Advanced search
Publication Cover
Expert Opinion on Drug Delivery Volume 5, 2008 - Issue 5
Submit an article Journal homepage
472
Views
38
CrossRef citations to date
0
Altmetric
Reviews

Target-specific drug release to the colon

Sanjay K Jain Professor in Pharmaceutics, Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour Vishwavidyalaya, Sagar-470 003 (MP), India +91 942 517 2184; +91 758 222 5782; +91 758 226 4236; [email protected]
&
Anekant Jain Senior Research Fellow-ICMR, Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya, Sagar-470 003, (MP), INDIA
Pages 483-498 | Published online: 20 May 2008

Bibliography

  • Ciftci K. Alternative approaches to the treatment of colon cancer. Eur J Pharm Biopharm 1996;42:160-70
  • Hanuer SB. Inflammatory bowel disease. N Engl J Med 1996;334:841-8
  • Davis SS. Overcoming barriers to the oral administration of peptide drugs. Trends Pharm Sci 1990;11:353-5
  • Van den Mooter G, Kinget R. Oral colon-specific drug delivery: a review. Drug Deliv 1995;2:81-93
  • Ashford M, Fell JT, Attwood D, et al. An evaluation of pectin as a carrier for drug targeting to the colon. J Control Rel 1993:26:213
  • Devereux JE, Newton JM, Short MB. The influence of density on the gastrointestinal transit of pellets. J Pharm Pharmacol 1990;42:500-1
  • Hunter E, Fell JT, Sharma H. The gastric emptying of pellets contained in hard gelatin capsules. Drug Dev Ind Pharm 1982;8:751-7
  • Meier R, Beglinger C, Dederding JP, et al. Influence of age, gender, hormonal status and smoking habits on colonic transit time. Neurogastroenterol Motil 1995;7:235-8
  • Price JMC, Davis SS, Sparrow RA, Wilding IR. The effect of meal composition on the gastrocolonic response: implications for drug delivery to the colon. Pharm Res 1993;10:722-6
  • Kaus LC, Fell JT, Sharma H, Taylor DC. On the intestinal transit of a single non-disintegrating object. Int J Pharm 1984;14:143-8
  • Hinton JM, Lennard-Jonnes JE, Young AC. A new method for studying gut transit times using radio-opaque markers. Gut 1969;10:842
  • Hollander D. Intestinal permeability, leaky gut, and intestinal disorders. Curr Gastroenterol Rep 1999;1(5):410-6
  • Ghosh S, Shand A, Ferguson A. Ulcerative colitis. BMJ 2000;320(7242):1119-23
  • Friend DR. Issues in oral administration of locally acting glucocorticosteroids for treatment of inflammatory bowel disease. Aliment Pharmacol Ther 1998;12(7):591-603
  • Ilyas M, Straub J, Tomlinson IP, Bodmer WF. Genetic pathways in colorectal and other cancers. Eur J Cancer 1999;35(14):1986-2002
  • El-Salhy M, Sandstrom O. How age changes the content of neuroendocrine peptides in the murine gastrointestinal tract. Gerontology 1999;45(1):17-22
  • Longrace TA, Fenoglio-Preiser CM. Value of colorectal biopsies. In: Phillips SF, Pemberton JH, Shorter RG, editors, The large intestine, physiology, pathophysiology and disease. New York: Raven; 1991
  • Smith AN. Diverticular disease of the colon. In: Phillips SF, Pemberton JH, Shorter RG, editors, The large intestine, physiology, pathophysiology and disease. New York: Raven; 1991
  • Macfarlane GT, Gibson GR, Cummings JH. Comparison of fermentation reactions in different regions of human colon. J Appl Bacteriol 1992;72:57-64
  • Reddy SM, Sinha VR, Reddy DS. Novel oral colon-specific drug delivery systems for pharmacotherapy of peptide and nonpeptide drugs. Drugs Today 1999;35:537-80
  • Mackay M, Tomlinson E. Colonic delivery of therapeutic peptides and proteins. In: Bieck P, editor, Colonic drug absorption and metabolism. New York: Marcel Dekker; 1993
