Advanced search
Publication Cover
Expert Opinion on Drug Delivery Volume 5, 2008 - Issue 8
Submit an article Journal homepage
148
Views
22
CrossRef citations to date
0
Altmetric
Review

Advances in non-viral gene delivery: using multifunctional envelope-type nano-device

Hidetaka Akita CREST Japan Science and Technology Agency (JST), Japan
&
Hideyoshi Harashima Hokkaido University, Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan +81 11 706 3919; +81 11 706 4879; [email protected]
Pages 847-859 | Published online: 19 Aug 2008

Bibliography

  • Gabizon A, Isacson R, Libson E, et al. Clinical studies of liposome-encapsulated doxorubicin. Acta Oncol 1994;33(7):779-86
  • Harada A, Kataoka K. Chain length recognition: core-shell supramolecular assembly from oppositely charged block copolymers. Science 1999;283(5398):65-7
  • Kataoka K, Matsumoto T, Yokoyama M, et al. Doxorubicin-loaded poly(ethylene glycol)-poly(beta-benzyl-l-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance. J Control Release 2000;64(1-3):143-53
  • Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 1986;46(12 Pt 1):6387-92
  • Allen TM, Chonn A. Large unilamellar liposomes with low uptake into the reticuloendothelial system. FEBS Lett 1987;223(1):42-6
  • Allen TM, Hansen C, Rutledge J. Liposomes with prolonged circulation times: factors affecting uptake by reticuloendothelial and other tissues. Biochim Biophys Acta 1989;981(1):27-35
  • Allen TM, Hansen C, Martin F, et al. Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo. Biochim Biophys Acta 1991;1066(1):29-36
  • Klibanov AL, Maruyama K, Torchilin VP, Huang L. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett 1990;268(1):235-7
  • Ishida O, Maruyama K, Tanahashi H, et al. Liposomes bearing polyethyleneglycol-coupled transferrin with intracellular targeting property to the solid tumors in vivo. Pharm Res 2001;18(7):1042-8
  • Litzinger DC, Buiting AM, van Rooijen N, Huang L. Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly (ethylene glycol)-containing liposomes. Biochim Biophys Acta 1994;1190(1):99-107
  • Liu D, Mori A, Huang L. Role of liposome size and RES blockade in controlling biodistribution and tumor uptake of GM1-containing liposomes. Biochim Biophys Acta 1992;1104(1):95-101
  • Uchiyama K, Nagayasu A, Yamagiwa Y, et al. Effects of the size and fluidity of liposomes on their accumulation in tumors: a presumption of their interaction with tumors. Int J Pharm 1995;121195-203
  • Kamiya H, Akita H, Harashima H. Pharmacokinetic and pharmacodynamic considerations in gene therapy. Drug Discov Today 2003;8(21):990-6
  • Boussif O, Lezoualc'h F, Zanta MA, et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA 1995;92(16):7297-301
  • Brown MD, Schatzlein AG, Uchegbu IF. Gene delivery with synthetic (non viral) carriers. Int J Pharm 2001;229(1-2):1-21
  • Oupicky D, Konak C, Ulbrich K, et al. DNA delivery systems based on complexes of DNA with synthetic polycations and their copolymers. J Control Release 2000;65(1-2):149-71
  • Felgner PL, Gadek TR, Holm M, et al. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA 1987;84(21):7413-7
  • Gao X, Huang L. Cationic liposome-mediated gene transfer. Gene Ther 1995;2(10):710-22
  • Li S, Tseng WC, Stolz DB, et al. Dynamic changes in the characteristics of cationic lipidic vectors after exposure to mouse serum: implications for intravenous lipofection. Gene Ther 1999;6(4):585-94
  • Tranchant I, Thompson B, Nicolazzi C, et al. Physicochemical optimisation of plasmid delivery by cationic lipids. J Gene Med 2004;6(Suppl 1):S24-35
  • Hatakeyama H, Akita H, Maruyama K, et al. Factors governing the in vivo tissue uptake of transferrin-coupled polyethylene glycol liposomes in vivo. Int J Pharm 2004;281(1-2):25-33
  • Iinuma H, Maruyama K, Okinaga K, et al. Intracellular targeting therapy of cisplatin-encapsulated transferrin-polyethylene glycol liposome on peritoneal dissemination of gastric cancer. Int J Cancer 2002;99(1):130-7
  • Khan Z, Hawtrey AO, Ariatti M. New cationized LDL-DNA complexes: their targeted delivery to fibroblasts in culture. Drug Deliv 2003;10(3):213-20
