Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines

Bibliography

• Chang KC, Bell TD, Lauer BA, Chai H. Altered theophylline pharmacokinetics during acute respiratory viral illness. Lancet 1978;1:1132-3
   PubMed Web of Science ®Google Scholar
• Renton KW. Alteration of drug biotransformation and elimination during infection and inflammation. Pharmacol Ther 2001;92:147-63
   PubMed Web of Science ®Google Scholar
• Slaviero KA, Clarke SJ, Rivory LP. Inflammatory response: an unrecognised source of variability in the pharmacokinetics and pharmacodynamics of cancer chemotherapy. Lancet Oncol 2003;4:224-32
   PubMed Web of Science ®Google Scholar
• Morgan ET. Regulation of cytochromes P450 during inflammation and infection. Drug Metab Rev 1997;29:1129-88
   PubMed Web of Science ®Google Scholar
• Shedlofsky SI, Israel BC, Tosheva R, Blouin RA. Endotoxin depresses hepatic cytochrome P450-mediated drug metabolism in women. Br J Clin Pharmacol 1997;43:627-32
   PubMed Web of Science ®Google Scholar
• Aitken AE, Richardson TA, Morgan ET. Regulation of drug-metabolizing enzymes and transporters in inflammation. Annu Rev Pharmacol Toxicol 2006;46:123-49
   PubMed Web of Science ®Google Scholar
• Kulmatycki KM, Jamali F. Drug disease interactions: role of inflammatory mediators in disease and variability in drug response. J Pharm Pharm Sci 2005;8:602-25
   PubMed Web of Science ®Google Scholar
• Feghali CA, Wright TM. Cytokines in acute and chronic inflammation. Front Biosci 1997;2:d12-26
   PubMedGoogle Scholar
• Morgan ET. Regulation of cytochrome p450 by inflammatory mediators: why and how? Drug Metab Dispos 2001;29:207-12
   PubMed Web of Science ®Google Scholar
• Morgan ET, Goralski KB, Piquette-Miller M, Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer. Drug Metab Dispos 2008;36:205-16
   PubMed Web of Science ®Google Scholar
• Abdel-Razzak Z, Loyer P, Fautrel A, Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Mol Pharmacol 1993;44:707-15
   PubMed Web of Science ®Google Scholar
• Aitken AE, Morgan ET. Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes. Drug Metab Dispos 2007;35:1687-93
   PubMed Web of Science ®Google Scholar
• Nakai K, Tanaka H, Hanada K, Decreased expression of cytochromes P450 1A2, 2E1, and 3A4 and drug transporters Na+-taurocholate-cotransporting polypeptide, organic cation transporter 1, and organic anion-transporting peptide-C correlates with the progression of liver fibrosis in chronic hepatitis C patients. Drug Metab Dispos 2008;36:1786-93
   PubMed Web of Science ®Google Scholar
• Assenat E, Gerbal-Chaloin S, Larrey D, Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance. Hepatology 2004;40:951-60
   PubMed Web of Science ®Google Scholar
• Pascussi JM, Gerbal-Chaloin S, Pichard-Garcia L, Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes. Biochem Biophys Res Commun 2000;274:707-13
   PubMed Web of Science ®Google Scholar
• Shitara Y, Horie T, Sugiyama Y. Transporters as a determinant of drug clearance and tissue distribution. Eur J Pharm Sci 2006;27:425-46
   PubMed Web of Science ®Google Scholar
• Faber KN, Muller M, Jansen PL. Drug transport proteins in the liver. Adv Drug Deliv Rev 2003;55:107-24
   PubMed Web of Science ®Google Scholar
• Geier A, Wagner M, Dietrich CG, Trauner M. Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration. Biochim Biophys Acta 2007;1773:283-308
   PubMed Web of Science ®Google Scholar
• Green RM, Beier D, Gollan JL. Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterology 1996;111:193-8