  • Atchison JA, Grizzle WE, Pillion DJ. Colonic absorption of insulin. An in vitro and in vivo evaluation. J Pharmacol Exp Ther 1989;248:567-72
  • Fara JW. Colonic drug absorption and metabolism. In: Prescott LF, Nimmo WS, editors, Novel drug delivery and its therapeutic application. Chichester: Wiley; 1989
  • Cummings JH, MacFarlane GT. The control and consequences of bacterial fermentation in the human colon. J Appl Bacterial 1991;70:443-59
  • Gorbach SL. Intestinal flora. Gastroenterology 1971;60:1110-29
  • Salyers AA. Bacteroides of the lower intestinal tract. Ann Rev Microbiol 1984;38:293-313
  • Cooke EM. A quantitative comparison of the fecal flora of patients with ulcerative colitis and that of normal persons. J Pathol Bacteriol 1967;9:439-44
  • Gorbach SL, Nahas L, Plaut AG, et al. Studies of intestinal microflora. V. Fecal microbial ecology to severity of disease and chemotherapy. Gastroenterology 1968;54:575-87
  • Van der Wiel-Korstanje JA, Winkler KC. The fecal flora in ulcerative colitis. J Med Microbiol 1974;8:491-501
  • Ruseler-van Embden JG, Both-Patoir HC. Anaerobic gram negative fecal flora in patients with Crohn's disease and healthy subjects. Ant Leeuwen 1983;49:125-32
  • Ruseler-van Embden JG, Van Lieshout LM. Increased fecal glycosidases in patients with Crohn's disease. Digestion 1987;37:43-50
  • Yamni J, Mizon C, Capon C, et al. Decreased fecal exoglycosidase activities identify a subset of patients with active Crohn's disease. Clin Sci 1992;83:409-15
  • Canva-Delcambre V, Soenen V, Mizon A, et al. L'activite beta-galactosidaseique fecale est diminuee a cours de la maladie de Crohn. Gastroenterol Clin Sci 1993;17:718-22
  • Scheline RR. Metabolism of foreign compounds by gastrointestinal microorganisms. Pharmacol Rev 1973;25:451-523
  • Lloyd AW, Martin GP, Soozandehfar SH. Azopolymers: a means of colon specific drug delivery? Int J Pharm 1994;106:255-60
  • Evans DF, Pye G, Bramley R, et al. Measurement of gastrointestinal pH profiles in normal ambulant human subjects. Gut 1988;29:1035-41
  • Friend DR. Colon-specific drug delivery. Adv Drug Del Rev 1991;7:49
  • Jain A, Gupta Y, Jain SK. Azo-chemistry and its potential for colonic delivery. Crit Rev Ther Drug Carrier Syst 2006;23(5):349-400
  • Friend DR, Tozer TN. Drug glycoside in colon-specific drug delivery. J Control Rel 1992;19:109-20
  • Friend DR, Philips S, McLeod A, Tozer TN. Relative anti-inflammatory effect of oral dexmamethasone-β-D-glucoside and dexamethasone in experimental inflammatory bowel disease in guinea pig. J Pharm Pharmacol 1991;43:353-5
  • Minami K, Hiramaya F, Uekama K. Colon-specific drug delivery based on cyclodextrin prodrug: release behaviour of biphenyl acetic acid form its cyclodextrin conjugates in rat intestinal tract after oral administration. J Pharm Sci 1998;87:715-20
  • Mcleod AD, Feclorak RN, Friend DR, et al. A glucocorticoid prodrug facilitates normal mucosal function in rat colitis without adrenal suppression. Gastroenterology 1994;106:405-13
  • Cui N, Friend DR, Fedorak RN. A Budesonide prodrug accelerates treatment of colitis in rats. Gut 1994;35:1439-46
  • Andersen GH, Robbins FM, Domingues FJ, et al. The utilisation of schardinger dextrins by the rat. Toxicol Appl Pharmacol 1983;5:257-66
  • Antenucci R, Palmer JK. Enzymatic degradation of α and β-cyclodextrins by bacteroids of the human colon. J Agric Food Chem 1984;32:1316-21