  • Dai FH, Chen Y, Ren CC, et al. Construction of an EGF receptor-mediated histone H1(0)-based gene delivery system. J Cancer Res Clin Oncol 2003;129(8):456-62
  • Gottschalk S, Cristiano RJ, Smith LC, Woo SL. Folate receptor mediated DNA delivery into tumor cells: potosomal disruption results in enhanced gene expression. Gene Ther 1994;1(3):185-91
  • Hofland HE, Masson C, Iginla S, et al. Folate-targeted gene transfer in vivo. Mol Ther 2002;5(6):739-44
  • Turk MJ, Reddy JA, Chmielewski JA, Low PS. Characterization of a novel pH-sensitive peptide that enhances drug release from folate-targeted liposomes at endosomal pHs. Biochim Biophys Acta 2002;1559(1):56-68
  • Muller K, Nahde T, Fahr A, et al. Highly efficient transduction of endothelial cells by targeted artificial virus-like particles. Cancer Gene Ther 2001;8(2):107-17
  • Zarovni N, Monaco L, Corti A. Inhibition of tumor growth by intramuscular injection of cDNA encoding tumor necrosis factor alpha coupled to NGR and RGD tumor-homing peptides. Hum Gene Ther 2004;15(4):373-82
  • Lechardeur D, Sohn KJ, Haardt M, et al. Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer. Gene Ther 1999;6(4):482-97
  • Pollard H, Toumaniantz G, Amos JL, et al. Ca2+-sensitive cytosolic nucleases prevent efficient delivery to the nucleus of injected plasmids. J Gene Med 2001;3(2):153-64
  • Allen TD, Cronshaw JM, Bagley S, et al. The nuclear pore complex: mediator of translocation between nucleus and cytoplasm. J Cell Sci 2000;113(Pt 10):1651-9
  • Hagstrom JE, Ludtke JJ, Bassik MC, et al. Nuclear import of DNA in digitonin-permeabilized cells. J Cell Sci 1997;110(Pt 18):2323-31
  • Ludtke JJ, Zhang G, Sebestyen MG, Wolff JA. A nuclear localization signal can enhance both the nuclear transport and expression of 1 kb DNA. J Cell Sci 1999;112(Pt 12):2033-41
  • Sebestyen MG, Ludtke JJ, Bassik MC, et al. DNA vector chemistry: the covalent attachment of signal peptides to plasmid DNA. Nat Biotechnol 1998;16(1):80-5
  • Mortimer I, Tam P, MacLachlan I, et al. Cationic lipid-mediated transfection of cells in culture requires mitotic activity. Gene Ther 1999;6(3):403-11
  • Tseng WC, Haselton FR, Giorgio TD. Mitosis enhances transgene expression of plasmid delivered by cationic liposomes. Biochim Biophys Acta 1999;1445(1):53-64
  • Wilke M, Fortunati E, van den Broek M, et al. Efficacy of a peptide-based gene delivery system depends on mitotic activity. Gene Ther 1996;3(12):1133-42
  • Pollard H, Remy JS, Loussouarn G, et al. Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells. J Biol Chem 1998;273(13):7507-11
  • Khalil IA, Kogure K, Futaki S, et al. Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery. Gene Ther 2007;14(8):682-9
  • Kogure K, Akita H, Kamiya H, Harashima H. In: Muller K, editor, Modern biopharmaceuticals. Wiley-VCH; 2005. p. 1521-36
  • Khalil IA, Kogure K, Akita H, Harashima H. Uptake pathways and subsequent intracellular trafficking in non-viral gene delivery. Pharmacol Rev 2006;58(1):32-45
  • Kogure K, Moriguchi R, Sasaki K, et al. Development of a non-viral multifunctional envelope-type nano device by a novel lipid film hydration method. J Control Release 2004;98(2):317-23
  • Brooks H, Lebleu B, Vives E. Tat peptide-mediated cellular delivery: back to basics. Adv Drug Deliv Rev 2005;57(4):559-77
  • Gupta B, Levchenko TS, Torchilin VP. Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides. Adv Drug Deliv Rev 2005;57(4):637-51
  • Fawell S, Seery J, Daikh Y, et al. Tat-mediated delivery of heterologous proteins into cells. Proc Natl Acad Sci USA 1994;91(2):664-8
  • Lindgren M, Gallet X, Soomets U, et al. Translocation properties of novel cell penetrating transportan and penetratin analogues. Bioconjug Chem 2000;11(5):619-26
  • Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 1999;285(5433):1569-72
  • Vocero-Akbani AM, Heyden NV, Lissy NA, et al. Killing HIV-infected cells by transduction with an HIV protease-activated caspase-3 protein. Nat Med 1999;5(1):29-33
