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Review

Biodegradable polymeric nanocarriers for pulmonary drug delivery

, PhD, , , PhD & , PhD
Pages 629-639 | Published online: 05 Jun 2008

Bibliography

  • Pison U, Welte T, Giersig M, Groneberg DA. Nanomedicine for respiratory diseases. Eur J Pharmacol 2006;533:341-50
  • Sung JC, Pulliam BL, Edwards DA. Nanoparticles for drug delivery to the lungs. Trends Biotechnol 2007;25:563-70
  • Sakagami M. in vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery. Adv Drug Deliv Rev 2006;58:1030-60
  • Scheuch G, Kohlhaeufl MJ, Brand P, Siekmeier R. Clinical perspectives on pulmonary systemic and macromolecular delivery. Adv Drug Deliv Rev 2006;58:996-1008
  • Shoyele SA, Cawthorne S. Particle engineering techniques for inhaled biopharmaceuticals. Adv Drug Deliv Rev 2006;58:1009-29
  • Steimer A, Haltner E, Lehr CM. Cell culture models of the respiratory tract relevant to pulmonary drug delivery. J Aerosol Med 2005;18:137-82
  • Patton JS, Byron PR. Inhaling medicines: delivering drugs to the body through the lungs. Nat Rev Drug Discov 2007;6:67-74
  • Vyas SP, Khatri K. Liposome-based drug delivery to alveolar macrophages. Expert Opin Drug Deliv 2007;4:95-9
  • Jaspart S, Bertholet P, Piel G, et al. Solid lipid microparticles as a sustained release system for pulmonary drug delivery. Eur J Pharm Biopharm 2007;65:47-56
  • Xiang QY, Wang MT, Chen F, et al. Lung-targeting delivery of dexamethasone acetate loaded solid lipid nanoparticles. Arch Pharm Res 2007;30:519-25
  • Azarmi S, Roa WH, Lobenberg R. Targeted delivery of nanoparticles for the treatment of lung diseases. Adv Drug Deliv Rev 2008; In press
  • Shi L, Plumley CJ, Berkland C. Biodegradable nanoparticle flocculates for dry powder aerosol formulation. Langmuir 2007;23:10897-901
  • Chow AH, Tong HH, Chattopadhyay P, Shekunov BY. Particle engineering for pulmonary drug delivery. Pharm Res 2007;24:411-37
  • Panyam J, Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev 2003;55:329-47
  • Shive MS, Anderson JM. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv Drug Deliv Rev 1997;28:5-24
  • Lin SY, Chen KS, Teng HH, Li MJ. In vitro degradation and dissolution behaviours of microspheres prepared by three low molecular weight polyesters. J Microencapsul 2000;17:577-86
  • Berkland C, King M, Cox A, et al. Precise control of PLG microsphere size provides enhanced control of drug release rate. J Control Release 2002;82:137-47
  • Yamamoto H, Kuno Y, Sugimoto S, et al. Surface-modified PLGA nanosphere with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctions. J Control Release 2005;102:373-81
  • Sanders LM, Kent JS, McRae GI, et al. Controlled release of a luteinizing hormone-releasing hormone analogue from poly(d,l-lactide-co-glycolide) microspheres. J Pharm Sci 1984;73:1294-7
  • Miyajima M, Koshika A, Okada J, Ikeda M. Effect of polymer/basic drug interactions on the two-stage diffusion-controlled release from a poly(L-lactic acid) matrix. J Control Release 1999;61:295-304
  • Youxin L, Kissel T. Synthesis and properties of biodegradable ABA triblock copolymers consisting of poly(-lactic acid) or poly (-lactic-co-glycolic acid) A-blocks attached to central poly (oxyethylene) B-blocks. J Control Release 1993;27:247-57
  • Kissel T, Li Y, Unger F. ABA-triblock copolymers from biodegradable polyester A-blocks and hydrophilic poly(ethylene oxide) B-blocks as a candidate for in situ forming hydrogel delivery systems for proteins. Adv Drug Deliv Rev 2002;54:99-134