   PubMed Web of Science ®Google Scholar
• Bolder U, Ton-Nu HT, Schteingart CD, Hepatocyte transport of bile acids and organic anions in endotoxemic rats: impaired uptake and secretion. Gastroenterology 1997;112:214-25
   PubMed Web of Science ®Google Scholar
• Vos TA, Hooiveld GJ, Koning H, Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver. Hepatology 1998;28:1637-44
   PubMed Web of Science ®Google Scholar
• Cherrington NJ, Slitt AL, Li N, Klaassen CD. Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats. Drug Metab Dispos 2004;32:734-41
   PubMed Web of Science ®Google Scholar
• Geier A, Dietrich CG, Voigt S, Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis. Hepatology 2003;38:345-54
   PubMed Web of Science ®Google Scholar
• Geier A, Dietrich CG, Voigt S, Cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liver. Am J Physiol Gastrointest Liver Physiol 2005;289:G831-41
   PubMed Web of Science ®Google Scholar
• Petrovic V, Teng S, Piquette-Miller M. Regulation of drug transporters during infection and inflammation. Mol Interv 2007;7:99-111
   PubMed Web of Science ®Google Scholar
• Teng S, Piquette-Miller M. Regulation of transporters by nuclear hormone receptors: implications during inflammation. Mol Pharm 2008;5:67-76
   PubMed Web of Science ®Google Scholar
• Le Vee M, Gripon P, Stieger B, Fardel O. Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta. Drug Metab Dispos 2008;36:217-22
   PubMed Web of Science ®Google Scholar
• Vee ML, Lecureur V, Stieger B, Fardel O. Regulation of drug transporter expression in human hepatocytes exposed to the proinflammatory cytokines tumor necrosis factor-alpha or interleukin-6. Drug Metab Dispos 2009;37:685-93
   PubMed Web of Science ®Google Scholar
• Li M, Yuan H, Li N, Identification of interspecies difference in efflux transporters of hepatocytes from dog, rat, monkey and human. Eur J Pharm Sci 2008;35:114-26
   PubMed Web of Science ®Google Scholar
• Kleine M, Schrem H, Borlak J, Klempnauer J. Clinical versatility of porcine hepatocytes in the light of interspecies differences in cytochrome P450 regulation and expression. Xenotransplantation 2008;15:208-17
   PubMed Web of Science ®Google Scholar
• Lecureur V, Courtois A, Payen L, Expression and regulation of hepatic drug and bile acid transporters. Toxicology 2000;153:203-19
   PubMed Web of Science ®Google Scholar
• Funk C. The role of hepatic transporters in drug elimination. Expert Opin Drug Metab Toxicol 2008;4:363-79
   PubMed Web of Science ®Google Scholar
• van Montfoort JE, Hagenbuch B, Groothuis GM, Drug uptake systems in liver and kidney. Curr Drug Metab 2003;4:185-211
   PubMed Web of Science ®Google Scholar
• Alrefai WA, Gill RK. Bile acid transporters: structure, function, regulation and pathophysiological implications. Pharm Res 2007;24:1803-23
   PubMed Web of Science ®Google Scholar
• Ho RH, Tirona RG, Leake BF, Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology 2006;130:1793-806
   PubMed Web of Science ®Google Scholar
• Hagenbuch B, Gui C. Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family. Xenobiotica 2008;38:778-801
   PubMed Web of Science ®Google Scholar
• Smith NF, Figg WD, Sparreboom A. Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination. Expert Opin Drug Metab Toxicol 2005;1:429-45
   PubMedGoogle Scholar
• Mikkaichi T, Suzuki T, Tanemoto M, The organic anion transporter (OATP) family. Drug Metab Pharmacokinet 2004;19:171-9
   PubMedGoogle Scholar
• Hagenbuch B, Meier PJ. Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch 2004;447:653-65
