Predictive tools for the evaluation of microbial effects on drugs during gastrointestinal passage

Bibliography

• Dickson M, Gagnon J. The cost of new drug discovery and development. Discov Med 2004;22:172-79
   Google Scholar
• Adams C, Brantner V. Estimating the cost of new drug development: is it really $802 million? Health Aff 2006;25:420-28
   PubMed Web of Science ®Google Scholar
• Ekins S. Predicting undesirable drug interactions with promiscuous proteins in silico. Drug Discov Today 2004;9:276-85
   PubMed Web of Science ®Google Scholar
• Lennernaes H. Modeling gastrointestinal drug absorption requires more in vivo biopharmaceutical data: experience from in vivo dissolution and permeability studies in humans. Curr Drug Metab 2007;8:645-57
   PubMed Web of Science ®Google Scholar
• Thelen K, Dressman JB. Cytochrome P450-mediated metabolism in the human gut wall. J Pharm Pharmacol 2009;61:541-58
   PubMed Web of Science ®Google Scholar
• Kerr KG. The gastrointestinal microflora: Friends or Foes? J Nutr Env Med 1991;2:39-44
   Google Scholar
• Cha C-J, Doerge DR, Cerniglia CE. Biotransformation of malachite green by the fungus Cunnighamella elegans. Appl Env Microbiol 2001;67:4358-60
   PubMed Web of Science ®Google Scholar
• Chatterjee P, Kouzi SA, Pezzuto JM, Biotransformation of the antimelanoma agent betulinic acid by Bacillus megaterium ATCC 13368. Appl Env Microbiol 2000;66:3850-55
   PubMed Web of Science ®Google Scholar
• Zhang D, Freeman JP, Sutherland JB, Biotransformation of chlorpromazine and methdilazine by Cunninghamella elegans. Appl Env Microbiol 1996;62:798-03
   PubMed Web of Science ®Google Scholar
• Griffiths DA, Best DJ, Jezequel SG. The screening of selected microorganisms for use as models of mammalian drug metabolism. Appl Microbiol Biotechnol 1991;35:373-81
   PubMed Web of Science ®Google Scholar
• Randez-Gil F, Aguilera J, Codon A, Baker's yeast: challenges and future prospects. In: de Winde JH editor, Topics in current genetics Vol. 2, Functional genetics of industrial Yeasts. Springer-Verlag: Heidelberg, 2003. p. 57-97
   Google Scholar
• De Souza Pereira R. The use of baker's yeast in the generation of asymmetric centers to produce chrial drugs and other compounds. Crit Rev Biotechnol 1998;18:25-64
   PubMed Web of Science ®Google Scholar
• Sugano K. Introduction to computational oral absorption simulation. Expert Opin Drug Metab Toxicol 2009;5:259-93
   PubMed Web of Science ®Google Scholar
• Chang C, Swaan PW. Computational approaches to modeling drug transporters. Eur J Pharm Sci 2006;27:411-24
   PubMed Web of Science ®Google Scholar
• Leahy DE. Progress in simulation modelling for pharmacokinetics. Curr Top Med Chem 2003;3:1257-68
   PubMed Web of Science ®Google Scholar
• Bugrim A, Nikolskaya T, Nikolsky Y. Early prediction of drug metabolism and toxicity: systems biology approach and modelling. Drug Discov Today 2004;9:127-35
   PubMed Web of Science ®Google Scholar
• Bertau M, Brusch l, Kummer U. Biosimulation of drug metabolism. In: Bertau M, Mosekilde E, Westerhoff HV, editors. Biosimulation in drug development. Wiley-VCH Verlag GmbH & C. KgaA, Weinheim, 2008
   Google Scholar
• Jolivette LJ, Ekins S. Methods for predicting human drug metabolism. Adv Clin Chem 2007;43:131-76
   PubMed Web of Science ®Google Scholar
• Ekins S, Ring BJ, Grace J, Present and future in vitro approaches for drug metabolism. J Pharmacol Toxicol Methods 2000;44:313-24
   PubMed Web of Science ®Google Scholar
• Riley RJ, McGinnity DF, Austin RP. A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic data in hepatocytes and microsomes. Drug Metab Dispos 2005;33:1304-11