  • Gerloczy A, Fonagy A, Keresztes P, et al. Absorption, distribution, excretion and metabolism of orally administered 14C-β-cyclodextrin in rat. Arzneim Forsch Drug Res 1985;35:1042-7
  • Flourie B, Molis C, Achour L, et al. Fate of β-cyclodextrin in the human intestine. J Nutr 1993;123:676-80
  • Harboe E, Larsen C, Johansen M, Olesen HP. Macromolecular prodrugs. XIV. Absorption characteristics of naproxen after oral administration of dextran T-70-naproxen ester prodrugs in pigs. Int J Pharm 1989;53:157-65
  • Nakamura J, Kido M, Nishida K, Sasaki H. Effect of oral pretreatment with antibiotics on the hydrolysis of salicylic acid-tyrosine and salicylic acidmethionine prodrugs in rabbit intestinal microorganisms. Chem Pharm Bull 1992;40:2572-6
  • Schacht E, Callant D, Verstraete W. Synthesis and evaluation of polymeric prodrugs of 5-aminosalicylic acid. Proc Int Symp Contr Rel Bioact Materl 1991;18:686-7
  • Jain A, Gupta Y, Jain SK. Perspectives of biodegradable natural polysaccharides for site-specific drug delivery to the colon. J Pharm Pharm Sci 2007b;10(1):86-128
  • Healey JNC. Enteric coatings and delayed release. In: Hardy JG, Davis SS, Wilson CG, editors. Drug delivery to the gastrointestinal tract. Chichester: Ellis Horwood Limited; 1989. p. 83
  • Agyilirah GA, Banker GS. Polymers for enteric coating applications. In: Tarcha PJ, editor. Polymers for controlled drug delivery. CRC Press: Boca Raton, FL; 1991. p. 39-66
  • Wright JC, Guittard GV. Dosage form for delivering drug at a controlled rate to the intestine and to the colon. US5650170; 1997
  • Murray JNC. Enteric coatings and delayed release. In: Hardy JG, Davis SS, Wilson CG, editors. Drug delivery to the gastrointestinal tract. Chichester: Ellis Horwood Limited. 1989;83
  • Ashford M, Fell JT. Targeting drugs to the colon: delivery systems for oral administration. J Drug Target 1994;2:241-58
  • Dipirio JT, Posey LM, Bowden TA. A pathophysiologic approach. In: Dipirio JT, editor, Pharmacotherapy. New York: Elsevier; 1989. p. 444
  • MacNeil ME, Rashid A, Stevens HNE. Dispensing device. WO9009168; 1990
  • Wilding IR, Hardy JG, Sparrow RA, et al. in vitro evaluation of enteric coated naproxan tablets using γ-scintigraphy. Pharm Res 1992;9:1436-41
  • Binns JS, Stevens HNE, Bakhashaer M, Wilson GG. Colon-targeted release using the Pulsincap delivery system. Int Symp Controlled Rel Bioact Mater 1994;21:260-1
  • Theeuwes F, Guittard GV, Wong PSL. US4904474; 1990
  • Swanson D, Barclay B, Wong P, Theeuwes F. Nifedipine gastro-intestinal therapeutics system. Am J Med 1987;83(Suppl 6B):3
  • Fox DA. Abstracts of the meeting on the oral delivery of proteins, peptides and other biopharmaceutical agents. Wakefield, Mass, USA; 1991
  • Gazzaniga A, Iamartino P, Maffione G, Sangalli ME. Oral delayed release system for colon specific drug delivery. Int J Pharm 1994;108:77-83
  • Gazzaniga A, Bussetti C, Moro L, et al. Time-dependent oral delivery system for colon targeting. STP Pharm Sci 1995;5:83-8
  • Gupta VK, Beckert TE, Price JC. A novel pH- and time-based multi-unit potential colonic drug delivery system. I. Development. Int J Pharm 2001a;213(1-2):83-91
  • Gupta VK, Assmus MW, Beckert TE, Price JC. A novel pH- and time-based multi-unit potential colonic drug delivery system. II. Optimization of multiple response variables. Int J Pharm 2001b;213:93-102
  • Ishibashi T, Hatano H, Kobayashi M, et al. Design and evaluation of a new capsule type dosage form for colon-targeted delivery of drugs. Int J Pharm 1998;168:31-40