   PubMed Web of Science ®Google Scholar
• Kullak-Ublick GA, Ismair MG, Stieger B, Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology 2001;120:525-33
   PubMed Web of Science ®Google Scholar
• Rizwan AN, Burckhardt G. Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles. Pharm Res 2007;24:450-70
   PubMed Web of Science ®Google Scholar
• Jonker JW, Schinkel AH. Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3). J Pharmacol Exp Ther 2004;308:2-9
   PubMed Web of Science ®Google Scholar
• Koepsell H, Lips K, Volk C. Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm Res 2007;24:1227-51
   PubMed Web of Science ®Google Scholar
• Chandra P, Brouwer KL. The complexities of hepatic drug transport: current knowledge and emerging concepts. Pharm Res 2004;21:719-35
   PubMed Web of Science ®Google Scholar
• Zelcer N, van de Wetering K, Hillebrand M, Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception. Proc Natl Acad Sci USA 2005;102:7274-9
   PubMed Web of Science ®Google Scholar
• Otsuka M, Matsumoto T, Morimoto R, A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci USA 2005;102:17923-8
   PubMed Web of Science ®Google Scholar
• Fardel O, Lecureur V, Guillouzo A. The P-glycoprotein multidrug transporter. Gen Pharmacol 1996;27:1283-91
   PubMedGoogle Scholar
• Couture L, Nash JA, Turgeon J. The ATP-binding cassette transporters and their implication in drug disposition: a special look at the heart. Pharmacol Rev 2006;58:244-58
   PubMed Web of Science ®Google Scholar
• Stieger B, Meier Y, Meier PJ. The bile salt export pump. Pflugers Arch 2007;453:611-20
   PubMed Web of Science ®Google Scholar
• Hirano M, Maeda K, Hayashi H, Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin. J Pharmacol Exp Ther 2005;314:876-82
   PubMed Web of Science ®Google Scholar
• Haimeur A, Conseil G, Deeley RG, Cole SP. The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation. Curr Drug Metab 2004;5:21-53
   PubMed Web of Science ®Google Scholar
• Fardel O, Jigorel E, Le Vee M, Payen L. Physiological, pharmacological and clinical features of the multidrug resistance protein 2. Biomed Pharmacother 2005;59:104-14
   PubMed Web of Science ®Google Scholar
• Nies AT, Keppler D. The apical conjugate efflux pump ABCC2 (MRP2). Pflugers Arch 2007;453:643-59
   PubMed Web of Science ®Google Scholar
• Robey RW, To KK, Polgar O, ABCG2: a perspective. Adv Drug Deliv Rev 2009;61:3-13
   PubMed Web of Science ®Google Scholar
• Kohle C, Bock KW. Coordinate regulation of phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2. Biochem Pharmacol 2007;73:1853-62
   PubMed Web of Science ®Google Scholar
• Jigorel E, Le Vee M, Boursier-Neyret C, Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes. Drug Metab Dispos 2006;34:1756-63
   PubMed Web of Science ®Google Scholar
• Courtois A, Payen L, Le Ferrec E, Differential regulation of multidrug resistance-associated protein 2 (MRP2) and cytochromes P450 2B1/2 and 3A1/2 in phenobarbital-treated hepatocytes. Biochem Pharmacol 2002;63:333-41
   PubMed Web of Science ®Google Scholar
• Plass JR, Mol O, Heegsma J, Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump. Hepatology 2002;35:589-96
   PubMed Web of Science ®Google Scholar
• Guillouzo A, Guguen-Guillouzo C. Evolving concepts in liver tissue modeling and implications for in vitro toxicology. Expert Opin Drug Metab Toxicol 2008;4:1279-94
   PubMed Web of Science ®Google Scholar