   PubMed Web of Science ®Google Scholar
• Cross DM, Bayliss MK. A commentary on the use of hepatocytes in drug metabolism studies during drug discovery and development1. Drug Metab Rev 2000;32:219-40
   PubMed Web of Science ®Google Scholar
• Wolf G. Gut microbiota: a factor in energy regulation. Nutr Rev 2006;64:47-50
   PubMed Web of Science ®Google Scholar
• Isolauri E, Kalliomäki M, Laitinen K, Modulation of the matring gut barrier and microbiota: a novel target in allergic disease. Curr Pharm Des 2008;14:1368-75
   PubMed Web of Science ®Google Scholar
• Macfarlane S, Macfarlane GT. Bacterial diversity in the human gut. Adv Appl Microbiol 2004;54:261-89
   PubMed Web of Science ®Google Scholar
• O'Hara AM, Shanahan F. The gut flora as a forgotten organ. EMBO Reports 2006;7:688-93
   PubMed Web of Science ®Google Scholar
• Cummings JH, Macfarlane GT. Role of the intestinal bacteria in nutrient metabolism. Clin Nutr 1997;16:3-11
   PubMed Web of Science ®Google Scholar
• Carrière V, Chambaz J, Rousset M. Intestinal responses to xenbiotics. Toxicol in Vitro 2001;15:373-78
   PubMed Web of Science ®Google Scholar
• Hooper LV, Bry L, Falk PG, Host-microbial symbiosis in the mammalian intestine: exploring an internal ecosystem. BioEssays 1998;20:336-43
   PubMed Web of Science ®Google Scholar
• Sousa T, Paterson R, Moore V, The gastrointestinal microbiota as a site for the biotransformation on drugs. Int J Pharm 2008;363:1-25
   PubMed Web of Science ®Google Scholar
• Macfarlane S, Macfarlane GT, Cummings JH. Review article: prebiotics in the gastrointestinal tract. Aliment Pharmacol Ther 2006;24:701-14
   PubMed Web of Science ®Google Scholar
• Young VB, Schmidt TM. Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the faecal microbiota. J Clin microbiol 2004;42:1203-06
   PubMed Web of Science ®Google Scholar
• Bohn M, Leppchen K, Katzberg M, Effects of caffeine on stereoselectivities of high cell density biotransformations of cyclic ß-keto esters with Saccharomyces cerevisiae. Org Biomol Chem 2007;5:3456-63
   PubMed Web of Science ®Google Scholar
• Bailey MT, Engler H, Sheridan JF. Stress induces the translocation of cutaneous and gastrointestinal microflora to secondary lymphoid organs of C57BL/6 mice. J Neuroimmunology 2006;171:29-37
   PubMed Web of Science ®Google Scholar
• Hopkins MJ, Sharp R, Macfarlane GT. Variation in human intestinal microbiota with age. Digest Liver Dis 2002;34:12-8
   Web of Science ®Google Scholar
• Whitehead WE, Engel BT, Schuster MM. Irritable Bowel Syndrome physiologiacal and psychological differences between diarrhea-predominant and constipation-predominant patients. Digest Dis Sci 1980;25:404-13
   PubMed Web of Science ®Google Scholar
• Isomaa B, Almgren P, Tuomi T, Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 2001;24:683-89
   PubMed Web of Science ®Google Scholar
• Subramanian S, Campbell BJ, Rhodes JM. Bacteria in the pathogenesis of inflammatory bowel disease. Curr Opin Infect Dis 2006;19:475-84
   PubMed Web of Science ®Google Scholar
• Yadav H, Jain S, Sinha PR. Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats. Nutr 2007;23:62-8
   PubMed Web of Science ®Google Scholar
• Cani PD, Bibiloni R, Knauf C, Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 2008;57:1470-81
   PubMed Web of Science ®Google Scholar
• O’Mahony L, Freeney M, O’Halloran S, Probiotic impact on microbial flora, inflammation and tumor development in IL-10 knock-out mice. Aliment Pharmacol Ther 2001;15:1219-25
   PubMed Web of Science ®Google Scholar
• Jia W, Li H, Zhao L, Gut microbiota: a potential new territory for drug targeting. Nat Rev Drug Discovery 2008;7:123-29