  • Arvanitoyannis I, Nakayama A, Kawasaki N, Yamamoto N. Novel star-shaped polylactide with glycerol using stannous octoate or tetraphenyl tin as catalyst. 1. Synthesis, characterization and study of their biodegradability. Polymer 1995;36:2947-56
  • Kim SH, Han YK, Ahn KD, et al. Preparation of star-shaped polylactide with pentaerythritol and stannous octoate. Makromol Chem 1993;194:3229-36
  • Dong CM, Qiu KY, Gu ZW, Feng XD. Synthesis of star-shaped poly (d, l-lactic acid-alt-glycolic acid) with multifunctional initiator and SnOct2 catalyst. Polymer 2001;42:6891-6
  • Arvanitoyannis I, Nakayama A, Kawasaki N, Yamamoto N. Novel polylactides with aminopropanediol or aminohydroxymethylpropanediol using stannous octoate as catalyst-synthesis, characterization and study of their biodegradability. 2. Polymer 1995;36:2271-9
  • Breitenbach A, Kissel T. Biodegradable comb polyesters. Part 1. Synthesis, characterization and structural analysis of poly (lactide) and poly (lactide-co-glycolide) grafted onto water-soluble poly (vinyl alcohol) as backbone. Polymer 1998;39:3261-71
  • Youxin L, Nothnagel J, Kissel T. Biodegradable brush-like graft polymers from poly (d,l-lactide) or poly (d,l-lactide-co-glycolide) and charge-modified, hydrophilic dextrans as backbone – synthesis, characterization and in vitro degradation properties. Polymer 1997;38:6197-206
  • Oster CG, Wittmar M, Unger F, et al. Design of amine-modified graft polyesters for effective gene delivery using DNA-loaded nanoparticles. Pharm Res 2004;21:927-31
  • Simon M, Wittmar M, Bakowsky U, Kissel T. Self-assembling nanocomplexes from insulin and water-soluble branched polyesters, poly [(vinyl-3-(diethylamino)-propylcarbamate-co-(vinyl acetate)-co-(vinyl alcohol)]-graft-poly (l-lactic acid): a novel carrier for transmucosal delivery of peptides. Bioconjug Chem 2004;15:841-9
  • Jung T, Kamm W, Breitenbach A, et al. Loading of tetanus toxoid to biodegradable nanoparticles from branched poly (sulfobutyl-polyvinyl alcohol)-g-(lactide-co-glycolide) nanoparticles by protein adsorption: a mechanistic study. Pharm Res 2002;19:1105-13
  • Li Z, Huang L. Sustained delivery and expression of plasmid DNA based on biodegradable polyester, poly(,-lactide-co-4-hydroxy-proline). J Control Release 2004;98:437-46
  • Dailey LA, Wittmar M, Kissel T. The role of branched polyesters and their modifications in the development of modern drug delivery vehicles. J Control Release 2005;101:137-49
  • Breitenbach A, Pistel KF, Kissel T. Biodegradable comb polyesters. Part II. Erosion and release properties of poly(vinyl alcohol)-g-poly(lactic-co-glycolic acid). Polymer 2000;41:4781-92
  • Frauke Pistel K, Breitenbach A, Zange-Volland R, Kissel T. Brush-like branched biodegradable polyesters, part III: Protein release from microspheres of poly(vinyl alcohol)-graft-poly (,-lactic-co-glycolic acid). J Control Release 2001;73:7-20
  • Yamaoka T, Tabata Y, Ikada Y. Comparison of body distribution of poly(vinyl alcohol) with other water-soluble polymers after intravenous administration. J Pharm Pharmacol 1995;47:479-86
  • Breitenbach A, Li YX, Kissel T. Branched biodegradable polyesters for parenteral drug delivery systems. J Control Release 2000;64:167-78
  • Li Y, Nothnagel J, Kissel T. Biodegradable brush-like graft polymers from poly(-lactide) or poly(-lactide-co-glycolide) and charge-modified, hydrophilic dextrans as backbone – synthesis, characterization and in vitro degradation properties. Polymer 1997;38:6197-206
  • Li Y, Volland C, Kissel T. Biodegradable brush-like graft polymers from poly(D,L-lactide) or poly(D,L-lactide-coglycolide) and charge-modified, hydrophilic dextrans as backbone – in vitro degradation and controlled releases of hydrophilic macromolecules. Polymer 1998;39:3087-97