• Elferink MG, Olinga P, Draaisma AL, LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process. Am J Physiol Gastrointest Liver Physiol 2004;287:G1008-16
   PubMed Web of Science ®Google Scholar
• Kleemann R, Verschuren L, de Rooij BJ, Evidence for anti-inflammatory activity of statins and PPARalpha activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro. Blood 2004;103:4188-94
   PubMed Web of Science ®Google Scholar
• Jung D, Elferink MG, Stellaard F, Groothuis GM. Analysis of bile acid-induced regulation of FXR target genes in human liver slices. Liver Int 2007;27:137-44
   PubMed Web of Science ®Google Scholar
• Lee G, Piquette-Miller M. Cytokines alter the expression and activity of the multidrug resistance transporters in human hepatoma cell lines; analysis using RT-PCR and cDNA microarrays. J Pharm Sci 2003;92:2152-63
   PubMed Web of Science ®Google Scholar
• Smith JW, McDonald TL. Production of serum amyloid A and C-reactive protein by HepG2 cells stimulated with combinations of cytokines or monocyte conditioned media: the effects of prednisolone. Clin Exp Immunol 1992;90:293-9
   PubMed Web of Science ®Google Scholar
• Teng S, Jekerle V, Piquette-Miller M. Induction of ABCC3 (MRP3) by pregnane X receptor activators. Drug Metab Dispos 2003;31:1296-9
   PubMed Web of Science ®Google Scholar
• Le Vee M, Jigorel E, Glaise D, Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line. Eur J Pharm Sci 2006;28:109-17
   PubMed Web of Science ®Google Scholar
• Guillouzo A, Corlu A, Aninat C, The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. Chem Biol Interact 2007;168:66-73
   PubMed Web of Science ®Google Scholar
• Aninat C, Piton A, Glaise D, Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. Drug Metab Dispos 2006;34:75-83
   PubMed Web of Science ®Google Scholar
• Ghibellini G, Leslie EM, Brouwer KL. Methods to evaluate biliary excretion of drugs in humans: an updated review. Mol Pharm 2006;3:198-211
   PubMed Web of Science ®Google Scholar
• Gomez-Lechon MJ, Castell JV, Donato MT. An update on metabolism studies using human hepatocytes in primary culture. Expert Opin Drug Metab Toxicol 2008;4:837-54
   PubMed Web of Science ®Google Scholar
• Pichard L, Raulet E, Fabre G, Human hepatocyte culture. Methods Mol Biol 2006;320:283-93
   PubMedGoogle Scholar
• Hoffmaster KA, Turncliff RZ, LeCluyse EL, P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide. Pharm Res 2004;21:1294-302
   PubMed Web of Science ®Google Scholar
• Payen L, Courtois A, Campion JP, Characterization and inhibition by a wide range of xenobiotics of organic anion excretion by primary human hepatocytes. Biochem Pharmacol 2000;60:1967-75
   PubMed Web of Science ®Google Scholar
• Jigorel E, Le Vee M, Boursier-Neyret C, Functional expression of sinusoidal drug transporters in primary human and rat hepatocytes. Drug Metab Dispos 2005;33:1418-22
   PubMed Web of Science ®Google Scholar
• Fardel O, Morel F, Guillouzo A. P-glycoprotein expression in human, mouse, hamster and rat hepatocytes in primary culture. Carcinogenesis 1993;14:781-3
   PubMed Web of Science ®Google Scholar
• Castell JV, Gomez-Lechon MJ, David M, Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6. Hepatology 1990;12:1179-86
   PubMed Web of Science ®Google Scholar
• Muntane-Relat J, Ourlin JC, Domergue J, Maurel P. Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture. Hepatology 1995;22:1143-53
   PubMed Web of Science ®Google Scholar
• Hinoshita E, Taguchi K, Inokuchi A, Decreased expression of an ATP-binding cassette transporter, MRP2, in human livers with hepatitis C virus infection. J Hepatol 2001;35:765-73