   PubMed Web of Science ®Google Scholar
• Shanahan F, Kiely B. The gut microbiota and disease-an inner repository for drug discovery. Drug Discov Today Ther Strateg 2007;4:195-00
   Google Scholar
• Isolauri E, Kalliomäki M, Laitinen K, Salminen. Modulation of the maturing gut Barrier and Micobiota: a Novel Target in Allergic Disease. Curr Pharm Des 2008;14:1368-75
   PubMed Web of Science ®Google Scholar
• Walker WA, Duffy LC. Diet and bacterial colonization: Role of probiotics and prebiotics. J Nutr Biochem 1998;9:668-75
   Web of Science ®Google Scholar
• Kaur IP, Chopra K, Saini A. Probiotics: potential pharmaceutical applications. Eur J Pharm Sci 2002;15:1-9
   PubMed Web of Science ®Google Scholar
• Allen SJ, Okoko B, Martinez E, Probiotics for treating infectious diarrhoea. Cochrane database Syst Rev 2004;2:CD003048
   PubMedGoogle Scholar
• He T, Priebe MG, Zhong Y, Effects of yogurt and bifidobacteria supplementation on the colonic microbiota in lactose-intolerant subjects. J Appl Microbiol 2008;104:595-04
   PubMed Web of Science ®Google Scholar
• Tuohy KM, Rouzaud GCM, Brück WM, Modulation of the human gut microflora towards improved health using prebiotics – assessment of efficacy. Curr Pharm Des 2005;11:75-90
   PubMed Web of Science ®Google Scholar
• Gibson GR, McCartney AL, Rastall RA. Prebiotic and resistance to gastrointestinal infections. Br J Nutr 2006;93:31-4
   Google Scholar
• Jeong S-H, Song Y-K, Cho J-H. Risk assessment of ciprofloxacin, flavomycin, olaquindox and colistin sulfate based on microbiological impact on human gut biota. Regulat Toxicol Pharmacol 2009;53:209-16
   PubMed Web of Science ®Google Scholar
• Wikoff WR, Anfora AT, Liu J, Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci USA 2009;106:3698-03
   PubMed Web of Science ®Google Scholar
• Schulz K, Bertau M, Schlenz K, Headspace solid-phase microextraction–gas chromatography-mass spectrometry determination of the characteristic flavourings menthone, isomenthone, neomenthol and menthol in serum samples with and without enzymatic cleavage to validate post-offence alcohol drinking claims. Anal Chim Acta 2009;646:128-40
   PubMed Web of Science ®Google Scholar
• Montalto M, d’Onofrio F, Gallo A, Intestinal microbiota and its function. Dig Liver Dis 2009;3:30-4
   Google Scholar
• Pitcher MCL, Cummings JH. Hydrogen suliphide: a bactirial toxin in ulcerative colitis? Gut 1996;39:1-4
   PubMed Web of Science ®Google Scholar
• Diakidou A, Vertzoni M, Goumas K, Characterization of the contents of ascending colon to which drugs are exposed after oral administration to healthy adults. Pharm Res 2009;26:2141-51
   PubMed Web of Science ®Google Scholar
• Okuda H, Ogura K, Kato A, A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs. J Pharmacol Exp Ther 1998;287:791-99
   PubMed Web of Science ®Google Scholar
• Davis SS. Formulation strategies for absorption windows. Drug Discovery Today 2005;10:249-57
   PubMed Web of Science ®Google Scholar
• Schrör K. Acetylsalicylic acid. Wiley-Blackwell: Weinheim; 2009. p. 36-39
   Google Scholar
• Deloménie C, Fouix S, Longuemaux S, Identification and functional characterisation of arylamine n-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol 2001;183:3417-27
   PubMed Web of Science ®Google Scholar
• Holt R. The bacterial degradation of chloramphenicol. Lancet 1967;1:1259
   PubMed Web of Science ®Google Scholar
• Rafii F, Hotchkiss C, Heinze TM, Metabolism of daidzein by intestinal bacteria from rhesus monkeys (macaca mulatta). Comparat Med 2004;54:165-69
   PubMed Web of Science ®Google Scholar
