270
Views
21
CrossRef citations to date
0
Altmetric
Reviews

Mechanisms of ketamine-involved regulation of cytochrome P450 gene expression

& , PhD
Pages 273-281 | Published online: 18 Feb 2010

Bibliography

  • Craven R. Ketamine. Anaesthesia 2007;62(Suppl 1):48-53
  • Guengerich FP. Reaction and significance of cytochrome P-450 enzymes. J Biol Chem 1991;266:10019-22
  • Nebert DW, Dalton TP. The role of cytochrome P450 enzymes in endogenous signaling pathways and environmental carcinogenesis. Nat Rev Cancer 2006;6:947-60
  • Hijazi Y, Boulieu R. Contribution of CYP3A4, CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes. Drug Metab Dispos 2002;30:853-8
  • Kimura F, Hashimoto Y, Shimodate Y. Clinical study on total intravenous anaesthesia with droperidol, fentanyl and ketamine. Hepatic and renal functions following prolonged surgical operation of over 10 h. Masui 1991;40:1371-5
  • Lee ST, Wu TT, Yu PY, Apoptotic insults to human HepG2 cells induced by S-(+)-ketamine occurs through activation of a Bax-mitochondria-caspase protease pathway. Br J Anaesth 2009;102:80-9
  • Martínez-Jiménez CP, Jover R, Donato MT, Transcriptional regulation and expression of CYP3A4 in hepatocytes. Curr Drug Metab 2007;8:185-94
  • Chang HC, Chen TL, Chen RM. Cytoskeleton interruption in human hepatoma HepG2 cells induced by ketamine occurs possibly through suppression of calcium mobilization and mitochondrial function. Drug Metab Dispos 2009;37:24-31
  • Guengerich FP, Martin MV, Beaune PH, Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism. J Biol Chem 1986;261:5051-60
  • Acharya P, Engel JC, Correia MA. Hepatic CYP3A suppression by high concentrations of proteasomal inhibitors: a consequence of endoplasmic reticulum (ER) stress induction, activation of RNA-dependent protein kinase-like ER-bound eukaryotic initiation factor 2alpha (eIF2alpha)-kinase (PERK) and general control nonderepressible-2 eIF2alpha kinase (GCN2), and global translational shutoff. Mol Pharmacol 2009;76:503-15
  • Brian P, Monahan MD, Clifford L, Torsades de Pointes occurring in association with terfenadine use. JAMA 1990;264:2788-90
  • Canton DA, Litchfield DW. The shape of things to come: an emerging role for protein kinase CK2 in the regulation of cell morphology and the cytoskeleton. Cell Signal 2006;18:267-75
  • Gourlay CW, Ayscough KR. The actin cytoskeleton: a key regulator of apoptosis and ageing? Nat Rev Mol Cell Biol 2005;6:583-9
  • Adrain C, Duriez PJ, Brumatti G, The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics. J Biol Chem 2006;281:8118-25
  • Cherng YG, Chang HC, Lin YL, Apoptotic insults to human chondrocytes induced by nitric oxide are involved in sequential events, including cytoskeletal remodeling, phosphorylation of mitogen-activated protein kinase kinase kinase-1, and Bax-mitochondria-mediated caspase activation. J Orthop Res 2008;26:1018-26
  • Dvorak Z, Ulrichova J, Modriansky M. Role of microtubules network in CYP genes expression. Curr Drug Metab 2005;6:545-52
  • Molitoris BA, Dahl R, Hosford M. Cellular ATP depletion induces disruption of the spectrin cytoskeletal network. Am J Physiol 1996;271:790-8
  • Fache S, Dalous J, Engelund M, Calcium mobilization stimulates Dictyostelium discoideum shear-flow-induced cell motility. J Cell Sci 2005;118:3445-7
  • Papucci L, Schiavone N, Witort E, Coenzyme q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical scavenging property. J Biol Chem 2003;278:28220-8
  • Green SM, Klooster M, Harris T, Ketamine sedation for pediatric gastroenterology procedures. J Pediatr Gastroenterol Nutr 2001;32:26-33
  • Bourgoin A, Albanese J, Wereszczynski N, Safety of sedation with ketamine in severe head injury patients: comparison with sufentanil. Crit Care Med 2003;31:711-17
  • Reich D, Silvay G. Ketamine: an update on the first twenty-five years of clinical experience. Can J Anaesth 1989;36:186-97
  • De Kock MF, Lavand’homme PM. The clinical role of NMDA receptor antagonists for the treatment of postoperative pain. Best Prac Res Clin Anaesthesiol 2007;21:85-98
  • Pekoe GM, Smith DJ. The involvement of opiate and monoaminergic neuronal systems in the analgesic effects of ketamine. Pain 1982;12:57-73