  • Jung T, Breitenbach A, Kissel T. Sulfobutylated poly(vinyl alcohol)-graft-poly(lactide-co-glycolide)s facilitate the preparation of small negatively charged biodegradable nanospheres. J Control Release 2000;67:157-69
  • Dailey LA, Jekel N, Fink L, et al. Investigation of the proinflammatory potential of biodegradable nanoparticle drug delivery systems in the lung. Toxicol Appl Pharmacol 2006;215:100-8
  • Dailey LA, Kleemann E, Wittmar M, et al. Surfactant-free, biodegradable nanoparticles for aerosol therapy based on the branched polyesters, DEAPA-PVAL-g-PLGA. Pharm Res 2003;20:2011-20
  • Shoyele SA, Slowey A. Prospects of formulating proteins/peptides as aerosols for pulmonary drug delivery. Int J Pharm 2006;314:1-8
  • Kissel T, Wang XY. Graft copolymers as drug delivery systems. EP07116143; 2007
  • Wang X, Xie X, Cai C, et al. Biodegradable branched polyesters poly(vinyl sulfonate-co-vinyl alcohol)- graft-P(D,L-lactic-co-glycolic acid) as negatively-charged polyelectrolyte platforms for drug delivery: synthesis and characterization. Macromolecules 2008;41:2791-9
  • Fiegel J, Fu J, Hanes J. Poly(ether-anhydride) dry powder aerosols for sustained drug delivery in the lungs. J Control Release 2004;96:411-23
  • Zhang Q, Shen Z, Nagai T. Prolonged hypoglycemic effect of insulin-loaded polybutylcyanoacrylate nanoparticles after pulmonary administration to normal rats. Int J Pharm 2001;218:75-80
  • Sanders LM, Kell BA, McRae GI, Whitehead GW. Prolonged controlled-release of nafarelin, a luteinizing hormone-releasing hormone analogue, from biodegradable polymeric implants: influence of composition and molecular weight of polymer. J Pharm Sci 1986;75:356-60
  • Zolnik BS, Burgess DJ. Effect of acidic pH on PLGA microsphere degradation and release. J Control Release 2007;122:338-44
  • Dutt M, Khuller GK. Chemotherapy of Mycobacterium tuberculosis infections in mice with a combination of isoniazid and rifampicin entrapped in Poly (DL-lactide-co-glycolide) microparticles. J Antimicrob Chemother 2001;47:829-35
  • Dutt M, Khuller GK. Sustained release of isoniazid from a single injectable dose of poly (DL-lactide-co-glycolide) microparticles as a therapeutic approach towards tuberculosis. Int J Antimicrob Agents 2001;17:115-22
  • Lu D, Garcia-Contreras L, Xu D, et al. Poly (lactide-co-glycolide) microspheres in respirable sizes enhance an in vitro T cell response to recombinant Mycobacterium tuberculosis antigen 85B. Pharm Res 2007;24:1834-43
  • Garcia-Contreras L, Sethuraman V, Kazantseva M, et al. Evaluation of dosing regimen of respirable rifampicin biodegradable microspheres in the treatment of tuberculosis in the guinea pig. J Antimicrob Chemother 2006;58:980-6
  • Pandey R, Sharma A, Zahoor A, et al. Poly (DL-lactide-co-glycolide) nanoparticle-based inhalable sustained drug delivery system for experimental tuberculosis. J Antimicrob Chemother 2003;52:981-6
  • Lee KY, Ha WS, Park WH. Blood compatibility and biodegradability of partially N-acylated chitosan derivatives. Biomaterials 1995;16:1211-6
  • Varum KM, Myhr MM, Hjerde RJ, Smidsrod O. In vitro degradation rates of partially N-acetylated chitosans in human serum. Carbohydr Res 1997;299:99-101
  • Tomihata K, Ikada Y. In vitro and in vivo degradation of films of chitin and its deacetylated derivatives. Biomaterials 1997;18:567-75
  • Nicod LP. Lung defences: an overview. Eur Respir Rev 2005;14:45-50
  • Skerrett SJ. Lysozyme in pulmonary host defense: new tricks for an old dog. Am J Respir Crit Care Med 2004;169:435-6