• Vermes A, Kuijper EJ, Guchelaar HJ, An in vitro study on the active conversion of flucytosine to fluorouracil by microorganisms in the human intestinal microflora. Chemotherapy 2003;49:17-23
   PubMed Web of Science ®Google Scholar
• Goldin BR, Peppercorn MA, Goldmann P. Contribution of host and intestinal microflora in the metabolism of L-dopa by the rat. J Pharmcol Exp Ther 1973;186:160
   PubMed Web of Science ®Google Scholar
• Shu YZ, Kingstone DGI, Van Tassell RL, Metabolism of levamisole, an anti-colon cancer drug by human intestinal bacteria. Xenobiotica 1991;21:737-50
   PubMed Web of Science ®Google Scholar
• Takeno S, Sakai T. The role of the gut flora metabolism in nitrazepam-induced teratogenicity in rats. Eur J Pharmacol 1990;183:2439-40
   Web of Science ®Google Scholar
• Rafii F, Sutherland JB, Hansen EB, Reduction of nitrazepam by clostridium leptum, a nitroreductase-production bacterium isolated from the human intestinal tract. Clin Infect Dis 1997;25:121-22
   PubMed Web of Science ®Google Scholar
• Gordon HA, Pesti L. The gnotobiotic animal as a tool in the study of host microbial relationships. Microbiol Mol Biol Rev 1971;35:390-29
   Google Scholar
• Ilett KF, Tee LBG, Reeves PT, Metabolism of drugs and other xenobiotics in the gut lumen and wall. Pharmacol Ther 1990;46:67-93
   PubMed Web of Science ®Google Scholar
• Karali TT. Comparison of the gastrointestinal anatomy, physiology and biochemistry of human and commonly used laboratory animals. Biopharm Drug Dispos 1995;16:351-80
   PubMed Web of Science ®Google Scholar
• Renwick AG. First-pass metabolism within the lumen of the gastrointestinal tract. In: Gorge CF, Shand G, Renwick AG, editors. Clinical pharmacology and therapeutics, presystemetic drug elimination. Vol. 1. Butterworth Scientific: London; 1982. p. 3-28
   Google Scholar
• Edwards CA, Parrett AM. Colonic fermentation–in vitro and in vivo approaches to measurement. Sciences des Aliments 1999;19:291-00
   Web of Science ®Google Scholar
• Rowland I, Mallett A, Bearne C, Enzyme activities of the hindgut microflora of laboratory animals and man. Xenobiotica 1986;16:519-23
   PubMed Web of Science ®Google Scholar
• Drasar BS, Hill MJ, William REO. The significance of the gut flora in safety testing of food additives. In: Roe FJC, editor. Metabolic aspects of food safety. Academic: New York; 1970
   Google Scholar
• Savage DC. Microbial ecology of the gastrointestinal tract. Ann Rev Microbiol 1977;37:107-33
   Google Scholar
• Dumas ME, Barton RH, Toye A, Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci USA 2006;103:12511-16
   PubMed Web of Science ®Google Scholar
• Richmond J. The 3Rs– Past, present and future. Scand J Lab Anim Sci 2000;2:84-92
   Google Scholar
• Gibson GR, Fuller R. Aspects of in vitro and in vivo research approaches directed toward indentifying probiotics and prebiotics for human use. J Nutr 2000;130:391-95
   PubMed Web of Science ®Google Scholar
• Aura A, Oikarinen S, Mutanen M. Suitability of batch in vitro fermentation model using human faecal microbiota for prediction of conversion of flaxseed lignans to enterolactone with reference to an in vivo rat model. Eur J Nutr 2006;45:45-51
   PubMed Web of Science ®Google Scholar
• Molly K, Vande Woestyne M, Verstraete W. Development of a 5-step multi-chamber reactor as a simulation of the human intestinal microbial ecosystem. Appl Microbiol Biotechnol 1993;39:254-58
   PubMed Web of Science ®Google Scholar
• Minekus M, Havenaar R. Reactor system. EP0642382; 1998
   Google Scholar
• De Boever P, Deplancke B, Verstraete W. Fermentation by gut microbiota cultured in a simulator of the human intestinal microbial ecosystem is improved by supplementing a soygerm powder. J Nutr 2000;130:2599-06
