Suppressive and pro-inflammatory roles for IL-4 in the pathogenesis of experimental drug-induced liver injury: a review

Bibliography

• Schiodt FV, Atillasoy E, Shakil AO, Etiology and outcome for 295 patients with acute liver failure in the United States. Liver Transpl Surg 1999;5:29-34
   PubMedGoogle Scholar
• Ostapowicz G, Fontana RJ, Schiodt FV, Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med 2002;137:947-54
   PubMed Web of Science ®Google Scholar
• Castell JV. Allergic hepatitis: a drug-mediated organ-specific immune reaction. Clin Exp Allergy 1998;28(Suppl 4):13-9
   PubMedGoogle Scholar
• Adkinson NF Jr, Essayan D, Gruchalla R, Task force report: future research needs for the prevention and management of immune-mediated drug hypersensitivity reactions. J Allergy Clin Immunol 2002;109:S461-78
   PubMed Web of Science ®Google Scholar
• Mackay IR, Toh BH. Autoimmune hepatitis: the way we were, the way we are today and the way we hope to be. Autoimmunity 2002;35:293-305
   PubMed Web of Science ®Google Scholar
• Neuberger J, Mieli-Vergani G, Tredger JM, Oxidative metabolism of halothane in the production of altered hepatocyte membrane antigens in acute halothane-induced hepatic necrosis. Gut 1981;22:669-72
   PubMed Web of Science ®Google Scholar
• Pohl LR, Thomassen D, Pumford NR, Hapten carrier conjugates associated with halothane hepatitis. Adv Exp Med Biol 1991;283:111-20
   PubMedGoogle Scholar
• Njoku D, Laster MJ, Gong DH, Biotransformation of halothane, enflurane, isoflurane, and desflurane to trifluoroacetylated liver proteins: association between protein acylation and hepatic injury. Anesth Analg 1997;84:173-8
   PubMed Web of Science ®Google Scholar
• Njoku DB, Talor MV, Fairweather D, A novel model of drug hapten-induced hepatitis with increased mast cells in the BALB/c mouse. Exp Mol Pathol 2005;78:87-100
   PubMed Web of Science ®Google Scholar
• Njoku DB, Li Z, Washington ND, Suppressive and pro-inflammatory roles for IL-4 in the pathogenesis of experimental drug-induced liver injury. Eur J Immunol 2009;39:1652-63
   PubMed Web of Science ®Google Scholar
• Martin JL, Kenna JG, Martin BM, Halothane hepatitis patients have serum antibodies that react with protein disulfide isomerase. Hepatology 1993;18:858-63
   PubMed Web of Science ®Google Scholar
• Eliasson E, Kenna JG. Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis. Mol Pharmacol 1996;50:573-82
   PubMed Web of Science ®Google Scholar
• Bourdi M, Chen W, Peter RM, Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis. Chem Res Toxicol 1996;9:1159-66
   PubMed Web of Science ®Google Scholar
• Njoku DB, Greenberg RS, Bourdi M, Autoantibodies associated with volatile anesthetic hepatitis found in the sera of a large cohort of pediatric anesthesiologists. Anesth Analg 2002;94:243-9, table of contents
   PubMed Web of Science ®Google Scholar
• Njoku DB, Mellerson JL, Talor MV, Role of CYP2E1 immunoglobulin G4 subclass antibodies and complement in pathogenesis of idiosyncratic drug-induced hepatitis. Clin Vaccine Immunol 2006;13:258-65
   PubMed Web of Science ®Google Scholar
• Aithal GP, Ramsay L, Daly AK, Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity. Hepatology 2004;39:1430-40
   PubMed Web of Science ®Google Scholar
• Gascan H, Gauchat JF, Roncarolo MG, Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clones. J Exp Med 1991;173:747-50
   PubMed Web of Science ®Google Scholar
• Zhang K, Clark EA, Saxon A. CD40 stimulation provides an IFN-gamma-independent and IL-4-dependent differentiation signal directly to human B cells for IgE production. J Immunol 1991;146:1836-42
   PubMed Web of Science ®Google Scholar
• Svensson L, Nandakumar KS, Johansson A, IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis. Eur J Immunol 2002;32:2944-53
   PubMed Web of Science ®Google Scholar
• Gascan H, Gauchat JF, Aversa G, Anti-CD40 monoclonal antibodies or CD4+ T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signaling pathways. J Immunol 1991;147:8-13
   PubMed Web of Science ®Google Scholar
• Anderson JS, Rose NR, Martin JL, Desflurane hepatitis associated with hapten and autoantigen-specific IgG4 antibodies. Anesth Analg 2007;104:1452-3, table of contents
   PubMed Web of Science ®Google Scholar