  • Learoyd TP, Burrows JL, French E, Seville PC. Chitosan-based spray-dried respirable powders for sustained delivery of terbutaline sulfate. Eur J Pharm Biopharm 2008;68:224-34
  • Corrigan DO, Healy AM, Corrigan OI. Preparation and release of salbutamol from chitosan and chitosan co-spray dried compacts and multiparticulates. Eur J Pharm Biopharm 2006;62:295-305
  • Amidi M, Pellikaan HC, de Boer AH, et al. Preparation and physicochemical characterization of supercritically dried insulin-loaded microparticles for pulmonary delivery. Eur J Pharm Biopharm 2008;68:191-200
  • Grenha A, Seijo B, Remunan-Lopez C. Microencapsulated chitosan nanoparticles for lung protein delivery. Eur J Pharm Sci 2005;25:427-37
  • Kawashima Y, Yamamoto H, Takeuchi H, et al. Pulmonary delivery of insulin with nebulized DL-lactide/glycolide copolymer (PLGA) nanospheres to prolong hypoglycemic effect. J Control Release 1999;62:279-87
  • Lungwitz U, Breunig M, Blunk T, Gopferich A. Polyethylenimine-based non-viral gene delivery systems. Eur J Pharm Biopharm 2005;60:247-66
  • Zou SM, Erbacher P, Remy JS, Behr JP. Systemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouse. J Gene Med 2000;2:128-34
  • Thomas M, Lu JJ, Zhang C, et al. Identification of novel superior polycationic vectors for gene delivery by high-throughput synthesis and screening of a combinatorial library. Pharm Res 2007;24:1564-71
  • Lv H, Zhang S, Wang B, et al. Toxicity of cationic lipids and cationic polymers in gene delivery. J Control Release 2006;114:100-9
  • Germershaus O, Mao S, Sitterberg J, et al. Gene delivery using chitosan, trimethyl chitosan or polyethylenglycol-graft-trimethyl chitosan block copolymers: establishment of structure-activity relationships in vitro. J Control Release 2008;125:145-54
  • MacLaughlin FC, Mumper RJ, Wang J, et al. Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery. J Control Release 1998;56:259-72
  • Koping-Hoggard M, Tubulekas I, Guan H, et al. Chitosan as a nonviral gene delivery system. Structure–property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo. Gene Ther 2001;8:1108-21
  • Koping-Hoggard M, Varum KM, Issa M, et al. Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers. Gene Ther 2004;11:1441-52
  • Issa MM, Koping-Hoggard M, Tommeraas K, et al. Targeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivo. J Control Release 2006;115:103-12
  • Fajac I, Briand P, Monsigny M, Midoux P. Sugar-mediated uptake of glycosylated polylysines and gene transfer into normal and cystic fibrosis airway epithelial cells. Hum Gene Ther 1999;10:395-406
  • Weis WI, Drickamer K. Structural basis of lectin–carbohydrate recognition. Ann Rev Biochem 1996;65:441-73
  • Andersen MO, Howard KA, Paludan SR, et al. Delivery of siRNA from lyophilized polymeric surfaces. Biomaterials 2008;29:506-12
  • Howard KA, Rahbek UL, Liu X, et al. RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system. Mol Ther 2006;14:476-84
  • Kong X, Zhang W, Lockey RF, et al. Respiratory syncytial virus infection in Fischer 344 rats is attenuated by short interfering RNA against the RSV-NS1 gene. Genet Vaccines Ther 2007;5:4
  • Palese P, Garcia-Sastre A. Influenza vaccines: present and future. J Clin Invest 2002;110:9-13
  • Orme IM, McMurray DN, Belisle JT. Tuberculosis vaccine development: recent progress. Trends Microbiol 2001;9:115-8
  • Bivas-Benita M, Ottenhoff THM, Junginger HE, Borchard G. Pulmonary DNA vaccination: Concepts, possibilities and perspectives. J Control Release 2005;107:1-29
  • Bivas-Benita M, Romeijn S, Junginger HE, Borchard G. PLGA-PEI nanoparticles for gene delivery to pulmonary epithelium. Eur J Pharm Biopharm 2004;58:1-6

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