  • Astriab-Fisher A, Sergueev DS, Fisher M, et al. Antisense inhibition of P-glycoprotein expression using peptide-oligonucleotide conjugates. Biochem Pharmacol 2000;60(1):83-90
  • Khalil IA, Futaki S, Niwa M, et al. Mechanism of improved gene transfer by the N-terminal stearylation of octaarginine: enhanced cellular association by hydrophobic core formation. Gene Ther 2004;11(7):636-44
  • Morris MC, Chaloin L, Heitz F, Divita G. Translocating peptides and proteins and their use for gene delivery. Curr Opin Biotechnol 2000;11(5):461-6
  • Snyder EL, Dowdy SF. Protein/peptide transduction domains: potential to deliver large DNA molecules into cells. Curr Opin Mol Ther 2001;3(2):147-52
  • Marty C, Meylan C, Schott H, et al. Enhanced heparan sulfate proteoglycan-mediated uptake of cell-penetrating peptide-modified liposomes. Cell Mol Life Sci 2004;61(14):1785-94
  • Torchilin VP, Rammohan R, Weissig V, Levchenko TS. TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors. Proc Natl Acad Sci USA 2001;98(15):8786-91
  • Vives E, Brodin P, Lebleu B. A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J Biol Chem 1997;272(25):16010-7
  • Wadia JS, Stan RV, Dowdy SF. Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis. Nat Med 2004;10(3):310-5
  • Nakase I, Niwa M, Takeuchi T, et al. Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement. Mol Ther 2004;10(6):1011-22
  • Nakase I, Tadokoro A, Kawabata N, et al. Interaction of arginine-rich peptides with membrane-associated proteoglycans is crucial for induction of actin organization and macropinocytosis. Biochemistry 2007;46(2):492-501
  • Suzuki T, Futaki S, Niwa M, et al. Possible existence of common internalization mechanisms among arginine-rich peptides. J Biol Chem 2002;277(4):2437-43
  • Bergelson JM, Cunningham JA, Droguett G, et al. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science 1997;275(5304):1320-3
  • Mayr GA, Freimuth P. A single locus on human chromosome 21 directs the expression of a receptor for adenovirus type 2 in mouse A9 cells. J Virol 1997;71(1):412-8
  • Tomko RP, Xu R, Philipson L. HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc Natl Acad Sci USA 1997;94(7):3352-6
  • Mizuguchi H, Koizumi N, Hosono T, et al. A simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob. Gene Ther 2001;8(9):730-5
  • Nemerow GR, Stewart PL. Role of alpha(v) integrins in adenovirus cell entry and gene delivery. Microbiol Mol Biol Rev 1999;63(3):725-34
  • Wickham TJ, Filardo EJ, Cheresh DA, Nemerow GR. Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization. J Cell Biol 1994;127(1):257-64
  • Wickham TJ, Mathias P, Cheresh DA, Nemerow GR. Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell 1993;73(2):309-19
  • Li E, Stupack D, Klemke R, et al. Adenovirus endocytosis via alpha(v) integrins requires phosphoinositide-3-OH kinase. J Virol 1998;72(3):2055-61
  • Imelli N, Meier O, Boucke K, et al. Cholesterol is required for endocytosis and endosomal escape of adenovirus type 2. J Virol 2004;78(6):3089-98
  • Meier O, Boucke K, Hammer SV, et al. Adenovirus triggers macropinocytosis and endosomal leakage together with its clathrin-mediated uptake. J Cell Biol 2002;158(6):1119-31
  • Iwasa A, Akita H, Khalil I, et al. Cellular uptake and subsequent intracellular trafficking of R8-liposomes introduced at low temperature. Biochim Biophys Acta 2006;1758(6):713-20
  • Khalil IA, Kogure K, Futaki S, Harashima H. High density of octaarginine stimulates macropinocytosis leading to efficient intracellular trafficking for gene expression. J Biol Chem 2006;281(6):3544-51
  • Farhood H, Serbina N, Huang L. The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer. Biochim Biophys Acta 1995;1235(2):289-95
  • Hui SW, Langner M, Zhao YL, et al. The role of helper lipids in cationic liposome-mediated gene transfer. Biophys J 1996;71(2):590-9
  • Harashima H, Shinohara Y, Kiwada H. Intracellular control of gene trafficking using liposomes as drug carriers. Eur J Pharm Sci 2001;13(1):85-9
  • Xu Y, Szoka FC Jr. Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection. Biochemistry 1996;35(18):5616-23