   PubMed Web of Science ®Google Scholar
• Yoo JY, Chen XD. GIT physicochemical modeling–a critical review. Int J Food Eng 2006;2
   Web of Science ®Google Scholar
• Kontula P, Jaskari J, Nollet l, The colonization of a simulator of the human intestinal microbial ecosystem by a probiotic strain fed on a fermented oat bran product: effects on the gastrointestinal microbiota. Appl Microbiol Biotechnol 1998;50:246-52
   PubMed Web of Science ®Google Scholar
• Alander M, De Smet I, Nollet L, The effect of probiotic strains on the microbiota of the Simulator of the Human Intestinal Microbial Ecosystem (SHIME). Int J Food Microbiol 1999;46:71-9
   PubMed Web of Science ®Google Scholar
• van de Wiele T, Boon N, Possemiers S, Prebiotic effects of chicory inulin in the simulator of the human intestinal microbial ecosystem. FEMS Microbiol Ecol 2004;51:143-53
   PubMed Web of Science ®Google Scholar
• Possemiers S, Bolca S, Grootaert C, The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine. J Nutr 2006;136:1862-67
   PubMed Web of Science ®Google Scholar
• Schacht E, Gevaert A, Kenawy ER, Polymers for colon specific drug delivery. J Controlled Release 1996;39:327-38
   Web of Science ®Google Scholar
• Possemiers S, Verthe K, Uyttendaele S, PCR-DGGE-based quantification of stability of the microbial community in a simulator of the human intestinal microbial ecosystem. FEMS Microbiol Ecol 2004;49:495-07
   PubMed Web of Science ®Google Scholar
• Blanquet S, Meunier JP, Minekus M, Recombinant Saccharomyces cerevisiae expressing a P450 in artificial digestive systems: a model for biodetoxication in the human digestive environment. Appl Env Microbiol 2003;69:2884-92
   PubMed Web of Science ®Google Scholar
• Havenaar R, Minekus M. Simulated assimilation. Dairy Ind Int 1996;61:17-3
   Google Scholar
• Avantaggiato G, Havenaar R, Visconti A. Assessing the zearalenone binding activity of adsorbent materials during passage through a dynamic gastrointestinal model. Food Chemical Tox 2003;41:1283-90
   PubMed Web of Science ®Google Scholar
• Marteau P, Minekus M, Havenaar R, Survival of lactic acid bacteria in a dynamic model of the stomach and small intestine: validation and the effects of bile. J Dairy Sci 1997;80:1031-37
   PubMed Web of Science ®Google Scholar
• van den Berg R, Havenaar R, Bast A. Bioavailability of ferulic acid is determined by its bioaccessibility. J Cerael Sci 2009;49:296-00
   Web of Science ®Google Scholar
• Naylor TA, Connolly PC, Martini LG, Use of a gastro-intestinal model and Gastroplus™ for the prediction of in vivo performance. Ind Pharm 2006;12:9-12
   Google Scholar
• Blanque S, Zeijdner E, Beyssac E, A dynamic artificial gastrointestinal system for studying the behavior of orally administered drug dosage forms under various physiological conditions. Pharm Res 2004;21:585-91
   PubMed Web of Science ®Google Scholar
• Verwei M, Freidig AP, Havenaar R, Predicted serum folate concentrations based on in vitro studies and kinetic modeling are consistent with measured folate concentrations in humans. J Nutr 2006;136:3074-78
   PubMed Web of Science ®Google Scholar
• Yap CW, Xue Y, Chen YZ. Application of support vector machines to in silico prediction of cytochrome P450 enzyme substrates and inhibitors. Curr Top Med Chem 2006;6:1593-07
   PubMed Web of Science ®Google Scholar
• Mosekilde E, Sosnovtseva OV, Holstein-Rathlou N-H. Mechanism-based modelling of complex biomedical systems. Basic Clin Pharmacol Toxicol 2005;96:212-24
   PubMed Web of Science ®Google Scholar