   PubMed Web of Science ®Google Scholar
• Hisaeda K, Inokuchi A, Nakamura T, Interleukin-1beta represses MRP2 gene expression through inactivation of interferon regulatory factor 3 in HepG2 cells. Hepatology 2004;39:1574-82
   PubMed Web of Science ®Google Scholar
• Lee G, Piquette-Miller M. Influence of IL-6 on MDR and MRP-mediated multidrug resistance in human hepatoma cells. Can J Physiol Pharmacol 2001;79:876-84
   PubMed Web of Science ®Google Scholar
• Rowell DL, Eckmann L, Dwinell MB, Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion. Am J Physiol 1997;273:G322-32
   PubMed Web of Science ®Google Scholar
• Ivashchenko Y, Kramer F, Schafer S, Protein kinase C pathway is involved in transcriptional regulation of C-reactive protein synthesis in human hepatocytes. Arterioscler Thromb Vasc Biol 2005;25:186-92
   PubMed Web of Science ®Google Scholar
• Li T, Chiang JY. A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene. Gastroenterology 2007;133:1660-9
   PubMed Web of Science ®Google Scholar
• Abdel-Razzak Z, Corcos L, Fautrel A, Transforming growth factor-beta 1 down-regulates basal and polycyclic aromatic hydrocarbon-induced cytochromes P-450 1A1 and 1A2 in adult human hepatocytes in primary culture. Mol Pharmacol 1994;46:1100-10
   PubMed Web of Science ®Google Scholar
• Hewitt NJ, Lechon MJ, Houston JB, Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. Drug Metab Rev 2007;39:159-234
   PubMed Web of Science ®Google Scholar
• Li AP. Human hepatocytes: isolation, cryopreservation and applications in drug development. Chem Biol Interact 2007;168:16-29
   PubMed Web of Science ®Google Scholar
• Ghibellini G, Vasist LS, Leslie EM, In vitro-in vivo correlation of hepatobiliary drug clearance in humans. Clin Pharmacol Ther 2007;81:406-13
   PubMed Web of Science ®Google Scholar
• Hartmann G, Cheung AK, Piquette-Miller M. Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. J Pharmacol Exp Ther 2002;303:273-81
   PubMed Web of Science ®Google Scholar
• Green RM, Whiting JF, Rosenbluth AB, Interleukin-6 inhibits hepatocyte taurocholate uptake and sodium-potassium-adenosinetriphosphatase activity. Am J Physiol 1994;267:G1094-100
   PubMed Web of Science ®Google Scholar
• Whiting JF, Green RM, Rosenbluth AB, Gollan JL. Tumor necrosis factor-alpha decreases hepatocyte bile salt uptake and mediates endotoxin-induced cholestasis. Hepatology 1995;22:1273-8
   PubMed Web of Science ®Google Scholar
• Li D, Zimmerman TL, Thevananther S, Interleukin-1 beta-mediated suppression of RXR:RAR transactivation of the Ntcp promoter is JNK-dependent. J Biol Chem 2002;277:31416-22
   PubMed Web of Science ®Google Scholar
• Sukhai M, Yong A, Kalitsky J, Piquette-Miller M. Inflammation and interleukin-6 mediate reductions in the hepatic expression and transcription of the mdr1a and mdr1b genes. Mol Cell Biol Res Commun 2000;4:248-56
   PubMedGoogle Scholar
• Sukhai M, Yong A, Pak A, Piquette-Miller M. Decreased expression of P-glycoprotein in interleukin-1beta and interleukin-6 treated rat hepatocytes. Inflamm Res 2001;50:362-70
   PubMed Web of Science ®Google Scholar
• Belliard AM, Lacour B, Farinotti R, Leroy C. Effect of tumor necrosis factor-alpha and interferon-gamma on intestinal P-glycoprotein expression, activity, and localization in caco-2 cells. J Pharm Sci 2004;93:1524-36
   PubMed Web of Science ®Google Scholar
• Liptrott NJ, Penny M, Bray PG, The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC. Br J Pharmacol 2009;156:497-508