  • Nakamura Y, Kogure K, Futaki S, Harashima H. Octaarginine-modified multifunctional envelope-type nano device for siRNA. J Control Release 2007;119(3):360-7
  • Bentz J, Mittal A. Deployment of membrane fusion protein domains during fusion. Cell Biol Int 2000;24(11):819-38
  • Jardetzky TS, Lamb RA. Virology: a class act. Nature 2004;427(6972):307-8
  • Parente RA, Nir S, Szoka FC Jr. pH-dependent fusion of phosphatidylcholine small vesicles. Induction by a synthetic amphipathic peptide. J Biol Chem 1988;263(10):4724-30
  • Parente RA, Nir S, Szoka FC Jr. Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA. Biochemistry 1990;29(37):8720-8
  • Ritter W, Plank C, Lausier J, et al. A novel transfecting peptide comprising a tetrameric nuclear localization sequence. J Mol Med 2003;81(11):708-17
  • Kakudo T, Chaki S, Futaki S, et al. Transferrin-modified liposomes equipped with a pH-sensitive fusogenic peptide: an artificial viral-like delivery system. Biochemistry 2004;43(19):5618-28
  • Sasaki K, Kogure K, Chaki S, et al. An artificial virus-like nano carrier system: enhanced endosomal escape of nanoparticles via synergistic action of pH-sensitive fusogenic peptide derivatives. Anal Bioanal Chem 2008
  • Nagasaki T, Myohoji T, Tachibana T, et al. Can nuclear localization signals enhance nuclear localization of plasmid DNA? Bioconjug Chem 2003;14(2):282-6
  • Tanimoto M, Kamiya H, Minakawa N, et al. No enhancement of nuclear entry by direct conjugation of a nuclear localization signal peptide to linearized DNA. Bioconjug Chem 2003;14(6):1197-202
  • Masuda T, Akita H, Harashima H. Evaluation of nuclear transfer and transcription of plasmid DNA condensed with protamine by microinjection: the use of a nuclear transfer score. FEBS Lett 2005;579(10):2143-8
  • Akita H, Tanimoto M, Masuda T, et al. Evaluation of the nuclear delivery and intra-nuclear transcription of plasmid DNA condensed with micro (mu) and NLS-micro by cytoplasmic and nuclear microinjection: a comparative study with poly-l-lysine. J Gene Med 2006;8(2):198-206
  • Nakamura T, Moriguchi R, Kogure K, et al. Delivery of condensed DNA by liposomal non-viral gene delivery system into nucleus of dendritic cells. Biol Pharm Bull 2006;29(6):1290-3
  • Duverger E, Carpentier V, Roche AC, Monsigny M. Sugar-dependent nuclear import of glycoconjugates from the cytosol. Exp Cell Res 1993;207(1):197-201
  • Duverger E, Pellerin-Mendes C, Mayer R, et al. Nuclear import of glycoconjugates is distinct from the classical NLS pathway. J Cell Sci 1995;108(Pt 4):1325-32
  • Masuda T, Akita H, Nishio T, et al. Development of lipid particles targeted via sugar-lipid conjugates as novel nuclear gene delivery system. Biomaterials 2008;29(6):709-23
  • Hatakeyama H, Akita H, Kogure K, et al. Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid. Gene Ther 2007;14(1):68-77
  • Akita H, Ito R, Khalil IA, et al. Quantitative three-dimensional analysis of the intracellular trafficking of plasmid DNA transfected by a nonviral gene delivery system using confocal laser scanning microscopy. Mol Ther 2004;9(3):443-51
  • Suda T, Liu D. Hydrodynamic gene delivery: its principles and applications. Mol Ther 2007;15(12):2063-9
  • Suda T, Suda K, Liu D. Computer-assisted hydrodynamic gene delivery. Mol Ther 2008;16(6):1098-104
  • Parker AL, Eckley L, Singh S, et al. (LYS)(16)-based reducible polycations provide stable polyplexes with anionic fusogenic peptides and efficient gene delivery to post mitotic cells. Biochim Biophys Acta 2007;1770(9):1331-7
  • Hama S, Akita H, Ito R, et al. Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems. Mol Ther 2006;13(4):786-94
  • Akita H, Ito R, Kamiya H, et al. Cell cycle dependent transcription, a determinant factor of heterogeneity in cationic lipid-mediated transgene expression. J Gene Med 2007;9(3):197-207
  • Hama S, Akita H, Iida S, et al. Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex. Nucleic Acids Res 2007;35(5):1533-43

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.