• Oláh J, Orosz F, Puskás LG, triosephosphate isomerase deficiency: consequences of an inherited mutation at mRNA, protein and metabolic level. Biochem J 2005;392:675-83
   PubMed Web of Science ®Google Scholar
• Chang C, Swaan PW. Computational approaches to modelling drug transporters. Pharm Sci 2006;27:411-24
   Web of Science ®Google Scholar
• Sugano K. Introduction to computational oral absorption simulation. Expert Opin Drug Metab Toxicol 2009;5:259-93
   PubMed Web of Science ®Google Scholar
• Kapetanovic IM. Computer-aided drug discovery and development (CADDD): in silico-chemico-biological approach. Chemico-biological Interaction 2008;171:165-76
   PubMed Web of Science ®Google Scholar
• Fox T, Kriegl J. Machine learning techniques for in silico modelling of drug metabolism. Curr Top Med Chem 2006;6:1579-91
   PubMed Web of Science ®Google Scholar
• Jones MH, Gardner IB, Watson KJ. Modelling and PBPK simulation in drug discovery. Am Assoc Pharm Scientists 2009;11:155-65
   Google Scholar
• Andersen R, Jørgensen FS, Olsen L, Development of a QSAR model for binding of tripeptides and tropeptidomimetics to the human intestinal di-/tripeptide transporter hPEPT1. Pharm Res 2006;23:483-92
   PubMed Web of Science ®Google Scholar
• Li H, Sun J, Fan X, Considerations and recent advances in QSAR models for cytochrome P450 -mediated drug metabolism prediction. J Comput Aided Mol Des 2008;22:843-55
   PubMed Web of Science ®Google Scholar
• Brusch L, Cuniberti G, Bertau M. Model evaluation for glycolytic oscillations in yeast biotransformations of xenobiotics. Biophys Chem 2004;109:413-26
   PubMed Web of Science ®Google Scholar
• Pieper I, Wechler K, Katzberg M, Biosimulation of drug metabolism-A yeast based model. Eur J Pharm Sci 2009;36:157-70
   PubMed Web of Science ®Google Scholar
• Giaever G, Chu AM, Ni L, Functional profiling of the Saccharomyces cerevisiae genome. Nature 2002;418:387-91
   PubMed Web of Science ®Google Scholar
• Lee TI, Rinaldi NJ, Robert F, Transcriptional regulatory networks in Saccharomyces cerevisiae. Science 2002;298:799-04
   PubMed Web of Science ®Google Scholar
• Cherry JM, Ball C, Weng S, Genetic and physical maps of Saccharomyces cerevisiae. Nature 1997;387:67-73
   PubMed Web of Science ®Google Scholar
• Mewes HW, Albermann K, Bähr M, Overview of the yeast genome. Nature 1997;387:7-8
   PubMed Web of Science ®Google Scholar
• Richard P, Teusink B, Westerhoff HV, Around the growth phase transition S. cerevisiae’s make-up favours sustained oscillations of intracellular metabolism. FEBS 1993;318:80-2
   PubMed Web of Science ®Google Scholar
• Rizzi M, Baltes M, Theobald U, In vivo analysis of metabolic dynamics in Saccharomyces cerevisiae. II: mathematical model. Biotech Bioeng 1997;55:592-08
   PubMed Web of Science ®Google Scholar
• Danø S, Sørensen PG, Hynne F. Sustained oscillations in living cells. Nature 1999;402:320-22
   PubMed Web of Science ®Google Scholar
• Wolf J, Heinrich R. Effect of cellular interaction on glycolytic oscillations in yeast: a theoretical investigation. Biochem J 2000;345:321-34
   PubMed Web of Science ®Google Scholar
• Teusink B, Passarge J, Reijenga CA, Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry. Eur J Biochem 2000;267:5313-29
   PubMed Web of Science ®Google Scholar
• Hynne F, Danø S, Sørensen PG. Full-scale model of glycolysis in Saccharomyces cerevisiae. Biophys Chem 2001;94:121-63
   PubMed Web of Science ®Google Scholar
• Reijenga KA, Westerhoff HV, Kholodenko BN, Control analysis of autonomously oscillating biochemical networks. Biophysic J 2002;82:99-08
   PubMed Web of Science ®Google Scholar