   PubMed Web of Science ®Google Scholar
• Fernandez C, Buyse M, German-Fattal M, Gimenez F. Influence of the pro-inflammatory cytokines on P-glycoprotein expression and functionality. J Pharm Pharm Sci 2004;7:359-71
   PubMed Web of Science ®Google Scholar
• Akazawa Y, Kawaguchi H, Funahashi M, Effect of interferons on P-glycoprotein-mediated rhodamine-123 efflux in cultured rat hepatocytes. J Pharm Sci 2002;91:2110-5
   PubMed Web of Science ®Google Scholar
• Moseley RH. Sepsis-associated cholestasis. Gastroenterology 1997;112:302-6
   PubMed Web of Science ®Google Scholar
• Donner MG, Keppler D. Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver. Hepatology 2001;34:351-9
   PubMed Web of Science ®Google Scholar
• Bastard JP, Maachi M, Lagathu C, Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 2006;17:4-12
   PubMed Web of Science ®Google Scholar
• Alam I, Lewis K, Stephens JW, Baxter JN. Obesity, metabolic syndrome and sleep apnoea: all pro-inflammatory states. Obes Rev 2007;8:119-27
   PubMed Web of Science ®Google Scholar
• Tilg H, Moschen AR. Inflammatory mechanisms in the regulation of insulin resistance. Mol Med 2008;14:222-31
   PubMed Web of Science ®Google Scholar
• Lee JB, Winstead PS, Cook AM. Pharmacokinetic alterations in obesity. Orthopedics 2006;29:984-8
   PubMed Web of Science ®Google Scholar
• Gwilt PR, Nahhas RR, Tracewell WG. The effects of diabetes mellitus on pharmacokinetics and pharmacodynamics in humans. Clin Pharmacokinet 1991;20:477-90
   PubMed Web of Science ®Google Scholar
• Cheng Q, Aleksunes LM, Manautou JE, Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity. Mol Pharm 2008;5:77-91
   PubMed Web of Science ®Google Scholar
• Saklatvala J, Dean J, Clark A. Control of the expression of inflammatory response genes. Biochem Soc Symp 2003;70:95-106
   PubMed Web of Science ®Google Scholar
• Teng S, Piquette-Miller M. The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice. J Pharmacol Exp Ther 2005;312:841-8
   PubMed Web of Science ®Google Scholar
• Qadri I, Iwahashi M, Kullak-Ublick GA, Simon FR. Hepatocyte nuclear factor (HNF) 1 and HNF4 mediate hepatic multidrug resistance protein 2 up-regulation during hepatitis C virus gene expression. Mol Pharmacol 2006;70:627-36
   PubMed Web of Science ®Google Scholar
• Jung D, Hagenbuch B, Fried M, Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse, and rat NTCP gene. Am J Physiol Gastrointest Liver Physiol 2004;286:G752-61
   PubMed Web of Science ®Google Scholar
• Jung D, Kullak-Ublick GA. Hepatocyte nuclear factor 1 alpha: a key mediator of the effect of bile acids on gene expression. Hepatology 2003;37:622-31
   PubMed Web of Science ®Google Scholar
• Saborowski M, Kullak-Ublick GA, Eloranta JJ. The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha. J Pharmacol Exp Ther 2006;317:778-85
   PubMed Web of Science ®Google Scholar
• Trauner M, Arrese M, Lee H, Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. J Clin Invest 1998;101:2092-100
   PubMed Web of Science ®Google Scholar
• Andrejko KM, Raj NR, Kim PK, IL-6 modulates sepsis-induced decreases in transcription of hepatic organic anion and bile acid transporters. Shock 2008;29:490-6
   PubMed Web of Science ®Google Scholar
• Muhlfeld A, Kubitz R, Dransfeld O, Taurine supplementation induces multidrug resistance protein 2 and bile salt export pump expression in rats and prevents endotoxin-induced cholestasis. Arch Biochem Biophys 2003;413:32-40
   PubMed Web of Science ®Google Scholar