warnick D, et al. Intravascular ultrasound molecular imaging of atheroma components in vivo. J Am Coll Cardiol 2004;43(3):453-60
  • Zou X, Shinde PV, Dagia NM, et al. PSGL-1 derived from human neutrophils is a high-efficiency ligand for endothelium-expressed E-selectin under flow. Am J Physiol Cell Physiol 2005;289(2):C415-24
  • Rinko LJ, Lawrence MB, Guilford WH. The molecular mechanics of P- and L-selectin lectin domains binding to PSGL-1. Biophys J 2004;86(1 Pt 1):544-54
  • Park EY, Smith MJ, Stropp ES, et al. Comparison of PSGL-1 microbead and neutrophil rolling: microvillus elongation stabilizes P-selectin bond clusters. Biophys J 2002;82(4):1835-47
  • Sakhalkar HS, Dalal MK, Salem AK, et al. Leukocyte-inspired biodegradable particles that selectively and avidly adhere to inflamed endothelium in vitro and in vivo. Proc Natl Acad Sci USA 2003;100(26):15895-900
  • Lindner JR, Song J, Christiansen J, et al. Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Circulation 2001;104(17):2107-12
  • Meoli DF, Sadeghi MM, Krassilnikova S, et al. Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction. J Clin Invest 2004;113(12):1684-91
  • Epstein FH. MRI of left ventricular function. J Nucl Cardiol 2007;14(5):729-44
  • Nahrendorf M, Jaffer FA, Kelly KA, et al. Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. Circulation 2006;114(14):1504-11
  • Thimister PW, Hofstra L, Liem IH, et al. In vivo detection of cell death in the area at risk in acute myocardial infarction. J Nucl Med 2003;44(3):391-6
  • Arayne MS, Sultana N, Qureshi F. Review: nanoparticles in delivery of cardiovascular drugs. Pak J Pharm Sci 2007;20(4):340-8
  • Hashida M, Kawakami S, Yamashita F. Lipid carrier systems for targeted drug and gene delivery. Chem Pharm Bull (Tokyo) 2005;53(8):871-80
  • Lian T, Ho RJ. Trends and developments in liposome drug delivery systems. J Pharm Sci 2001;90(6):667-80
  • Moghimi SM, Hunter AC, Murray JC. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol Rev 2001;53(2):283-318
  • Ding BS, Dziubla T, Shuvaev VV, et al. Advanced drug delivery systems that target the vascular endothelium. Mol Interv 2006;6(2):98-112
  • Tomalia DA, Reyna LA, Svenson S. Dendrimers as multi-purpose nanodevices for oncology drug delivery and diagnostic imaging. Biochem Soc Trans 2007;35(Pt 1):61-7
  • El Sayed M, Kiani MF, Naimark MD, et al. Extravasation of poly(amidoamine) (PAMAM) dendrimers across microvascular network endothelium. Pharm Res 2001;18(1):23-8
  • Eniola AO, Hammer DA. Characterization of biodegradable drug delivery vehicles with the adhesive properties of leukocytes II: effect of degradation on targeting activity. Biomaterials 2005;26(6):661-70
  • Bloch SH, Dayton PA, Ferrara KW. Targeted imaging using ultrasound contrast agents. Progress and opportunities for clinical and research applications. IEEE Eng Med Biol Mag 2004;23(5):18-29
  • Porter TR. Cardiovascular imaging of remote myocardial ischemia: detecting a molecular trace of evidence left behind. Circulation 2007;115(3):292-3
  • Hiasa K, Egashira K, Kitamoto S, et al. Bone marrow mononuclear cell therapy limits myocardial infarct size through vascular endothelial growth factor. Basic Res Cardiol 2004;99(3):165-72

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.