  • Cook DJ, Carton EG, Housmans PR. Mechanism of the positive inotropic effect of ketamine in isolated ferret ventricular papillary muscle. Anesthesiology 1991;74:880-8
  • Chen RM, Chen TL, Lin YL, Ketamine reduces nitric oxide biosynthesis in human umbilical vein endothelial cells through downregulating endothelial nitric oxide synthase expression and intracellular calcium levels. Crit Care Med 2005;33:1044-9
  • Lundy PM, Lockwood PA, Thompson G, Differential effects of ketamine isomers on neuronal and extraneuronal catecholamine uptake mechanisms. Anesthesiology 1986;64:359-63
  • Lau TT, Zed PJ. Does ketamine have a role in managing severe exacerbation of asthma in adults? Pharmacotherapy 2001;21:110-6
  • Strayer RJ. Nelson LS. Adverse events associated with ketamine for procedural sedation in adults. Am J Emerg Med 2008;26:985-1028
  • Guengerich FP. Reaction and significance of cytochrome P-450 enzymes. J Biol Chem 1991;266:10019-22
  • Nebert DW, Dalton TP. The role of cytochrome P450 enzymes in endogenous signaling pathways and environmental carcinogenesis. Nat Rev Cancer 2006;6:947-60
  • Guengerich FP. Cytochrome P450 and chemical toxicology. Chem Res Toxicol 2008;21:70-83
  • Iyer M, Reschly EJ, Krasowski MD. Functional evolution of the pregnane X receptor Export. Expert Opin Drug Metab Toxicol 2006;2:381-97
  • Zhang YY, Yang L. Interactions between human cytochrome P450 enzymes and steroids: physiological and pharmacological implications. Expert Opin Drug Metab Toxicol. 2009;5:621-9
  • Guengerich FP, Martin MV, Beaune PH, Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism. J Biol Chem 1986;261:5051-60
  • Woolf TF, Adams JD. Biotransformation of ketamine, (Z)-6-hydroxyketamine, and (E)-6-hydroxyketamine by rat, rabbit, and human liver microsomal preparations. Xenobiotica 1987;17:839-47
  • Yanagihara Y, Kariya S, Ohtani M, Involvement of CYP2B6 in the N-demethylation of ketamine in human liver microsomes. Drug Metab Dispos 2001;29:887-90
  • Wang H, Tompkins LM. CYP2B6: New insights into a historically overlooked cytochrome P450 isozyme. Curr Drug Metab 2008;9:598-610
  • Chang T, Savory A, Albin M, Metabolic disposition of tritium-labelled ketamine. Clin Res 1970;18:597
  • Zhou S, Chan E, Lim LY, Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4. Curr Drug Metab 2004;5:415-42
  • Tanaka E. Clinically important pharmacokinetic drug-drug interactions: role of cytochrome P450 enzymes. J Clin Pharm Ther 1998;23:403-16
  • Bailey DG, Dresser GK, Bend JR. Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice. Clin Pharmacol Ther 2003;73:529-37
  • Lin JH. CYP induction-mediated drug interactions: in vitro assessment and clinical implications. Pharm Res 2006;23:1089-116
  • Plant N. The human cytochrome P450 sub-family: transcriptional regulation, inter-individual variation and interaction networks. Biochim Biophys Acta 2007;1770:478-88
  • Li W, Harper PA, Tang BK, Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene. Biochem Pharmacol 1998;56:599-612
  • Goodwin B, Hodgson E, D’Costa DJ, Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor. Mol Pharmacol 2002;62:359-65
  • Gnerre C, Blattler S, Kaufmann MR, Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene. Pharmacogenetics 2004;14:635-45
  • Watt AJ, Garrison WD, Duncan SA. HNF4: a central regulator of hepatocyte differentiation and function. Hepatology 2003;37:1249-53
  • Marietta MP, White PF, Pudwill CR, Biodisposition of ketamine in the rat: self-induction of metabolism. J Pharmacol Exp Ther 1976;196:536-44
  • Marietta MP, Vore ME, Way WL, Characterization of ketamine induction of hepatic microsomal drug metabolism. Biochem Pharmacol 1977;26:2451-3
  • Loch JM, Potter J, Bachmann KA. The influence of anesthetic agents on rat hepatic cytochromes P450 in vivo. Pharmacology 1995;50:146-53
  • Meneguz A, Fortuna S, Lorenzini P, Influence of urethane and ketamine on rat hepatic cytochrome P450 in vivo. Exp Toxicol Pathol 1999;51:392-6
  • Lupp A, Kerst S, Karge E. Evaluation of possible pro- or antioxidative properties and of the interaction capacity with the microsomal cytochrome P450 system of different NMDA-receptor ligands and of taurine in vitro. Exp Toxicol Pathol 2003;54:441-8
  • Chan WH, Sun WZ, Ueng TH. Induction of rat hepatic cytochrome P-450 by ketamine and its toxicological implications. J Toxicol Environ Health A 2005;68:1581-97