• Nguyen C, Rose NR, Njoku DB. Trifluoroacetylated IgG4 antibodies in a child with idiosyncratic acute liver failure after first exposure to halothane. J Pediatr Gastroenterol Nutr 2008;47:199-202
   PubMed Web of Science ®Google Scholar
• Tato CM, Laurence A, O'Shea JJ. Helper T cell differentiation enters a new era: le roi est mort; vive le roi! J Exp Med 2006;203:809-12
   PubMed Web of Science ®Google Scholar
• Abdel-Razzak Z, Loyer P, Fautrel A, Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Mol Pharmacol 1993;44:707-15
   PubMed Web of Science ®Google Scholar
• Pricop L, Redecha P, Teillaud JL, Differential modulation of stimulatory and inhibitory Fc gamma receptors on human monocytes by Th1 and Th2 cytokines. J Immunol 2001;166:531-7
   PubMed Web of Science ®Google Scholar
• Moretta L, Ferlazzo G, Bottino C, Effector and regulatory events during natural killer-dendritic cell interactions. Immunol Rev 2006;214:219-28
   PubMed Web of Science ®Google Scholar
• Balato A, Unutmaz D, Gaspari AA. Natural killer T cells: an unconventional T-cell subset with diverse effector and regulatory functions. J Invest Dermatol 2009;129:1628-42
   PubMed Web of Science ®Google Scholar
• Nelms K, Keegan AD, Zamorano J, The IL-4 receptor: signaling mechanisms and biologic functions. Annu Rev Immunol 1999;17:701-38
   PubMed Web of Science ®Google Scholar
• Huppa JB, Davis MM. T-cell-antigen recognition and the immunological synapse. Nat Rev Immunol 2003;3:973-83
   PubMed Web of Science ®Google Scholar
• Zhou H, Su HS, Zhang X, CIITA-dependent and -independent class II MHC expression revealed by a dominant negative mutant. J Immunol 1997;158:4741-9
   PubMed Web of Science ®Google Scholar
• Douhan J, Lieberson R, Knoll JH, An isotype-specific activator of major histocompatibility complex (MHC) class II genes that is independent of class II transactivator. J Exp Med 1997;185:1885-95
   PubMed Web of Science ®Google Scholar
• Outschoorn I, Rowley MJ, Cook AD, Mackay IR. Subclasses of immunoglobulins and autoantibodies in autoimmune diseases. Clin Immunol Immunopathol 1993;66:59-66
   PubMedGoogle Scholar
• Caturegli P, Kuppers RC, Mariotti S, IgG subclass distribution of thyroglobulin antibodies in patients with thyroid disease. Clin Exp Immunol 1994;98:464-9
   PubMed Web of Science ®Google Scholar
• Aalberse RC, Stapel SO, Schuurman J, Rispens T. Immunoglobulin G4: an odd antibody. Clin Exp Allergy 2009;39:469-77
   PubMed Web of Science ®Google Scholar
• Makino S, Kunimoto K, Muraoka Y, Breeding of a non-obese, diabetic strain of mice. Jikken Dobutsu 1980;29:1-13
   PubMedGoogle Scholar
• Turley S, Poirot L, Hattori M, Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. J Exp Med 2003;198:1527-37
   PubMed Web of Science ®Google Scholar
• Yu L, Robles DT, Abiru N, Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes. Proc Natl Acad Sci USA 2000;97:1701-6
   PubMed Web of Science ®Google Scholar
• McDevitt HO, Unanue ER. Autoimmune diabetes mellitus--much progress, but many challenges. Adv Immunol 2008;100:1-12
   PubMed Web of Science ®Google Scholar
• Yamamoto AM, Chernajovsky Y, Lepault F, The activity of immunoregulatory T cells mediating active tolerance is potentiated in nonobese diabetic mice by an IL-4-based retroviral gene therapy. J Immunol 2001;166:4973-80
   PubMed Web of Science ®Google Scholar
• Brusko TM, Putnam AL, Bluestone JA. Human regulatory T cells: role in autoimmune disease and therapeutic opportunities. Immunol Rev 2008;223:371-90
   PubMed Web of Science ®Google Scholar
• Skapenko A, Kalden JR, Lipsky PE, Schulze-Koops H. The IL-4 receptor alpha-chain-binding cytokines, IL-4 and IL-13, induce forkhead box P3-expressing CD25+CD4+ regulatory T cells from CD25-CD4+ precursors. J Immunol 2005;175:6107-16
   PubMed Web of Science ®Google Scholar
• You S, Alyanakian MA, Segovia B, Immunoregulatory pathways controlling progression of autoimmunity in NOD mice. Ann NY Acad Sci 2008;1150:300-10
   PubMed Web of Science ®Google Scholar
• Xu L, Huang Y, Yang J, Dendritic cell-derived nitric oxide is involved in IL-4-induced suppression of experimental allergic encephalomyelitis (EAE) in Lewis rats. Clin Exp Immunol 1999;118:115-21
   PubMed Web of Science ®Google Scholar
• Horsfall AC, Butler DM, Marinova L, Suppression of collagen-induced arthritis by continuous administration of IL-4. J Immunol 1997;159:5687-96