  • Fukui E, Miyamura N, Uemura K, Kobayashi M. Preparation of enteric-coated timed release press-coated tablets and evaluation of their function by in vitro and in vivo tests for colon targeting. Int J Pharm 2000;204:7-15
  • Fukui E, Miyamura N, Kobayashi M. An in vitro investigation of the suitability of press-coated tablets with hydroxypropylmethylcellulose acetate succinate (HPMCAS) and hydrophobic additives in the outer shell for colon targeting. J Control Rel 2001;70:97-107
  • Pozzi F, Furlani P, Gazzaiga A, et al. A new oral dosage form for fast and complex release of drug after a predetermined lag time. J Control Rel 1994;31:99-104
  • Niwa K, Takaya T, Morimoto T, Takada I. Preparation and evaluation of a time-controlled release capsule made of ethyl cellulose for colon delivery of drugs. J Drug Target 1995;3:83-9
  • Muraoka M, Hu Z, Shimokawa T, et al. Evaluation of intestinal pressure-controlled colon delivery capsule containing caffeine as a model drug in human volunteers. J Control Rel 1998a;52:119-29
  • Muraoka M, Kimura G, Zhaopeng H, Takada K. Ulcerative colitis – colon delivery of 5-aminosalicylic acid. Nippon Rinsho 1998b;56:788-94
  • Takaya T, Niwa K, Muraoka M, et al. Importance of dissolution process on systemic availability of drugs delivered by colon delivery system. J Control Rel 1998;50:111-22
  • Shibata N, Ohno T, Shimokawa T, et al. Application of pressure-controlled colon delivery capsules to oral administration of glycyrrizin in dogs. J Pharm Pharmacol 2001;53:441-7
  • Sangalli ME, Maroni A, Zema L, et al. in vitro and in vivo evaluation of an oral system for time- and/or site-specific drug delivery. J Control Rel 2001;73:103-10
  • Katsuma M, Watanabe S, Kawai H, et al. Studies on lactulose formulations for colon-specific drug delivery. Int J Pharm 2002;249:33-43
  • Yang L, Watanabe S, Li J, et al. Effect of colonic lactulose availability on the timing of drug release onset in vivo from a unique colon-specific delivery system (CODESTM). Pharm Res 2003;20:429-34
  • Jain Nitin K, Chourasia MK, Jain S, et al. Development and characterization of engineered commensal bacteria for the delivery of enzymes. Ind J Pharm Sci 2003;65:113-21
  • Hope ME, Hold GL, Kain R, et al. Sporadic colorectal cancer – role of the commensal microbiota. FEMS Microbiol Lett 2005;244(1):1-7
  • Gingell R, Walker R. Mechanism of azo reduction by non-specificity of Streptococcus faecalis azo reductase. Xenobiotica 1975;5:563-71
  • Roxon JJ, Ryan AJ, Wright SE. Enzymatic reduction of tartrazine by Proteus vulgaris from rats. Food Cosmet Toxicol 1967;5:645-56
  • Bragger JL, Lloyd AW, Soozandehfar SH, et al. Investigations into the azo reducing activity of a common colonic microorganism. Int J Pharm 1997;157:61-71
  • Larsel GL, Larson JP, Gustafsson JA. Cystein conjugate beta-lyase in the gastrointestinal bacterium Fusobacterium necrophorum. Xenobiotica 1983;13:687-93
  • Schacht E, Wilding IR. Process for the preparation of azo- and/or disulfide-containing polymers. WO9111175; 1996
  • Kimura Y, Kim S, Nishiura A. Polyurethanes. European Patent. EP0398472; 1991
  • Kimura Y, Makita Y, Kumagai T. Degradation of azo-containing polyurethane by the action of intestinal flora: its mechanism and application as a drug delivery. Polymer 1992;33:5294-9
  • Sinha VR, Kumria R. Polysaccharides in colon-specific drug delivery. Int J Pharm 2001;224:19-38