  • Osaka Y, Inomata S, Tanaka E, Effect of propofol on ropivacaine metabolism in human liver microsomes. J Anesth 2006;20:60-3
  • Yang LQ, Yu WF, Cao YF, Potential inhibition of cytochrome P450 3A4 by propofol in human primary hepatocytes. World J Gastroenterol 2003;9:1959-62
  • Pasanen M, Pellinen P, Stenback F, The role of CYP enzymes in cocaine-induced liver damage. Arch Toxicol 1995;69:287-90
  • Willard FS, Crouch MF. Nuclear and cytoskeletal translocation and localization of heterotrimeric G-proteins. Immunol Cell Biol 2000;78:387-94
  • Janmey PA. The cytoskeleton and cell signaling: component localization and mechanical coupling. Physiol Rev 1998;78:763-81
  • Németh ZH, Deitch EA, Davidson MT, Disruption of the actin cytoskeleton results in nuclear factor-kappaB activation and inflammatory mediator production in cultured human intestinal epithelial cells. J Cell Physiol 2004;200:71-81
  • Rosette C, Karin M. Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa B. J Cell Biol 1995;128:1111-9
  • Dvorák Z, Vrzal R, Ulrichová J, Involvement of cytoskeleton in AhR-dependent CYP1A1 expression. Curr Drug Metab 2006;7:301-13
  • Schöller A, Hong NJ, Bischer P, Short and long term effects of cytoskeleton-disrupting drugs on cytochrome P450 Cyp1a-1 induction in murine hepatoma 1c1c7 cells: suppression by the microtubule inhibitor nocodazole. Mol Pharmacol 1994;45:944-54
  • Dvorak Z, Modriansky M, Pichard-Garcia L, Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation. Mol Pharmacol 2003;64:160-9
  • Modrianský M, Dvorák Z. Microtubule disruptors and their interaction with biotransformation enzymes. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2005;149:213-5
  • Zheng X, Diraviyam K, Sept D. Nucleotide effects on the structure and dynamics of actin. Biophys J 2007;93:1277-83
  • Nogales E. Structural insights into microtubule function. Ann Rev Biochem 2000;69:277-302
  • Andrew WH, Linda W. How motor proteins influence microtubule polymerization dynamics. J Cell Sci 2000;113:4379-89
  • Karcher RL, Roland JT, Zappacosta F, Cell cycle regulation of myosin-V by calcium/calmodulin-dependent protein kinase II. Science 2001;293:1317-20
  • Adamíková L, Straube A, Schulz I, Calcium signaling is involved in dynein-dependent microtubule organization. Mol Biol Cell 2004;15:1969-80
  • Rappaport L, Oliviero P, Samuel JL. Cytoskeleton and mitochondrial morphology and function. Mol Cell Biochem 1998;184:101-5
  • Yoon YS, Byun HO, Cho H, Complex II defect via down-regulation of iron-sulfur subunit induces mitochondrial dysfunction and cell cycle delay in iron chelation-induced senescence-associated growth arrest. J Biol Chem 2003;278:51577-86
  • de Cavanagh EM, Ferder M, Inserra F, Angiotensin II, mitochondria, cytoskeletal, and extracellular matrix connections: an integrating viewpoint. Am J Physiol Heart Circ Physiol 2009;296:550-8
  • Markham A, Cameron I, White SJ. The effect of ketamine hydrochloride, a non-barbiturate parenteral anaesthetic on oxidative phosphorylation in rat liver mitochondria. Biochem Pharmacol 1981;30:2165-8
  • Chang Y, Chen TL, Sheu JR, Suppressive effects of ketamine on macrophage functions. Toxicol Appl Pharmacol. 2005;204:27-35
  • Pearce LL, Epperly MW, Greenberger JS, Identification of respiratory complexes I and III as mitochondrial sites of damage following exposure to ionizing radiation and nitric oxide. Nitric Oxide 2001;5:128-36
  • Ogawa K, Tanaka S, Murray PA. Inhibitory effects of etomidate and ketamine on endothelium-dependent relaxation in canine pulmonary artery. Anesthesiology 2001;94:668
  • Kamel IR, Wendling WW, Chen D, N-methyl-D-aspartate (NMDA) antagonists–S(+)-ketamine, dextrorphan, and dextromethorphan–act as calcium antagonists on bovine cerebral arteries. J Neurosurg Anesthesiol 2008;20:241-8
  • Haugen DA, Coon MJ. Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone-inducible forms of liver microsomal cytochrome P-450. J Biol Chem 1976;251:7929-39
  • Ueng TH, Ueng YF, Tsai JN, Induction and inhibition of cytochrome P-450-dependent monooxygenases in hamster tissues by ethanol. Toxicology 1993;81:145-54

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.