   PubMed Web of Science ®Google Scholar
• Cihakova D, Barin JG, Afanasyeva M, Interleukin-13 protects against experimental autoimmune myocarditis by regulating macrophage differentiation. Am J Pathol 2008;172:1195-208
   PubMed Web of Science ®Google Scholar
• Harrill AH, Ross PK, Gatti DM, Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel. Toxicol Sci 2009;110:235-43
   PubMed Web of Science ®Google Scholar
• Jaruga B, Hong F, Sun R, Crucial role of IL-4/STAT6 in T cell-mediated hepatitis: up-regulating eotaxins and IL-5 and recruiting leukocytes. J Immunol 2003;171:3233-44
   PubMed Web of Science ®Google Scholar
• Moscat J, Rennert P, Diaz-Meco MT. PKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathways. Cell Death Differ 2006;13:702-11
   PubMed Web of Science ®Google Scholar
• Sass G, Heinlein S, Agli A, Cytokine expression in three mouse models of experimental hepatitis. Cytokine 2002;19:115-20
   PubMed Web of Science ®Google Scholar
• Tsutsui H, Adachi K, Seki E, Nakanishi K. Cytokine-induced inflammatory liver injuries. Curr Mol Med 2003;3:545-59
   PubMed Web of Science ®Google Scholar
• Shi Z, Wakil AE, Rockey DC. Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses. Proc Natl Acad Sci USA 1997;94:10663-8
   PubMed Web of Science ®Google Scholar
• Bourdi M, Eiras DP, Holt MP, Role of IL-6 in an IL-10 and IL-4 double knockout mouse model uniquely susceptible to acetaminophen-induced liver injury. Chem Res Toxicol 2007;20:208-16
   PubMed Web of Science ®Google Scholar
• Pohl LR, Kenna JG, Satoh H, Neoantigens associated with halothane hepatitis. Drug Metab Rev 1989;20:203-17
   PubMed Web of Science ®Google Scholar
• Anderson CF, Oukka M, Kuchroo VJ, Sacks D. CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J Exp Med 2007;19(204):285-97
   Google Scholar
• Ji H, Pettit A, Ohmura K, Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J Exp Med 2002;196:77-85
   PubMed Web of Science ®Google Scholar
• Selzner N, Selzner M, Tian Y, Cold ischemia decreases liver regeneration after partial liver transplantation in the rat: a TNF-alpha/IL-6-dependent mechanism. Hepatology 2002;36:812-18
   PubMed Web of Science ®Google Scholar
• Williams BD, White N, Amlot PL, Circulating immune complexes after repeated halothane anaesthesia. Br Med J 1977;2:159-62
   PubMed Web of Science ®Google Scholar
• Itoh N, Hanafusa T, Katsura H, Two types of autoantibodies to adrenal medullary cells in Type 1 (insulin-dependent) diabetic patients: prevalence, properties and implications. J Autoimmun 1991;4:807-18
   PubMed Web of Science ®Google Scholar
• Horneff G, Lenard HG, Wahn V. Severe adverse reaction to carbamazepine: significance of humoral and cellular reactions to the drug. Neuropediatrics 1992;23:272-5
   PubMed Web of Science ®Google Scholar
• van der Zee JS, van Swieten P, Aalberse RC. Inhibition of complement activation by IgG4 antibodies. Clin Exp Immunol 1986;64:415-22
   PubMed Web of Science ®Google Scholar
• Oliveira DB. Membranous nephropathy: an IgG4-mediated disease. Lancet 1998;351:670-1
   PubMed Web of Science ®Google Scholar
• Porubsky PR, Meneely KM, Scott EE. Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates. J Biol Chem 2008;283:33698-707
   PubMed Web of Science ®Google Scholar
• Vidali M, Occhino G, Ivaldi A, Detection of auto-antibodies against cytochrome P4502E1 (CYP2E1) in chronic hepatitis C. J Hepatol 2007;46:605-12
   PubMed Web of Science ®Google Scholar
• Nakai K, Tanaka H, Hanada K, Decreased expression of cytochromes P450 1A2, 2E1, and 3A4 and drug transporters Na+-taurocholate-cotransporting polypeptide, organic cation transporter 1, and organic anion-transporting peptide-C correlates with the progression of liver fibrosis in chronic hepatitis C patients. Drug Metab Dispos 2008;36:1786-93
   PubMed Web of Science ®Google Scholar
• Rigamonti C, Vidali M, Donato MF, Serum autoantibodies against cytochrome P450 2E1 (CYP2E1) predict severity of necroinflammation of recurrent hepatitis C. Am J Transplant 2009;9:601-9
   PubMed Web of Science ®Google Scholar
• Sulkowski MS. Viral hepatitis and HIV coinfection. J Hepatol 2008;48:353-67
   PubMed Web of Science ®Google Scholar
• Iannello A, Samarani S, Debbeche O, Role of interleukin-18 in the development and pathogenesis of AIDS. AIDS Rev 2009;11:115-25
   PubMed Web of Science ®Google Scholar