  • Rubinstein A. Natural polysaccharides as targeting tools of drugs to the human colon. Drug Dev Res 2000;50:435-9
  • Vandamme TF, Lenourry A, Charrueaub C, Chaumeilb JC. The use of polysaccharides to target drugs to the colon. Carbohydr Polym 2002;48(3):219-31
  • Chourasia MK, Jain SK. Pharmaceutical approaches to colon-targeted drug delivery systems. J Pharm Pharmaceut Sci 2003;6(1):33-66
  • Molly K, Woestyne V, Verstraete W. Development of a 5-step multichamber reactor as a simulation of the human intestinal microbial ecosystem. Appl Microbiol Biotechnol 1993;39:254-8
  • Schacht E, Gavert A, Kenawy ER. Polymers for colon-specific drug delivery. J Control Rel 1996;39:327-38
  • Kumar RM, Sameti M. Polymeric nanoparticles for drug and gene delivery. In: Nalwa HS, editor. Encyclopedia of nanoscience & nanotechnology. American Scientific Publishers; 2003. p. 1-19
  • Lamprecht A, Ubrich N, Yamamoto H, et al. Biodegradable nanoparticles for the targeted drug delivery in treatment of inflammatory bowel disease. J Pharmacol Exp Ther 2001;299(2):775-81
  • Knutson L, Odlind B, Hullgren R. A new technique for segmental jejunum perfusion in man. Am J Gastroenterol 1989;84:1278
  • Read NW, Janabi AI, Bates MN, Barber DC. The effect of gastrointestinal intubation on the passage of solid meal through the stomach and small intestine in humans. Gastroenterology 1983;84:1568
  • Hirst PH, Houzego PJ, Morgan PN, et al. Ingestible device. US6632216 (2003).
  • Hirst PH, Houzego PJ, Morgan PN, et al. Ingestible device. US7282045 (2007)
  • Harder S, Fuhr U, Beerman D, Staib AH. Ciprofloxacin absorption in different regions of the gastrointestinal tract. Investigations with the hf-capsule. Brit J Clin Pharmacol 1990;30(1):35
  • Staib AH, Loew D, Harder S, et al. Measurement of theophylline absorption from different regions of the gastrointestinal tract using a remote controlled drug delivery device. Eur J Cli Pharmacol 1986;30(6):691
  • Schentag JJ, Andrea DT. Telemetry capsule and process. US Patent. US5279607; 1994
  • Lambert A, Vaxman F, Crenner F, et al. Autonomous telemetric capsule to explore the small bowel. Med Biol Eng Comput 1991;29:191-6
  • Gardner D, Casper R, Leith F, Wilding IR. The InteliSiteTM capsule: a new easy to use approach for assessing regional drug absorption from the gastrointestinal tract. Pharm Tech 1997;21:82
  • Hawksworth G, Drasar BS, Hill MJ. Intestinal bacteria and the hydrolysis of glycosidic bonds. J Med Microbiol 1971;155:451-9
  • Raghavan CV, Muthulingam C, Jenita JA, Ravi TK. An in vitro and in vivo investigation into the suitability of bacterially triggered delivery system for colon targeting. Chem Pharm Bull 2002;50:892-5
  • Rubinstein A, Radai R, Ezra M, et al. in vitro evaluation of calcium pectinate: a potential colon-specific drug delivery carrier. Pharm Res 1993;10:258-63
  • Van den Mooter G, Samyn C, Kinget R. The relation between swelling properties and enzymatic degradation of azo polymers designed for colon-specific drug delivery. Pharm Res 1994;11:1737-41
  • Stephen AM, Cummings JH. The microbial contribution to human faecal mass. J Med Microbiol 1980;13:45-56
  • Moore WE, Cato EP, Holdeman LV. Some current concepts in intestinal bacteriology. Am J Clin Nutr 1978;31:S33-42
  • Siew LF, Man SM, Newton JM, Basit AW. Amylose formulations for drug delivery to the colon: a comparison of two fermentation models to assess colonic targeting performance in vitro. Int J Pharm 2004;273:129-34

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.